InSightec
InSightec is an Israel-based medical device company that develops MR-guided focused ultrasound (Exablate Neuro/Prime) systems for incisionless neurosurgical treatment of essential tremor and Parkinson's disease, sold to hospitals and treatment centers globally with 160+ systems and 30,000+ patients treated.
- Company typePrivate
- Founded1999
- HeadquartersTirat Carmel, Israel
- Headcount251–500
- GTM typeB2B
- OfferingHardware or Manufacturing
What InSightec does
InSightec Ltd. is an Israel-based, privately held medical device company founded in 1999 that develops and commercializes MR-guided focused ultrasound (MRgFUS) systems for incisionless neurosurgery. Its core product platform, the Exablate family (Exablate Neuro, Exablate Prime, and the international ExAblate 4000), uses high-intensity focused ultrasound beams focused through the intact skull to thermally ablate targets in the thalamus and other deep brain structures, with real-time MRI providing sub-millimeter treatment planning, continuous thermometry, and intra-procedural feedback. The system is FDA-approved for medication-refractory essential tremor and, as of July 2025, for staged bilateral pallidothalamic tractotomy in advanced Parkinson's disease, with more than 30,000 patients treated across 160+ installed systems worldwide.
The company generates revenue through capital equipment sales of Exablate systems to hospitals and treatment centers, supported by service contracts and per-procedure economics billed under CPT code 0398T, with reimbursement secured from Medicare in all 50 US states and major private insurers including Aetna, CIGNA, and Anthem. Distribution is hybrid: direct field sales in core markets combined with a network of regional channel partners and a Fosun-Insightec joint venture in China, backed by regional headquarters in Miami (Americas), Frankfurt (EMEA), Tokyo (Japan/APAC), and Shanghai (China). In December 2025, InSightec spun out Lotus Neuro, a clinical-stage biotechnology company focused on using low-frequency focused ultrasound to enable drug delivery across the blood-brain barrier, initially in glioblastoma and diffuse midline gliomas, while InSightec retained the device innovation and commercialization business. The company has raised over $900M in cumulative equity and debt funding across multiple rounds, including a $150M Series G led by Fidelity Management & Research Company in June 2024 and a $200M credit facility from Perceptive Advisors and The Community Fund in 2022.
InSightec firmographics
Firmographics- Name
- InSightec
- Legal name
- INSIGHTEC Ltd.
- Website
- https://insightec.com
- Company type
- Private
- Founded year
- 1999
- Operating status
- Operating
- Headcount range
- 251–500 employees
- Short description
- InSightec is an Israel-based medical device company that develops MR-guided focused ultrasound (Exablate Neuro/Prime) systems for incisionless neurosurgical treatment of essential tremor and Parkinson's disease, sold to hospitals and treatment centers globally with 160+ systems and 30,000+ patients treated.
- Ownership category
- akta.pro rank
InSightec industry classification
Industry- Product category
- Therapeutic Medical Devices (MR-guided Focused Ultrasound Systems)
- NAICS
- Electromedical and Electrotherapeutic Apparatus Manufacturing (334510)
- SIC
- Surgical & Medical Instruments & Apparatus (3841), Electromedical & Electrotherapeutic Apparatus (3845)
- akta.pro primary industry
- Intraoperative Imaging & Guidance (C-arms, O-arm, IOUS, fluorescence) (HLAHADAH)
Keywords
Where InSightec is headquartered
LocationHeadquarters
- HQ city
- Tirat Carmel
- HQ country
- Israel
- HQ region
- Middle East
Offices6 records
Markets served
InSightec business model
Business model- GTM type
- B2B
- Offering type
- Hardware or Manufacturing
- Cost components
- Technology or R&D, Personnel, Supply Chain, Operations, Marketing or Sales, Infrastructure
Revenue model
- Medical Device Capital Equipment Sales: Insightec generates revenue primarily through the sale and placement of Exablate focused ultrasound systems to hospitals and treatment centers. Systems are installed at medical facilities globally where procedures are performed on patients.
- Treatment Procedures: Hospitals and treatment centers bill for focused ultrasound procedures using CPT code 0398T. Insurance coverage includes Medicare in all 50 states and private insurers including Aetna, CIGNA, and Anthem.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| One time/ perpetual license | Multi-year contract | CPT Code 0398T for MR-guided focused ultrasound procedure |
Go-to-market motion3 records
Distribution channels2 records
Marketing channels6 records
InSightec product offering
Product offeringCore offering
InSightec develops, manufactures, and commercializes the Exablate MR-guided focused ultrasound (MRgFUS) platform, an FDA-approved medical device that enables incisionless neurosurgery for medication-refractory essential tremor and tremor-dominant Parkinson's disease. Hospitals and treatment centers purchase the Exablate systems and use them to perform outpatient thalamotomy procedures with sub-millimeter precision, real-time MRI guidance, and continuous temperature monitoring.
Product overview
InSightec offers a focused ultrasound technology platform centered around the Exablate product line. The flagship Exablate Prime is the current-generation MR-guided focused ultrasound system for incisionless neurosurgery, while Exablate Neuro serves as the FDA-approved indication-specific branding for essential tremor and Parkinson's disease treatment. The ExAblate 4000 is the underlying device platform (known as Exablate Neuro internationally). The company has also spun out Lotus Neuro to advance focused ultrasound for drug delivery across the blood-brain barrier. The platform uses MRI guidance for real-time treatment planning, temperature monitoring, and sub-millimeter precision targeting, enabling outpatient treatment of movement disorders without surgical incisions.
Differentiator
Problem solved
Functional benefit
Brands
- Exablate: MR-guided focused ultrasound platform for incisionless neurosurgery treatment
- Exablate Neuro
- Exablate Prime
- ExAblate 4000
Products and services
- Exablate Prime MR-guided focused ultrasound platform for incisionless neurosurgery, enabling precise treatment of essential tremor and tremor-dominant Parkinson's disease with real-time MRI guidance, sub-millimeter precision, and same-day outpatient treatment. Sold to hospitals and treatment centers.
- Exablate Neuro FDA-approved MR-guided focused ultrasound system specifically designed for treating movement disorders including essential tremor and Parkinson's disease through incisionless thalamotomy procedures. Sold to hospitals, neurosurgeons, and neurologists.
- ExAblate 4000 MR-guided focused ultrasound treatment device that enables incisionless treatment without craniotomy or implants by focusing ultrasound through the skull to treat tremor-causing neural circuits in the thalamus. Sold to Japanese hospitals and treatment centers.
Quantifiable outcome
- 66.8% improvement in motor complications for Parkinson's disease patients
- +4 more outcomes
Companies that use InSightec
Customer profileNamed customers4 records
Segments3 records
Ideal customer profiles3 records
InSightec technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Integration3 records
Feature4 records
InSightec partnerships and signals
Strategic signalPartnerships
Four partnerships are on record, tiered core.
- Florida Atlantic University (FAU)coreFAU's NeuroInnovate Center partners with Insightec to advance focused ultrasound treatments for Alzheimer's and Parkinson's diseases. $1 million funding supports the center. FAU unveiled world's first integrated MRI and focused ultrasound research platform with Insightec technology.
- Lotus NeurocoreInsightec spun out Lotus Neuro, a clinical-stage biotechnology company advancing brain-targeted therapeutics using precision, low-frequency focused ultrasound to enable drug delivery across the blood-brain barrier. Led by former Insightec CSIO Arjun (JJ) Desai. Insightec retains device innovation business while collaborating with Lotus on platform integration.
- GE HealthcarecoreEquipment supplier for FAU's integrated MRI and focused ultrasound research platform. Exablate Prime has expanded compatibility with GE Healthcare MR systems along with Philips and Siemens systems.
- Fosun-Insightec Medical Technology Co. LtdcoreAuthorized distributor in China (Room 710 and 711, 7/F, Building 1, No. 83 Yejiazhai Road, Putuo District, Shanghai, China). Distributes Exablate focused ultrasound systems in the Chinese market.
Scale indicators7 records
Recent moves7 records
Expansion highlights6 records
InSightec competitors and assessment
Company assessmentBroad incumbents
- Medtronic plc: Medtronic is the dominant manufacturer of deep brain stimulation (DBS) systems for movement disorders including essential tremor and Parkinson's disease. It is a direct therapeutic competitor to InSightec for the same patient population, but uses an implantable neurostimulator approach rather than an incisionless modality.
- Stryker Corporation: Stryker is a broad neurosurgical and spine equipment incumbent, including navigation systems and surgical tools used in neurosurgery suites. As the acquirer of MAKO Surgical (where InSightec CEO Maurice Ferré previously led), Stryker is both an industry peer and a relevant comparable for capital equipment commercialization in neurosurgery.
- Boston Scientific Corporation: Boston Scientific offers the Vercise DBS system for Parkinson's disease and essential tremor, positioning it as a competing modality for the same medication-refractory movement-disorder patients that InSightec targets. It is a broad incumbent neuromodulation player with overlapping clinical use cases.
- Abbott Laboratories: Abbott's neuromodulation business (formerly St. Jude Medical) offers the Infinity DBS system for movement disorders. As one of three major DBS manufacturers, it competes for the same clinical patient population as InSightec's Exablate, though through implantable pulse generator technology rather than focused ultrasound.
- Elekta AB: Elekta manufactures the Leksell Gamma Knife system for stereotactic radiosurgery of brain targets, historically used to treat tremor and other functional disorders. It competes with InSightec for hospital neuroscience capital budgets, though Gamma Knife uses radiation rather than focused ultrasound.
Others
- GE Healthcare: GE Healthcare is both a long-standing InSightec shareholder and the supplier of compatible MRI systems used alongside Exablate. It is an enabling partner and ecosystem participant rather than a direct competitor, but its MRI scanner footprint materially affects InSightec's addressable market for system sales.
Direct peers
- EDAP TMS SA: EDAP TMS manufactures the Focal One and Ablatherm high-intensity focused ultrasound (HIFU) devices for prostate cancer and other urological applications. Comparable as a commercial-stage focused ultrasound therapy company selling capital equipment into hospitals globally, though focused on urology rather than neurosurgery.
- Profound Medical Corp. Profound Medical develops the TULSA-PRO and Sonalleve MR-guided focused ultrasound systems for incisionless prostate and uterine fibroid ablation. It is the closest direct peer to InSightec in MR-guided focused ultrasound therapy, addressing a different anatomical indication but using the same core imaging-and-ultrasound integration architecture.
- Chongqing Haifu Medical Technology: Haifu is a China-based pioneer in clinical focused ultrasound ablation (HIFU) systems used across multiple indications including uterine fibroids, liver, and bone tumors. It is a direct technology peer in the focused ultrasound therapy space, although it competes primarily in Asian markets and non-neurological indications.
Emerging players
- Brainlab AG: Brainlab develops image-guided surgery and neurosurgical navigation platforms used in operating rooms worldwide. It is adjacent to InSightec's MR-guidance workflow and competes for hospital neurosurgery capital budgets, though Brainlab's primary offering is software and navigation rather than focused ultrasound ablation.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat6 records
Key risks6 records
Key highlights7 records
Customer concentration
InSightec social profiles
Digital presenceInSightec compliance and trust
Trust signalCompliance2 records
InSightec financial estimates
Financial estimateRevenue estimate
Valuation estimate
InSightec leadership team
Management profileNumber of profiles
Profiles10 records
InSightec subsidiaries and ownership
Company hierarchySubsidiaries1 record
InSightec funding detail
Funding detailFunding overview
Funding rounds14 records
Investors21 records
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
InSightec M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about InSightec
What does InSightec do?
InSightec develops, manufactures, and commercializes the Exablate MR-guided focused ultrasound (MRgFUS) platform, an FDA-approved medical device that enables incisionless neurosurgery for medication-refractory essential tremor and tremor-dominant Parkinson's disease. Hospitals and treatment centers purchase the Exablate systems and use them to perform outpatient thalamotomy procedures with sub-millimeter precision, real-time MRI guidance, and continuous temperature monitoring.
Is InSightec a public or private company?
InSightec is a private company. It is classified as venture growth investor backed and is currently operating.
When was InSightec founded?
InSightec was founded in 1999. It employs 251 to 500 people.
Where is InSightec based?
InSightec is headquartered in Tirat Carmel, Israel, in the Middle East region.
How does InSightec make money?
Two revenue lines are on record. Medical Device Capital Equipment Sales are the primary driver. The others are treatment Procedures.
Who are InSightec's main competitors?
Broad incumbents on record are Medtronic plc, Stryker Corporation, Boston Scientific Corporation, Abbott Laboratories and Elekta AB. GE Healthcare is listed as an others. Direct peers are EDAP TMS SA, Profound Medical Corp. and Chongqing Haifu Medical Technology. Brainlab AG is listed as an emerging player.
Does InSightec have an API?
No public API is recorded for InSightec.
What industry is InSightec in?
InSightec's product category is Therapeutic Medical Devices (MR-guided Focused Ultrasound Systems). Its primary akta.pro industry code is HLAHADAH, Intraoperative Imaging & Guidance (C-arms, O-arm, IOUS, fluorescence). Its NAICS code is 334510 and its SIC code is 3841.