TriNetX
TriNetX is a privately held healthcare technology company that operates a global federated real-world data network of 300M+ patients across 20+ countries, serving pharmaceutical companies, CROs, healthcare providers, and academic researchers with clinical trial planning, site identification, and real-world evidence generation tools.
- Company typePrivate
- Founded2013
- HeadquartersCambridge, United States
- Headcount251–500
- GTM typeB2B
- OfferingSoftware
What TriNetX does
TriNetX is a privately held healthcare technology company that operates a global federated real-world data network connecting pharmaceutical companies, contract research organizations, healthcare providers, and academic researchers to a pool of more than 300 million de-identified patient records spanning 20+ countries and 13,000+ clinical sites. Its core platform, TriNetX LIVE™, is a web-based, no-code interface that enables cohort definition, feasibility analysis, site identification, and patient recruitment support for clinical trials, with patient data remaining within source healthcare organizations and queries traveling to the data through an OMOP-harmonized federated architecture. The product suite is layered: the core LIVE platform is complemented by downloadable datasets (TriNetX Dataworks™), linked EHR-plus-claims longitudinal datasets (TriNetX Linked™), the EVIDEX® pharmacovigilance signal-detection platform (acquired from Advera Health Analytics in 2022), the XetaBase multiomic analytics platform (acquired from Zetta Genomics in 2026), and expert consulting services.
TriNetX firmographics
Firmographics- Name
- TriNetX
- Legal name
- TriNetX, LLC
- Website
- https://trinetx.com
- Company type
- Private
- Founded year
- 2013
- Operating status
- Operating
- Headcount range
- 251–500 employees
- Short description
- TriNetX is a privately held healthcare technology company that operates a global federated real-world data network of 300M+ patients across 20+ countries, serving pharmaceutical companies, CROs, healthcare providers, and academic researchers with clinical trial planning, site identification, and real-world evidence generation tools.
- Ownership category
- akta.pro rank
TriNetX industry classification
Industry- Product category
- Clinical Research Data Platform
- NAICS
- Medical and Diagnostic Laboratories (62151), Computer Systems Design and Related Services (54151)
- SIC
- Services-Medical Laboratories (8071)
- akta.pro primary industry
- Clinical Triage, Care Navigation & Routing Engines (HLALAKAH)
- akta.pro secondary industry
- Diagnostic & Triage Decision Support (HLACAGAA)
Keywords
Where TriNetX is headquartered
LocationHeadquarters
- HQ city
- Cambridge
- HQ country
- United States
- HQ region
- North America
Offices3 records
Markets served
TriNetX business model
Business model- GTM type
- B2B
- Offering type
- Software
- Cost components
- Personnel, Technology or R&D, Marketing or Sales, Operations, Infrastructure
Revenue model
- TriNetX LIVE™ Subscription: Subscription-based access to the federated health data network platform for querying patient populations, site identification, and clinical trial feasibility analysis. Likely operates on annual subscription contracts with enterprise clients.
- Dataset Licensing: Fine-grained, date-stamped de-identified EHR patient datasets (Dataworks™ and Linked™) provided to clients for internal analysis. Data is refreshed regularly (every 3-4 weeks) and available for specific therapeutic areas or pan-therapeutic analyses.
- EVIDEX® Platform Access: Pharmacovigilance signal detection and management platform subscription providing access to safety databases, automated workflows, and compliance tools.
- Consulting Services: Expert consulting services for regulatory engagements, study design, real-world evidence research, external control arms, and epidemiological services.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Subscription | Annual | Enterprise subscription model with customized pricing |
Go-to-market motion3 records
Distribution channels3 records
Marketing channels6 records
TriNetX product offering
Product offeringCore offering
TriNetX operates a global federated health data network connecting 240+ healthcare organizations across 20+ countries with pharmaceutical companies, biotech firms, and academic researchers. The platform enables real-time querying of de-identified patient records (300M+) for clinical trial feasibility, site identification, patient recruitment, and real-world evidence generation. Supporting offerings include downloadable datasets (TriNetX Dataworks™, TriNetX Linked™), the EVIDEX® pharmacovigilance signal detection platform, the XetaBase multiomic analytics platform, and expert consulting services for regulatory engagements and study design.
Product overview
TriNetX operates as a federated health data network company offering a platform-plus-modules architecture. The core product is TriNetX LIVE™, a web-based platform connecting to over 318 million de-identified patient records across 20+ countries, which provides cohort definition, site identification, and real-world evidence generation capabilities. Supporting modules include TriNetX Dataworks™ (downloadable datasets), TriNetX Linked™ (linked claims and EHR data), and EVIDEX® (pharmacovigilance signal detection, originally from Advera Health Analytics acquisition). The company also offers Consulting Services with world-renowned scientific experts and acquired Zetta Genomics' XetaBase platform for multiomic data capabilities. Additional products span Analytics modules (Query Builder, Basic Analytics, Advanced Analytics), collaboration tools (CONNECT), Premium Services, and the TriNetX API for system integration. Data is refreshed every 3-4 weeks and harmonized to OMOP common data model standards.
Differentiator
Problem solved
Functional benefit
Brands
- TriNetX LIVE™: The powerful, no-code real-world data platform for clinical research, connecting researchers to over 300 million global patients through an intuitive, web-based interface.
- EVIDEX®
- TriNetX Dataworks™
- TriNetX Linked™
Products and services
- TriNetX LIVE™ Web-based, no-code real-world data platform that connects researchers to over 300 million de-identified patient records worldwide for clinical trial feasibility analysis, cohort definition, site identification, and HEOR/regulatory evidence generation.
- TriNetX Dataworks™ Downloadable, row-level, de-identified EHR patient data offered in a ready-to-use format for analysis or incorporation into internal research platforms, with datasets aligned to specific therapeutic areas and refreshed every 3-4 weeks.
- TriNetX Linked™ Linked dataset combining enriched EHR with medical and pharmacy claims, mortality, and social determinants of health data to enable detailed longitudinal analysis of patient journeys, costs, and outcomes across care settings.
- Consulting Services Expert-led consulting services covering real-world evidence consulting, RWE research, external control arms, and epidemiological services for regulatory engagements, study design, and evidence generation, delivered by scientists ranked in the top 2% most-cited worldwide.
- TherapyMonitor™ European oncology data service providing patient-level insights from European oncology data, curated by Europe-based oncology experts for real-world analyses of disease prevalence, treatment patterns, and market dynamics.
- TriNetX API Secure API that enables seamless integration of location-based patient data and standardized site intelligence into customers' own systems, allowing researchers to send study queries using medical codes or natural language to receive real-time patient counts, feasibility data, and site intelligence.
- XetaBase Multiomic capture and analytics platform enabling scalable genomic analysis across populations and supporting federated querying across genomic and phenotypic data at population scale.
Quantifiable outcome
- Protocol amendments reduced by up to 50%
- +7 more outcomes
Companies that use TriNetX
Customer profileNamed customers6 records
Segments4 records
Ideal customer profiles4 records
TriNetX technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- Yes
- API docs
- API detail
Core technology
AI maturity
App detail
AI capability7 records
Feature6 records
TriNetX partnerships and signals
Strategic signalPartnerships
Three partnerships are on record, tiered core.
- Zetta GenomicscoreAcquisition of key assets from Zetta Genomics, a Cambridge UK-based healthcare technology company. The acquisition brought Zetta's XetaBase multiomic capture and analytics platform into TriNetX's ecosystem, enhancing genomics data management capabilities. Companies had collaborated since 2024 on federated querying across genomic and phenotypic data.
- DatabrickscoreTriNetX uses Databricks' platform to accelerate drug development processes and improve clinical research efficiency. The collaboration has resulted in reducing protocol amendments by up to 50% and developing predictive models that forecast disease risks years in advance.
- Harvard T.H. Chan School of Public Health / CAUSALabcoreTriNetX Chief Scientific Officer Jeffrey Brown collaborates with Dr. Miguel Hernán, Director of CAUSALab at Harvard, on frameworks for RWD study design and causal inference. Joint webinar planned for July 2026 on practical frameworks for designing rigorous RWD studies.
Scale indicators12 records
Recent moves6 records
Expansion highlights6 records
TriNetX competitors and assessment
Company assessmentBroad incumbents
- IQVIA: IQVIA is the largest contract research organization and real-world evidence provider globally, combining clinical research services with proprietary RWD assets. It competes with TriNetX across clinical trial feasibility, RWE generation, and pharma data analytics, though it is a much broader incumbent with services across the full drug development lifecycle.
- Optum (UnitedHealth Group): Optum operates one of the largest U.S. claims and clinical data assets and competes with TriNetX for pharma RWD, outcomes research, and clinical trial enablement. It is a broad incumbent with significant data scale advantages via UnitedHealth's claims footprint.
- Health Catalyst: Health Catalyst provides healthcare data and analytics infrastructure to providers and life sciences companies. While more provider-anchored, it competes with TriNetX in health data analytics and population-level insights.
- Medidata Solutions (Dassault Systèmes): Medidata is a clinical trial technology platform (Rave EDC, RTSM) that overlaps with TriNetX in clinical trial enablement workflows. Several TriNetX leaders (including COO Steve Kundrot) previously worked at Medidata, illustrating the operational overlap.
- Veradigm (Allscripts): Veradigm combines EHR data with life sciences research enablement via its Veradigm Network and Real-World Data offerings. It competes with TriNetX for de-identified EHR data licensing and clinical research insights.
Direct peers
- Flatiron Health: Flatiron Health (acquired by Roche) operates an oncology-focused real-world data platform aggregating EHR data from oncology clinics. It is a direct competitor in the RWD/RWE space, particularly for oncology trials, with a similar federated approach to oncology patient data.
- ConcertAI: ConcertAI is an oncology-focused real-world data and AI company serving pharma and providers, with a federated data network similar in concept to TriNetX LIVE. It directly competes for pharma RWD and clinical trial feasibility business in oncology.
- Datavant: Datavant provides health data connectivity and de-identification linking services across multiple data sources, similar to TriNetX's Linked™ dataset offering. It is a direct competitor in the federated/linked real-world data infrastructure layer.
Emerging players
- Tempus: Tempus combines molecular/clinical data with AI to support oncology and other therapeutic areas. It is an emerging player in the RWD/RWE space with strong genomics capabilities that increasingly overlaps with TriNetX's XetaBase multiomic offering.
- COTA Healthcare: COTA focuses on real-world oncology data and evidence generation for pharma, similar to ConcertAI and Flatiron. It is an emerging player competing for the same oncology RWE customers TriNetX serves.
Market position
Strengths4 records
Weaknesses4 records
Competitive moat6 records
Key risks6 records
Key highlights7 records
Customer concentration
TriNetX social profiles
Digital presenceTriNetX compliance and trust
Trust signalCompliance4 records
TriNetX financial estimates
Financial estimateRevenue estimate
Valuation estimate
TriNetX leadership team
Management profileNumber of profiles
Profiles14 records
TriNetX subsidiaries and ownership
Company hierarchySubsidiaries2 records
TriNetX funding detail
Funding detailFunding overview
Funding rounds4 records
Investors8 records
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
TriNetX M&A and investment
M&A and investmentM&A4 records
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about TriNetX
What does TriNetX do?
TriNetX operates a global federated health data network connecting 240+ healthcare organizations across 20+ countries with pharmaceutical companies, biotech firms, and academic researchers. The platform enables real-time querying of de-identified patient records (300M+) for clinical trial feasibility, site identification, patient recruitment, and real-world evidence generation. Supporting offerings include downloadable datasets (TriNetX Dataworks™, TriNetX Linked™), the EVIDEX® pharmacovigilance signal detection platform, the XetaBase multiomic analytics platform, and expert consulting services for regulatory engagements and study design.
Is TriNetX a public or private company?
TriNetX is a private company. It is classified as venture growth investor backed and is currently operating.
When was TriNetX founded?
TriNetX was founded in 2013. It employs 251 to 500 people.
Where is TriNetX based?
TriNetX is headquartered in Cambridge, United States, in the North America region.
How does TriNetX make money?
Four revenue lines are on record. TriNetX LIVE™ Subscription is the primary driver. The others are dataset Licensing, EVIDEX® Platform Access and consulting Services.
Who are TriNetX's main competitors?
Broad incumbents on record are IQVIA, Optum (UnitedHealth Group), Health Catalyst, Medidata Solutions (Dassault Systèmes) and Veradigm (Allscripts). Direct peers are Flatiron Health, ConcertAI and Datavant. Emerging players are Tempus and COTA Healthcare.
Does TriNetX have an API?
Yes. TriNetX API enables seamless integration of location-based patient data and standardized site intelligence into users' own systems. The API is part of TriNetX LIVE™ and allows pharmaceutical companies to access real-world data for clinical trial planning across a network spanning 300 million patients in more than 20 countries. The platform allows researchers to send study queries using medical codes or natural language directly from their own systems to receive real-time patient counts, feasibility data, and site intelligence. Enhanced API capabilities were recognized with the Clinical Trial Innovation Award in the 10th annual MedTech Breakthrough Awards program. Developer documentation is at trinetx.com/solutions/trinetx-live/api.
What industry is TriNetX in?
TriNetX's product category is Clinical Research Data Platform. Its primary akta.pro industry code is HLALAKAH, Clinical Triage, Care Navigation & Routing Engines, with a secondary code of HLACAGAA, Diagnostic & Triage Decision Support. Its NAICS code is 62151 and its SIC code is 8071.