What Pluto Biosciences does

Pluto Biosciences, Inc. (operating as Pluto Bio) is a Denver-based, Delaware-incorporated life sciences software company that develops a cloud-based, AI-native multi-omics analysis SaaS platform for translational discovery. The platform supports transcriptomics, proteomics, spatial omics, and multi-omics data integration, with end-to-end single-cell RNA-seq analysis, differential expression, pathway analysis, batch effect correction, and survival analysis capabilities built into a web application with API, Python SDK, and third-party integrations. Its core differentiator is a structured four-module Translational Decision framework (Therapeutic Hypothesis, Target Prioritization, Translational Confidence, Reverse Translation) that connects programs, experiments, datasets, decisions, and scientific evidence in a shared workspace, positioning the product as scientific program management infrastructure rather than a point bioinformatics tool.

The company sells primarily through an enterprise field sales motion targeting pharmaceutical and biotech companies, augmented by a self-serve Lab Space for organic adoption and a tiered referral program ($250-$500 per referral, or 10% commission for CRO/service providers). Revenue is generated via annual subscription SaaS agreements (per-seat and organizational tiers, quote-based and not publicly disclosed) supplemented by a Scientific Insights professional services offering that provides bioinformatics consulting. The customer base spans pharmaceutical companies (including Novo Nordisk, Nimbus Therapeutics, Septerna, Biomea Fusion, Prelude, and an unnamed Top 20 Pharma), academic and research institutions (Harvard, University of Michigan, MD Anderson Cancer Center, Wyss Institute, New York Blood Center), foundations, and CROs. The platform is SOC 2 Type II, GDPR, and CCPA compliant, with AES-256 encryption and continuous trust-center monitoring, supporting enterprise procurement and European data residency requirements.

Pluto was founded as a spinout from Harvard's Wyss Institute for Biologically Inspired Engineering and has raised approximately $8.3 million across three rounds ($1M seed in October 2021, $3.7M seed led by Silverton Partners in May 2023, and $3.6M led by Kickstart in May 2025). The company holds 11-50 employees, distributes primarily in North America with growing European coverage, and is led by Founder and CEO Rani Powers, PhD. Strategic distribution is anchored by a native integration with Benchling R&D Cloud and GraphPad Prism support, embedding Pluto within established R&D software stacks used by major pharma and biotech customers.

Name

Pluto Biosciences

Legal name

Pluto Biosciences, Inc.

Website

https://pluto.bio

Company type

Private

Founded year

2021

Operating status

Operating

Headcount range

11–50 employees

Short description

Pluto Bio is a Denver-based, AI-native multi-omics SaaS platform for translational discovery, serving pharmaceutical, biotech, academic, and research institution customers with integrated omics analysis, decision-review modules, and Benchling-compatible workflows.

Ownership category

akta.pro rank

Product category

Bioinformatics & Multi-Omics Analytics Software

NAICS

Research and Development in Biotechnology (except Nanobiotechnology) (541714), Software Publishers (51321), Computer Systems Design and Related Services (5415)

SIC

Services-Commercial Physical & Biological Research (8731)

akta.pro primary industry

Bioinformatics & Multi-omics Analysis Software (HLAGAJAD)

akta.pro secondary industries

AI/ML Platforms for Drug Discovery & Experiment Optimization (HLAGAJAO), Multi-Omics Precision Medicine Platforms (genomics/proteomics/metabolomics) (HLAAANAF), Scientific Data Management & Data Platforms (SDMS/Data Lakehouse for R&D) (HLAGAJAC)

Keywords

• Multi-omics analysis software
• Bioinformatics SaaS platform
• Translational discovery platform
• Life sciences data analytics
• AI drug discovery tools

Headquarters

HQ city

Denver

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Software

Cost components

Personnel, Technology or R&D, Infrastructure, Marketing or Sales, Operations

Revenue model

1. SaaS Subscription Services: Subscription-based online services for organizing, storing, visualizing, and managing biological data. Subscription terms are annual with automatic renewal. Revenue is generated through per-seat licensing and volume-based tiers for organizations of different sizes.
2. Professional Services: Implementation, configuration, integration, training, and bioinformatics advisory services provided under Statements of Work. Includes Scientific Insights team offering bioinformatics consulting and professional services to augment in-house capabilities of pharma customers.

Pricing tiers

Go-to-market motion2 records

Distribution channels3 records

Marketing channels10 records

Core offering

Pluto Biosciences sells a cloud-based, AI-native multi-omics SaaS platform that enables translational research teams in pharma, biotech, and academia to organize, analyze, visualize, and manage biological data (transcriptomics, proteomics, spatial omics, multi-omics) and make structured go/no-go decisions across therapeutic hypothesis, target prioritization, translational confidence, and reverse translation. The platform is offered via annual subscription with a web app, REST API, Python SDK, and native Benchling integration, supplemented by Scientific Insights professional services for bioinformatics consulting.

Product overview

Pluto Bio is a unified multi-omics platform for translational discovery, combining AI-powered analysis, collaborative workflows, and decision support modules. The core product encompasses the Pluto Bio Platform with four structured decision reviews (Therapeutic Hypothesis, Target Prioritization, Translational Confidence, Reverse Translation), the Research Assistant for AI-powered insights, and the Scientific Insights consulting team. Key capabilities include end-to-end scRNA-seq analysis, batch effect correction, multi-omics integration (RNA-seq, ATAC-seq, ChIP-seq, proteomics), survival analysis, and differential expression analysis. The platform also offers Labspace as the user workspace, API & SDKs for programmatic access, and integration support for Benchling and GraphPad Prism.

Differentiator

Problem solved

Functional benefit

Products and services

• Pluto Bio Platform Core AI-powered, multi-omics SaaS platform for translational discovery that enables scientific teams to organize, analyze, visualize, and manage biological data (transcriptomics, proteomics, spatial, multi-omics) in a unified environment, with four structured Translational Decision modules, AI Research Assistant, and Scientific Canvas. Sold via annual subscription to pharma, biotech, academic, CRO, and foundation customers.
• Pluto API & SDKs Programmatic developer product exposing Pluto's multi-omics data, analyses, and visualizations via REST API and Python SDK so developers can run custom analyses outside the web app and push results back into Pluto.
• End-to-End scRNA-seq Analysis End-to-end single-cell RNA sequencing analysis capability within Pluto, supporting comprehensive scRNA-seq data processing, marker gene expression analysis with UMAP/ridge/violin plots, and biomarker discovery for translational research teams.
• Labspace User workspace within Pluto (app.pluto.bio) where individual users access experiments, analyses, collaborative tools, compute, and storage; also the entry point for self-serve exploration of the platform.
• Scientific Insights (Professional Services) Statement-of-Work bioinformatics consulting and professional services team that augments customer in-house bioinformatics expertise with implementation, configuration, integration, training, and bespoke analysis support.

Quantifiable outcome

• 90% of scientists at a Top 20 Pharma company agreed that Pluto increased efficiency in their scientific work

Named customers12 records

Segments4 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

Yes

API docs

API detail

Core technology

AI maturity

App detail

Integration3 records

AI capability8 records

Feature9 records

Partnerships

Three partnerships are on record, tiered core and minor.

• Wyss Institute at HarvardcoreStrategic or Co-development PartnerThe Wyss Institute for Biologically Inspired Engineering at Harvard University is the founding institution of Pluto Biosciences. The Wyss Brain Targeting Program uses Pluto's target discovery platform to analyze omics data, integrate literature evidence, and identify genes and proteins for brain drug delivery. The relationship includes published research citing Pluto (Nature Communications, Cardiovascular Research).
• BenchlingcoreTechnology or IntegrationNative product integration with Benchling R&D Cloud. The integration allows users to sync interactive Pluto visualizations directly to Benchling, connecting bioinformatics analysis outputs with electronic lab notebooks and R&D workflows used by major pharma and biotech companies.
• Seqera Labs, Form Bio, Code Ocean, Galaxy, BioconductorminorOthersReferenced alongside Pluto in a Harvard article discussing the convergence of AI, cloud computing, and accessible software platforms transforming biological research. Listed as peer platforms in the democratized computational biology ecosystem, not formal partners.

Scale indicators4 records

Recent moves7 records

Expansion highlights6 records

Direct peers

• Benchling: Cloud-based R&D platform for life sciences with electronic lab notebooks, LIMS, and registry capabilities. Directly comparable because Pluto integrates with Benchling and competes for the same translational R&D software budget within pharma and biotech organizations.
• Dotmatics: Scientific informatics platform for R&D spanning ELN, data management, and analytics. Directly comparable as a life sciences R&D SaaS suite targeting similar pharma and biotech translational research workflows.
• DNAnexus: Cloud-based genomics and multi-omics data analysis platform. Directly comparable as cloud-hosted bioinformatics infrastructure used by pharma and clinical research organizations to manage and analyze large-scale omics data.
• Genedata: Enterprise bioinformatics and R&D data analytics platform serving pharma and biotech. Directly comparable as a multi-omics and translational data management software provider with similar enterprise customer base.
• Sapio Sciences: Lab informatics platform combining ELN, LIMS, and scientific data management for life sciences. Comparable as a direct peer offering scientific data management and analysis solutions to pharma and biotech R&D organizations.

Broad incumbents

• Schrödinger: Established computational chemistry, molecular simulation, and AI drug discovery platform. Comparable as a broader, well-capitalized incumbent offering AI-enabled discovery and informatics solutions that overlap with Pluto's AI-native translational discovery positioning.
• QIAGEN Digital Insights (QIAGEN): Bioinformatics and data analysis offerings from QIAGEN spanning genomics, interpretation, and clinical insights. Comparable as a broader incumbent providing multi-omics analysis and interpretation software widely used in translational research.

Emerging players

• Seqera Labs: Workflow orchestration and data analysis platform for genomics and multi-omics. Comparable as an emerging player enabling reproducible computational biology pipelines for translational and clinical research teams.
• Form Bio: Computational biology platform supporting multi-omics workflows and analyses. Comparable as an emerging player in cloud-based bioinformatics and omics analysis tooling for life sciences researchers.
• Code Ocean: Cloud-based computational reproducibility and collaboration platform for scientific research. Comparable as an emerging player offering compute, data management, and reproducibility features used alongside multi-omics workflows.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights6 records

Customer concentration

• Xx.com/tryplutobio
• YouTubeyoutube.com/channel/UCDCnL58lbfFF8oA1YyXH28A
• LinkedInlinkedin.com/company/pluto-biosciences

Compliance3 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles2 records

Funding overview

Funding rounds3 records

Investors2 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Pluto Biosciences