What LIS Technologies does

LIS Technologies Inc. (LIST) is a U.S.-based, privately held nuclear technology company developing the patented CRISLA (Condensation Repression Isotope Selective Laser Activation) process — the only U.S.-origin and patented laser uranium enrichment technology. The company's current-generation CRISLA-3G variant uses infrared lasers at 5.3µm to selectively excite the 3ν3 vibrational mode of 235UF6 molecules, separating them from other isotopes; this approach was independently evaluated at TRL-4 (with 60% of TRL-5 elements met) per DOE guide DOE G 413.3-4A and is positioned to address both LEU production for the existing 94-reactor U.S. civilian fleet and HALEU production for next-generation SMRs and microreactors. LIST's primary revenue streams today are pre-commercial: a prime contractor slot on the U.S. DOE's $3.4 billion / 10-year Low-Enriched Uranium Enrichment Acquisition Program IDIQ (one of six domestic awardees, December 2024), an AFWERX SBIR Phase I feasibility contract (March 2025), and other government/defense research work; commercial LEU and HALEU sales from the planned $1.38 billion LEU-3 facility on LIST Island (206 acres at the historic K-25 site in Oak Ridge, TN) are targeted before 2030. The company also operates the Stable and Medical Isotope Laser Enrichment Program (Project SMILE), extending CRISLA into non-uranium markets such as silicon-28 for advanced semiconductors and quantum computing, and medical isotopes. LIST is led by Executive Chairman & CEO Jay Yu (also founder of NASDAQ-listed NANO Nuclear Energy), President & Co-Founder Christo Liebenberg, and Co-Founder & CTO Dr. Jeff W. Eerkens — the original patent-holder known as the "father of laser enrichment" — alongside senior advisors including former NNSA Deputy Administrator Brent Park, retired Lt. Gen. Hinote (USAF), retired Gen. Paxton (USMC), and former Congressman Shimkus.

Name

LIS Technologies

Legal name

LIS Technologies Inc.

Website

https://laseristech.com

Company type

Private

Founded year

2021

Operating status

Operating

Headcount range

11–50 employees

Short description

LIS Technologies Inc. is a U.S.-based, privately held nuclear-technology company developing the patented CRISLA laser process — the only U.S.-origin patented laser uranium enrichment technology — to produce LEU for the existing 94-reactor U.S. civilian fleet and HALEU for next-generation SMRs and microreactors, serving the DOE, U.S. Air Force, and future utility customers.

Ownership category

akta.pro rank

Product category

Nuclear Fuel Enrichment

NAICS

Irradiation Apparatus Manufacturing (334517)

SIC

X-Ray Apparatus & Tubes & Related Irradiation Apparatus (3844)

akta.pro primary industry

Uranium Enrichment Services (Centrifuge/Laser, SWU Supply) (EUAKACAD)

Keywords

• Laser uranium enrichment
• Isotope separation technology
• Nuclear fuel enrichment
• HALEU production
• Stable isotope enrichment

Headquarters

HQ city

New York

HQ country

United States

HQ region

North America

Offices3 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Technology or R&D, Personnel, Infrastructure, Operations, Marketing or Sales, Supply Chain

Revenue model

1. Government Contract Revenue (DOE IDIQ): Prime contractor on the U.S. Department of Energy's Low-Enriched Uranium (LEU) Enrichment Acquisition Program — a 10-year IDIQ contract worth up to $3.4 billion across six awardees, with a minimum task order value of $2 million. Revenue is task-order based and depends on DOE-issued bids.
2. Defense/Government Research Contracts: SBIR Phase I contract awarded by AFWERX (U.S. Air Force) for feasibility study on enriching uranium to support Department of the Air Force global operations. Additional NRC Facility Clearance enables access to classified matter and further defense contracting opportunities.
3. Future Uranium Enrichment Sales (LEU and HALEU): Planned commercial sales of Low-Enriched Uranium (LEU) and High-Assay Low-Enriched Uranium (HALEU) from the planned LEU-3 commercial facility on LIST Island in Oak Ridge, TN, with a target annual capacity of up to 5.5 million Separative Work Units (SWU). Commercial operations targeted before 2030.
4. Stable and Medical Isotope Sales (Future): Future revenue from enriched stable isotopes (e.g., silicon-28 for advanced semiconductor/AI chips and quantum computing) and medical isotopes, sold via the Stable and Medical Isotope Laser Enrichment Program (Project SMILE). Accepts custom isotope product requests via website form.

Pricing tiers

Go-to-market motion1 record

Distribution channels5 records

Marketing channels7 records

Core offering

LIS Technologies develops and commercializes CRISLA (Condensation Repression Isotope Selective Laser Activation), a U.S.-origin patented laser uranium enrichment technology that uses 5.3μm infrared CO2 lasers to selectively excite 235UF6 molecules for separation. The technology produces Low-Enriched Uranium (LEU) for the existing 94-reactor U.S. fleet and High-Assay Low-Enriched Uranium (HALEU) for next-generation small modular and microreactors, and is being extended via Project SMILE into stable isotopes (e.g., silicon-28) and medical isotopes. Commercial production is being built out at the LEU-3 facility on LIST Island in Oak Ridge, Tennessee, with a target capacity of up to 5.5 million Separative Work Units (SWU) annually.

Product overview

LIS Technologies Inc. operates a single core patented technology platform — CRISLA (Condensation Repression Isotope Selective Laser Activation) and its third-generation variant CRISLA-3G — applied across a portfolio of physical/nuclear products and programs. The core laser uranium enrichment technology powers the flagship commercial LEU-3 Enrichment Facility under the Project F.U.E.L. (Future Uranium Enrichment with Lasers) initiative being built on LIST Island in Oak Ridge, Tennessee. R&D activities for the platform run through the licensed Test Demonstration Facility at the K-1330 building on the historic K-25 site, while a parallel adjacent program, Project SMILE (Stable and Medical Isotope Laser Enrichment Program), extends the same CRISLA technology into stable and medical isotope enrichment for advanced electronics, quantum computing, and healthcare applications.

Differentiator

Problem solved

Functional benefit

Products and services

• CRISLA Laser Uranium Enrichment Technology The only U.S.-origin, USPTO-patented laser uranium enrichment technology, using infrared lasers to selectively excite 235UF6 molecules at the 3ν3 vibrational mode for isotope separation. Conceptualized and patented by Dr. Jeff Eerkens ("the father of laser enrichment") and experimentally demonstrated at LEU levels in the 1980s and 1990s, it serves as the foundational technology platform for all of LIST's uranium and isotope enrichment products.
• CRISLA-3G Third-generation CRISLA laser isotope separation technology featuring a proprietary 5.3μm CO2 laser architecture with high throughput, high duty cycle, and reduced complexity. Designed to demonstrate LEU production in a single stage and HALEU production in two stages with fully scaled and industrialized equipment.
• Low-Enriched Uranium (LEU) Low-Enriched Uranium (LEU) fuel product for the existing 94-reactor U.S. commercial nuclear fleet. Produced via CRISLA-3G technology with a single-stage enrichment process; planned commercial output of up to 5.5 million Separative Work Units (SWU) annually from the LEU-3 facility on LIST Island.
• High-Assay Low-Enriched Uranium (HALEU) High-Assay Low-Enriched Uranium (HALEU) fuel product for next-generation Small Modular Reactors (SMRs) and microreactors. Produced via a two-stage CRISLA-3G enrichment process at the LEU-3 commercial facility planned for LIST Island, Oak Ridge, TN.
• Project SMILE Stable and Medical Isotopes Enriched stable isotopes (including silicon-28 for advanced semiconductors and quantum computing) and medical isotopes for detection, treatment, and theranostic applications, produced via the same CRISLA laser excitation principle applied to non-uranium elements. Customers can request custom isotope products via an online form on laseristech.com.

Quantifiable outcome

• Target annual production of up to 5.5 million Separative Work Units (SWU) of enriched uranium
• +5 more outcomes

Named customers3 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature5 records

Partnerships

Nine partnerships are on record, tiered core, flagship and minor.

• State of Tennessee / Tennessee Department of Economic and Community DevelopmentcoreOthers · 16 January 2026Tennessee Governor Bill Lee and Deputy Governor / Department of Economic and Community Development Commissioner Stuart C. McWhorter jointly announced LIS Technologies' $1.38 billion investment in Oak Ridge alongside company leadership. State support enabled the 206-acre LIST Island acquisition, regulatory licensing (Radioactive Material License), and workforce development for 203 jobs.
• Enveniam, LLC (a Bernhard Capital Partners platform)flagshipImplementation/ SI/ Consulting Partner · 4 November 2025Enveniam signed an agreement with LIS Technologies Inc. to serve as Lead Project Integrator for the development of the laser-based uranium enrichment facility (Project F.U.E.L. / LEU-3 facility) on LIST Island in Oak Ridge, Tennessee. Enveniam will lead engineering, procurement, and construction coordination for the $1.38 billion facility investment on the 206-acre K-25 site.
• American Museum of Science and Energy FoundationminorGTM or Marketing Partner · 20 March 2025LIS Technologies sponsored the 4th Annual Energy & Elements Gala at the American Museum of Science and Energy in Oak Ridge, Tennessee (March 20, 2026) and has been a recurring sponsor of museum and community events to support STEM and nuclear education.
• AFWERX (U.S. Air Force)coreOthers · 7 March 2025LIS Technologies ("LIST") was selected by AFWERX for a SBIR Phase I contract focused on enhancing its Condensation Repression Isotope Selective Laser Activation (CRISLA) technology. Contract covers a feasibility study on enriching uranium to empower Department of the Air Force's global operations.
• NANO Nuclear Energy Inc. (NASDAQ: NNE)flagshipStrategic or Co-development Partner · 1 December 2024NANO Nuclear Energy is a key subcontractor and strategic partner of LIS Technologies under the DOE Low-Enriched Uranium Enrichment Acquisition Program IDIQ contract (Dec 2024). NANO brings technical and regulatory expertise in advanced nuclear solutions including fuel deconversion, fuel fabrication, and fuel transportation. The companies share certain common ownership and commonality of officers and directors (Jay Yu is founder of both). Collaboration goal: vertically integrated fuel pipeline for LEU and HALEU production.
• U.S. Department of Energy (DOE)flagshipStrategic or Co-development Partner · 1 December 2024LIS Technologies is a prime contractor (with NANO Nuclear Energy as subcontractor) on the DOE's Low-Enriched Uranium (LEU) Enrichment Acquisition Program — a $3.4 billion / 10-year IDIQ contract with a minimum $2 million task order value. DOE issues task orders that LIST bids on to support domestic fuel supply chain development for current 94 reactors and future advanced reactors.
• Nuclear Energy Institute (NEI)minorOthers · 1 December 2024LIS Technologies joined the Nuclear Energy Institute (NEI) on March 7, 2025 — a leading policy organization in support of the nuclear energy industry in the United States and abroad. Membership supports policy advocacy and industry collaboration.
• American Nuclear Society (ANS)minorOthers · 1 September 2024LIS Technologies became a member of the American Nuclear Society (ANS), the premier nuclear science organization. The company also sponsored the 2025 ANS Winter Conference & Expo in Washington D.C. (Nov 8-12, 2025) at the Elite Level.
• World Nuclear Association & Nuclear InstituteminorOthers · 1 March 2024LIS Technologies officially joined the World Nuclear Association (WNA), a global advocate for the nuclear industry, and established corporate affiliation with the Nuclear Institute. The company also sponsors the World Nuclear Symposium 2024 and World Nuclear Fuel Cycle 2025/2026 events.

Scale indicators11 records

Recent moves8 records

Expansion highlights6 records

Direct peers

• Centrus Energy: U.S.-based uranium enricher operating HALEU production at the Piketon, Ohio site with NRC-licensed centrifuge capacity. Directly competes with LIS Technologies for DOE LEU/HALEU task orders under the same IDIQ program and the same 94-reactor fleet customers.
• Global Laser Enrichment: Wholly owned by CAMECO and GE Hitachi, GLE holds the SILEX laser enrichment license and operates a test loop at the Paducah, Kentucky site. Pursues commercial-scale laser enrichment using a competing (third-party-origin) laser method, directly overlapping with LIST's domestic laser enrichment thesis.
• NANO Nuclear Energy: NASDAQ-listed (NNE) advanced nuclear micro-reactor and fuel transportation company that is LIST's key subcontractor on the DOE IDIQ and shares executive overlap (Jay Yu, Christo Liebenberg). Competes in adjacent fuel-cycle services (HALEU transport, fuel fabrication, deconversion) and serves as LIST's strategic vertical-integration partner.

Emerging players

• General Matter: U.S. laser uranium enrichment startup that raised a substantial 2024 private round and is explicitly listed alongside LIS Technologies as a beneficiary of domestic enrichment investment. Competes for the same DOE funding and advanced-reactor fuel customers.
• Shine Technologies: U.S. fusion-and-medical-isotope company producing medical isotopes using accelerator and fusion-based technologies. Direct competitor to LIST's Project SMILE medical isotope program.
• Lightbridge Corporation: U.S. advanced nuclear fuel developer designing next-generation metallic fuel rods for SMRs and large reactors. Adjacent peer in the HALEU-fuel value chain that LIST would supply as an upstream enricher.
• NorthStar Medical Radioisotopes: U.S. medical and stable isotope producer competing for the same therapeutic and diagnostic isotope end-markets LIST targets through Project SMILE, using non-laser production methods.

Broad incumbents

• Urenco: Foreign (UK/Germany/Netherlands) centrifuge uranium enrichment incumbent supplying a large share of Western LEU. Provides the incumbent benchmark against which LIST and other U.S. domestic producers are positioning for reshored supply.
• Orano: French state-owned uranium enricher (formerly Areva) operating the Georges Besse II centrifuge plant. Major non-Russian, non-U.S. foreign enricher whose customers LIST could displace in U.S. utility procurement.
• BWX Technologies: U.S. nuclear components, fuel, and naval propulsion specialist. Operates NRC-licensed nuclear fuel fabrication and is a potential competitor/customer for HALEU supply to U.S. Navy propulsion reactors, a use case LIST is also pursuing.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/LaserisTech
• Facebookfacebook.com/profile.php
• Instagraminstagram.com/laseristech
• LinkedInlinkedin.com/company/laser-isotope-separation-technologies-lis-technologies-inc

Compliance8 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles12 records

Subsidiaries1 record

Funding overview

Funding rounds6 records

Investors3 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about LIS Technologies