WISE
WISE S.p.A. is an Italian medical device company that develops stretchable implantable electrodes for intraoperative neuromonitoring and spinal cord stimulation using its proprietary Supersonic Technology, serving hospitals and neurosurgical centers in Europe, the US, and Australia.
- Company typePrivate
- Founded2011
- HeadquartersCologno Monzese, Italy
- Headcount11–50
- GTM typeB2B
- OfferingHardware or Manufacturing
What WISE does
WISE S.p.A. is an Italian medical device company founded in 2011 and headquartered in Cologno Monzese (Milan), with an independent branch in Berlin. The company develops implantable electrodes for two clinical applications: intraoperative neurophysiological monitoring (IONM) during brain tumor and epilepsy surgeries via the commercially available WISE Cortical Strip (WCS), and spinal cord stimulation (SCS) for chronic pain via the Heron lead, currently in development. Its differentiation rests on proprietary Supersonic Technology, a patented manufacturing process that embeds platinum or iridium nanoparticles inside polymer substrates at high velocity to form conductive nanocomposite layers, enabling stretchable, flexible, biocompatible electrodes as thin as a few microns that conform intimately to neural tissue. The WISE Cortical Strip holds CE marking under EU MDR (the first cortical strip for IONM to do so), FDA 510(k) clearance (K221123), and TGA approval (ARTG #413731); ISO 13485:2016 certification covers design, production, and sales at the Milan manufacturing site.
The company generates revenue through hardware sales of the WISE Cortical Strip, distributed via exclusive regional partners — EB Neuro (Italy), Soinde Neuro (Spain), Neuroclast (Australia), and Axontronic (Germany/Austria) — supplemented by direct sales activity led by a Director of Sales covering Northwestern Italy. Pricing is quote-based and not publicly disclosed. Beyond its commercial monitoring business, WISE is pursuing a Heron lead, the first expandable percutaneous multicolumn lead for SCS, toward regulatory certification and first-in-human study, funded by an oversubscribed €30 million Series D closed in June 2026. The company's long-term "WISEinside" vision contemplates licensing its stretchable-electronics platform into non-medical verticals such as wearables, optics, and aerospace. Customer segments are hospitals and neurosurgical centers performing brain tumor and epilepsy resection, with pain management clinics representing a secondary future segment tied to the Heron SCS indication.
WISE firmographics
Firmographics- Name
- WISE
- Legal name
- WISE SpA
- Website
- https://wiseneuro.com
- Company type
- Private
- Founded year
- 2011
- Operating status
- Operating
- Headcount range
- 11–50 employees
- Short description
- WISE S.p.A. is an Italian medical device company that develops stretchable implantable electrodes for intraoperative neuromonitoring and spinal cord stimulation using its proprietary Supersonic Technology, serving hospitals and neurosurgical centers in Europe, the US, and Australia.
- Ownership category
- akta.pro rank
WISE industry classification
Industry- Product category
- Neurostimulation Medical Devices
- NAICS
- Electromedical and Electrotherapeutic Apparatus Manufacturing (334510)
- SIC
- Electromedical & Electrotherapeutic Apparatus (3845)
- akta.pro primary industry
- Implantable Neuromodulation & Neurostimulation (SCS/DBS/VNS/PNS) (HLAHAEAK)
Keywords
Where WISE is headquartered
LocationHeadquarters
- HQ city
- Cologno Monzese
- HQ country
- Italy
- HQ region
- Europe
Offices2 records
Markets served
WISE business model
Business model- GTM type
- B2B
- Offering type
- Hardware or Manufacturing
- Cost components
- Personnel, Operations, Technology or R&D, Marketing or Sales, Infrastructure, Supply Chain
Revenue model
- Medical Device Hardware Sales: WISE generates revenue through the sale of its medical device products including the WISE Cortical Strip (WCS) for intraoperative neuromonitoring and the Heron lead for spinal cord stimulation. Products are sold through direct sales and regional distribution partners.
- WISEinside Licensing: The company indicates broader potential through its 'WISEinside' vision to provide electrodes for applications beyond medical devices including wearable devices, optics, aerospace industry, and other fields requiring stretchable electronics.
Go-to-market motion3 records
Distribution channels4 records
Marketing channels5 records
WISE product offering
Product offeringCore offering
WISE S.p.A. develops and manufactures a new generation of implantable leads for neuromonitoring and neuromodulation, built on its proprietary Supersonic Technology. Its commercially available product is the WISE Cortical Strip (WCS), a single-use platinum electrode array for intraoperative neurophysiological monitoring (IONM) during brain tumor and epilepsy surgeries, while the Heron lead, an expandable percutaneous multicolumn paddle lead for Spinal Cord Stimulation (SCS), is in development. The company also offers the WCS Link connecting cable as an accessory and pursues a broader 'WISEinside' vision for licensing its stretchable electrode technology to non-medical applications.
Product overview
WISE is a medical device company developing a new generation of implantable leads for neuromonitoring and neuromodulation using its proprietary Supersonic Technology. The company offers two distinct product families under the WISEneuro® brand: the Monitoring family (anchored by the commercially available WISE Cortical Strip) and the Modulation family (featuring the Heron® lead in development). The Supersonic Technology enables stretchable, flexible electrodes embedded in thin elastomeric foils, providing superior conformability and adaptability for neural applications. The product portfolio also includes the WCS Link connecting cable as an accessory.
Differentiator
Problem solved
Functional benefit
Brands
- WISEneuro: Product portfolio brand for neuromonitoring and neuromodulation products including WISE Cortical Strip and Heron lead
- Heron
- WCS (WISE Cortical Strip)
- Supersonic Technology
- WISEinside
Products and services
- WISE Cortical Strip (WCS) A single-use sterile medical device for Intraoperative Neurophysiological Monitoring (IONM) during brain tumor and epilepsy surgeries. Comprises stretchable platinum electrodes embedded in a soft, thin (0.25 mm) medical-grade silicone film, offering extreme conformability to the brain surface, minimum impedance, and maximum stability for hospitals and neurosurgical centers.
- Heron lead The first expandable percutaneous lead for Spinal Cord Stimulation (SCS), built on the EXPandable PERcuTaneous (EXPERT) concept. A multicolumn paddle lead that can be folded into a catheter for percutaneous insertion and then expand like a heron's wings after implantation, combining the coverage and energy efficiency of paddle leads with the minimally invasive implantation of cylindrical leads. Aimed at interventional pain practitioners and pain management clinics treating chronic pain patients.
- WCS Link
Quantifiable outcome
- Lower electrical impedance under physiological conditions demonstrated in WIN study
- +2 more outcomes
Companies that use WISE
Customer profileNamed customers2 records
Segments2 records
Ideal customer profiles2 records
WISE technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Feature6 records
WISE partnerships and signals
Strategic signalPartnerships
Five partnerships are on record, tiered strategic and core.
- SMARTSPINE Consortium Partnersstrategic€2.4 million collaborative project with Newronika S.p.A., Università degli Studi di Milano, and FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA. Ranked 6th out of 138 proposals in Regione Lombardia's Collabora & Innova call. Aims to develop new-generation neuromodulation system combining advanced sensors, adaptive intelligence, and novel materials.
- Axontronic GmbHcoreExclusive distribution agreement signed May 2024 for Germany and Austria market. Axontronic aims to serve healthcare professionals as partner of choice in Clinical and Surgical Neurophysiology.
- Neuroclast Pty LtdcoreExclusive distribution agreement signed December 2023 for Australian market. Neuroclast is described as a novel and industry-leading distributor of cutting-edge clinical neuroscience technologies.
- Soinde Neuro S.L.coreExclusive distribution agreement signed October 2023 for Spanish market for distribution of WISE Cortical Strip.
- EB Neuro SpAcoreExclusive distribution agreement signed September 2023 for Italian market. EB Neuro is a leading Italian provider of cutting-edge neurophysiological and neurodiagnostic solutions.
Scale indicators5 records
Recent moves7 records
Expansion highlights6 records
WISE competitors and assessment
Company assessmentBroad incumbents
- Medtronic: Global leader in neuromodulation with the broadest portfolio of spinal cord stimulation systems (Intellis with Vanta, Inceptiv). Directly competes with WISE's Heron lead in the SCS market and dominates IONM-adjacent neurosurgical device categories.
- Abbott (formerly St. Jude Medical): Markets Proclaim XR and Eterna SCS systems following its St. Jude Medical acquisition. A direct competitor in SCS and a potential acquirer of WISE given portfolio gaps in stretchable electrode technology.
- Integra LifeSciences (PMT): Owns PMT, a leading supplier of cortical electrodes and depth electrodes for IONM and epilepsy monitoring. The most direct incumbent competitor to WISE's WISE Cortical Strip in neurosurgical IONM.
Others
- Boston Scientific: Major SCS player with the WaveWriter Alpha and Precision Montage systems. Competes head-on with the Heron lead in chronic pain and has the scale to outpace WISE in commercial reach and clinical evidence generation.
Direct peers
- Nevro: Pure-play SCS company with the Senza and HFX platforms, including 10 kHz high-frequency therapy. Closest direct competitor to WISE's Heron lead given its focus on differentiated waveform/lead technology in chronic pain.
- Ad-Tech Medical: Specialist manufacturer of intracranial electrodes for epilepsy monitoring, IONM, and research. Directly competes with the WISE Cortical Strip in intraoperative neurophysiological monitoring electrode category.
- DIXI Medical: European manufacturer of intracranial electrodes (SEEG, strip, depth) for epilepsy surgery and IONM. Closest European-headquartered peer to WISE's Cortical Strip business with overlapping neuroscience applications.
Emerging players
- Saluda Medical: Closed-loop SCS developer with the Evoke system that measures evoked compound action potentials. Comparable to WISE in stage (commercializing a sensing-enabled SCS) and focus on next-generation lead technology.
- Mainstay Medical: Developer of the ReActiv8 implantable neurostimulator for restorative therapy in chronic low back pain. Comparable to WISE as a smaller, technology-differentiated neuromodulation challenger backed by European investors.
- SPR Therapeutics: Pioneer of peripheral nerve stimulation (PNS) with the Sprint PNS system. Overlaps with WISE's stretchable electrode know-how and neuromodulation focus, though targeting a different anatomical application.
Market position
Strengths5 records
Weaknesses4 records
Competitive moat5 records
Key risks6 records
Key highlights7 records
Customer concentration
WISE social profiles
Digital presenceWISE compliance and trust
Trust signalCompliance7 records
WISE financial estimates
Financial estimateRevenue estimate
Valuation estimate
WISE leadership team
Management profileNumber of profiles
Profiles22 records
WISE funding detail
Funding detailFunding overview
Funding rounds8 records
Investors19 records
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
WISE M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about WISE
What does WISE do?
WISE S.p.A. develops and manufactures a new generation of implantable leads for neuromonitoring and neuromodulation, built on its proprietary Supersonic Technology. Its commercially available product is the WISE Cortical Strip (WCS), a single-use platinum electrode array for intraoperative neurophysiological monitoring (IONM) during brain tumor and epilepsy surgeries, while the Heron lead, an expandable percutaneous multicolumn paddle lead for Spinal Cord Stimulation (SCS), is in development. The company also offers the WCS Link connecting cable as an accessory and pursues a broader 'WISEinside' vision for licensing its stretchable electrode technology to non-medical applications.
Is WISE a public or private company?
WISE is a private company. It is classified as venture growth investor backed and is currently operating.
When was WISE founded?
WISE was founded in 2011. It employs 11 to 50 people.
Where is WISE based?
WISE is headquartered in Cologno Monzese, Italy, in the Europe region.
How does WISE make money?
Two revenue lines are on record. Medical Device Hardware Sales are the primary driver. The others are WISEinside Licensing.
Who are WISE's main competitors?
Broad incumbents on record are Medtronic, Abbott (formerly St. Jude Medical) and Integra LifeSciences (PMT). Boston Scientific is listed as an others. Direct peers are Nevro, Ad-Tech Medical and DIXI Medical. Emerging players are Saluda Medical, Mainstay Medical and SPR Therapeutics.
Does WISE have an API?
No public API is recorded for WISE.
What industry is WISE in?
WISE's product category is Neurostimulation Medical Devices. Its primary akta.pro industry code is HLAHAEAK, Implantable Neuromodulation & Neurostimulation (SCS/DBS/VNS/PNS). Its NAICS code is 334510 and its SIC code is 3845.