What Biotalys does

Biotalys NV is a Belgian AgTech company that develops protein-based biocontrol products for crop protection using its proprietary AGROBODY™ / AGROBODY Foundry™ 2.0 platform, an antibody-engineering technology that produces proteins with novel modes of action against fungal and insect pests. Founded in 2013 as a spin-off from VIB (Flanders Institute for Biotechnology) and headquartered in Ghent, Belgium, the company listed on Euronext Brussels in July 2021 (ticker: BTLS). Its lead product, the biofungicide EVOCA™, became the first protein-based biocontrol to receive full U.S. EPA registration in December 2025 and the first AGROBODY product to gain U.S. state registration (Florida) in April 2026; the next-generation commercial candidate EVOCA NG is targeted for U.S. registration in 2028-2029 and EU registration in 2029-2030. The pipeline extends to BioFun-6 (a higher-potency biofungicide candidate), a bioinsecticide co-developed with Syngenta (first research milestone achieved April 2026), and a post-harvest biofungicide developed with AgroFresh Solutions.

Biotalys is currently pre-commercial, with future revenue expected to come from direct enterprise sales to high-value fruit and vegetable growers (grapes, strawberries, tomatoes, cucurbits), supplemented by partnership-based commercialization: Syngenta for bioinsecticides, AgroFresh for post-harvest applications, and 21st.BIO for industrial-scale precision fermentation manufacturing. The company has reported a 2025 net loss of €15.8M (vs €13.2M in 2024), ended 2025 with €8.0M of cash, and in February 2026 cut approximately 30 jobs (~half its workforce) as part of a strategic refocus to save €20M by end-2028; it subsequently closed a €12.05M private placement in May 2026 to extend its cash runway.

Revenue mechanics today consist almost entirely of one-off R&D milestone payments (e.g., from Syngenta) and dilutive equity financings (€54.6M IPO in 2021, €15M in October 2024, €12.05M in May 2026), with no recurring product sales until EVOCA NG launches in 2028-2030. Customer segments are B2B enterprise growers and ag-input distributors in the U.S. (initially California and Florida) and the EU, with a combined target market estimated at approximately USD 1.1-1.2 billion. Backed by more than 25 patents, 700+ field trials across 10 countries, and recognition from the EPA, FRAC (new F10 class), IBMA (Bernard Blum Award 2024), and FoodTech 500 (#32 in 2025), the company is positioning AGROBODY-based biocontrols as a third category of crop protection that combines biological safety with chemical-like performance.

Name

Biotalys

Legal name

Biotalys NV

Website

https://biotalys.com/

Company type

Public

Founded year

2013

Operating status

Operating

Headcount range

51–100 employees

Short description

Biotalys is a Belgian AgTech company developing protein-based biocontrol crop protection products using its proprietary AGROBODY™ platform, targeting fruit and vegetable growers through partnerships ahead of its first commercial launch in 2028-2030.

Ownership category

akta.pro rank

Product category

Agricultural Biologicals / Crop Protection Biocontrols

NAICS

Pesticide and Other Agricultural Chemical Manufacturing (325320)

SIC

Agricultural Chemicals (2870)

akta.pro primary industry

Bio-based Fertilizers, Soil Amendments & Biostimulants (Digestate-derived, biochar-based inputs) (EUAAAIAH)

akta.pro secondary industry

Bio-based Pharmaceuticals, Nutraceuticals & Specialty Bioactives (EUAAAIAK)

Keywords

• Protein-based biocontrols
• Crop protection products
• Agricultural biotechnology
• Biofungicide solutions
• Precision fermentation

Headquarters

HQ city

Ghent

HQ country

Belgium

HQ region

Europe

Offices2 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Technology or R&D, Personnel, Supply Chain, Operations, Marketing or Sales

Revenue model

1. Pre-commercial / R&D stage: Biotalys is pre-commercial; first revenue-generating product (EVOCA NG) targeted for 2028-2029 (U.S.) and 2029-2030 (EU). Reported 2025 net loss of €15.8M (vs €13.2M in 2024) and €8.0M cash at year-end 2025, with runway only until end of May 2026.
2. Partnership milestone payments (e.g., Syngenta bioinsecticide collaboration): Biotalys receives milestone payments from R&D and co-development partners (e.g., Syngenta paid a first milestone in April 2026 for progress on a bioinsecticide using AGROBODY technology). Such payments are expected to be one-off milestone receipts tied to research and development progress.
3. Future biocontrol product sales (EVOCA NG, post-harvest biofungicides): Future revenue expected from direct product sales and/or partnership-based commercialization of EVOCA NG (targeted U.S. 2028-29, EU 2029-30) and post-harvest biofungicides developed with AgroFresh. Target market of approximately USD 1.1-1.2 billion combined U.S./EU.
4. Post-harvest market product sales (with AgroFresh): Future revenue from biological fungicides for post-harvest use to reduce food waste caused by fungal decay, co-developed with AgroFresh Solutions for global post-harvest supply chains.

Pricing tiers

Go-to-market motion3 records

Distribution channels5 records

Marketing channels8 records

Core offering

Biotalys develops and commercializes protein-based biocontrol products for crop protection using its proprietary AGROBODY™ technology platform. Its lead product EVOCA is a protein-based biofungicide that received full U.S. EPA registration in December 2025, targeting Botrytis and powdery mildew in high-value fruits and vegetables. The next-generation candidate EVOCA NG, the pipeline candidate BioFun-6, a bioinsecticide co-developed with Syngenta, and a postharvest biofungicide developed with AgroFresh extend the portfolio across the food value chain.

Product overview

Biotalys offers a unified platform-plus-product portfolio: the proprietary AGROBODY Foundry™ (currently in its AGROBODY 2.0 version) technology platform is the engine that rapidly generates novel protein-based biocontrols, while named product candidates are built on top of it. The first product derived from this platform is EVOCA™, a protein-based biofungicide that received full U.S. EPA registration in December 2025 and achieved its first U.S. state registration (Florida) in April 2026. The next-generation candidate EVOCA NG, the pipeline candidate BioFun-6, a bioinsecticide co-developed with Syngenta, and a postharvest biofungicide developed with AgroFresh are all built on the same AGROBODY platform and together target pre- and post-harvest crop protection across the food value chain.

Differentiator

Problem solved

Functional benefit

Brands

• EVOCA: Biotalys' first protein-based biofungicide, the first of its kind approved by the U.S. EPA (December 2025), targeting Botrytis and powdery mildew in high-value fruits and vegetables (grapes, tomatoes, strawberries, cucurbits) with a new FRAC F10 mode of action.
• EVOCA NG
• AGROBODY Foundry
• BioFun-6

Products and services

• AGROBODY Foundry™ Proprietary protein-engineering technology platform that rapidly generates novel protein-based biocontrols with new modes of action, designed to combine multiple AGROBODY bioactives into a single product to expand optionality and lower resistance risk. Manufactured via industrial-scale precision fermentation.
• EVOCA™ Biotalys' first protein-based biofungicide, targeting fungal pathogens (Botrytis and powdery mildew) in high-value crops such as grapes, tomatoes, strawberries, and cucurbits. Tested in over 700 field trials across 10 countries since 2017, with a clean residue profile (exempt from MRLs) suitable for spray rotation programs.
• EVOCA NG Biotalys' next-generation biofungicide candidate, the lead commercial product, targeting a combined U.S. and European market estimated at around USD 1.1-1.2 billion. Production will be supported by the strategic partnership with 21st.BIO's precision fermentation platform.
• BioFun-6 Next-generation biofungicide candidate in Biotalys' pipeline targeting Botrytis (grey mould) and powdery mildew in high-value fruits and vegetables. Demonstrated the same level of performance as EVOCA at significantly lower dosage rates, highlighting increased potency.
• Bioinsecticide (Syngenta collaboration) Bioinsecticide co-developed with Syngenta using Biotalys' AGROBODY technology to address key insect pests. Aims to address growing insect resistance and tightening regulatory constraints on conventional chemistries; Syngenta will lead future commercialization.
• Postharvest Biofungicide (AgroFresh collaboration) Biological fungicide for post-harvest use in food supply chains being developed in collaboration with AgroFresh Solutions to reduce food waste caused by fungal decay in high-value, highly perishable crops.

Quantifiable outcome

• BioFun-6 AGROBODY biocontrol candidate achieved same level of performance as EVOCA at significantly lower dosage rates (2/3 dose against Botrytis in grapes; 1/2 dose against powdery mildew in cucumber).
• +4 more outcomes

Named customers2 records

Segments4 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature6 records

Partnerships

Five partnerships are on record, tiered flagship and core.

• SyngentaflagshipStrategic or Co-development Partner · 7 April 2026Strategic co-development partnership to develop a novel bioinsecticide using Biotalys' AGROBODY technology against key insect molecular targets. In April 2026 the partners achieved the first research milestone (promising in vitro results), with Syngenta making a milestone payment; both parties will proceed to the next research phase (in vivo testing on living organisms). Targets growing insect resistance and tightening regulatory constraints on conventional chemistries.
• Gates FoundationcoreStrategic or Co-development Partner · 9 February 2026Biotalys continues its collaboration with the Gates Foundation despite the February 2026 restructuring; one of three named external collaborations alongside Syngenta and AgroFresh that the company plans to maintain.
• 21st.BIOflagshipStrategic or Co-development Partner · 23 January 2026Strategic partnership to leverage 21st.BIO's precision fermentation platform for large-scale, cost-competitive production of Biotalys' AGROBODY biocontrol products. Supports Biotalys' first commercial biofungicide EVOCA NG, targeting a combined U.S./EU market estimated at USD 1.1-1.2 billion, with regulatory submissions planned for 2028-29 in the U.S. and 2029-30 in the EU. Replaces Biotalys' prior collaboration with Novonesis, whose technology underpins 21st.BIO's platform.
• AgroFresh SolutionscoreStrategic or Co-development Partner · 28 May 2025Collaboration to develop sustainable biological fungicides for post-harvest use in food supply chains, providing environmentally friendly solutions to reduce food waste caused by fungal decay in fresh produce. Targets the highly perishable, high-value produce market.
• VIB (Flanders Institute for Biotechnology)flagshipStrategic or Co-development Partner · 1 January 2013Biotalys was founded in 2013 as a spin-off from VIB (Flanders Institute for Biotechnology). VIB participated as a shareholder in the May 2026 private placement, indicating an ongoing strategic and shareholder relationship.

Scale indicators15 records

Recent moves7 records

Expansion highlights6 records

Broad incumbents

• Novonesis (formerly Novozymes): Global leader in industrial enzymes and microbial biotechnology, with a substantial biocontrol and biopesticide portfolio (formerly Novozymes BioAg). Directly comparable as a broad incumbent in biological crop protection whose fermentation technology underpins Biotalys' new manufacturing partner 21st.BIO.
• Syngenta: Global #1 crop protection company with both a large conventional chemistry portfolio and growing biologicals business. Both Biotalys' partner (bioinsecticide co-development) and a future competitor as a broad incumbent in the same high-value crop segments Biotalys targets.
• Bayer Crop Science: Global crop protection and seed major with extensive biologicals offerings alongside its chemistry portfolio. Comparable as a broad incumbent with overlapping biocontrol products (e.g., Serenade, Sonata) competing for the same high-value fruit and vegetable growers.
• BASF Agricultural Solutions: Global crop protection major with both chemistry and biologicals portfolios, including biofungicides (e.g., Serifel) targeting Botrytis and powdery mildew in fruit and vegetables. Directly comparable as a broad incumbent competing in Biotalys' target disease-crop segments.

Emerging players

• Indigo Ag: U.S.-based agricultural technology company developing microbial seed treatments and biological crop inputs, with overlapping pre-commercial biological crop protection products and similar reliance on deep venture capital and partnership-driven commercialization.
• Pivot Bio: U.S.-based agtech company developing microbial nitrogen-fixing crop nutrition products, with overlap in the protein-/microbe-based crop input category and similar partnership-driven go-to-market. Comparable as a venture-backed biological input developer with similar capital-intensity and partnership-led commercialization model.
• Bioceres Crop Solutions: Argentina-based agricultural biotechnology company developing biological crop inputs including biofungicides and bioinsecticides, with comparable pre-commercial biological pipeline and Latin American commercialization footprint that complements Biotalys' U.S./EU focus.

Direct peers

• Koppert Biological Systems: Dutch global leader in biological crop protection with a broad portfolio of biopesticides and bumblebee pollination. Comparable as a focused biologicals company headquartered in the Netherlands, targeting the same high-value European fruit and vegetable growers with overlapping biocontrol offerings.
• AgBiome: U.S.-based agricultural biotechnology company developing biological crop protection products from microbial collections, with a similar pre-commercial / early-commercial model targeting high-value crop disease and pest control. Directly comparable as a venture-backed microbial/protein-based biocontrol developer competing for the same grower segments.

Others

• AgroFresh Solutions: Global post-harvest solutions provider for fresh produce. Listed as Biotalys' partner for post-harvest biofungicides rather than a direct competitor; included because it represents the channel through which Biotalys' post-harvest pipeline reaches the global market and provides context on Biotalys' go-to-market dependencies.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/biotalys
• LinkedInlinkedin.com/company/biotalys-nv

Compliance4 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles11 records

Subsidiaries1 record

Funding overview

Funding rounds10 records

Investors18 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Biotalys