What Mass General Brigham does

Mass General Brigham is a 501(c)(3) non-profit integrated healthcare delivery system headquartered in Somerville, Massachusetts, formed in 1994 through the merger of Massachusetts General Hospital and Brigham and Women's Hospital (originally as Partners HealthCare, rebranded in 2019). The system operates 14+ hospitals and numerous outpatient, urgent care, rehabilitation, and home-hospital sites across Massachusetts and New Hampshire, including flagship academic medical centers Mass General and Brigham and Women's, alongside specialty institutions such as Mass Eye and Ear, McLean Hospital, the Spaulding Rehabilitation network, and community hospitals from Martha's Vineyard to Wentworth-Douglass. It also owns a health plan and a specialty pharmacy. The system serves approximately 2.5 million patients annually through an integrated care delivery model with Harvard Medical School teaching affiliations, runs one of the largest hospital-based research enterprises in the U.S. with an annual research budget of nearly $2 billion, and has 3,700+ ongoing clinical trials.

Revenue is generated through five streams: patient care services billed to insurers and patients (subject to CMS machine-readable charge disclosures), research grants and clinical trial funding (NIH, pharma), graduate medical education, technology commercialization and venture investments via Mass General Brigham Innovation, and insurance premiums through Mass General Brigham Health Plan. The system is governed as a non-profit with no parent company or equity ownership; CEO Anne Klibanski earned $8.4M in fiscal year 2024 and the top 14 executives combined for $35.9M.

The technology stack includes an enterprise EHR backbone, the Patient Gateway patient portal (Epic MyChart-based), and a substantial proprietary AI portfolio: the APOLLO foundation model trained on 25.2 billion medical events, the BRIDGE multilingual clinical LLM benchmark with a 100+ model leaderboard, FaceAge (computer-vision mortality predictor), the RECTIFIER clinical-trial eligibility screener now spun out into AIwithCare, an 88%-accuracy intimate-partner-violence risk model, polygenic risk scores for 8 cardiovascular conditions validated on the 53,000-patient Biobank, AI scribes reducing clinician burnout by 21.2% over 84 days, and the Care Connect AI-powered telehealth platform built with K Health. AI deployment is led by Chief Health Information Officer Rebecca Mishuris and Chief Information and Digital Officer Jane Moran under a documented cautious, evidence-based governance posture.

Name

Mass General Brigham

Legal name

Mass General Brigham Incorporated

Website

https://massgeneralbrigham.org

Company type

Private

Founded year

1994

Operating status

Operating

Headcount range

5,001–10,000 employees

Short description

Mass General Brigham is a non-profit integrated healthcare system operating 14+ hospitals across Massachusetts and New Hampshire, serving 2.5 million patients annually through academic medical centers, community hospitals, and a $2 billion research enterprise. It monetizes patient care, research grants, health-plan premiums, and an emerging portfolio of proprietary clinical AI tools.

Ownership category

akta.pro rank

Product category

Integrated Hospital and Healthcare Delivery Services

NAICS

General Medical and Surgical Hospitals (622110), General Medical and Surgical Hospitals (62211)

SIC

Services-Hospitals (8060), Services-General Medical & Surgical Hospitals, Nec (8062), Services-Home Health Care Services (8082)

akta.pro primary industry

Community & Regional General Hospitals (HLAFAAAB)

akta.pro secondary industries

Hospital-at-Home / Acute Care at Home Programs (HLAFAEAH), Hospital-at-Home & Acute Virtual Care Platforms (HLALABAC), Primary Care & General Medicine Virtual Care (HLALAAAA), Virtual Specialty Care Platforms (tele-stroke, tele-ICU, tele-derm, tele-cardiology) (HLALABAD), Home Health Remote Patient Monitoring & Virtual Nursing Providers (HLAFAEAN)

Keywords

• Integrated healthcare delivery
• Academic medical centers
• Clinical research services
• Telehealth and virtual care
• Graduate medical education

Headquarters

HQ city

Somerville

HQ country

United States

HQ region

North America

Offices18 records

Markets served

GTM type

B2C

Offering type

Services

Cost components

Personnel, Operations, Technology or R&D, Infrastructure, Supply Chain, Marketing or Sales

Revenue model

1. Patient Care Services: Core revenue from providing medical care services across hospitals, outpatient facilities, and virtual care platforms. Services are billed to patients and insurance providers through established medical billing processes with negotiated rates with insurance companies.
2. Research Grants and Clinical Trials: Mass General Brigham operates one of the largest hospital-based research enterprises in the U.S. with an annual research budget of nearly $2 billion, funded by NIH grants, pharmaceutical company partnerships, and other research funding sources.
3. Graduate Medical Education: Revenue from residency and fellowship training programs across multiple specialties, preparing future healthcare professionals.
4. Innovation and Venture Investments: Mass General Brigham Innovation manages venture capital investments and licensing of technologies developed by researchers. The system has spun out companies including AIwithCare. Also manages corporate partnerships and technology commercialization.
5. Health Plan Operations: Mass General Brigham Health Plan provides insurance products including Mass General Brigham Health Plan, Health Plan Select, and Health Insurance Company, offering insurance coverage to individuals and employers.

Pricing tiers

Go-to-market motion3 records

Distribution channels7 records

Marketing channels6 records

Core offering

Mass General Brigham is an integrated, non-profit academic healthcare delivery system that provides comprehensive medical care across 14+ hospitals, outpatient facilities, and 24/7 virtual care platforms, serving approximately 2.5 million patients annually. The system also operates one of the largest U.S. hospital-based research enterprises with nearly $2 billion in annual funding, supports over 3,700 active clinical trials, and runs graduate medical education programs across multiple Harvard-affiliated teaching hospitals. Additional offerings include the Mass General Brigham Health Plan insurance products, the Patient Gateway patient portal, the Care Connect AI-assisted telehealth service, and various proprietary AI clinical decision tools developed through its research programs.

Product overview

Mass General Brigham operates a comprehensive integrated healthcare delivery system with five nationally-ranked hospitals and a research enterprise with an annual budget of nearly $2 billion supporting over 3,700 clinical trials. The organization's technology portfolio includes patient-facing digital tools (Patient Gateway portal, Care Connect telehealth), AI/ML products developed through research initiatives (BRIDGE benchmark, FaceAge, RECTIFIER clinical trial matching), and spinout companies (AIwithCare). Key products include the MESH Incubator for AI evaluation, the BRIDGE multilingual clinical language benchmark with public leaderboard, the Care Connect AI-assisted telehealth platform built with K Health, and AIwithCare's RECTIFIER tool for clinical trial eligibility screening. The system also includes specialized institutes for Heart & Vascular, Neuroscience, Gene & Cell Therapy, AI, and Personalized Medicine, alongside digital mental health tools and brain-computer interface research.

Differentiator

Problem solved

Functional benefit

Brands

• Mass General Brigham Cancer Institute: Comprehensive cancer care center integrating research, clinical trials, and treatment across the health system
• Mass General Brigham Heart and Vascular Institute
• Mass General Brigham Neuroscience Institute
• Mass General Brigham Gene and Cell Therapy Institute
• RECTIFIER
• Patient Gateway
• Care Connect
• Mass General Brigham Health Plan

Products and services

• Patient Gateway Mass General Brigham's secure patient portal powered by Epic MyChart that enables patients to review test results, manage appointments, message doctors, renew prescriptions, pay bills, and access cost estimation tools and 24/7 virtual urgent care.
• Care Connect AI-powered telehealth program developed in partnership with K Health providing 24/7 virtual access to urgent care, mental health concerns, and chronic disease management. Features an AI agent that routes patients to remote physicians, each handling 40-50 patients per day.
• Mass General Brigham Health Plan Health insurance products offered by Mass General Brigham, including Mass General Brigham Health Plan, Health Plan Select, and Health Insurance Company, providing coverage to individuals and employers.
• Graduate Medical Education Programs Residency and fellowship training programs across multiple specialties offered through Mass General Brigham member hospitals, preparing future healthcare professionals across centers of expertise including Global & Community Health, Health Policy & Management, Healthcare Quality & Patient Safety, and Medical Education.
• 24/7 Virtual Urgent Care 24/7 virtual urgent care service offering on-demand access to clinicians for non-emergency medical issues, available through the Patient Gateway portal and Mass General Brigham's digital platform.
• Online Second Opinions Virtual second opinion service providing patients access to Mass General Brigham specialists for review of diagnoses and treatment plans from outside providers.
• MGB Home Hospital (Healthcare at Home) Home Hospital program providing hospital-level care in patients' homes through MGB Home Care clinicians as an alternative to traditional inpatient hospitalization, including post-acute and skilled nursing services.
• Mass General Brigham Specialty Pharmacy Specialty pharmacy service providing complex and specialty medications to patients receiving care across Mass General Brigham's clinical enterprise.
• Mass General Brigham Cancer Institute Comprehensive cancer care center integrating research, clinical trials, and treatment across Mass General Brigham. Receives philanthropic support including a $50 million gift to advance gene and cell therapy research.
• Mass General Brigham Gene and Cell Therapy Institute Research institute focused on gene and cell therapy development, supported by a $50 million philanthropic gift to build clinical trial infrastructure, cell pharmacy, and research facilities at the Cancer Institute.

Quantifiable outcome

• 80% response rate for connectivity-based TMS targeting vs 60% for scalp-based targeting in depression treatment
• +5 more outcomes

Named customers5 records

Segments5 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

AI capability9 records

Feature8 records

Partnerships

13 partnerships are on record, tiered core and minor.

• CVS Health / MinuteCliniccoreStrategic or Co-development Partner · 17 April 2026Proposed primary care partnership between CVS MinuteClinics and Mass General Brigham to bring MGB clinicians and care pathways into 37 pharmacy locations across Massachusetts. The partnership would serve up to 120,000 patients but is estimated by the Massachusetts Health Policy Commission to add approximately $40 million in annual healthcare spending due to MGB's higher pricing rates.
• Hallmark Health Care SolutionscoreTechnology or IntegrationHallmark's AI-enabled workforce operating system integrates with existing systems including Epic, Workday and UKG while adding proprietary market-rate and physician-contract data. MGB partners report achieving 15% to 25% reductions in contingent labor expenses and 25% reductions in overtime costs.
• CrescomminorStrategic or Co-development PartnerGlobal clinical proof-of-concept study of pediatric musculoskeletal AI solutions in collaboration with MGB Department of Radiology. Three MediAI solutions being evaluated: bone age analysis, lower-limb length measurement, and scoliosis measurement against expert clinical interpretations.
• Saudi Arabia Health Holding Co.minorStrategic or Co-development PartnerAgreement to advance Saudi Arabia's healthcare model through collaboration in management, clinical operations, and strategic planning. MGB's role in helping Saudi Arabia develop its healthcare infrastructure under Vision 2030.
• Tampa General HospitalminorStrategic or Co-development PartnerJoint healthcare venture between Tampa General Hospital and Mass General Brigham to expand services in Florida. MGB provides clinical expertise, operational support, and strategic guidance for Tampa General's continued growth.
• Neurizon TherapeuticsminorStrategic or Co-development PartnerHEALEY ALS Platform Trial evaluating NUZ-001 for ALS treatment, with philanthropic funds from Sean M. Healey & AMG Center for ALS at Mass General Brigham. Expanded from 160 to 240 participants.
• VectorY TherapeuticsminorStrategic or Co-development PartnerPhase 1/2 PIONEER-ALS clinical trial for VTx-002 conducted at Mass General Brigham's Sean M. Healey & AMG Center for ALS. First-ever clinical evaluation of a therapy targeting TDP-43 pathology in ALS.
• INOVIO and AkesominorStrategic or Co-development PartnerPhase 2 INSIGhT clinical trial for glioblastoma combining INO-5412 DNA immunotherapy with Akeso's cadonilimab. MGB Cancer Care participating as clinical trial site.
• C-Further Pediatric Oncology ConsortiumminorStrategic or Co-development PartnerInternational consortium dedicated to childhood cancer therapeutics with two programs: CF-012 for Ewing sarcoma partnered with UVA Comprehensive Cancer Center, Dana-Farber Cancer Institute, and Mass General Brigham; CF-033 for multiple children's cancers.
• AllelicaminorStrategic or Co-development PartnerPROACT 3 clinical trial at Mass General Brigham evaluating how polygenic risk score disclosure influences cardiovascular health and behaviors. Trial involves 500 adults assessing LDL cholesterol levels and preventive behaviors over 12 months.
• Vanderbilt University / UCSF / OHSU (VAMOS Collaborative)minorStrategic or Co-development PartnerOpen-source collaborative for trustworthy AI monitoring with early adopter health systems including UCSF, OHSU, and Mass General Brigham. Working with HL7 and Trustworthy and Responsible AI Network to build infrastructure for AI at scale.
• Digital Medicine Society (DiMe)minorStrategic or Co-development PartnerMulti-stakeholder initiative 'Scaling Trusted, High-Impact AI Care Navigation' with founding partners including Google for Health, Boston Children's Hospital, Mass General Brigham, and others developing standards for AI-enabled patient care navigation.
• Regent Surgical HealthminorChannel Partner/ Reseller/ DistributorJoint venture for ambulatory surgery center in Cambridge, Massachusetts with Mass General Brigham holding 70% ownership. Designed to address backlog of 26,500+ patients awaiting endoscopy procedures.

Scale indicators16 records

Recent moves8 records

Expansion highlights8 records

Direct peers

• Stanford Health Care: Academic medical center integrated delivery system affiliated with Stanford University, comparable on research scale, AI/clinical informatics leadership, and U.S. News-ranked tertiary care.
• Mayo Clinic: Non-profit academic medical center system with a comparable integrated delivery model, research enterprise, and reputation for specialty care. Both anchor U.S. News-ranked hospital systems with multi-state footprints and AI/digital health initiatives.
• Cleveland Clinic: Non-profit integrated academic health system with a flagship hospital, multi-hospital network, and large research enterprise. Direct competitor in tertiary/quaternary care and clinical trial leadership.
• Johns Hopkins Medicine: Academic medical center system with a flagship hospital, research enterprise, and integrated delivery model. Comparable on research funding scale, U.S. News rankings, and AI/digital health initiatives like MGB's BRIDGE.
• NewYork-Presbyterian Hospital: Non-profit academic medical center affiliated with Columbia and Cornell, operating a multi-campus integrated delivery system in the New York region. Comparable academic health system model with similar research and tertiary care positioning.
• UCSF Health: Academic medical center system with flagship hospital, research enterprise, and AI/health informatics initiatives. Direct comparable on academic-research model and is a named MGB partner in the VAMOS AI monitoring collaborative.
• Mount Sinai Health System: Non-profit integrated academic health system in New York with multiple hospitals, research enterprise, and digital health initiatives. Comparable on multi-hospital academic delivery model and AI clinical applications.
• NYU Langone Health: Non-profit academic medical center system with integrated delivery, large research enterprise, and digital health investments. Comparable on academic health system scale, U.S. News rankings, and tertiary care orientation.
• Cedars-Sinai Medical Center: Non-profit academic medical center in Los Angeles with substantial research enterprise and digital health initiatives (including its own AI spinouts). Comparable on academic delivery model and brand premium positioning.

Broad incumbents

• HCA Healthcare: Largest for-profit hospital operator in the U.S. with 180+ hospitals across multiple states. Broad incumbent providing a benchmark for hospital operating economics at scale, though operating under a different ownership and reimbursement model.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat7 records

Key risks5 records

Key highlights7 records

Customer concentration

• Xx.com/MassGenBrigham
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• Facebookfacebook.com/MassGeneralBrigham
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• Instagraminstagram.com/massgeneralbrigham

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles18 records

Subsidiaries20 records

Funding overview

Funding rounds

Investors

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M&A1 record

Investments17 records

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Frequently asked questions about Mass General Brigham