Sixty Degree Capital
Sixty Degree Capital is a Toronto-based multi-stage venture capital firm managing over $620M in AUM, investing from pre-seed to growth across Technology (AI, cybersecurity, digital infrastructure, SaaS) and Healthcare (drug development, diagnostics, digital health, medical devices) with a team of 20+ professionals.
- Company typePrivate
- Founded2017
- HeadquartersToronto, Canada
- Headcount11–50
- GTM typeB2B
- OfferingServices
What Sixty Degree Capital does
Sixty Degree Capital is a Toronto-headquartered, multi-stage venture capital firm founded in 2017 by Robert Guo. The firm manages over $620M USD in assets under management with a team of more than 20 professionals, investing from pre-seed to growth stages across two core verticals: Technology (AI, Cybersecurity, Digital Infrastructure, SaaS) and Healthcare (Drug Development, Diagnostics, Digital Health, Medical Devices). Its most recent fund, Fund III, closed at $250M in November 2023 and is actively deployed across both enterprise software and biotech opportunities. The firm operates from offices in Toronto (headquarters at 251 Consumers Rd, North York), San Francisco, Silicon Valley, and New York, with portfolio exposure extending to Europe and Asia through co-investments and direct deals.
The firm's underlying capability is a thesis-driven investment process backed by deep scientific and technical bench strength — the team includes multiple PhD-holders in molecular genetics, immunology, chemistry, and biotechnology, alongside CFA charterholders and operators with prior roles at BMO Nesbitt Burns, TD, State Street, Nasdaq, and Thomson Reuters Labs. Portfolio impact metrics disclosed by the firm include 12+ successful exits, 21+ products entering clinical trials, 3,800+ patients treated, 2.64M+ managed lives through healthcare portfolio companies, and 21B+ cyber attacks thwarted through cybersecurity holdings. The portfolio spans 60+ companies including Arcellx, Paperspace, Kraken, Monte Rosa Therapeutics, Aqua Security, HawkEye 360, Eclypsium, and Strive Health.
Revenue mechanics follow the standard venture capital model: management fees (typically 1.5–2.0% annually on committed or deployed capital) covering operations, plus performance-based carried interest (typically 20% above a hurdle rate) on realized exits. Go-to-market is thesis-driven and community-led, leveraging a global co-investor network that includes RA Capital Management, Sofinnova Partners, Jeito Capital, Taiho Ventures, Arkin Bio Capital, Andreessen Horowitz, and Merantix Capital. The firm serves two primary customer segments: visionary founders seeking capital and operational support, and institutional Limited Partners seeking exposure to high-growth healthcare and technology companies.
Sixty Degree Capital firmographics
Firmographics- Name
- Sixty Degree Capital
- Legal name
- Sixty Degree Capital
- Website
- https://sixtydegreecapital.com
- Company type
- Private
- Founded year
- 2017
- Operating status
- Operating
- Headcount range
- 11–50 employees
- Short description
- Sixty Degree Capital is a Toronto-based multi-stage venture capital firm managing over $620M in AUM, investing from pre-seed to growth across Technology (AI, cybersecurity, digital infrastructure, SaaS) and Healthcare (drug development, diagnostics, digital health, medical devices) with a team of 20+ professionals.
- Ownership category
- akta.pro rank
Sixty Degree Capital industry classification
Industry- Product category
- Venture Capital
- NAICS
- Portfolio Management and Investment Advice (523940), Other Investment Pools and Funds (5259)
- SIC
- Investment Advice (6282)
- akta.pro industry
- Sector-Focused Venture Capital (Vertical Specialists)
Keywords
Where Sixty Degree Capital is headquartered
LocationHeadquarters
- HQ city
- Toronto
- HQ country
- Canada
- HQ region
- North America
Offices4 records
Markets served
Sixty Degree Capital business model
Business model- GTM type
- B2B
- Offering type
- Services
- Cost components
- Personnel, Operations, Marketing or Sales, Technology or R&D, Infrastructure
Revenue model
- Management Fees: VC firms typically charge management fees on committed capital, typically 1.5-2% annually, to cover operational expenses and investment sourcing activities.
- Carried Interest: Performance-based carried interest typically 20% of profits above the hurdle rate, representing the primary upside for the GP team after returning LP capital.
Go-to-market motion2 records
Distribution channels1 record
Marketing channels5 records
Sixty Degree Capital product offering
Product offeringCore offering
Sixty Degree Capital is a global multi-stage venture capital firm that invests capital from pre-seed to growth stages into visionary founders building transformative companies in Technology (AI, Cybersecurity, Digital Infrastructure, SaaS) and Healthcare (Drug Development, Diagnostics, Digital Health, Medical Devices). The firm deploys thesis-driven equity capital, provides hands-on operational support, and connects portfolio companies to its global network across North America, Europe, and Asia. Fund III ($250M) is the most recent active fund targeting Series A to pre-IPO investments.
Product overview
Sixty Degree Capital is a global multi-stage venture capital firm that operates as a single investment platform rather than a product-based company. The firm provides capital investment, strategic guidance, and operational support to high-potential companies across Technology (AI, Cybersecurity, Digital Infrastructure, SaaS) and Healthcare (Drug Development, Diagnostics, Digital Health, Medical Devices) sectors. The firm manages multiple investment funds, including Fund III with $250M earmarked for Series A to pre-IPO investments, and has achieved 12+ successful exits. The firm does not offer standalone software products or modules; rather, its service offering centers on venture capital deployment, portfolio company support, and value creation through strategic partnership with founders.
Differentiator
Problem solved
Functional benefit
Products and services
- Sixty Degree Capital Fund III
- Multi-Stage Venture Capital Investment Services
- Portfolio Company Operational Support
Quantifiable outcome
- 21+ products entered clinical trials across portfolio companies
- +4 more outcomes
Companies that use Sixty Degree Capital
Customer profileNamed customers26 records
Segments4 records
Ideal customer profiles3 records
Sixty Degree Capital technology and API
TechnologyTechnology focussed No
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Sixty Degree Capital partnerships and signals
Strategic signalScale indicators15 records
Recent moves7 records
Expansion highlights5 records
Sixty Degree Capital competitors and assessment
Company assessmentDirect peers
- Inovia Capital: Canadian multi-stage VC with a similar focus on technology and healthcare. Both firms are Toronto-headquartered, invest from pre-seed to growth, and target similar Canadian and US tech/healthcare founders.
- Whitecap Ventures: Canadian early-to-growth stage VC investing in healthcare and technology. Comparable mandate, stage range, and sector focus, though typically with a stronger enterprise SaaS tilt.
- Georgian Partners: Canadian growth-stage VC focused on B2B software, applied AI, and cybersecurity. Direct competitor for many of Sixty Degree's later-stage tech deals (Aqua Security, Cato, Arctic Wolf overlap).
- Radical Ventures: Toronto-based AI-focused VC investing from seed to growth. Highly comparable in thesis-driven AI infrastructure and applied AI focus, overlapping with Sixty Degree's Mohan Zhang-led AI deals.
- Real Ventures: Canadian early-stage VC with focus on technology and deep tech founders. Comparable in stage range and Canadian tech mandate, with overlapping deal flow in Montreal/Toronto ecosystems.
Broad incumbents
- BDC Capital: Canada's largest VC and growth investor with $5B+ AUM across multiple funds. Larger incumbent offering overlapping healthcare and technology exposure plus broader cleantech and industrial mandates.
- ARCH Venture Partners: US-based, science-heavy VC focused on early-stage biotech, life sciences, and deep tech. Highly comparable in the biotech/pharma crossover (cell therapy, RNA editing, gene therapy) where Sixty Degree's PhD-led team competes.
- Andreessen Horowitz (a16z): US mega-VC with overlapping cybersecurity (Eclypsium), enterprise software, and digital infrastructure thesis. Co-invests in Sixty Degree portfolio rounds; comparable on cybersecurity, dev tools, and AI infra themes, but vastly larger AUM and brand.
Regional players
- Sofinnova Partners: European healthcare-specialist VC and recurring co-investor with Sixty Degree (Bionyra, others). Comparable biotech mandate and stage profile, but primarily Europe-anchored with deeper EU LP base.
- RA Capital Management: US healthcare-focused crossover fund and frequent co-lead (Kinaset, Parabilis). Comparable clinical-stage biotech underwriting discipline and crossover growth-stage approach, but US-anchored with much larger fund size.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat4 records
Key risks5 records
Key highlights7 records
Customer concentration
Sixty Degree Capital social profiles
Digital presenceSixty Degree Capital financial estimates
Financial estimateRevenue estimate
Valuation estimate
Sixty Degree Capital leadership team
Management profileNumber of profiles
Profiles14 records
Sixty Degree Capital funding detail
Funding detailFunding overview
Funding rounds
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Sixty Degree Capital M&A and investment
M&A and investmentM&A
Investments55 records
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Sixty Degree Capital
What does Sixty Degree Capital do?
Sixty Degree Capital is a global multi-stage venture capital firm that invests capital from pre-seed to growth stages into visionary founders building transformative companies in Technology (AI, Cybersecurity, Digital Infrastructure, SaaS) and Healthcare (Drug Development, Diagnostics, Digital Health, Medical Devices). The firm deploys thesis-driven equity capital, provides hands-on operational support, and connects portfolio companies to its global network across North America, Europe, and Asia. Fund III ($250M) is the most recent active fund targeting Series A to pre-IPO investments.
Is Sixty Degree Capital a public or private company?
Sixty Degree Capital is a private company. It is classified as founder individual operated bootstrapped and is currently operating.
When was Sixty Degree Capital founded?
Sixty Degree Capital was founded in 2017. It employs 11 to 50 people.
Where is Sixty Degree Capital based?
Sixty Degree Capital is headquartered in Toronto, Canada, in the North America region.
How does Sixty Degree Capital make money?
Two revenue lines are on record. Management Fees are the primary driver. The others are carried Interest.
Who are Sixty Degree Capital's main competitors?
Direct peers on record are Inovia Capital, Whitecap Ventures, Georgian Partners, Radical Ventures and Real Ventures. Broad incumbents are BDC Capital, ARCH Venture Partners and Andreessen Horowitz (a16z). Regional players are Sofinnova Partners and RA Capital Management.
Does Sixty Degree Capital have an API?
No public API is recorded for Sixty Degree Capital.
What industry is Sixty Degree Capital in?
Sixty Degree Capital's product category is Venture Capital. Its primary akta.pro industry code is FSANAAAD, Sector-Focused Venture Capital (Vertical Specialists). Its NAICS code is 523940 and its SIC code is 6282.