What ABclonal does

ABclonal is a privately held life science reagents company founded in 2011 and headquartered in Wuhan, China, with US corporate operations (ABclonal, Inc.) based in Woburn, Massachusetts. The company develops and supplies research-grade antibodies, recombinant proteins, ELISA kits, molecular biology reagents, and next-generation sequencing solutions to academic and pharmaceutical researchers globally, organized around sub-brands including SMab (recombinant rabbit monoclonal antibodies), ABflo (flow cytometry), and PathoQ (IHC pathology). Its proprietary SMab™ platform integrates B cell sorting, enrichment, bioinformatics, and monoclonal antibody expression to produce recombinant rabbit monoclonal antibodies as the company's core technology differentiation, with a catalog spanning 4,000+ targets, 5,000+ SKUs, and 10,000+ antibody clones.

The company's business model is a hybrid of self-serve e-commerce through abclonal.com, direct phone/email sales for enterprise customers, and a global distributor network, with unit-based pay-as-you-go pricing and no publicly disclosed tiered subscription structure. Custom antibody, protein, and peptide synthesis services are offered through the toYurogen platform following the 2021 acquisition of Yurogen Biosystems. ABclonal monetizes primarily through one-time research reagent sales, targeting life science researchers (primary segment, including individual academic labs at institutions such as UCLA, Washington University in St. Louis, and McGill University) and pharmaceutical/biotech companies (secondary segment, for drug discovery and target validation). Two large funding rounds in 2021 totaling approximately $282 million (Series B: $93M; Series C: $189M) and recognition in CiteAb's 2024 Top 100 Most Cited RUO Antibodies dataset indicate the company has achieved meaningful scale relative to peers but remains an emerging challenger to established incumbents Cell Signaling Technology, Abcam, and Thermo Fisher Scientific.

Name

ABclonal

Legal name

ABclonal, Inc.

Website

https://abclonal.com

Company type

Private

Founded year

2011

Operating status

Operating

Headcount range

501–1,000 employees

Short description

ABclonal is a China-founded, privately held life science reagents company that develops and supplies research antibodies, recombinant proteins, ELISA kits, and molecular biology reagents to academic and pharmaceutical researchers worldwide via direct e-commerce, distributor networks, and US operations in Woburn, MA.

Ownership category

akta.pro rank

Product category

Life Science Research Reagents

NAICS

In-Vitro Diagnostic Substance Manufacturing (325413)

SIC

In Vitro & In Vivo Diagnostic Substances (2835)

akta.pro primary industry

Reagents, Chemicals & Assay Kits (Buffers, Antibodies, ELISA, Enzymes) (HLAGAIAI)

akta.pro secondary industries

Antibody Discovery & Engineering Platforms (display tech, bispecifics, Fc engineering) (HLAAAIAB), Biomarker Assay & Reagent Development (LDT/IVD assay design, antibodies/standards/controls) (HLAAAMAL)

Keywords

• Research antibodies
• Recombinant proteins
• Molecular biology reagents
• ELISA kits
• Flow cytometry reagents

Headquarters

HQ city

Wuhan

HQ country

China

HQ region

Asia

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Technology or R&D, Personnel, Supply Chain, Operations, Marketing or Sales

Revenue model

1. Research reagent product sales: ABclonal generates revenue through the sale of research reagents including antibodies (primary, secondary, flow cytometry, IHC), proteins, ELISA kits, molecular biology reagents (PCR, qPCR, cloning, electrophoresis), next-generation sequencing reagents, and recombinant proteins to life science researchers in academia and pharma.

Pricing tiers

Go-to-market motion1 record

Distribution channels3 records

Marketing channels4 records

Core offering

ABclonal develops, manufactures, and sells research-use antibodies and molecular reagents to life science laboratories. Its core catalog spans primary and secondary antibodies, recombinant rabbit monoclonal antibodies made with proprietary SMab™ technology, flow cytometry antibodies (ABflo), IHC pathology antibodies (PathoQ), molecular biology reagents (PCR, qPCR, cloning, electrophoresis), next-generation sequencing library prep reagents, recombinant proteins, and ELISA kits. Products are sold globally to academic researchers, pharmaceutical companies, and biotech firms.

Product overview

ABclonal is a life science reagents company offering a comprehensive portfolio of research antibodies, proteins, molecular biology reagents, next-generation sequencing solutions, and ELISA kits. The core products include SMab recombinant monoclonal antibodies (a proprietary technology integrating B cell sorting, bioinformatics, and antibody expression), primary antibodies (polyclonal, monoclonal, and recombinant), secondary antibodies, and specialized antibodies for flow cytometry (ABflo), immunohistochemistry (PathoQ), and post-translational modifications. The molecular biology reagent portfolio spans PCR, reverse transcription, qPCR, cloning, and nucleic acid electrophoresis. NGS solutions cover library preparation for DNA, RNA, and single cells, plus epigenetic analysis. Recombinant proteins include cell culture reagents, CAR-T/NK proteins, viral antigens, and kinases. Services include custom antibody, protein, and peptide development through the toYurogen platform.

Differentiator

Problem solved

Functional benefit

Brands

• SMab: A new generation of recombinant rabbit monoclonal antibodies generated with SMab technology that integrates B cell sorting, enrichment, bioinformatics, and monoclonal antibody expression.
• ABflo
• PathoQ

Products and services

• SMab Recombinant Monoclonal Antibodies Next-generation recombinant rabbit monoclonal antibodies generated using SMab™ technology that integrates B cell sorting, enrichment, bioinformatics, and monoclonal antibody expression for high-specificity research applications.
• Primary Antibodies (Polyclonal and Monoclonal) Catalog of polyclonal and monoclonal antibodies covering 4,000+ targets with 5,000+ catalog items and 10,000+ antibody clones for research use across multiple applications.
• Secondary Antibodies Secondary antibodies used in immunoassays and detection methods to amplify signal in antibody-based experiments.
• ABflo Flow Cytometry Antibodies Flow cytometry antibodies for immunophenotyping and cell analysis applications, including anti-monkey variants and flow cytometry panels.
• PathoQ IHC Pathology Antibodies Immunohistochemistry-validated antibodies for pathological tissue analysis and diagnostic research applications.
• KO/KD Validated Antibodies Knockout/knockdown validated antibodies providing orthogonal specificity validation to support reproducible research results.
• PTM-specific Antibodies Post-translational modification-specific antibodies including phospho-specific, methyl-specific, acetyl-specific, and other PTM-targeting variants.
• Molecular Biology Reagents Reagents for PCR (conventional, fast, isothermal, high-fidelity, direct), reverse transcription kits, qPCR reagents (dye-based, probe-based, one-step RT-qPCR, SNP genotyping), cloning tools, restriction endonucleases, ligases, and nucleic acid electrophoresis products.
• Next-Generation Sequencing (NGS) Solutions NGS library preparation reagents including DNA and RNA library prep, single-cell library preparation, epigenetic analysis tools, hybridization capture reagents, and raw material enzymes.
• Recombinant Proteins Cell culture proteins for macrophage/osteoclast, dendritic cell, T/B/NK cell, stem cell, and organoid culture; CAR-T and CAR-NK proteins; CD antigens; biomarker proteins; Fc/Fc receptor proteins; viral antigens (SARS-CoV-2, influenza, monkeypox, coronavirus); and enzymes including kinases.
• ELISA Kits Enzyme-linked immunosorbent assay kits available in economical, high-sensitivity, fast-detection, and high-performance formats, including matched antibody pairs for analyte quantification.
• Multiplex Assay Kits Multiplex assay kits enabling simultaneous detection of multiple analytes within a single sample.
• Custom Antibody and Protein Services (toYurogen) Custom antibody and protein development services offered through the toYurogen platform acquired in 2021.
• Custom Peptide Synthesis Services (toYurogen) Custom peptide synthesis services offered through the toYurogen platform.

Named customers3 records

Segments2 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature1 record

Partnerships

Three partnerships are on record, tiered minor.

• YCharOSminorStrategic or Co-development PartnerPartnership for antibody characterization and standardization efforts
• Michael J. Fox Foundation (MJFF)minorStrategic or Co-development PartnerCollaboration supporting Parkinson's disease research through antibody development
• mAb3D AtlasminorStrategic or Co-development PartnerPartnership for 3D antibody atlas characterization

Scale indicators3 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• Cell Signaling Technology: US-based leading supplier of research antibodies with a deep catalog across key signaling pathways and applications including WB, IHC, IP, and flow cytometry. Directly comparable to ABclonal as a primary antibody-focused reagent supplier serving academic and pharma researchers.
• Abcam: Global research antibody reagent supplier (now part of Danaher) with one of the broadest catalogs in the industry, cited extensively in publications. Directly comparable to ABclonal in target coverage, validation approach, and customer base.
• Proteintech: Research antibody supplier with a large catalog and a reputation for KO/KD-validated antibodies. Closely comparable to ABclonal in its China-origin emergence story, recombinant antibody offering, and academic customer base.
• Santa Cruz Biotechnology: Long-established research antibody supplier offering polyclonal, monoclonal, and secondary antibodies across a wide target range. Comparable to ABclonal in catalog breadth and academic customer focus, though with a more US-centric footprint.
• BioLegend (Revvity): Major supplier of antibodies and reagents for flow cytometry, immunology, and cell biology research, now part of Revvity. Comparable to ABclonal's ABflo flow cytometry product line and broader immunology/cell biology focus.
• GenScript: Global biotech with research reagent, custom antibody service, and gene synthesis businesses, including the GenScript Antibody platform. Comparable to ABclonal in custom antibody services, recombinant protein catalog, and China-to-global commercial trajectory.
• Atlas Antibodies: Sweden-based supplier of precision antibodies with a focus on tissue-specific targets and IHC-validated reagents. Comparable to ABclonal's PathoQ IHC pathology line and emphasis on application-specific validation.

Broad incumbents

• Bio-Techne: Diversified life science tools company encompassing R&D Systems, Novus Biologicals, ProteinSimple, and other reagent/antibody brands. Comparable to ABclonal in research antibody and protein reagent offerings, with a much broader portfolio across proteins, antibodies, and instruments.
• Thermo Fisher Scientific: Largest life science tools conglomerate with antibodies sold under Invitrogen, Thermo Scientific, and Pierce brands. Comparable to ABclonal in catalog breadth and customer base, but operates as a broad incumbent across instruments, consumables, and reagents rather than a focused antibody specialist.

Emerging players

• HuaBio (Hangzhou HuaAn Biotechnology): China-based research antibody supplier with growing global presence and a similar China-origin, catalog-focused GTM motion. Most directly comparable to ABclonal as a near-peer emerging competitor from the same Chinese ecosystem.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• LinkedInlinkedin.com/company/4811892
• Xx.com/ABclonal_USA

Revenue estimate

Valuation estimate

Number of profiles

Profiles1 record

Funding overview

Funding rounds2 records

Investors11 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A1 record

Investments2 records

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about ABclonal