UpToDate

What UpToDate does

UpToDate, founded in 1992 and headquartered in Waltham, Massachusetts, is a clinical decision support (CDS) platform serving physicians, specialists, residents, fellows, students, and healthcare institutions. It is a wholly-owned subsidiary of Wolters Kluwer, the Dutch publicly-traded information services company, and operates within Wolters Kluwer's Health division. The platform provides evidence-based medical guidance across more than 25 specialties, drug information, practice guidelines, and continuing medical education (CME/CE/CPD) credits, delivered via web, mobile applications, and EHR integrations.

The core technology combines a continuously curated clinical content library with UpToDate Expert AI, a generative AI decision support tool validated by 7,600 clinical experts who review AI-generated responses for accuracy and clinical appropriateness. UpToDate also offers the Clinical Intelligence Model formalizing this human-AI loop, UpToDate Patient Engagement for AI-personalized patient education (ranked #1 in Best in KLAS for Patient Education in 2025 and 2026), and a Clinical AI Validation Framework for hospital governance committees. The platform embeds into clinician workflows through partnerships with Abridge (ambient documentation, 250 health systems) and Microsoft, as well as direct EHR integration capabilities.

UpToDate's business model is subscription-based with annual billing, distributed through direct enterprise sales to hospitals and group practices, self-serve individual subscriptions via store.uptodate.com, mobile app stores, and OEM/EHR/ambient-documentation channels. The company has reached approximately 2,000 hospital subscribers for its Expert AI tier, complemented by an unspecified base of individual clinician subscribers and add-on products, supporting a recurring-revenue model with diversified enterprise and SMB/individual customer segments.

Name

UpToDate

Legal name

UpToDate, Inc.

Website

https://uptodate.com

Company type

Private

Founded year

1992

Operating status

Operating

Headcount range

251–500 employees

Short description

UpToDate is a Wolters Kluwer-owned clinical decision support platform serving physicians, specialists, residents, and hospitals with evidence-based medical guidance, drug information, and CME content across 25+ specialties, delivered via web, mobile, and EHR integrations to approximately 2,000 hospital subscribers.

Ownership category

akta.pro rank

Product category

Clinical Decision Support

SIC

Services-Prepackaged Software (7372)

akta.pro primary industry

Adherence, Reminders & Engagement Automation (Medication/Follow-up) (HLACAEAJ)

Keywords

• Clinical decision support
• Evidence-based medicine
• Medical reference platform
• Healthcare decision support
• Clinical knowledge system

Headquarters

HQ city

Waltham

HQ country

United States

HQ region

North America

Markets served

GTM type

B2B

Offering type

Software

Cost components

Personnel, Technology or R&D, Operations, Marketing or Sales, Infrastructure

Revenue model

1. Institutional Subscriptions: UpToDate generates revenue primarily through recurring subscriptions sold to hospitals, health systems, and group practices. These institutional licenses provide organization-wide access to the clinical decision support platform.
2. Individual Subscriptions: Individual clinicians can subscribe directly through the UpToDate store, with various subscription tiers and add-on products available for purchase.

Pricing tiers

Go-to-market motion3 records

Distribution channels4 records

Marketing channels4 records

Core offering

UpToDate provides evidence-based clinical decision support to clinicians at the point of care, covering more than 25 medical specialties. The platform delivers peer-reviewed treatment recommendations, drug information, and clinical guidance through web, mobile apps, and EHR integrations, combining a network of 7,600 clinical expert reviewers with generative AI (UpToDate Expert AI). It is sold via institutional subscriptions to hospitals and health systems and individual subscriptions to clinicians, residents, fellows, and students.

Product overview

UpToDate is a comprehensive clinical decision support platform that offers a suite of products including the core UpToDate resource, UpToDate Expert AI (a generative AI-powered decision support tool), and UpToDate Patient Engagement solutions. The platform covers more than 25 medical specialties and integrates with ambient documentation partners like Abridge and Microsoft. The Clinical Intelligence Model combines human expertise (7,600 clinical experts) with generative AI to validate AI-generated responses. UpToDate was ranked #1 in the 2026 Best in KLAS Software and Services report for Patient Education.

Differentiator

Problem solved

Functional benefit

Brands

• UpToDate Expert AI: Evidence-based GenAI decision support tool that was stress-tested across 1,669 clinical queries and 15,000 unique criteria, achieving 99.9% clinically aligned information.
• Clinical Intelligence Model
• UpToDate Patient Engagement

Products and services

• UpToDate Comprehensive evidence-based clinical decision support resource providing peer-reviewed medical information, drug references, and clinical guidance across more than 25 medical specialties. Accessible via web, mobile apps, and EHR integration. Used by physicians, specialists, residents, fellows, students, and institutions.
• UpToDate Expert AI Evidence-based generative AI clinical decision support tool that combines UpToDate's trusted editorial content with AI capabilities. Involves 7,600 clinical experts who continuously review and validate AI-generated responses to ensure they are grounded in current evidence and clinically appropriate, including specific benchmarks requiring the tool to recognize when it cannot answer.
• UpToDate Patient Engagement AI-powered patient education solutions that personalize evidence-based health information in patients' preferred mediums, languages, and comprehension levels. Ranked #1 in the 2025 and 2026 Best in KLAS Software and Services reports for Patient Education.
• Clinical AI Validation Framework for Hospital Governance Specialized validation framework designed to help hospital governance committees audit and evaluate generative AI at the point of care. Stress-tested across 1,669 clinical queries and 15,000 unique criteria, achieving 99.9% clinically aligned information.

Quantifiable outcome

• 99.9% clinically aligned information in validation testing across 1,669 clinical queries and 15,000 unique criteria
• +1 more outcomes

Named customers2 records

Segments4 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration4 records

AI capability3 records

Feature4 records

Partnerships

Five partnerships are on record, tiered core and major.

• AbridgecoreTechnology or Integration · 31 March 2026Abridge and UpToDate partnership enables clinicians using Abridge's ambient documentation technology to access UpToDate's evidence-based clinical guidance directly within existing workflows without switching applications. The integration aims to reduce administrative burden, standardize care practices, and improve clinician efficiency and patient experiences. Abridge currently works with 250 health systems and is targeting support for 100 million patient-clinician conversations in 2026.
• NEJM GroupcoreStrategic or Co-development Partner · 31 March 2026Abridge partnership with UpToDate includes new content partnerships with the NEJM Group, combining real-time clinical evidence from NEJM publications with AI-powered clinical notes to deliver context-aware insights within the ambient documentation workflow.
• American Medical Association (JAMA publications)coreStrategic or Co-development Partner · 31 March 2026Abridge partnership with UpToDate includes content partnerships with the American Medical Association for JAMA publications, integrating JAMA clinical evidence with AI-powered clinical notes for context-aware insights.
• MicrosoftmajorTechnology or Integration · 5 March 2026Microsoft and UpToDate announced a partnership to provide clinicians with evidence-backed treatment recommendations, integrating UpToDate's clinical content with Microsoft's healthcare technology solutions.
• AbridgecoreTechnology or Integration · 20 October 2025Abridge, in partnership with Wolters Kluwer, is integrating UpToDate's clinical content into its platform to provide real-time clinical decision support within existing clinician workflows, delivering targeted evidence-based insights during patient documentation, especially in complex cases such as asthma management.

Scale indicators1 record

Recent moves6 records

Expansion highlights5 records

Direct peers

• VisualDx: VisualDx is a clinical decision support system focused on differential diagnosis and visual clinical guidance, serving overlapping hospital and clinician customers.
• ClinicalKey: Elsevier's ClinicalKey is a clinical reference and decision support platform covering similar specialties, drug information, and guidelines, competing for the same hospital and clinician subscriptions.
• DynaMed: DynaMed is an evidence-based clinical decision support reference used by clinicians at the point of care, directly competing with UpToDate across similar specialties and institutional customers.
• Epocrates: Epocrates (athenahealth) provides drug reference and point-of-care clinical information to individual clinicians and institutions, overlapping with UpToDate's clinician-facing reference product.
• Lexicomp: Lexicomp, also owned by Wolters Kluwer, provides drug information and clinical reference content to hospitals and clinicians, closely overlapping with UpToDate's drug information and decision support capabilities.
• BMJ Best Practice: BMJ Best Practice is a clinical decision support tool providing evidence-based guidance to clinicians worldwide, with overlapping customer base in hospitals and group practices.
• Micromedex: Micromedex provides drug and clinical reference content to hospitals and clinicians, directly competing for institutional pharmacy and clinical decision support budgets.

Emerging players

• Isabel Healthcare: Isabel Healthcare offers AI-driven differential diagnosis decision support used by clinicians and hospitals, providing narrower but overlapping clinical decision support functionality.
• OpenEvidence: OpenEvidence is an AI-native clinical evidence platform aimed at clinicians, representing an emerging AI-first alternative that could challenge UpToDate's clinician workflow position.
• Glass Health: Glass Health provides AI-powered clinical decision support for clinicians, ranked alongside UpToDate Expert AI in 2026 industry evaluations and competing for the same AI-first clinician workflows.

Market position

Strengths4 records

Weaknesses4 records

Competitive moat6 records

Key risks5 records

Key highlights6 records

Customer concentration

• LinkedInlinkedin.com/company/21924
• Xx.com/uptodate
• Facebookfacebook.com/uptodateebm

Revenue estimate

Valuation estimate

Number of profiles

Funding overview

Funding rounds1 record

Investors1 record

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about UpToDate