What Sepax Technologies does

Sepax Technologies, Inc. is a privately held Delaware-incorporated chromatography product manufacturer headquartered in Newark, Delaware, founded in 2009. The company designs and produces HPLC columns and bulk separation media for biological molecules, serving biopharmaceutical developers, gene therapy groups, RNA therapeutics programs, ADC developers, and academic research institutions. Its product portfolio spans all five core separation modes — Size Exclusion (SEC), Hydrophobic Interaction (HIC), Ion Exchange (IEX), Reversed Phase (RP), and Affinity — built on three proprietary base-bead platforms (silica, polystyrene-divinylbenzene, and polymethacrylate) with particle sizes from 1.7 to 100 µm and pore sizes from non-porous to 2000 Å. Differentiated surface chemistries include stand-up and lay-down monolayer coatings, polymeric brush (Nanofilm) coatings, and hydrophilic coatings optimized for ADC DAR analysis, supported by over 70 patents and citations in 1,500+ peer-reviewed publications. Manufacturing spans from micro-bore (75 µm) to industrial-scale (800 mm) columns and includes 100+ chromatographic resins and 1,000+ LC column SKUs produced in-house.

The company monetizes through four revenue streams: HPLC column sales (hardware, with unit prices typically $1,275–$3,219 for standard configurations and quote-based enterprise pricing for larger formats), professional chromatography services (analytical method development, SEC-MALS screening, custom column packing, and purification services from mg to g scale), custom affinity conjugation services with multiple immobilization chemistries, and OEM/ODM arrangements. Go-to-market combines a five-region direct field-sales organization (US East/Central/West, Europe, AMEA) with inside sales, technical support, and a self-serve e-commerce portal that exposes registered-user pricing and online ordering. Distribution extends to 13+ countries across the Americas, Europe, and Asia-Pacific, with a stated base of 5,000+ global customers. Quality is anchored by ISO 9001:2015 certification held since August 2013, and an affiliated entity (Sepax Bioscience) sells process-scale media to complement the analytical-column business.

Name

Sepax Technologies

Legal name

Sepax Technologies, Inc.

Website

https://sepax-tech.com

Company type

Private

Founded year

2009

Operating status

Operating

Headcount range

251–500 employees

Short description

Sepax Technologies designs and manufactures proprietary HPLC columns and chromatography media for biopharmaceutical, gene therapy, ADC, and RNA therapeutic developers, spanning SEC, HIC, IEX, RP, and affinity separation modes across global analytical and process-scale markets.

Ownership category

akta.pro rank

Product category

Liquid Chromatography Columns and Resins

NAICS

Analytical Laboratory Instrument Manufacturing (334516)

SIC

Laboratory Analytical Instruments (3826), Miscellaneous Chemical Products (2890)

akta.pro primary industry

Analytical Instruments & Chromatography Systems (HLAGAIAA)

akta.pro secondary industries

Downstream Processing & Purification Technologies (chromatography, filtration, centrifugation) (HLAAAJAB), Bioprocess Consumables & Reagents (resins, membranes, media components, buffers) (HLAAAJAI)

Keywords

• Chromatography columns
• HPLC columns
• Size exclusion chromatography
• Ion exchange chromatography
• Affinity chromatography resins

Headquarters

HQ city

Newark

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Technology or R&D, Supply Chain, Operations, Marketing or Sales

Revenue model

1. HPLC Column Sales: Sale of chromatography columns including SEC, HIC, IEX, RP, and Affinity columns for analytical and preparative applications. Products sold directly through website and sales team.
2. Chromatography Services: Services including Analytical Method Development, SEC-MALS Screening, Custom Column Packing, and Purification Service. Professional services for method development, validation, and scale-up purification.
3. Affinity Conjugation Services: Custom affinity conjugation services including resin and ligand chemistry selection, immobilization chemistries (epoxy, NHS, Streptavidin Biotin, reductive amination, disulfide exchange) for fusion proteins, mAb purification, and other applications.
4. OEM and ODM Services: Sepax provides OEM (Original Equipment Manufacturing) and ODM (Original Design Manufacturing) services for chromatography products.

Pricing tiers

Go-to-market motion2 records

Distribution channels3 records

Marketing channels7 records

Core offering

Sepax Technologies manufactures and sells proprietary HPLC chromatography columns and bulk chromatographic resins for biological separation and purification, spanning SEC, HIC, IEX, RP, Affinity, and Mixed-Mode chemistries, supported by three in-house base bead platforms (Silica, PS/DVB, PMA) with proprietary surface coatings. The company complements its column portfolio with professional services including custom affinity conjugation, analytical method development and validation, SEC-MALS screening, custom column packing, and analytical-to-preparative purification services. Its products serve the biopharmaceutical industry for separation, characterization, and downstream processing of mAbs, bispecific antibodies, ADCs, proteins, AAV, VLP, mRNA, DNA, and oligonucleotides.

Product overview

Sepax Technologies is a chromatography product manufacturer and service provider specializing in biological separation for the biopharmaceutical industry. The company offers a comprehensive portfolio of HPLC columns and process media organized by separation mode: Size Exclusion Chromatography (SEC) products including SRT SEC, SRT-C SEC, Zenix SEC, Zenix-C SEC, SRT-10 SEC, SRT-10C SEC, Unix SEC, Unix-C SEC, SRT-LVL SEC, BIOMIX SEC, Nanofilm SEC, and Monomix MC10-SEC; Ion Exchange Chromatography (IEX) products including Proteomix IEX, Antibodix WCX, Proteomix AAV SAX, and Proteomix POR IEX; Hydrophobic Interaction Chromatography (HIC) including Proteomix HIC and Proteomix HIC-ADC DARx; Reversed Phase (RP) including Proteomix RP, Bio-C4/Bio-C8/Bio-C18, HP-C18, GP-C4/C8/C18/Phenyl, and BR-C18; and Affinity Chromatography including ProAqa Excel, Monomix dT20, Proteomix POR50-dT20, BioService Affinity HSA, and Proteomix POR-SA. The product portfolio also includes specialty columns for organic acids (Carbomix), surfactants (Tween Trap), and mixed-mode applications. Sepax complements its product offerings with services including affinity conjugation, analytical method development, SEC-MALS screening, custom column packing, and purification services ranging from analytical to preparative scale.

Differentiator

Problem solved

Functional benefit

Brands

• Sepax Bioscience: Process media products for downstream purification in biopharmaceutical manufacturing
• SRT SEC
• Zenix SEC
• Unix SEC
• Proteomix HIC
• Proteomix IEX
• Antibodix
• Bio Series

Products and services

• SRT SEC Columns Size exclusion chromatography column using proprietary stand-up monolayer surface technology with uniform, hydrophilic, neutral nanometer-thick films chemically bonded to high-purity silica. Features the widest pore size selection (100–2000 Å) and highest loading capacity for high-resolution protein and biomolecule separation.
• SRT-C SEC Columns Size exclusion chromatography column using lay-down monolayer surface chemistry, designed for hydrophobic samples such as insulin, membrane proteins, and PEGylated biomolecules.
• Zenix SEC Columns 3-µm particle size SEC column providing high separation efficiency and resolution for biological molecules, water-soluble polymers, and peptides with pore sizes of 80, 100, 150, and 300 Å.
• Zenix-C SEC Columns 3-µm particle size SEC column with lay-down monolayer chemistry for hydrophobic samples including insulin, membrane proteins, and polymer-derivatized monoclonal antibodies.
• SRT-10 SEC Columns Preparative-scale SEC column with 10-µm silica particles for fast protein purification on FPLC and HPLC systems, with pore sizes of 100, 300, 500, and 2000 Å.
• SRT-LVL SEC Column SEC column designed for large biomacromolecules including viral particles, high molecular weight polymers, long-chain oligonucleotides (sgRNA, plasmid DNA), lipid nanoparticles, and PEG/lipid conjugates.
• Unix SEC Columns UHPLC SEC column with 1.8-µm particle size providing the highest separation efficiency through a small particle size and large pore volume combination.
• BIOMIX SEC Columns 3-µm mixed-mode SEC column designed for bispecific antibodies and hydrophobic samples with high resolution and maximum recovery.
• Nanofilm SEC Columns SEC column with polymeric brush coating suitable for positively charged proteins and hydrophobic proteins, including membrane proteins.
• Monomix MC10-SEC Columns SEC column packed with highly crosslinked polymethacrylate-based particles offering broad pH tolerance (1–14), temperature stability up to 80°C, and operating pressures up to 10 bar.
• Proteomix IEX Columns Ion exchange column using non-porous PS/DVB beads with hydrophilic polymer coating for high ion-exchange capacity and resolution of proteins and biomolecules.
• Antibodix WCX Columns Weak cation exchange column optimized for antibody analysis with high resolution, efficiency, and recovery, featuring particle sizes of 1.7, 3, 5, and 10 µm.
• Proteomix AAV SAX Columns Strong anion exchange column specifically designed for gene therapy applications supporting separation and quantification of empty and full AAV capsids.
• Proteomix POR IEX Columns Porous ion exchange resin based on uniform PS/DVB beads (15/30 µm) for biological sample separation and purification with good physical and chemical stability.
• Proteomix HIC Columns Hydrophobic interaction chromatography column using non-porous PS/DVB beads for high-resolution separation of proteins, mAbs, ADCs, oligonucleotides, and peptides.
• Proteomix HIC-ADC DARx Columns HIC column optimized for ADC analysis using hydrophilic coating technology with Butyl and Phenyl variants for high-resolution ADC DAR separation and enhanced selectivity for mAbs, protein fragments, DNA, and oligonucleotides.
• Proteomix RP Columns Reversed phase column with porous PS/DVB polymer resins featuring phenyl and substituted phenyl groups for hydrophobic interaction chromatography applications.
• Bio Series RP Columns (Bio-C4, Bio-C8, Bio-C18) Bio Series reversed phase columns with monomeric, fully endcapped chemistry and large pore sizes (200–300 Å) for high-resolution peptide and small protein separations.
• HP-C18 Column High surface area silica-based reversed phase column with full ODS bonding providing excellent aqueous compatibility and loading capacity.
• GP Series RP Columns (GP-C4, GP-C8, GP-C18, GP-Phenyl) GP Series reversed phase columns with monomeric bonding chemistries suitable for acidic, neutral, and basic organic compounds including pharmaceuticals and organic acids.
• BR-C18 Column Reversed phase column with special bonding chemistry for wide pH range applications (1.5–10.5).
• ProAqa Excel Affinity Column Affinity column developed for monoclonal antibody titer determination using a Protein A platform.
• Monomix dT20 Affinity Column Methacrylate-based affinity column and resin for oligonucleotides with poly A tail applications.
• Proteomix POR50-dT20 Affinity Column PS/DVB-based affinity column and resin for oligonucleotides with poly A tail using dT20 ligand.
• BioService Affinity HSA Column Affinity column with human serum albumin conjugated to resin for studying molecular interactions of biomolecules with HSA.
• Proteomix POR-SA Affinity HTP Column Affinity HTP column designed for high-speed analysis of biotinylated biomolecules under high-pressure conditions.
• Carbomix Columns Ion exclusion column for organic acid, sugar, and alcohol analysis with calcium, lead, hydrogen, and sodium forms available.
• Tween Trap Column Mixed-mode column for surfactant analysis including Tween quantification in biotherapeutic drug production.
• Monomix H2P SAX Mixed-Mode Column Mixed-mode column for poloxamer and surfactant profiling and fingerprinting using comprehensive liquid chromatography-charge reduction mass spectrometry analysis.
• Affinity Conjugation Service Custom affinity resin development service with multiple immobilization chemistries including epoxy, NHS, Streptavidin Biotin, reductive amination, and disulfide exchange for fusion proteins, cross-reactivity studies, RNA purification, glycosylated compounds, and mAb purification.
• Analytical Method Development Service Method development and optimization services including column screening, validation, USP monograph testing, stability and batch release testing for affinity, IEX, HIC, SEC, and RP applications.
• SEC-MALS Screening Service Size exclusion chromatography coupled with multi-angle light scattering for accurate characterization of protein and particle size, shape, and molar mass with individually QC-tested columns.
• Custom Column Packing Service Custom column packing service supporting a wide range of resins and chromatography techniques from micro (75 µm to 1.0 mm ID) to industrial scale (50–800 mm ID) and FPLC columns.
• Purification Service Analytical to preparative scale purification service from mg to g scale for antibodies, recombinant proteins, and native proteins with method development and scouting.
• OEM and ODM Manufacturing Services Original Equipment Manufacturing (OEM) and Original Design Manufacturing (ODM) services for chromatography products, enabling partner-branded or custom-designed chromatography offerings.

Quantifiable outcome

• Run time reduced from 2 hours to 20 minutes (85% time savings) with same or higher resolution in SEC purification
• +5 more outcomes

Segments5 records

Ideal customer profiles5 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature9 records

Partnerships

One partnership is on record.

• Sepax BiosciencecoreOthersSepax Bioscience is a related company website (sepax-bio.com) offering process media for downstream purification. While not technically a partnership, it represents an affiliated entity within the Sepax corporate ecosystem, providing complementary bulk products and process-level purification solutions distinct from the analytical products on sepax-tech.com.

Scale indicators6 records

Recent moves6 records

Expansion highlights5 records

Regional players

• Sartorius: Sartorius supplies bioprocess chromatography resins and membrane adsorbers for downstream purification of biologics. Directly comparable to Sepax Bioscience on the process media side, particularly for monoclonal antibody and recombinant protein purification.

Direct peers

• Phenomenex (Danaher): Phenomenex manufactures HPLC columns and sample preparation products serving pharma, biotech and analytical chemistry labs. Comparable as a chromatography consumables specialist with similar go-to-market through catalogs, technical content, and direct sales.
• Bio-Rad Laboratories: Bio-Rad's Life Science segment sells a broad portfolio of chromatography columns, resins, and analytical instruments for protein and nucleic acid separation. Highly comparable product overlap (SEC, IEX, affinity) and similar biopharma customer targeting.
• Tosoh Bioscience: Tosoh Bioscience manufactures chromatography resins and columns for SEC, IEX, HIC and affinity modes used in biopharmaceutical purification. Directly comparable to Sepax in product type (resins and columns) and customer base (biopharma process development and manufacturing).

Broad incumbents

• SCIEX (Danaher): SCIEX provides mass spectrometry and capillary electrophoresis instruments used in biopharmaceutical characterization alongside columns and consumables. Comparable on the biopharma analytical characterization customer set and adjacent to Sepax's SEC-MALS and characterization offerings.
• Agilent Technologies: Agilent is a major manufacturer of HPLC columns, instruments, and biocolumns (AdvanceBio) for protein and biologic characterization. Overlaps with Sepax in HPLC column SKUs targeting analytical chemists in biopharma and academic labs.
• Cytiva (Danaher): Cytiva (part of Danaher's Life Sciences segment) is a leading global supplier of process chromatography resins (e.g., MabSelect, Capto), columns and systems for biomanufacturing. Broad incumbent serving the same biopharma downstream-processing customers as Sepax/Sepax Bioscience.
• Thermo Fisher Scientific: Thermo Fisher offers HPLC columns (Acclaim, MAbPac, ProPac, DNAPac), bioprocess resins, and analytical instruments across pharma and bioseparation markets. Broad incumbent with significant overlap in both analytical and process chromatography.
• Shimadzu Scientific Instruments: Shimadzu is a large manufacturer of HPLC systems and associated columns serving pharmaceutical and analytical labs globally. Overlaps with Sepax on the column side and competes for the same analytical chemistry budgets.
• Waters Corporation: Waters is a leading HPLC/UPLC instrument and column vendor with strong presence in biopharmaceutical characterization. Comparable as a chromatography column supplier to overlapping analytical chemists and QC labs, though at much larger scale.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks5 records

Key highlights7 records

Customer concentration

• LinkedInlinkedin.com/company/sepax-technologies-inc

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles9 records

Subsidiaries1 record

Funding overview

Funding rounds2 records

Investors8 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Sepax Technologies