ReactWise

What ReactWise does

ReactWise is an AI-driven chemical process optimization platform that serves pharmaceutical, biotechnology, materials science, and fine chemicals R&D teams. Founded in 2022 in London, the company has established a US entity (ReactWise Inc.) in San Francisco and operates an R&D laboratory in Cambridge, UK. Its named customer base spans 5 of the top 10 global pharmaceutical companies, with disclosed engagements at Pfizer, Amgen, Biogen, Pharmaron, and On Demand Pharmaceuticals, supported by 12 active pilot studies and new-vertical accounts in materials science (A&B Smart Materials) and fine chemicals (AmarFLO).

The company's core technology combines Bayesian optimization with its proprietary MemoryBO multi-task learning algorithm, pre-trained on more than 25,000 proprietary high-throughput experimentation (HTE) data points. The product portfolio comprises a software optimization platform, HTE Plate Designer, Solvent Selector, HTE Data on Demand, Kinetic Modeling tools, an in-platform AI assistant named Vera, and physical Glass HTE Plates. The platform is designed to integrate with existing laboratory infrastructure and ELN systems, including an established integration partnership with AI4Green, and exposes SHAP-based interpretability to chemists.

ReactWise operates a primarily SaaS-based business model with per-user licensing and annual enterprise contracts, complemented by data monetization through HTE Data on Demand and hardware revenue from Glass HTE Plates. The company is pre-seed stage with $3.4M raised, holds SOC 2 Type 2 (achieved June 2026) and ISO 27001 certifications, and is part of the Y Combinator Summer 2024 batch. Its scientific advisory board includes Klavs Jensen (MIT) and Steven Ley (Cambridge), and the founding team comprises Cambridge-trained PhDs in machine learning and chemistry.

Name

ReactWise

Legal name

ReactWise Inc.

Website

https://reactwise.com

Company type

Private

Founded year

2022

Operating status

Operating

Headcount range

11–50 employees

Short description

ReactWise is an AI-driven chemical process optimization platform that uses proprietary multi-task Bayesian optimization (MemoryBO) to help pharmaceutical, biotech, materials science, and fine chemicals R&D teams accelerate reaction development. Founded in 2022 in London, it serves major pharmaceutical companies including Pfizer, Amgen, and Biogen.

Ownership category

akta.pro rank

Product category

Chemical Process Optimization Software

NAICS

Research and Development in Biotechnology (except Nanobiotechnology) (541714), Custom Computer Programming Services (541511)

SIC

Services-Prepackaged Software (7372)

akta.pro primary industry

AI/ML Platforms for Drug Discovery & Experiment Optimization (HLAGAJAO)

akta.pro secondary industry

End-to-End Enterprise AI Platforms (MLOps & Model Lifecycle Management) (HDAEANAA)

Keywords

• Chemical process optimization
• Bayesian optimization software
• High throughput experimentation
• Machine learning chemistry
• Drug manufacturing AI

Headquarters

HQ city

London

HQ country

United Kingdom

HQ region

Europe

Offices3 records

Markets served

GTM type

B2B

Offering type

Software

Cost components

Technology or R&D, Personnel, Operations, Marketing or Sales, Supply Chain

Revenue model

1. Software Subscription (User Subscriptions): SaaS subscription model based on user seats. Clients purchase user subscriptions that entitle Authorised Users to access the Services. Fees calculated as number of User Subscriptions multiplied by price per User Subscription. Service Capacity of 1,000 experiments per User Subscription per day.
2. HTE Data on Demand: Large-scale HTE data generation service to support reactivity models. Generates structured, machine-readable, FAIR datasets in ORD format. Can deliver data as a service or validated production-ready reactivity models.
3. Professional Services: Hands-on onboarding, technical documentation, and ongoing support included. Standard and enhanced support fees waived for Subscription Term. Technical team available via email and next-day calls.
4. Glass HTE Plates: Physical product: reusable glass well-plates for high throughput experimentation (Borosilicate, Quartz). Compatible with standard 96/384-well plate chemistry equipment. Includes sealing kit.

Pricing tiers

Go-to-market motion3 records

Distribution channels5 records

Marketing channels9 records

Core offering

ReactWise provides a cloud-based AI software platform for chemical reaction and process optimization, using proprietary multi-task Bayesian optimization (MemoryBO) to recommend experimental conditions and accelerate pharmaceutical and chemical R&D. The platform includes the Optimization Platform, HTE Plate Designer, Solvent Selector, and Kinetic Modeling tools, with optional HTE data-generation services, glass well-plates, and programmable API connectivity to automated laboratory hardware for closed-loop, self-driving workflows.

Product overview

ReactWise is an AI-powered chemical process optimization platform consisting of four core products: the Optimization Platform (Bayesian optimization engine with MemoryBO® transfer learning), HTE Plate Designer (generates machine-readable plate layouts for high-throughput experimentation), Solvent Selector (identifies green solvent replacements using Hansen space analysis), and HTE Data on Demand (large-scale data generation service). The platform is complemented by Glass HTE Plates (reusable laboratory equipment) and Kinetic Modeling capabilities (automated model fitting for scale-up). ReactWise serves pharmaceutical, biotech, and fine chemicals R&D teams, integrating with ELNs, LIMS, and automated laboratory hardware for closed-loop optimization.

Differentiator

Problem solved

Functional benefit

Brands

• MemoryBO: ReactWise's proprietary multi-task Bayesian optimization algorithm that can learn from previous data and transfer learning across related reactions.

Products and services

• Optimization Platform A Bayesian optimization engine with transfer learning capabilities for chemical process development, formulations, and method development. Replaces trial-and-error approaches with data-driven optimization that learns from every experiment.
• HTE Plate Designer Generates structured, machine-readable plate layouts for high-throughput experimentation in 24, 48, 96, or 384-well formats. Provides intelligent plate balancing with automated validation against well budget.
• Solvent Selector Identifies green single and binary mix solvent replacements for toxic or polluting industrial solvents using Hansen space analysis. Shows solvent similarity and greenness trade-offs.
• HTE Data on Demand Large-scale HTE data generation service to support reactivity models. Designs and runs experimental campaigns generating structured, machine-readable, FAIR datasets in ORD format. Includes validated production-ready reactivity models.
• Glass HTE Plates Reusable glass well-plates for high-throughput experimentation made from Borosilicate, Quartz, and other materials. Compatible with industrially relevant solvents like toluene and dioxane that are incompatible with plastic single-use plates. Includes sealing kit.

Quantifiable outcome

• Accelerates chemical process development by 30x, cutting up to 95% of experimental work
• +5 more outcomes

Named customers9 records

Segments4 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

Yes

API docs

API detail

Core technology

AI maturity

App detail

Integration6 records

AI capability8 records

Feature6 records

Partnerships

Two partnerships are on record, tiered core and minor.

• AI4GreencoreTechnology or IntegrationReactWise integrated with AI4Green's electronic lab notebook (ELN) enabling two-way data exchange. Historical ELN data supports MemoryBO and improves future recommendations, while ReactWise data is sent back to the ELN. Reduces manual data handling and links optimization with laboratory records.
• University of Warwick (Polymer Group)minorStrategic or Co-development PartnerCollaborative research partnership with University of Warwick polymer group on Henry Royce Institute-funded project for sustainable polymer development using ReactWise optimization platform.

Scale indicators10 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• Citrine Informatics: AI platform for materials and chemicals R&D using Bayesian optimization and machine learning. Comparable in applying AI/ML to chemistry and materials experimentation, with similar enterprise pharma/chemicals customer base.
• Schrödinger: Public AI-driven molecular simulation and drug discovery platform with materials science and process optimization offerings. Most directly comparable as an AI-for-chemistry software company serving pharma R&D with subscription-based enterprise SaaS.

Broad incumbents

• Insilico Medicine: AI-driven drug discovery company with chemistry optimization capabilities. Comparable in using AI/ML across pharma R&D workflows, though more focused on target identification and lead generation than process chemistry optimization.
• Recursion Pharmaceuticals: Public AI-driven drug discovery company combining high-throughput experimentation with machine learning. Comparable in the AI-for-pharma-R&D category, though focused more on phenotypic screening and target discovery than process optimization.
• Exscientia: Public AI-driven precision medicine company applying ML to drug design and optimization. Overlaps with ReactWise in pharma AI platform positioning, though more focused on small molecule design than chemical process optimization.
• Dotmatics: Enterprise scientific intelligence platform for R&D including ELN, LIMS, and data analysis. Comparable as enterprise software serving pharma/biotech R&D with chemistry workflow integration, though broader in scope than ReactWise's optimization focus.
• IBM RXN: IBM's AI chemistry platform for reaction prediction and retrosynthesis. Overlaps with ReactWise in applying AI to chemical reaction optimization, but as part of IBM's broader R&D portfolio rather than a specialized startup.

Emerging players

• Strateos: Cloud-based automated chemistry and biology lab platform with AI-driven experimental design. Comparable in the self-driving lab category and integration with optimization software for chemistry workflows.
• Emerald Cloud Lab: Remote-controlled automated laboratory platform enabling self-driving experimentation. Comparable in combining AI optimization with closed-loop lab automation, though primarily focuses on general-purpose lab access rather than pharma-specific process optimization.
• Benchling: Cloud-based platform for biotech R&D including ELN, LIMS, and molecular biology tools. Adjacent competitor in pharma R&D software; ReactWise integrates with ELNs like AI4Green that complement Benchling's offerings.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks5 records

Key highlights6 records

Customer concentration

• Xx.com/ReactWise
• LinkedInlinkedin.com/company/reactwise

Compliance2 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles13 records

Funding overview

Funding rounds3 records

Investors2 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about ReactWise