Repligen
Repligen is a publicly traded bioprocessing technology company that develops consumables, filtration, chromatography, and process analytics systems used by biopharmaceutical manufacturers, CDMOs, and advanced therapy developers to produce monoclonal antibodies, viral vectors, mRNA, pDNA, and ADCs.
- Company typePublic
- Founded1981
- HeadquartersWaltham, United States
- Headcount1,001–5,000
- GTM typeB2B
- OfferingHardware or Manufacturing
What Repligen does
Repligen Corporation (NASDAQ: RGEN) is a publicly traded bioprocessing technology company founded in 1981 and headquartered in Waltham, Massachusetts. It develops and manufactures consumables, equipment, and integrated systems used by biopharmaceutical manufacturers, contract development and manufacturing organizations (CDMOs), and advanced therapy developers for the production of biological drugs including monoclonal antibodies, viral vectors, mRNA, pDNA, and antibody-drug conjugates.
The product portfolio spans four integrated franchises: upstream filtration (XCell ATF perfusion systems for cell retention and process intensification), downstream processing (KrosFlo TFF systems, TangenX cassettes, Spectrum hollow fiber filters), chromatography (KRM systems, OPUS pre-packed columns spanning 1.2cm to 80cm diameters, AVIPure and HiPer affinity/ion exchange resins), and process analytics (PATsmart family including FlowVPX, SoloVPE, REBEL XT, and ZipChip instruments built on proprietary Variable Pathlength Spectroscopy). Supporting these are fluid management solutions (ProConnex flow paths, Metenova magnetic mixing), cell culture supplements (LONG R3 IGF-I, LONG EGF), ligands (rSPA, Protein A, NGL-Impact A), and the Real-time Process Management (RPM) platform that ties FlowVPX analytics directly into KrosFlo TFF for closed-loop concentration control. Manufacturing spans 13+ ISO-certified facilities across the US, Netherlands, Germany, Sweden, Ireland, Estonia, and Taiwan.
Repligen operates a hybrid B2B go-to-market combining direct enterprise field sales supported by field application specialists, an e-commerce storefront for standard products, and a global distributor network. Revenue is generated through capital equipment sales (TFF, chromatography, perfusion systems), recurring consumables (resins, cassettes, filters, flow paths), professional services (installation, qualification, maintenance, training), and software — under a quote-based, configuration-driven pricing model. Growth has been driven by a sustained M&A program (Tantti 2024, Metenova 2023, Avitide 2021 ~$150M, Polymem 2021, plus earlier Spectrum, C Technologies, ARTeSYN, TangenX, and Atoll deals) and strategic partnerships (notably Sartorius AG for integrated upstream solutions), supported by a $600M convertible senior notes offering in December 2023.
Repligen firmographics
Firmographics- Name
- Repligen
- Legal name
- Repligen Corporation
- Website
- https://repligen.com
- Company type
- Public
- Founded year
- 1981
- Operating status
- Operating
- Headcount range
- 1,001–5,000 employees
- Short description
- Repligen is a publicly traded bioprocessing technology company that develops consumables, filtration, chromatography, and process analytics systems used by biopharmaceutical manufacturers, CDMOs, and advanced therapy developers to produce monoclonal antibodies, viral vectors, mRNA, pDNA, and ADCs.
- Ownership category
- akta.pro rank
Repligen industry classification
Industry- Product category
- Bioprocessing Equipment and Consumables
- NAICS
- Analytical Laboratory Instrument Manufacturing (334516)
- SIC
- Laboratory Analytical Instruments (3826)
- akta.pro primary industry
- Bioprocess Consumables & Reagents (resins, membranes, media components, buffers) (HLAAAJAI)
Keywords
Where Repligen is headquartered
LocationHeadquarters
- HQ city
- Waltham
- HQ country
- United States
- HQ region
- North America
Offices20 records
Markets served
Repligen business model
Business model- GTM type
- B2B
- Offering type
- Hardware or Manufacturing
- Cost components
- Supply Chain, Personnel, Operations, Technology or R&D, Marketing or Sales, Infrastructure
Revenue model
- Capital Equipment Sales: Sale of bioprocessing capital equipment including TFF systems (KrosFlo family), chromatography systems (KRM), XCell ATF systems, and real-time process management systems. Equipment ranges from bench-scale development tools to large-scale GMP production systems.
- Consumables: Recurring revenue from single-use consumables including chromatography resins (AVIPure, HiPer, CaptivA), TFF cassettes (TangenX), hollow fiber filters (Spectrum), flow paths (ProConnex), and process analytics consumables.
- Services and Support: Professional services including installation, qualification (IQ/OQ), preventive maintenance, calibration, spare parts, and service plans (Essential, Protected, Complete). Also includes training and application support services.
- Software: Software solutions including KF Comm 2, KlariFi, and VPT software for process control, monitoring, and data management in bioprocessing operations.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Unit Pricing | Multi-year contract | Enterprise/Bulk pricing |
| Unit Pricing | Pay-as-you-go | Standard product pricing |
Go-to-market motion2 records
Distribution channels4 records
Marketing channels10 records
Repligen product offering
Product offeringCore offering
Repligen designs, manufactures, and sells bioprocessing technologies used in the manufacture of biological drugs. Its offering spans upstream cell-culture intensification (XCell ATF), single-use and process filtration (KrosFlo TFF, TangenX cassettes, Spectrum hollow fibers), downstream purification (OPUS pre-packed chromatography columns, KRM chromatography systems, AVIPure and other resins, ProConnex flow paths), and process analytics (PATsmart variable-pathlength UV instruments). Products are sold to biopharmaceutical manufacturers and contract development and manufacturing organizations (CDMOs) for use in clinical and commercial biologics production.
Product overview
Repligen offers an integrated bioprocessing technology platform for biopharmaceutical manufacturing, spanning both upstream and downstream operations. The portfolio centers on XCell ATF perfusion systems, KrosFlo TFF systems (tangential flow filtration), KRM chromatography systems, and OPUS pre-packed chromatography columns as core platforms. Supporting these are PATsmart process analytics products (FlowVPX, SoloVPE, REBEL XT, MAVEN, MAVERICK, ZipChip) for real-time monitoring, ProConnex flow paths for single-use fluid management, and a comprehensive range of consumables including AVIPure and HiPer affinity/ion exchange resins, cell culture supplements (LONG R3 IGF-I, LONG EGF), ligands (rSPA, Protein A), ELISA kits, and SpectraPor dialysis products. The company serves monoclonal antibodies, viral vectors, mRNA, pDNA, ADC, and cell therapy manufacturing workflows, providing both hardware systems and consumables that scale from process development through GMP commercial manufacturing.
Differentiator
Problem solved
Functional benefit
Brands
- XCell ATF: Single-use perfusion system with controller and hollow fiber module for intensified cell culture processes
- KrosFlo
- OPUS
- TangenX
- Spectrum
- PATsmart
- ProConnex
- AVIPure
- KRM
- Metenova
Products and services
- XCell ATF (Alternating Tangential Flow) Systems
Quantifiable outcome
- 14% organic revenue growth achieved in FY2025
- +3 more outcomes
Companies that use Repligen
Customer profileNamed customers4 records
Segments4 records
Ideal customer profiles2 records
Repligen technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Feature9 records
Repligen partnerships and signals
Strategic signalPartnerships
One partnership is on record.
- Sartorius AGcoreIn August 2023, Germany-based Sartorius AG partnered with US-based Repligen Corporation to introduce an integrated upstream bioprocessing system combining BIOSTAT STR and XCell ATF technologies for biopharmaceutical manufacturing. The partnership enables end-to-end process solutions for customers seeking integrated perfusion bioreactor and cell retention solutions.
Scale indicators13 records
Recent moves7 records
Expansion highlights6 records
Repligen competitors and assessment
Company assessmentDirect peers
- Cytiva (Danaher): Global bioprocessing leader within Danaher providing ÄKTA chromatography systems, MabSelect resins, Xuri cell expansion, and filtration solutions. Competes directly with Repligen across TFF, chromatography columns, and process analytics across all major biopharma markets.
- Merck KGaA (Life Science / MilliporeSigma): Major bioprocessing player offering Mobius single-use solutions, filtration, chromatography, and cell culture media through MilliporeSigma. Competes with Repligen in TFF cassettes, chromatography resins, and bioprocess consumables.
- Asahi Kasei Medical: Japanese bioprocessing company offering Planova virus filters, bioprocess equipment, and hollow fiber membranes. Competes with Repligen in filtration and selected bioprocessing product categories, particularly in Asia-Pacific.
- Sartorius AG: German bioprocessing leader offering bioreactors (BIOSTAT STR), filtration, and cell culture media. Direct competitor in upstream bioprocessing and Repligen's strategic partner for integrated BIOSTAT STR + XCell ATF systems — competing in perfusion and single-use bioreactors globally.
- Eppendorf: German bioprocessing and lab equipment provider offering bioreactors (BioFlo), cell culture, and consumables. Competes with Repligen in selected bioprocessing equipment and consumables categories globally.
- Pall Corporation (Danaher): Filtration and bioprocessing specialist providing TFF cassettes, hollow fiber filters, and chromatography systems under Danaher. Direct competitor in tangential flow filtration and single-use fluid management solutions.
Emerging players
- Waters Corporation: Analytical instruments specialist providing chromatography and mass spectrometry systems used in bioprocess analytics and quality control. Comparable to Repligen's PATsmart analytics franchise in bioprocess analytical instrumentation.
- Bio-Techne: Life sciences company with a growing bioprocessing presence through ProteinSimple (analytical instruments) and cell culture supplements. Provides complementary process monitoring and analytical solutions adjacent to Repligen's PAT portfolio.
Broad incumbents
- Avantor: Global supplier of laboratory products, bioprocessing materials, and single-use consumables through its bioproduction segment. Competes with Repligen in bioprocess fluids, buffers, and single-use fluid management solutions.
- Thermo Fisher Scientific: Diversified life sciences giant competing through its Life Sciences Solutions segment (Gibco cell culture, Patheon CDMO, Poros chromatography resins). Competes with Repligen across chromatography, bioprocessing consumables, and PAT instruments as part of a broader portfolio.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat5 records
Key risks6 records
Key highlights7 records
Customer concentration
Repligen social profiles
Digital presenceRepligen compliance and trust
Trust signalCompliance3 records
Repligen financial estimates
Financial estimateRevenue estimate
Valuation estimate
Repligen leadership team
Management profileNumber of profiles
Profiles6 records
Repligen subsidiaries and ownership
Company hierarchySubsidiaries4 records
Repligen funding detail
Funding detailFunding overview
Funding rounds6 records
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Repligen M&A and investment
M&A and investmentM&A11 records
Investments1 record
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Repligen
What does Repligen do?
Repligen designs, manufactures, and sells bioprocessing technologies used in the manufacture of biological drugs. Its offering spans upstream cell-culture intensification (XCell ATF), single-use and process filtration (KrosFlo TFF, TangenX cassettes, Spectrum hollow fibers), downstream purification (OPUS pre-packed chromatography columns, KRM chromatography systems, AVIPure and other resins, ProConnex flow paths), and process analytics (PATsmart variable-pathlength UV instruments). Products are sold to biopharmaceutical manufacturers and contract development and manufacturing organizations (CDMOs) for use in clinical and commercial biologics production.
Is Repligen a public or private company?
Repligen is a public company. It is classified as public and is currently operating.
When was Repligen founded?
Repligen was founded in 1981. It employs 1,001 to 5,000 people.
Where is Repligen based?
Repligen is headquartered in Waltham, United States, in the North America region.
How does Repligen make money?
Four revenue lines are on record. Capital Equipment Sales are the primary driver. The others are consumables, services and Support and software.
Who are Repligen's main competitors?
Direct peers on record are Cytiva (Danaher), Merck KGaA (Life Science / MilliporeSigma), Asahi Kasei Medical, Sartorius AG, Eppendorf and Pall Corporation (Danaher). Emerging players are Waters Corporation and Bio-Techne. Broad incumbents are Avantor and Thermo Fisher Scientific.
Does Repligen have an API?
No public API is recorded for Repligen.
What industry is Repligen in?
Repligen's product category is Bioprocessing Equipment and Consumables. Its primary akta.pro industry code is HLAAAJAI, Bioprocess Consumables & Reagents (resins, membranes, media components, buffers). Its NAICS code is 334516 and its SIC code is 3826.