Integrated DNA Technologies

What Integrated DNA Technologies does

Integrated DNA Technologies (IDT), founded in 1987 and headquartered in Coralville, Iowa, manufactures custom DNA and RNA oligonucleotides together with adjacent genomics reagents for academic researchers, pharmaceutical and biotechnology companies, clinical diagnostic laboratories, and agricultural science customers across more than 100 countries. The company's product portfolio spans standard and long (up to 200-base) custom oligos, oligo pools, locked nucleic acid variants, CRISPR-Cas9/Cas12a reagents and CGMP guide RNAs, NGS library preparation kits and hybridization capture panels under the xGen brand, Anchored Multiplex PCR-based Archer assays, gene fragments (gBlocks, Rapid Genes), qPCR and genotyping reagents, and in-house GMP oligonucleotide manufacturing.

Its core technology rests on vertically integrated proprietary synthesis platforms with custom-engineered synthesizers and in-house formulated reagents, delivering 99.4-99.6% coupling efficiency versus competitors at approximately 99.1%, supported by specialized processes such as TruGrade (sub-0.10% crosstalk) and oPools (sub-0.8% dropout). The company is ISO 9001 and ISO 13485 certified, employs over 325 engineers and PhD scientists within a 1,001-5,000 employee base, and announced a more than threefold expansion of its Coralville synthesis capacity in April 2026. In March 2026, IDT launched its first IVD products, Archer FUSIONPlex-HT Dx and VARIANTPlex-HT Dx, marking entry into regulated clinical oncology diagnostics.

IDT operates as a wholly-owned subsidiary of Danaher Corporation and generates revenue primarily through one-time purchase sales priced per base (standard desalted oligos from $0.47/base at 25nmole scale up to $2.10/base for 20nmole Ultramer), with SameDay expedited service at $0.81/base and quote-based pricing for GMP and IVD products. Its go-to-market combines a global direct e-commerce storefront on idtdna.com (with SameDay regional fulfillment across the US, Europe, and Singapore) and an enterprise field sales motion for GMP, IVD, and large custom orders. Recent strategic moves include collaborations with Illumina, Ansa Biotechnologies, Beckman Coulter Life Sciences, Hamilton, Profluent Bio, and Cytiva, the IVD product launch, the Coralville capacity expansion, and a December 2025 restructuring that reduced Iowa headcount by 4.7%.

Name

Integrated DNA Technologies

Legal name

Integrated DNA Technologies, Inc.

Website

https://idtdna.com

Company type

Private

Founded year

1987

Operating status

Operating

Headcount range

1,001–5,000 employees

Short description

Integrated DNA Technologies manufactures custom DNA and RNA oligonucleotides, CRISPR gene editing reagents, NGS library preparation kits, and IVD oncology assay kits. A Danaher subsidiary, it serves over 130,000 researchers across 100+ countries from its Coralville, Iowa headquarters.

Ownership category

akta.pro rank

Product category

Genomics Reagents and Custom Oligonucleotide Synthesis

NAICS

In-Vitro Diagnostic Substance Manufacturing (325413), Medical Laboratories (621511)

SIC

In Vitro & In Vivo Diagnostic Substances (2835), Laboratory Analytical Instruments (3826)

akta.pro primary industry

Molecular Biology & Genomics Instruments (PCR/qPCR, Sequencing, Microarrays) (HLAGAIAF)

akta.pro secondary industries

CRISPR & Functional Genomics Screening Platforms (pooled/arrayed screens, perturb-seq) (HLAAAIAG), Molecular Diagnostics (PCR/NAAT/NGS-based IVD) (HLAHAAAD), Molecular Diagnostics (PCR/qPCR, NGS-based assays) (HLAAALAA)

Keywords

• Custom oligonucleotide synthesis
• DNA RNA oligos
• NGS library preparation
• CRISPR gene editing reagents
• GMP oligo manufacturing

Headquarters

HQ city

Coralville

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Operations, Technology or R&D, Supply Chain, Infrastructure, Marketing or Sales

Revenue model

1. Custom Oligonucleotide Sales: IDT generates revenue primarily through the sale of custom DNA and RNA oligonucleotides, including standard desalted oligos, purified oligos (PAGE, HPLC), long oligos (Ultramer), and specialized products (TruGrade, Affinity Plus). Revenue is one-time purchase based with scale-based pricing per base.
2. Large-Scale/GMP Oligo Manufacturing: Bulk synthesis services ranging from milligram to gram quantities for commercial applications, including GMP manufacturing with ISO 13485 compliance for customers requiring controlled processes and traceability for diagnostic and therapeutic applications.
3. NGS Products and Library Preparation: Sale of next-generation sequencing products including library preparation kits, hybridization capture panels, amplicon sequencing solutions, adapters, and indexing primers for various sequencing platforms.
4. IVD Assay Kits: Clinical diagnostics products including Archer FUSIONPlex-HT Dx and VARIANTPlex-HT Dx assay kits for oncology testing in clinical laboratories, representing IDT's entry into the IVD market.

Pricing tiers

Go-to-market motion2 records

Distribution channels3 records

Marketing channels9 records

Core offering

IDT manufactures and sells custom DNA and RNA oligonucleotides (oligos) along with related genomics reagents, CRISPR gene-editing tools, next-generation sequencing (NGS) library preparation and capture panels, double-stranded gene fragments, qPCR probes and assays, and ISO 13485-certified GMP oligos. Products support the full research-to-clinical workflow from basic PCR primers to in vitro diagnostic (IVD) oncology assay kits (Archer FUSIONPlex-HT Dx and VARIANTPlex-HT Dx).

Product overview

Integrated DNA Technologies (IDT) is a Danaher company offering a comprehensive genomics solutions portfolio centered on custom oligonucleotide synthesis, CRISPR gene editing reagents, gene synthesis fragments, and next-generation sequencing (NGS) products. The core product lines include Custom DNA/RNA Oligos with over 1,000 modification options (offered as standard, Ultramer long oligos, oPools pools, SameDay expedited, TruGrade, and Affinity Plus locked nucleic acid variants), the Alt-R CRISPR-Cas9 and Cas12a systems with guide RNAs and CGMP manufacturing capabilities, gBlocks HiFi and Rapid Genes gene fragments, the xGen NGS portfolio encompassing library preparation kits, hybridization capture panels (xGen Exome v2, predesigned and custom hyb panels), amplicon sequencing panels for oncology, and the Archer Anchored Multiplex PCR-based assays for RNA/DNA analysis and IVD solutions (FUSIONPlex-HT Dx and VARIANTPlex-HT Dx). Supporting offerings include PrimeTime qPCR probes and assays, rhAmp SNP genotyping, GMP oligo manufacturing, and the SciTools Plus API for e-commerce integration.

Differentiator

Problem solved

Functional benefit

Brands

• xGen: NGS library preparation and hybridization capture product line
• Archer
• Alt-R
• TruGrade
• Ultramer
• gBlocks
• PrimeTime
• rhAmp
• IDT Align

Products and services

• Custom DNA Oligos Single-stranded and duplexed DNA sequences synthesized for PCR primers, qPCR probes, indexed adapters, and custom research applications. Over 90% of standard desalted orders ship within 24 hours.
• Custom RNA Oligos Custom-synthesized single-stranded RNA oligonucleotides for research applications including gene expression analysis, RNA interference, and antisense studies.
• Ultramer DNA Oligos Long single- and double-stranded DNA oligos up to 200 bases using IDT's proprietary synthesis method with over 99.6% coupling efficiency, designed for demanding applications such as cloning, ddRNAi, and homology-directed repair (HDR).
• oPools Oligo Pools Pooled single-stranded DNA oligos for CRISPR libraries, multiplex PCR primer pools, gene construction, and DNA data storage with high fidelity and uniformity up to 350 bases. Scale ranges from 100 to 20,000 oligos per pool with <0.8% average dropout across 900,000+ oligos tested.
• SameDay Oligos Standard desalted DNA oligos shipped same business day when ordered before geographical deadlines (US 3:00pm ET, Europe 1:00pm CET, Singapore 10:00am SGT).
• TruGrade DNA Oligos DNA oligos manufactured using IDT's proprietary process to reduce index crosstalk with cross-contamination levels as low as 0.01% for multiplexed NGS applications.
• Affinity Plus DNA & RNA Oligonucleotides Custom oligos containing 1-20 locked nucleic acid nucleotides for enhanced hybridization specificity, stability, and nuclease resistance in hybridization-based applications such as qPCR probes and antisense oligos.
• Alt-R CRISPR-Cas9 System Optimized Alt-R genome editing reagents for producing on-target double-stranded DNA breaks using CRISPR-Cas9 technology, including guide RNAs, donor templates, and HDR enhancers.
• Alt-R CRISPR-Cas12a (Cpf1) System CRISPR genome editing system using the Cas12a (Cpf1) enzyme for additional targeting capabilities and AT-rich PAM recognition in genomes.
• Alt-R CRISPR Libraries Genome-wide and custom CRISPR guide RNA libraries for functional genomics screening applications, supported by a new online design and ordering tool.
• CGMP CRISPR gRNA Manufacturing Full CGMP guide RNA manufacturing and regulatory documentation services for CRISPR therapeutic applications, supported by an ISO 13485:2016 quality management system.
• gBlocks HiFi Gene Fragments NGS-verified clonal double-stranded DNA gene fragments from 126 bp to 2000 bp designed to reduce screening time and minimize cloning errors.
• Rapid Genes Ready-to-use NGS-verified clonal genes delivered in as little as 5 days for accelerated high-throughput screening workflows.
• xGen NGS Library Preparation Kits DNA and RNA library preparation kits for next-generation sequencing workflows on Illumina and other sequencing platforms, including the DNA EZ v2 kit.
• xGen Hybridization Capture Panels Predesigned and custom hybridization capture panels for targeted DNA sequencing, including exome panels (xGen Exome v2) and oncology research panels.
• xGen Oncology Amplicon Panels Predesigned amplicon panels for targeted sequencing in oncology and inherited disease research applications.
• Archer NGS Assays (Anchored Multiplex PCR) RNA and DNA assays based on IDT's proprietary anchored multiplex PCR (AMP) chemistry for fusion detection, variant analysis, ctDNA panels, and T/B cell immune profiling in solid tumor, blood cancer, and genetic disease research.
• Archer FUSIONPlex-HT Dx In vitro diagnostic (IVD) assay kit for fusion detection in molecular pathology laboratories. Color-coded, robot-friendly reagents for streamlined clinical oncology diagnostics.
• VARIANTPlex-HT Dx In vitro diagnostic (IVD) assay kit for variant detection in molecular pathology laboratories, part of IDT's entry into the NGS IVD market for clinical oncology diagnostics.
• PrimeTime qPCR Probes and Assays Predesigned and custom qPCR probes and primer assays (including PrimeTime Gene Expression, Pathogen Research, and Sexual Health Research Panels) for gene expression analysis, SNP genotyping, and pathogen research.
• rhAmp SNP Genotyping System SNP genotyping assays using rnase H2-dependent PCR (rhAmp) chemistry for high-performance allele discrimination, including rhAmpSeq CRISPR data analysis system.
• GMP Oligo Manufacturing ISO 13485-certified custom GMP oligos, primers, and probes for commercial and molecular diagnostic applications, with full regulatory documentation and traceability.
• SciTools Plus API E-commerce integration API for enterprise customers needing punchout, portal, or API connectivity for ordering, design tools, and account management with IDT.

Quantifiable outcome

• 99.4-99.6% coupling efficiency vs competitors at ~99.1%, resulting in more full-length product
• +3 more outcomes

Named customers1 record

Segments4 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration2 records

Feature6 records

Partnerships

Seven partnerships are on record, tiered core and minor.

• IlluminacoreStrategic or Co-development Partner · 1 June 2026Strategic collaboration to deliver integrated end-to-end oncology research workflows combining IDT's xGen FFPE and cfDNA library preparation with Illumina's DRAGEN secondary analysis platform. Initial workflows include DRAGEN Somatic for IDT Custom Panels with low-quality FFPE mode, with a cfDNA liquid biopsy version planned for 2027. Data compatible with Illumina Connected Insights.
• Ansa BiotechnologiescoreStrategic or Co-development Partner · 27 March 2026Strategic collaboration to expand IDT's synthetic biology portfolio with Ansa's Clonal DNA and XL Clonal DNA products (100 bp to 50 kb). Combines IDT's 40-year legacy and global presence with Ansa's enzymatic DNA synthesis platform for cell and gene therapy discovery, vaccine research, and agrigenomics applications. Products exclusively manufactured in the US.
• Cytiva (Danaher)coreStrategic or Co-development Partner · 23 March 2026Multi-year collaboration with San Raffaele Telethon Institute for Gene Therapy (SR-TIGET) and Cytiva to advance next-generation genomic medicine platforms. First Danaher Beacon in EU. Focus on lentiviral vector production and homology-directed repair-based gene editing in hematopoietic stem cells. IDT contributes alongside Aldevron.
• AldevroncoreStrategic or Co-development Partner · 27 February 2026Manufacturing partnership for world's first mRNA-based personalized CRISPR therapy. IDT and Aldevron manufactured critical components for Baby KJ Muldoon's individualized therapy, demonstrating capability in rare disease gene editing treatments.
• Beckman Coulter Life SciencescoreTechnology or Integration · 13 November 2025Strategic partnership to automate NGS assay solutions on the Biomek i3 Liquid Handler. Focuses on automating targeted sequencing assays and hybrid capture workflows to enhance precision, scalability, and reproducibility in cancer research laboratories.
• Profluent BiominorStrategic or Co-development Partner · 22 October 2025Collaboration to develop new enzymes using AI-driven protein design and genomics expertise. Partnership aims to accelerate creation of next-generation enzymes for various applications including oncology research.
• HamiltoncoreTechnology or Integration · 2 October 2025Global strategic partnership to automate next-generation sequencing workflows for biomarker discovery in cancer research. Development of automation scripts for IDT's xGen and Archer NGS products compatible with Hamilton's Microlab STAR and NIMBUS liquid handling platforms to reduce manual laboratory processes.

Scale indicators9 records

Recent moves7 records

Expansion highlights6 records

Broad incumbents

• Agilent Technologies: Provides SureSelect target enrichment and NGS library prep products that overlap with IDT's xGen hybridization capture panels, alongside oligo synthesis and qPCR/PCR reagent offerings through its Life Sciences and Diagnostics segments.
• Thermo Fisher Scientific: Identified alongside IDT as a key player in the $5.7B global oligonucleotide synthesis market. Thermo Fisher competes directly with IDT in custom oligos, qPCR probes, and NGS library prep through its Life Sciences Solutions segment and is a much larger diversified incumbent.
• Merck KGaA (MilliporeSigma): Named alongside IDT and Thermo Fisher as a key player in the global oligonucleotide synthesis market. Merck's MilliporeSigma and Sigma-Aldrich brands supply custom oligos, qPCR reagents, and bioprocess materials, competing with IDT across research and GMP oligo manufacturing.
• Qiagen: Established sample-prep and molecular diagnostics company whose QIAseq NGS panels and oncology IVD workflows compete directly with IDT's Archer AMP-based clinical assays and xGen hybridization capture products.

Direct peers

• Twist Bioscience: Silicon-platform DNA synthesis competitor that overlaps with IDT's gBlocks gene fragments, oligo pools for CRISPR libraries, and NGS target enrichment panels. Twist's NGS product line competes directly with IDT's xGen hybridization capture and amplicon offerings.
• Eurofins Genomics: One of the largest global custom oligonucleotide manufacturers, directly competing with IDT on standard and modified DNA/RNA oligos for research and diagnostics customers across Europe, North America, and Asia.
• Bio-Techne: Provides custom oligos, qPCR reagents, and protein-based research tools, with overlap to IDT's PrimeTime qPCR probes and gene expression assays, plus competition in GMP-grade oligo and reagent manufacturing for diagnostics customers.
• GenScript: Global provider of custom gene synthesis, oligo synthesis, and CRISPR reagents with overlapping offerings to IDT's gBlocks, Alt-R CRISPR, and cell/gene therapy manufacturing services, particularly in the gene and cell therapy CDMO value chain.
• LGC Biosearch Technologies: Specialist oligo and probe manufacturer competing directly with IDT in custom DNA oligos, fluorescent probes for qPCR, and NGS library prep kits, with particular strength in genomics tools serving agricultural and clinical diagnostic customers.

Emerging players

• Ansa Biotechnologies: Enzymatic DNA synthesis startup whose Clonal DNA and XL Clonal DNA products (100 bp-50 kb) are now distributed by IDT under a strategic partnership. Represents both a complementary partner for longer constructs and a potential disruptive alternative to IDT's chemical synthesis platform.

Market position

Strengths5 records

Weaknesses4 records

Competitive moat6 records

Key risks5 records

Key highlights6 records

Customer concentration

• Xx.com/idtdna
• YouTubeyoutube.com/user/idtdnabio
• Facebookfacebook.com/idtdna
• LinkedInlinkedin.com/company/21041
• Instagraminstagram.com/idtdna

Compliance2 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles2 records

Funding overview

Funding rounds1 record

Investors1 record

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A4 records

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Integrated DNA Technologies