Lerner Research Institute

Name

Lerner Research Institute

Legal name

Lerner Research Institute

Website

https://lerner.ccf.org

Company type

Private

Founded year

1921

Operating status

Operating

Headcount range

1,001–5,000 employees

Ownership category

akta.pro rank

Product category

Biomedical Research Services

NAICS

Research and Development in Biotechnology (except Nanobiotechnology) (541714), Research and Development in the Physical, Engineering, and Life Sciences (54171), Scientific Research and Development Services (5417), Medical and Diagnostic Laboratories (6215)

SIC

Services-Commercial Physical & Biological Research (8731), Services-Medical Laboratories (8071)

akta.pro primary industry

Biomedical Sciences & Medical Research Institutes (University-Based) (EDAHAGAI)

akta.pro secondary industries

Clinical Trial Site Operations & Study Coordination (HLAGACAE), Disease-Specific Research & Support (e.g., Cancer, Diabetes, ALS) (BPAGACAA), Medical, Clinical & Biomedical Scholarly Publishing (EDAGAFAB)

Keywords

• Biomedical research
• Clinical trials
• Translational medicine
• Genomic medicine
• Immuno-oncology research

Headquarters

HQ city

Cleveland

HQ country

United States

HQ region

North America

Offices3 records

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Technology or R&D, Infrastructure, Operations, Supply Chain

Revenue model

1. Research Funding: Federal and foundation grants including NIH, DoD, NSF, AHRQ, AHA, and PCORI funding. The institution manages approximately $479M in annual research funding (2025).
2. Institutional Support: Support from Cleveland Clinic's operational budget and strategic investments such as the $500M investment from JobsOhio and Cleveland Clinic for the Global Center for Pathogen & Human Health Research.
3. Philanthropic Donations: Research donations from individuals and organizations to support specific research initiatives and programs.

Go-to-market motion2 records

Distribution channels4 records

Marketing channels5 records

Core offering

Lerner Research Institute conducts basic, translational, and clinical biomedical research across 13 departments and 30+ core facilities, supported by $479M in annual funding. It delivers clinical trials, biorepository services, genomics, bioimaging, biomechanical testing, 3D printing, computational oncology, and proteomics services to internal and external investigators, while partnering with academic institutions and pharmaceutical developers to advance discoveries from bench to bedside.

Product overview

Lerner Research Institute is a comprehensive biomedical research institution offering a platform of research departments, specialized centers, and core facility services. The core structure includes 13 research departments (Biomedical Engineering, Cancer Biology, Cardiovascular & Metabolic Sciences, Computational Life Sciences, Genomic Medicine, Immunotherapy & Precision Immuno-Oncology, Infection Biology, Inflammation & Immunity, Neurosciences, Ophthalmic Research, Quantitative Health Sciences, Translational Hematology & Oncology, and Clinical & Translational Research) complemented by 12+ specialized centers and programs including the Global Center for Pathogen & Human Health Research, Florida Research & Innovation Center, and Microbiome & Human Health Center. The institute provides 30+ shared core service facilities including Genomics, Bioimage Analysis, BioRobotics & Mechanical Testing, Cell Culture, 3D Printing, and Computational Oncology Platform services. Research spans basic, translational, and clinical research with 236 labs transforming $479M annual funding into leading-edge discoveries.

Differentiator

Problem solved

Functional benefit

Products and services

• Clinical Research (Clinical Trials) Clinical research services testing new treatment options including medications, treatment regimens, and devices, providing patients access to investigational therapies and personalized care at Cleveland Clinic facilities.
• BioRepository Services Sample library services including Cleveland Clinic BioRepository, Lerner Research Institute BioRepository, and Genomic Medicine Institute Biorepository for storing and managing research samples from patients and research participants.
• Genomics Core Comprehensive genomics services and resources for researchers including sequencing, genetic analysis, and bioinformatics capabilities available to internal and external investigators.
• Bioimage Analysis Core Image analysis services for biological and medical research including segmentation, pixel classification, quantification, morphometric analysis, 3D reconstruction, and high-content imaging.
• BioRobotics & Mechanical Testing Core Biomechanical testing facilities for measuring mechanical properties of biological structures and biomaterials, including simVITRO robotic musculoskeletal testing systems for orthopedic and tissue research.
• Cell Culture Core Cell culture services with Mycoplasma testing and quarantine facilities, cell banking capacity for 10,000 vials, and researcher training programs.
• 3D Printing Core 3D printing services with six machines including Stratasys J750, 3D Systems CJP660, Formlabs 3BL, and Ultimaker S5 for medical device prototyping and research applications.
• Computational Oncology Platform Bioinformatics and computational biology support for processing and analyzing high-throughput next-generation sequencing data, including mutation calling, neoantigen analysis, and single cell RNA sequencing for oncology research.
• SomaScan & Biomarker Services Targeted proteomics assays using advanced SomaScan 7k and 11k Proteomic Platforms - the only such facility in Northeast Ohio, supporting biomarker discovery and validation research.
• Global Center for Pathogen & Human Health Research Center broadening understanding of viral pathogens and the human immune response toward preparing and protecting against future public health threats, backed by $500M in total investment.

Quantifiable outcome

• Immune checkpoint inhibitors improved survival rates for metastatic MSI-H colorectal cancer patients in study of nearly 19,000 patients
• +3 more outcomes

Named customers5 records

Segments4 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

AI capability8 records

Feature5 records

Partnerships

Three partnerships are on record, tiered core and major.

• Case Western Reserve UniversitycoreStrategic or Co-development PartnerPartnership through Clinical & Translational Science Collaborative of Cleveland, a catalyst for high quality clinical and translational research locally and nationally. Collaboration between Cleveland Clinic, Case Western Reserve University, MetroHealth, University Hospitals and the Louis Stokes Veterans Administration Medical Center.
• IBMcoreTechnology or IntegrationPartnership for IBM Quantum System One quantum computing infrastructure at Cleveland Clinic, supporting quantum computing research including drug design and molecular modeling. Cleveland Clinic was selected for the first National Institutes of Health quantum computing challenge.
• Arthritis FoundationmajorStrategic or Co-development PartnerPartnership to build a national Osteoarthritis Imaging Center for clinical trials. The library will house data from clinicians and researchers working on treatments and care, as well as institutions conducting clinical trials.

Scale indicators13 records

Recent moves9 records

Expansion highlights5 records

Direct peers

• Dana-Farber Cancer Institute: Specialized Harvard-affiliated cancer research and treatment center with deep programs in immuno-oncology, precision medicine, and translational research. Directly comparable to Lerner's CITI center and translational hematology/oncology department.
• Mass General Brigham Research (Massachusetts General Hospital): Research enterprise of Mass General Brigham, the largest hospital-based research program in the U.S. with >$2B annual research funding. Directly comparable in translational research, NIH scale, and biomedical breadth across cancer, immunology, genomics, and neurosciences.
• Brigham and Women's Hospital Research: Major hospital-based research enterprise within Mass General Brigham with leading programs in immunology, genomics, and translational medicine. Comparable scale, funding profile, and hospital-integrated research model.
• Memorial Sloan Kettering Cancer Center Research: Specialized cancer research powerhouse integrated with a leading cancer hospital. Strong comparability to Lerner's immunotherapy, precision immuno-oncology, and translational hematology/oncology programs, with similar hospital-integrated model and patient-data leverage.
• Stanford Medicine Research: Research enterprise of Stanford School of Medicine, with comparable translational model and leadership in genomics, biomedical engineering, computational life sciences, and AI-driven biomedical research — areas where Lerner is also actively investing.
• Johns Hopkins Medicine Research: Research arm of Johns Hopkins Medicine, one of the largest U.S. academic research enterprises. Comparable translational research model, large NIH portfolio, and similar disease-area breadth including genomics, cancer, and immunotherapy.
• UCSF Research (UC San Francisco): Major NIH-funded biomedical research enterprise at UCSF with strong programs in cancer, immunology, neurosciences, and computational health science — directly overlapping with Lerner's department and center portfolio.
• Mayo Clinic Research: Research division of Mayo Clinic, a top U.S. nonprofit academic medical center. Directly comparable to Lerner as a translational biomedical research enterprise with comparable scale, NIH funding scale, hospital-integrated research model, and disease-focused institutes (cancer, cardiovascular, neurosciences, immunology).
• MD Anderson Cancer Center (Research): One of the world's largest cancer research enterprises, embedded in a top hospital system. Directly comparable to Lerner's Center for Immunotherapy & Precision Immuno-Oncology and Cancer Biology department in translational oncology, genomic medicine, and clinical trial scale.

Broad incumbents

• National Institutes of Health (NIH Clinical Center): The largest biomedical research funder and operator in the U.S., running its own clinical research hospital. A broader incumbent that both funds and competes with academic medical center research institutes like Lerner across virtually every disease area.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks5 records

Key highlights7 records

Customer concentration

• Xx.com/CCLRI
• LinkedInlinkedin.com/company/lerner-research-institute

Revenue estimate

Valuation estimate

Number of profiles

Profiles16 records

Subsidiaries2 records

Funding overview

Funding rounds3 records

Investors2 records

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M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Lerner Research Institute