What MiRus does

MiRus, LLC is a privately-held medical device company headquartered in Marietta, Georgia, that designs and commercializes implants and procedural solutions built on a proprietary molybdenum-rhenium superalloy (MoRe) for the treatment of cardiovascular, orthopedic, and spinal disease. The company's core technology is a nickel-free Mo-47.5Re biomaterial — adapted from material science originally developed for NASA rocket engines — that delivers roughly 2.5x the yield strength (280 ksi vs ~115 ksi for titanium), superior fatigue resistance (350N max run-out load for a 4.0mm rod vs 150-200N for 5.5mm conventional rods), minimal recoil (<2% vs 6-9%), and lower metal ion release than titanium or cobalt-chromium alloys. This material platform, protected by global patent coverage, underwrites the company's product portfolio across three verticals: spine (EUROPA pedicle screw and posterior cervical systems, CYGNUS anterior cervical plate, 3DR interbody fusion, RIGEL, ANTARES, VITESSE), extremity (ATLAS foot and ankle plating, AURORA screws, IO Expandable Wedge Osteotomy), and structural heart (SIEGEL balloon-expandable TAVR with 8 French delivery — currently investigational in the STAR pivotal trial). The portfolio also includes GALILEO, a wireless intra-operative spine alignment monitoring system using disposable MEMS sensors.

The company operates a vertically-segmented go-to-market targeting hospitals and healthcare systems across spine, orthopedic, and cardiovascular surgery. Its commercial motion combines a direct enterprise field sales organization (led by CCO Mahesh Krishnan) with a US distributor network managed through a dedicated distributor portal (distributor.mirusmed.com). Revenue is generated through one-time hardware sales of proprietary implants and procedural kits to hospitals, with no public pricing disclosed. Clinical adoption is driven by medical conference presentations (NY Valves, TCT, NASS, AANS/CNS Spine Summit, AOFAS), peer-reviewed publications, and an in-house CME webinar series ("EXPECT MoRe"), and reinforced by KOL engagement at high-volume academic centers (Piedmont Heart Institute, Cedars Sinai, Stanford, Mayo Clinic, Hospital for Special Surgery, University of Illinois Chicago).

The business has scaled rapidly since founding, achieving over 250% growth in the two years prior to 2022 (Atlanta Business Chronicle 2022 Pacesetter Award) and accumulating FDA 510(k) clearances across each product vertical, plus an FDA Breakthrough Device Designation and CMS New Technology Add-on Payment (up to $80,548) for the EUROPA Posterior Cervical Fusion System. In May 2026, Boston Scientific invested $1.5 billion for approximately 34% equity, with an exclusive option to acquire the SIEGEL TAVR business for up to an additional $3 billion upon clinical and regulatory milestones, plus an option on mitral and tricuspid replacement valve assets — effectively validating the company as a strategic cardiovascular acquisition target and providing capital to drive the 1,025-patient STAR pivotal trial toward potential SIEGEL TAVR approval.

Name

MiRus

Legal name

MiRus, LLC

Website

https://mirusmed.com

Company type

Private

Founded year

2019

Operating status

Operating

Headcount range

101–250 employees

Short description

MiRus designs and commercializes proprietary molybdenum-rhenium (MoRe) superalloy medical implants and procedural solutions for hospitals and healthcare systems, serving spine, extremity/foot-ankle, and structural heart (TAVR) surgery markets across the US.

Ownership category

akta.pro rank

Product category

Orthopedic and Cardiovascular Medical Devices

NAICS

Surgical Appliance and Supplies Manufacturing (339113), Electromedical and Electrotherapeutic Apparatus Manufacturing (334510)

SIC

Orthopedic, Prosthetic & Surgical Appliances & Supplies (3842), Electromedical & Electrotherapeutic Apparatus (3845)

akta.pro primary industry

Orthopedic Trauma & Extremities Fixation (Plates/Screws/Nails/External Fixation) (HLAHAEAB)

akta.pro secondary industries

3D-Printed & Patient-Specific Implants (Custom Ortho/Spine/Cranial) (HLAHAEAJ), Surgical Navigation, Robotics & Patient-Matched Instrumentation (Ortho/Spine) (HLAHAEAL), Cardiac Assist & Heart Failure Therapies (Implantables, Neuromodulation) (HLAHAFAL)

Keywords

• Orthopedic medical devices
• Spinal implants
• Cardiovascular implants
• Biomaterial medical devices
• Structural heart devices

Headquarters

HQ city

Marietta

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Technology or R&D, Supply Chain, Marketing or Sales, Personnel, Operations

Revenue model

1. Medical Device Sales (Spine, Orthopedic, Structural Heart): MiRus generates revenue through the sale of proprietary medical implants and procedural solutions for spine, orthopedic/extremity, and structural heart diseases. Products include pedicle screw systems, interbody cages, plating systems, osteotomy devices, and the SIEGEL TAVR system (investigational, not yet approved). Revenue is one-time product-based with recurring purchasing by hospital/healthcare system customers.

Go-to-market motion2 records

Distribution channels2 records

Marketing channels5 records

Core offering

MiRus designs, manufactures, and commercializes medical implants and procedural solutions for spine, extremity/orthopedic, and structural heart applications, all built on its proprietary MoRe (Molybdenum-47.5 Rhenium) nickel-free superalloy. The integrated platform spans pre-operative planning (e.g., GALILEO), intra-operative implants (pedicle screws, interbody cages, cervical plates, foot/ankle plates, TAVR), and post-operative monitoring. The company sells these products to hospitals and healthcare systems in the United States through an enterprise field sales team and a distributor network.

Differentiator

Problem solved

Functional benefit

Brands

• MoRe: Proprietary molybdenum-rhenium superalloy used in MiRus implants, offering superior strength, ductility, durability, and biological safety compared to traditional implant materials like titanium and cobalt chromium.
• Siegel TAVR
• EUROPA
• CYGNUS
• ATLAS
• 3DR
• IO
• GALILEO
• RIGEL
• ANTARES
• AURORA
• VITESSE

Products and services

• SIEGEL TAVR (Transcatheter Aortic Valve Replacement) First nickel-free balloon-expandable transcatheter aortic valve replacement system, targeting severe aortic stenosis. Designed for interventional cardiologists and cardiac surgeons performing TAVR procedures at hospital systems; the device enables a 50% smaller delivery sheath than current commercial TAVR systems.
• EUROPA Pedicle Screw System Spinal fusion implant system using MoRe alloy for thoracolumbar pedicle screw fixation, targeting spine surgeons and hospitals performing spinal fusion and deformity correction procedures. The 4.5mm MoRe rod offers 350N max run-out load versus 150-200N for conventional 5.5mm rods.
• EUROPA Posterior Cervical Fusion (PCF) System Posterior cervical fusion system for treatment of the cervical and upper thoracic spine using proprietary rhenium alloy. Aimed at spine surgeons at hospital systems, with FDA Breakthrough Designation and CMS NTAP reimbursement status.
• CYGNUS Anterior Cervical Plate System Anterior cervical plate system using MoRe alloy, positioned as the world's lowest profile and smallest footprint anterior cervical plate. Targeted at spine surgeons performing anterior cervical discectomy and fusion (ACDF) procedures.
• 3DR Lateral Lumbar Interbody Fusion System 3D-printed titanium lateral lumbar interbody fusion cage with randomized lattice structure mimicking cancellous bone (elastic modulus 0.53 GPa) for superior bone apposition and ingrowth. Designed for spine surgeons performing lateral lumbar interbody fusion (LLIF) procedures.
• ATLAS Foot and Ankle Plating System Foot and ankle plating system using MoRe alloy with 1.0mm thickness, the thinnest foot and ankle plate on the market. Targeted at orthopedic foot and ankle surgeons performing fracture fixation and reconstruction procedures.
• IO Expandable Wedge Osteotomy System Expandable wedge osteotomy implant using MoRe alloy and MiRus's MoRe Expansion Engine technology, enabling surgeons to make controlled, incremental intraoperative adjustments during foot and ankle osteotomy procedures.
• GALILEO Spine Alignment Monitoring System Wireless, real-time intraoperative spine alignment monitoring system using disposable miniaturized wireless MEMS sensors, providing dynamic measurement of intervertebral angles and overall spinal alignment with accuracy within +/- 3 degrees. Targeted at spine surgeons for pre-operative and intra-operative alignment verification.
• RIGEL Cervical Interbody System Cervical interbody system including corpectomy and standalone anterior cervical options with flexible fixation choices. Targeted at spine surgeons performing cervical reconstruction and fusion procedures.
• ANTARES Standalone ALIF System Standalone anterior lumbar interbody fusion (ALIF) system with multiple screw configuration options for maximal intraoperative fixation. Aimed at spine surgeons performing ALIF procedures at hospital systems.
• AURORA Foot and Ankle Screw System Foot and ankle screw system using MoRe alloy, designed for orthopedic foot and ankle surgeons performing fracture fixation and reconstruction procedures.
• VITESSE Pedicle Screw Insertion System Pedicle screw insertion instrumentation system used to implant MiRus's pedicle screw-based spinal fusion products. Targeted at spine surgeons and hospital operating room staff.

Quantifiable outcome

• Zero rod fractures in 159 consecutive complex spine surgery patients at mean 22-month follow-up (vs ~9% rod fracture rate with conventional alloys)
• +4 more outcomes

Named customers8 records

Segments3 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature5 records

Partnerships

Four partnerships are on record, tiered core and minor.

• Piedmont Heart InstitutecoreOthers · 8 April 2026Piedmont Heart Institute served as the site for first patient enrollment and treatment in the STAR pivotal trial of the Siegel TAVR. Pradeep K. Yadav, MD (National Co-Principal Investigator) and Vinod H. Thourani, MD (Marcus Chairman of Cardiovascular Surgery and National Co-Chairman) performed the first procedures. Piedmont Heart Institute is the Marcus Valve Center and a key clinical trial site.
• Cedars Sinai Heart InstituteminorOthersCedars Sinai Heart Institute participated as one of five US medical centers in the Siegel TAVR Early Feasibility Study (EFS). Raj R. Makkar, MD presented 30-day EFS results at the NY Valves meeting.
• Mayo ClinicminorOthersMayo Clinic participated as one of five US medical centers in the Siegel TAVR Early Feasibility Study (EFS).
• StanfordminorOthersStanford participated as one of five US medical centers in the Siegel TAVR Early Feasibility Study (EFS).

Scale indicators5 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• Edwards Lifesciences: TAVR market leader (SAPIEN platform, ~60% global share) and the most direct competitor for MiRus's SIEGEL TAVR system. Comparable on transcatheter aortic valve replacement technology, structural heart commercial model, and regulatory pathway.
• Orthofix Medical: Mid-cap orthopedic company with spine (Mesa, Firebird, CONSTRUX), extremity (foot/ankle and biologics), and procedural solution portfolios. Closest peer in scale and vertical scope to MiRus with similar breadth across cervical/lumbar/extremity.
• Alphatec Holdings: Pure-play spine implant company with cervical (DT, Invictus), thoracolumbar, and interbody products directly competing with MiRus's EUROPA, CYGNUS, RIGEL, ANTARES, and 3DR. Comparable on growth-stage spine implant commercialization.
• Globus Medical: Pure-play spine and orthopedic implant company (now merged with NuVasive). Directly comparable as a spine-focused implant manufacturer with pedicle screw, interbody, and cervical plate product lines that compete head-to-head with MiRus's EUROPA, CYGNUS, 3DR, and IO systems across similar hospital customers.
• SeaSpine (now Globus Medical): Spine-only implant company with cervical, thoracolumbar, interbody, and orthobiologics portfolios; now combined with Globus Medical. Direct overlap with MiRus's spine implant franchise in similar hospital channels.
• Wright Medical (Stryker Trauma & Extremities): Foot/ankle/upper extremity orthopedic implant specialist (now part of Stryker) directly comparable to MiRus's extremity franchise (ATLAS plating, AURORA screw, IO Expandable Wedge Osteotomy System) in similar podiatric/orthopedic foot and ankle surgeon customers.

Broad incumbents

• Medtronic: Large diversified medtech incumbent with spine (CD Horizon, Mazor robotics), structural heart (Evolut TAVR), and broad orthopedic portfolios. Competes with MiRus on both spine implants and the TAVR market SIEGEL targets, with a much broader product portfolio and established hospital relationships.
• Stryker: Large diversified orthopedic medtech major with spine (acquired via Wright Medical/K2M) and extremity (foot/ankle from Wright Medical) portfolios that overlap with MiRus's spine (EUROPA, RIGEL, ANTARES) and extremity (ATLAS, AURORA, IO) franchises. Approached as a broad incumbent likely to evaluate MoRe alloy via M&A or competing material science.
• Boston Scientific: Now MiRus's largest shareholder (34% stake, May 2026, with exclusive $3B TAVR acquisition option). Comparable as a broad structural heart/TAVR incumbent (ACURATE neo) with overlapping cardiovascular ambitions, and a likely future acquirer of the TAVR business.

Emerging players

• 4WEB Medical: Privately held 3D-printed spinal implant manufacturer with proprietary lattice/truss structure technology analogous to MiRus's 3DR system. Comparable as a niche 3D-printed spine technology peer pursuing structural bone-ingrowth advantages in similar cervical/thoracolumbar indications.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key highlights7 records

Customer concentration

• LinkedInlinkedin.com/company/mirus-spine-and-orthopaedics

Revenue estimate

Valuation estimate

Number of profiles

Profiles6 records

Funding overview

Funding rounds2 records

Investors2 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about MiRus