Aprexis Health Solutions

What Aprexis Health Solutions does

Aprexis Health Solutions, operating as the Aprexis MTM Pharmacy Network, is a privately held Vermont-based clinical services and technology company that delivers pharmacist-led medication therapy management (MTM) to enterprise healthcare payers. The platform is a cloud-based MTM system featuring AI-driven patient stratification, a proprietary library of over 100 clinical triggers linked to estimated cost avoidance (ECA) values, and a recommendation engine that produces guideline-supported automated notes integrated into prescriber workflows. On top of the core MTM module (Comprehensive Medication Reviews, Targeted Medication Reviews, and triggerable opportunities), the company offers three specialty clinical programs: Diabetes360 (integrated DPP + DSME), a 12-month GLP-1 RA Lifestyle Medicine program, and a Transformative Opioid Management program targeting high-MME and multi-prescriber risk patterns. The product supports multi-channel patient engagement across telephone, video, text, mobile app, and in-person modalities, with EHR interoperability for longitudinal patient records and outcome reporting.

The company sells exclusively through a direct enterprise field sales motion to health plans, Medicare Advantage organizations, Medicaid programs, and self-insured employers, with quote-based subscription pricing structured around per-member-per-month or per-intervention fees. Aprexis reports a 90% provider recommendation acceptance rate and a 15% reduction in combined medical and pharmacy costs as headline outcomes. The company is led by co-founders Mike Howe (COO, serial entrepreneur with prior $1.5B+ exit via GNI/Novetta/Accenture Federal) and Keri LeCompte (Chief Pharmacy Officer, double board-certified in MTM and Lifestyle Medicine), with original founder Rob Squire having departed in 2013. Capitalization is thin: a $700K raise in 2011 and a 2024 SEC Form D filing for a $1.5M debt offering (with $721,504 raised) represent the only disclosed funding events, with proceeds from the 2024 round directed primarily to officer and director compensation.

Name

Aprexis Health Solutions

Legal name

Aprexis HS LLC

Website

https://aprexis.com

Company type

Private

Founded year

2008

Operating status

Operating

Headcount range

1–10 employees

Short description

Aprexis Health Solutions is a Vermont-based clinical technology company that delivers pharmacist-led medication therapy management to health plans, Medicare Advantage, Medicaid, and self-insured employers via a cloud platform with AI-driven patient stratification, 100+ clinical triggers, and specialty programs in diabetes, GLP-1 lifestyle medicine, and opioid management.

Ownership category

akta.pro rank

Product category

Medication Therapy Management Software

NAICS

Offices of Physicians (6211)

SIC

Services-Prepackaged Software (7372), Services-Offices & Clinics Of Doctors Of Medicine (8011)

akta.pro primary industry

Medication Therapy Management (MTM) & Clinical Pharmacy Services Tools (HLACAKAH)

akta.pro secondary industries

Medication Adherence & Therapy Management Platforms (refills, reminders, MTM) (HLALAIAG), Chronic Condition Medication Programs (e.g., diabetes, hypertension) with Integrated Prescribing (HLALAIAH)

Keywords

• Medication therapy management
• Clinical decision support
• Pharmacy care platform
• Patient stratification software
• Chronic disease management

Headquarters

HQ city

Burlington

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Software

Cost components

Personnel, Technology or R&D, Operations, Marketing or Sales

Revenue model

1. MTM Services to Health Plans: Aprexis provides medication therapy management services to health plans, Medicare Advantage plans, Medicaid programs, and self-insured employers. Services include Comprehensive Medication Reviews (CMRs), Targeted Medication Reviews (TMRs), and clinical intervention programs. Revenue is generated through per-member-per-month (PMPM) fees or per-intervention pricing with health plan clients.

Pricing tiers

Go-to-market motion1 record

Distribution channels1 record

Marketing channels4 records

Core offering

Aprexis Health Solutions operates the Aprexis MTM Pharmacy Network, a cloud-based medication therapy management platform that enables local pharmacists to deliver AI-driven clinical programs via telephone, video, text, mobile app, or in-person. The platform combines AI patient stratification, a library of clinical triggers linked to estimated cost avoidance, guideline-supported automated recommendations, and EHR interoperability to deliver MTM services and lifestyle medicine programs (diabetes, opioid management, GLP-1) to health plans, Medicare, Medicaid, and self-insured employers.

Product overview

Aprexis MTM Pharmacy Network is a unified medication therapy management platform built around pharmacists delivering patient-centric clinical care. The platform integrates a core MTM program with specialized clinical programs (Diabetes360, GLP-1 RA Lifestyle Medicine, and Transformative Opioid Management), all powered by AI-driven patient stratification, hundreds of clinical triggers, guideline-supported automated recommendations, and EHR interoperability to identify intervention opportunities and optimize patient outcomes.

Differentiator

Problem solved

Functional benefit

Products and services

• Aprexis MTM Pharmacy Network A cloud-based medication therapy management platform that enables local pharmacists to deliver clinical programs via telephone, video, text, mobile app, or in person, featuring AI-driven patient stratification, clinical triggers, longitudinal patient records, and interoperability with EHR systems.
• MTM Program (CMRs, TMRs & Triggerable Opportunities) Medication therapy management program featuring comprehensive medication reviews (CMRs), targeted medication reviews (TMRs), and over 100 clinical triggers identifying opportunities for improved patient outcomes and cost-effective interventions from pharmacy and medical claims data.
• Diabetes360 Integrated diabetes care program combining Diabetes Prevention Program (DPP) and Diabetes Self-Management Education (DSME), utilizing lifestyle medicine and pharmacist-driven expertise for comprehensive diabetes management and prevention.
• GLP-1 RA Lifestyle Medicine A 12-month pharmacist-led GLP-1 RA lifestyle change program designed to combat obesity through patient education, medication recommendations, deprescribing strategies, and behavioral change guidance using lifestyle medicine principles.
• Transformative Opioid Management MTM-based opioid management program integrating advanced clinical triggers to identify high-risk scenarios such as high morphine milligram equivalent (MME) use and multiple prescriber engagement, enabling proactive and personalized patient care interventions.

Quantifiable outcome

• 90% recommendation acceptance rate from providers
• +1 more outcomes

Segments4 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

AI capability7 records

Feature8 records

Scale indicators2 records

Recent moves6 records

Expansion highlights4 records

Direct peers

• Aspen RxHealth: Pharmacist network platform that connects health plans to clinicians for MTM and CMR delivery. Closest direct peer to Aprexis's MTM Pharmacy Network model.
• RxAnte: Provides predictive analytics and MTM targeting for health plans and PBMs. Direct competitor in the medication adherence and therapy management analytics space where Aprexis sells its trigger library.
• OutcomesMTM: National MTM services network contracting with health plans and pharmacists to deliver CMRs, TMRs, and adherence interventions. Operates in the same payer-sponsored MTM category as Aprexis.
• Tabula Rasa HealthCare (CareVention HealthCare): Provides medication therapy management, risk stratification, and pharmacy services to health plans, particularly for senior and dual-eligible populations. Directly comparable MTM and clinical pharmacy platform.
• AdhereHealth: AI-driven medication adherence and MTM platform serving health plans and Medicare Advantage plans. Overlaps directly with Aprexis's AI patient stratification and payer-focused MTM offering.
• Arine: AI-powered medication intelligence platform for health plans and provider groups optimizing prescribing and adherence. Competes with Aprexis on AI-driven clinical recommendations and trigger logic.

Broad incumbents

• MedImpact Healthcare Systems: Independent PBM offering MTM, adherence programs, and clinical pharmacy services to health plans at scale. Larger, established incumbent competing for the same payer MTM contracts.
• OptumRx (UnitedHealth Group): Largest U.S. PBM with embedded MTM and adherence programs serving UnitedHealthcare and external payers. Dominant incumbent that bundles MTM into broader PBM contracts.
• CVS Caremark: Major PBM and retail pharmacy operator offering MTM and adherence services as part of integrated pharmacy benefits. Competes for the same health plan and Medicare contracts.

Emerging players

• Pack4U: Tech-enabled medication management and adherence platform with pharmacist-led clinical services. Comparable scope to Aprexis across chronic condition, telehealth pharmacist delivery, and health plan partnerships.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat4 records

Key risks6 records

Key highlights6 records

Customer concentration

• Xx.com/aprexis
• Facebookfacebook.com/210004209060582
• LinkedInlinkedin.com/company/aprexis-health-solutions

Revenue estimate

Valuation estimate

Number of profiles

Profiles3 records

Funding overview

Funding rounds3 records

Investors1 record

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Aprexis Health Solutions