Texas Heart Institute

What Texas Heart Institute does

Texas Heart Institute (THI), founded in 1962 by Dr. Denton A. Cooley in Houston, Texas, is a nonprofit academic medical research institute now operating as "The Texas Heart Institute at Baylor College of Medicine" following a 2023 strategic affiliation. The institute operates from the Texas Medical Center — the world's largest medical complex — with 501-1,000 employees and delivers an integrated model combining cardiovascular patient care, biomedical research, and professional education. Its clinical arm, the Center for Cardiovascular Care (formerly Texas Heart Medical Group), provides comprehensive cardiovascular services including cardiology, cardiothoracic surgery, heart transplantation, vascular care, and specialty clinics for AFib, heart failure, valve disease, and women's heart health, performed by a surgical team that has executed over 115,000 open-heart surgeries.

THI's research infrastructure spans 10+ specialized laboratories and centers covering cardiomyocyte renewal and gene therapy (Cardiomyocyte Renewal Laboratory), stem cell medicine (Stem Cell Center), regenerative medicine, molecular cardiology, cardiac electrophysiology and device innovation (ECRI), pediatric cardiovascular devices (IDEA Lab — NeoVAD, ReVolution Fontan Pump), heart valve disease, preclinical surgical research, and a CAP-accredited Biorepository Core Laboratory housing 50,000+ biospecimens that serves as the core lab for the NHLBI Cardiovascular Cell Therapy Research Network. Active research domains include Hippo pathway gene therapy (YAP101, in Phase 1 trials via Medley Therapeutics partnership), first-in-class anti-inflammatory drug development for atherosclerosis, mechanical circulatory support devices, and non-invasive imaging for plaque identification.

The revenue model is multi-stream: (1) clinical patient care services through the Center for Cardiovascular Care, billed via insurance (Medicare and private); (2) research grants from federal sources including NHLBI ($1.14M in 2023) and NIH R01 grants; (3) professional education revenue from the School of Perfusion Technology (first accredited in the U.S., 1972), fellowships, residencies, and CME programs; and (4) fee-for-service core laboratory services (pathology, histology, biorepository) to external medical companies and institutions. Patient access occurs via physician referrals, direct scheduling, and clinical trial enrollment, supplemented by extensive community outreach including the Houston HeartReach registry, bilingual health newsletters, and K-12 educational programs.

Name

Texas Heart Institute

Legal name

The Texas Heart Institute at Baylor College of Medicine

Website

https://texasheart.org

Company type

Private

Founded year

1962

Operating status

Operating

Headcount range

501–1,000 employees

Short description

Texas Heart Institute is a nonprofit academic cardiovascular research and care center in Houston's Texas Medical Center, affiliated with Baylor College of Medicine. It delivers integrated patient care, biomedical research across 10+ specialized labs, and professional education, serving cardiovascular disease patients, medical fellows, and research collaborators.

Ownership category

akta.pro rank

Product category

Cardiovascular Medical Research and Patient Care

NAICS

Specialty (except Psychiatric and Substance Abuse) Hospitals (622310), Diagnostic Imaging Centers (621512), Other Scientific and Technical Consulting Services (54169)

SIC

Services-Health Services (8000), Services-Offices & Clinics Of Doctors Of Medicine (8011), Services-Engineering, Accounting, Research, Management (8700)

akta.pro primary industry

Cardiac & Cardiothoracic Specialty Hospitals (HLAFAHAA)

akta.pro secondary industries

Electrophysiology (Heart Rhythm) (HLAKABAC), General Cardiology (Consultative) (HLAKABAA), Cardiac Diagnostic Centers (Echo/Stress Testing/Holter) (HLAFAKAE), Imaging & Cardiac Safety Core Labs (ECOG/EEG/ECG) (HLAGAAAJ)

Keywords

• Cardiovascular research services
• Heart disease treatment
• Medical professional education
• Cardiology clinical trials
• Cardiac surgery services

Headquarters

HQ city

Houston

HQ country

United States

HQ region

North America

Offices3 records

Markets served

GTM type

B2B and B2C

Offering type

Services

Cost components

Personnel, Operations, Technology or R&D, Infrastructure, Marketing or Sales, Supply Chain

Revenue model

1. Clinical Patient Care Services: Revenue from direct patient care services provided through the Center for Cardiovascular Care, including consultations, procedures, surgeries, and ongoing cardiovascular treatment
2. Heart Transplantation Services: High-cost transplant procedures covered by Medicare and private insurers for qualifying patients with advanced heart failure
3. Research Grants and Funding: Federal and institutional research grants including NHLBI funding for drug development, NIH R01 grants for pediatric VAD development, and NHLBI Cardiovascular Cell Therapy Research Network participation
4. Professional Education Programs: Revenue from educational programs including the School of Perfusion Technology, fellowships and residencies, and continuing medical education
5. Core Laboratory Services: Fee-for-service specialized pathology and histology services including TEM and SEM provided to external medical companies and institutions

Pricing tiers

Go-to-market motion2 records

Distribution channels1 record

Marketing channels15 records

Core offering

Texas Heart Institute is a nonprofit academic medical research and care center delivering integrated cardiovascular healthcare through its Center for Cardiovascular Care, conducting basic and clinical research across multiple specialized labs, and providing professional medical education including the School of Perfusion Technology and fellowship programs. The institution offers services spanning prevention, diagnosis, surgery, heart transplantation, and clinical trials, anchored in the Texas Medical Center in Houston.

Product overview

The Texas Heart Institute at Baylor College of Medicine is a comprehensive cardiovascular center delivering healthcare through its integrated Center for Cardiovascular Care, which combines clinical services with world-class research programs and professional education. The institution operates multiple specialized research labs (Cardiomyocyte Renewal, Molecular Cardiology, Regenerative Medicine, IDEA Lab, Electrophysiology, Stem Cell Center) and provides clinical care through the Center for Cardiovascular Care with specialty clinics. Educational offerings include the School of Perfusion Technology, fellowships/residencies, the Texas Heart Institute Journal, Grand Rounds, Podcasts, and Texas Heart TV. Patient education is delivered through the Heart Information Center and Women's Heart Health programs. The research infrastructure includes a CAP-accredited Biorepository and clinical trials program spanning gene therapy, stem cells, medical devices, and pharmaceutical interventions.

Differentiator

Problem solved

Functional benefit

Brands

• THI Journal: Peer-reviewed medical journal covering cardiovascular disease research and treatment, published for 50 years before ceasing after June 2025.
• Center for Women's Heart & Vascular Health
• Cardiomyocyte Renewal Laboratory
• Electrophysiology Clinical Research & Innovations (ECRI)
• Innovative Device & Engineering Applications (IDEA) Lab
• Center for Preclinical Surgical & Interventional Research
• Stem Cell Center

Products and services

• Center for Cardiovascular Care A comprehensive, integrated cardiovascular care practice offering specialty clinics including AFib, Heart Failure & Transplant, Cardiothoracic Surgery, and comprehensive vascular care, powered by THI's research and education arms.
• Cardiovascular Healthcare Services Comprehensive cardiovascular care including cardiology and preventive care, cardiothoracic surgery, heart transplantation, comprehensive vascular care, and cardiometabolic syndrome treatment.
• School of Perfusion Technology An 18-month post-baccalaureate certificate program training students in cardiopulmonary bypass machine operation and open heart surgery support. First accredited cardiovascular perfusion program in the United States.
• Fellowships and Residencies Advanced clinical and research fellowship programs including Cardiovascular Disease Fellowship, Advanced Heart Failure and Transplant Cardiology Fellowship, and Clinical Cardiac Electrophysiology Fellowship.
• Clinical Trials Program Clinical research trials testing new devices, techniques and therapies for cardiovascular issues including ACT Study, Apple Watch Study, BiVACOR, CATO stem cell therapy, and PREVAIL cholesterol study.
• Biorepository and Biospecimen Profiling Core Laboratory CAP-accredited biospecimen storage, blood processing, and biomarker profiling services with equipment including flow cytometers and Luminex Magpix for cytokine profiling. Holds 50,000+ de-identified biological samples.
• Cardiovascular Pathology Services Specialized pathology and histology services including transmission electron microscopy, scanning electron microscopy, and GLP-compliant preclinical studies provided as fee-for-service to external medical companies and institutions.
• Center for Women's Heart & Vascular Health Dedicated women's cardiovascular health program providing education, research, community outreach, and clinical care focused on women-specific heart disease risks and conditions.
• Cardiomyocyte Renewal Laboratory Research lab focused on genetic pathways in adult tissue regeneration, developing gene therapies for heart failure and atrial fibrillation using Hippo pathway inhibition.
• Molecular Cardiology Research Lab Small molecule and cell-based therapeutics development for cardiovascular disease, including non-invasive imaging for atherosclerotic plaques and stem cell therapy improvements. Offers medicinal chemistry and flow cytometry/sorting core services.
• Regenerative Medicine Research Bio-artificial organs and tissues engineering, stem cell therapies for heart and vascular disease, and sex differences research in cardiovascular disease treatments.
• IDEA Lab (Innovative Device & Engineering Applications) Lab focused on designing, evaluating, and optimizing minimally invasive cardiovascular devices, including NeoVAD for pediatric heart failure, ReVolution Fontan pump, ex vivo lung perfusion systems, and catheter-deployed intra-atrial blood pumps. Also offers Applied Engineering core services.
• Electrophysiology Clinical Research & Innovations (ECRI) Cardiac arrhythmia research, new pacemaker technology development, and implantable cardioverter defibrillator improvements through collaborations with Rice University and UCLA.
• Stem Cell Center

Quantifiable outcome

• Over 115,000 open-heart surgeries performed by the surgical team
• +3 more outcomes

Named customers4 records

Segments5 records

Ideal customer profiles5 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature8 records

Partnerships

13 partnerships are on record, tiered minor and core.

• Medley TherapeuticsminorStrategic or Co-development Partner · 11 November 2025Medley Therapeutics announced the first clinical trial dosing of YAP101 gene therapy for cardiac regeneration in heart failure patients at The Texas Heart Institute at Baylor College of Medicine.
• Baylor College of MedicinecoreStrategic or Co-development PartnerStrategic affiliation agreement integrating The Texas Heart Institute with Baylor College of Medicine to bolster education efforts and positively impact programs including the School of Perfusion Technology. THI is now officially The Texas Heart Institute at Baylor College of Medicine, combining research, patient care, and education under one academic partnership.
• Rice UniversitycoreStrategic or Co-development PartnerCollaborative partnership with Rice University for cardiovascular research, including joint development of improved pacemaker technology and collaboration with the Rice Neuroengineering Initiative for cardiac electrophysiology innovations.
• University of California, Los Angeles (UCLA)coreStrategic or Co-development PartnerCollaborative partnership for improving pacemaker technology and cardiac electrophysiology research and innovations.
• University of HoustonminorStrategic or Co-development PartnerCollaboration with engineering colleagues at University of Houston for cardiac electrophysiology device development and innovation.
• Texas A&M UniversityminorStrategic or Co-development PartnerCollaboration with Texas A&M University engineering colleagues for cardiac electrophysiology device development and innovation.
• NHLBI Cardiovascular Cell Therapy Research NetworkcoreStrategic or Co-development PartnerTHI Biorepository serves as the Biorepository Core Laboratory for the NHLBI Cardiovascular Cell Therapy Research Network and Cardiovascular Surgical Trials Network for the past decade.
• Baylor St. Luke's Medical CentercoreStrategic or Co-development PartnerCollaborating hospital where heart transplants, cardiothoracic surgeries, and clinical research activities are conducted; home to THI Cardiovascular Disease Fellowship program.
• Rice Neuroengineering InitiativecoreStrategic or Co-development PartnerStrategic collaboration with Rice Neuroengineering Initiative for advancing cardiac electrophysiology research and device innovation, including Mehdi Razavi's joint appointment.
• Hall-Garcia Cardiology at Baylor College of MedicinecoreStrategic or Co-development PartnerCollaborating cardiology department for cardiac electrophysiology research, clinical trials, and patient care activities.
• International Collaborators (Japan and U.K.)minorStrategic or Co-development PartnerInternational collaboration with partners in Japan and the U.K. for pediatric cardiovascular device innovation including NeoVAD and other VAD development.
• Michael E. DeBakey Department of SurgerycoreStrategic or Co-development PartnerVascular surgeons are members of the renowned Michael E. DeBakey Department of Surgery at Baylor College of Medicine, offering both minimally invasive and surgical treatments for vascular conditions.
• BCM Center for Cardiometabolic Disease PreventionminorStrategic or Co-development PartnerPartnership with BCM Center for Cardiometabolic Disease Prevention for genetic and metabolic testing to refine risk stratification and guide therapy.

Scale indicators9 records

Recent moves8 records

Expansion highlights6 records

Direct peers

• Cleveland Clinic — Heart, Vascular & Thoracic Institute: One of the largest U.S. cardiovascular specialty centers with integrated research, clinical care and education. Directly comparable to THI as a comprehensive cardiovascular center of excellence with pioneering surgical volumes and a strong brand.
• Mayo Clinic — Cardiovascular Medicine: Top-ranked U.S. cardiovascular program with research, specialty surgery and education missions structurally similar to THI, including NIH-funded research labs and fellowship programs.
• Cedars-Sinai Smidt Heart Institute: Major U.S. cardiovascular research and treatment center with strong translational research programs. Comparable to THI in scale, integrated research-care-education structure and competitive positioning for specialty cardiac referrals.
• Mount Sinai Heart: Icahn School of Medicine–affiliated cardiovascular institute offering clinical cardiology, cardiothoracic surgery and research. Closely comparable to THI as an academic cardiovascular specialty center.
• Massachusetts General Hospital — Corrigan Minehan Heart Center: Harvard-affiliated cardiovascular specialty center combining clinical care, translational research and education. Comparable to THI in its academic-medical-center model and cardiac specialty focus.
• Johns Hopkins — Heart and Vascular Institute: Academic cardiovascular center combining research, advanced clinical care and education. Comparable to THI in the academic cardiovascular specialty model and translational research focus.
• Stanford Cardiovascular Institute: Stanford-affiliated cardiovascular research and clinical institute. Comparable to THI in regenerative medicine, biomedical engineering collaborations and academic cardiovascular research orientation.
• Brigham and Women's Hospital — Heart & Vascular Center: Harvard-affiliated cardiovascular specialty center with deep research programs, advanced heart failure and transplant services. Comparable to THI for academic cardiovascular medicine and surgical volume.

Emerging players

• Medley Therapeutics: Biotech company partnered with THI on the YAP101 cardiac regeneration gene therapy Phase 1 trial. Comparable as a translational partner that takes THI-originated science into clinical development, reflecting THI's role as a research originator.

Others

• NIH National Heart, Lung, and Blood Institute (NHLBI): Primary federal funder of cardiovascular research and a key partner of THI through grants (including the $1.14M NHLBI grant) and the Cardiovascular Cell Therapy Research Network. Listed as a peer because it is the dominant ecosystem counterpart in cardiovascular research funding.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/texas_heart
• YouTubeyoutube.com/@TexasHeartInstitute
• Facebookfacebook.com/texas.heart.institute
• LinkedInlinkedin.com/company/texas-heart-institute
• Instagraminstagram.com/texasheartinstitute

Compliance3 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles8 records

Subsidiaries4 records

Funding overview

Funding rounds1 record

Investors1 record

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Texas Heart Institute