Gladstone Institutes
Gladstone Institutes is an independent nonprofit biomedical research organization operating five interconnected institutes in San Francisco's Mission Bay. Founded in 1979, it employs 600+ scientists across 30+ labs to advance therapies for cardiovascular, neurological, infectious, and immunological diseases.
- Company typePrivate
- Founded1979
- HeadquartersSan Francisco, United States
- Headcount251–500
- GTM typeB2B
- OfferingServices
What Gladstone Institutes does
Gladstone Institutes is an independent, nonprofit biomedical research organization founded in 1979 through a planned gift from real estate developer J. David Gladstone. Headquartered at 1650 Owens Street in San Francisco's Mission Bay district, it operates five interconnected research institutes — Cardiovascular Disease, Data Science and Biotechnology, Genomic Immunology, Infectious Disease, and Neurological Disease — across more than 30 laboratories employing 600+ scientists and 189 graduate students and postdocs. The organization's research portfolio spans cardiovascular, neurological, infectious, immunological, and genetic diseases, with notable concentration on cardiovascular and HIV cure research.
The organization's core technology stack includes CRISPR-Cas9 genome editing (co-invented by senior investigator and 2020 Nobel laureate Jennifer Doudna), induced pluripotent stem cell technology (developed by 2012 Nobel laureate Shinya Yamanaka), AI-driven research tools (the MaxToki cell-aging model, an AI-powered "thinking microscope," and machine-learning algorithms at the Center for PhAIge Therapy for designing bacteriophage treatments), and precision genome editing combined with bacteriophage engineering. Recent product developments include Hypoxistat (a small-molecule diabetes drug that completely reversed high blood sugar in mouse models), the HIV-seq single-cell profiling tool, the CyTOF-Lec single-cell glycomics technique, and research identifying the Nell2 protein as a potential early-intervention target for APOE4-driven Alzheimer's disease.
Gladstone operates on an annual budget of approximately $125 million, with roughly $80 million sourced from NIH grants and the balance from philanthropy and industry partnerships. It generates value through scientific publications, technology licensing, collaborations with pharmaceutical partners (Vir Biotechnology, Takeda, Eli Lilly), and formation of spin-out companies — most notably Tenaya Therapeutics, launched in 2016 with $50 million Series A financing from The Column Group to advance cardiovascular regenerative medicine. The organization is offsetting an approximate 10 percent federal funding reduction through an active $350 million philanthropy campaign launched in 2024, which had raised approximately $200 million by early 2026. Co-leads of multi-institutional initiatives such as the HOPE Collaboratory ($26.5M NIH grant, 16 member institutions) and the CAPT-CEP phage therapy network anchor its translational research positioning.
Gladstone Institutes firmographics
Firmographics- Name
- Gladstone Institutes
- Legal name
- J. David Gladstone Institutes
- Website
- https://gladstone.org
- Company type
- Private
- Founded year
- 1979
- Operating status
- Operating
- Headcount range
- 251–500 employees
- Short description
- Gladstone Institutes is an independent nonprofit biomedical research organization operating five interconnected institutes in San Francisco's Mission Bay. Founded in 1979, it employs 600+ scientists across 30+ labs to advance therapies for cardiovascular, neurological, infectious, and immunological diseases.
- Ownership category
- akta.pro rank
Gladstone Institutes industry classification
Industry- Product category
- Biomedical Research
- NAICS
- Research and Development in Biotechnology (except Nanobiotechnology) (541714), Scientific Research and Development Services (5417)
- SIC
- Services-Commercial Physical & Biological Research (8731), In Vitro & In Vivo Diagnostic Substances (2835)
- akta.pro primary industry
- Protein Interaction & Structural Biology Platforms (cryo-EM, X-ray, NMR, biophysics) (HLAAAIAH)
- akta.pro secondary industry
- Biomedical Sciences & Medical Research Institutes (University-Based) (EDAHAGAI)
Keywords
Where Gladstone Institutes is headquartered
LocationHeadquarters
- HQ city
- San Francisco
- HQ country
- United States
- HQ region
- North America
Offices2 records
Markets served
Gladstone Institutes business model
Business model- GTM type
- B2B
- Offering type
- Services
- Cost components
- Personnel, Technology or R&D, Infrastructure, Operations
Revenue model
- NIH Grant Funding: Primary revenue source at approximately $80 million of the $125 million annual budget, from National Institutes of Health grants for various research programs
- Philanthropy and Donations: Tax-deductible donations from individuals, foundations, and planned giving programs including the Gladstone Society legacy giving program
- Industry Partnerships: Collaborations with pharmaceutical and biotech companies including Vir Biotechnology, Takeda, and Eli Lilly; licensing of technologies and formation of spinout companies
- Philanthropy Campaign: Active fundraising campaign launched in 2024 with goal of $350 million, having raised roughly $200 million
Go-to-market motion1 record
Distribution channels3 records
Marketing channels5 records
Gladstone Institutes product offering
Product offeringCore offering
Gladstone Institutes is an independent nonprofit biomedical research organization operating five interconnected institutes (Cardiovascular Disease, Data Science and Biotechnology, Genomic Immunology, Infectious Disease, and Neurological Disease) that conduct disease-driven basic and translational research. The organization develops drug candidates, AI research tools, genome editing techniques, and clinical-stage therapies, and advances discoveries through technology licensing and spinout companies such as Tenaya Therapeutics.
Product overview
Gladstone Institutes is an independent nonprofit biomedical research organization operating five interconnected research institutes: Cardiovascular Disease, Data Science and Biotechnology, Genomic Immunology, Infectious Disease (formerly Virology), and Neurological Disease. The organization offers research programs including the HOPE Collaboratory for HIV cure research and BioFulcrum entrepreneurial model. Recent product launches include the Center for PhAIge Therapy (AI-driven phage therapy), MaxToki AI model (cell aging prediction), HIV-seq tool (HIV research), and Hypoxistat drug candidate (diabetes treatment). The organization also facilitates spin-off companies like Tenaya Therapeutics to advance promising therapies.
Differentiator
Problem solved
Functional benefit
Quantifiable outcome
- Survival extended by more than 40 times in mouse model of rare genetic disorder through vitamin B3 supplementation
- +2 more outcomes
Companies that use Gladstone Institutes
Customer profileNamed customers6 records
Segments5 records
Ideal customer profiles4 records
Gladstone Institutes technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
AI capability7 records
Feature8 records
Gladstone Institutes partnerships and signals
Strategic signalPartnerships
18 partnerships are on record, tiered supporting and core.
- Topos BiosupportingResearch partnership focused on alpha-synuclein targeting intrinsically disordered proteins implicated in Alzheimer's and Parkinson's
- The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & TechnologycoreCo-lead of the HOPE Collaboratory focused on HIV cure research using 'block-lock-excise' approach; Susana Valente serves as co-principal investigator
- Weill Cornell MedicinecoreCo-lead of the HOPE Collaboratory with Lishomwa Ndhlovu serving as Co-Principal Investigator; 16 member institutions worldwide
- UC San Diego (Last Gift Study)supportingClinical partnership providing data and samples from people living with HIV for HOPE Collaboratory research
- US Military HIV Research Program (AFRICOS)supportingPartnership with African Cohort Study providing clinical samples from Africa for HIV cure research
- San Francisco AIDS FoundationsupportingCommunity engagement partner for HOPE Collaboratory ensuring resulting therapeutics are welcomed by people living with HIV
- AmgensupportingIndustry partner providing insight into development of potential therapeutics from drugs studied in HOPE labs
- Sangamo TherapeuticssupportingIndustry partner with insight into development of potential HIV therapeutics from HOPE research
- ProvirexsupportingIndustry partner for HIV cure therapeutic development
- UC BerkeleycoreScientific partner in BioFulcrum Viral and Infectious Disease Research Program including Jeff Cox; also partnered with Jennifer Doudna's lab for CRISPR research
- UC San FranciscocoreKey partner in Mission Bay innovation hub; co-development of genomic immunology institute; multiple collaborative research programs
- Stanford UniversitycoreAcademic partner in BioFulcrum and CAPT-CEP network for phage therapy research
- Vir BiotechnologysupportingIndustry partner working with Gladstone on biotech research
- Takeda PharmaceuticalsupportingIndustry partner for drug discovery and development collaborations
- Eli Lilly and CompanysupportingIndustry partner for therapeutic development
- American Society for Microbiology (ASM)supportingASM's Phage Therapy Coordination Network collaborating with CAPT-CEP network through quarterly scientific exchanges and shared database
- Stanford University (CAPT-CEP)coreOne of three Centers for Accelerating Phage Therapy funded by NIH to combat antibiotic-resistant ESKAPE pathogens
- University of Pittsburgh (CAPT-CEP)coreOne of three Centers for Accelerating Phage Therapy funded by NIH to combat antibiotic-resistant ESKAPE pathogens
Scale indicators10 records
Recent moves9 records
Expansion highlights6 records
Gladstone Institutes competitors and assessment
Company assessmentDirect peers
- Scripps Research: Independent nonprofit biomedical research organization with comparable scale (~3,000 staff) and broad disease-area coverage, including chemistry, neuroscience, immunology, and structural biology. Highly comparable to Gladstone in mission, funding mix, and PhD/postdoc training model.
- Salk Institute for Biological Studies: Independent nonprofit biological research institute in La Jolla covering cancer, neuroscience, immunology, and plant biology. Closely comparable to Gladstone in governance structure, funding model, and investigator-driven basic research orientation.
- Whitehead Institute for Biomedical Research: MIT-affiliated nonprofit research institute focused on cancer, regenerative biology, and genetic disease. Directly comparable to Gladstone in size, mission, and the university-adjacent operating model, with similar spinout activity (e.g., Alnylam Pharmaceuticals).
- Stowers Institute for Medical Research: Independent nonprofit biomedical research institute in Kansas City with ~500 researchers across ~20 independent programs. Closely comparable to Gladstone in endowment-style philanthropy funding and investigator-led disease research.
- Allen Institute: Nonprofit medical research organization founded by Paul Allen, operating multiple institutes (Brain, Cell Science, Immunology, AI for Health). Directly comparable as an independent nonprofit with strong technology platform development and AI/biomedicine integration, similar to Gladstone's MaxToki and thinking-microscope work.
- Broad Institute of MIT and Harvard: Joint MIT/Harvard biomedical and genomic research institute. Comparable to Gladstone in scale (~4,000 scientists), heavy use of genomic and computational biology, and major NIH funding. Both compete and collaborate in CRISPR and genomic immunology research.
- Koch Institute for Integrative Cancer Research (MIT): MIT-based cancer-focused research institute combining engineering, biology, and clinical translation. Comparable to Gladstone in mission-driven basic-to-translational research model and industry partnership approach.
- Buck Institute for Research on Aging: Independent nonprofit biomedical research institute solely focused on aging and age-related disease. Comparable to Gladstone's Neurological Disease Institute in disease focus and to its independent nonprofit operating model.
Broad incumbents
- Howard Hughes Medical Institute (HHMI): Largest U.S. private biomedical research organization, supporting ~300 Investigators across HHMI-operated and university-affiliated labs. Operates a similar nonprofit research model at greater scale than Gladstone, with comparable focus on investigator-driven basic science and translational pipelines.
Emerging players
- Genomics Institute of the Novartis Research Foundation (GNF): Pharma-affiliated (Novartis) biomedical research organization with strong high-throughput biology and drug discovery platforms. Comparable to Gladstone's drug-discovery platforms and industry-partnership orientation, though operating under a for-profit umbrella rather than independent nonprofit.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat6 records
Key risks6 records
Key highlights7 records
Customer concentration
Gladstone Institutes social profiles
Digital presenceGladstone Institutes financial estimates
Financial estimateRevenue estimate
Valuation estimate
Gladstone Institutes leadership team
Management profileNumber of profiles
Profiles5 records
Gladstone Institutes subsidiaries and ownership
Company hierarchySubsidiaries1 record
Gladstone Institutes funding detail
Funding detailFunding overview
Funding rounds1 record
Investors1 record
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Gladstone Institutes M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Gladstone Institutes
What does Gladstone Institutes do?
Gladstone Institutes is an independent nonprofit biomedical research organization operating five interconnected institutes (Cardiovascular Disease, Data Science and Biotechnology, Genomic Immunology, Infectious Disease, and Neurological Disease) that conduct disease-driven basic and translational research. The organization develops drug candidates, AI research tools, genome editing techniques, and clinical-stage therapies, and advances discoveries through technology licensing and spinout companies such as Tenaya Therapeutics.
Is Gladstone Institutes a public or private company?
Gladstone Institutes is a private company. It is classified as nonprofit foundation owned and is currently operating.
When was Gladstone Institutes founded?
Gladstone Institutes was founded in 1979. It employs 251 to 500 people.
Where is Gladstone Institutes based?
Gladstone Institutes is headquartered in San Francisco, United States, in the North America region.
How does Gladstone Institutes make money?
Four revenue lines are on record. NIH Grant Funding is the primary driver. The others are philanthropy and Donations, industry Partnerships and philanthropy Campaign.
Who are Gladstone Institutes's main competitors?
Direct peers on record are Scripps Research, Salk Institute for Biological Studies, Whitehead Institute for Biomedical Research, Stowers Institute for Medical Research, Allen Institute, Broad Institute of MIT and Harvard, Koch Institute for Integrative Cancer Research (MIT) and Buck Institute for Research on Aging. Howard Hughes Medical Institute (HHMI) is listed as a broad incumbent. Genomics Institute of the Novartis Research Foundation (GNF) is listed as an emerging player.
Does Gladstone Institutes have an API?
No public API is recorded for Gladstone Institutes.
What industry is Gladstone Institutes in?
Gladstone Institutes's product category is Biomedical Research. Its primary akta.pro industry code is HLAAAIAH, Protein Interaction & Structural Biology Platforms (cryo-EM, X-ray, NMR, biophysics), with a secondary code of EDAHAGAI, Biomedical Sciences & Medical Research Institutes (University-Based). Its NAICS code is 541714 and its SIC code is 8731.