What Diagenode does

Diagenode, operating as Hologic Diagenode since its 2017 acquisition by Hologic (NASDAQ: HOLX), is a Belgium-based provider of epigenomics profiling services and sample preparation products for next-generation sequencing, proteomics, and epigenetics research. Founded in 2003 and headquartered in Seraing, Belgium with 101–250 employees, the company sells an integrated workflow comprising shearing instruments (Bioruptor, Megaruptor, One), the IP-Star automated chromatin immunoprecipitation platform, and an extensive catalog of reagent kits for DNA methylation analysis (Premium Bisulfite Kit, Premium RRBS Kit V2, Premium WGBS Kit, MagMeDIP, hMeDIP, MethylCap), chromatin profiling (ChIPmentation, CUT&Tag, ATAC-seq), ChIP-seq-grade histone antibodies, NGS library preparation enzymes, and UDI-UMI adapter modules. Proprietary technologies include ChIPmentation, a 60-minute bisulfite conversion chemistry, and RRBS chemistry capable of detecting up to 7 million CpGs from as little as 25 ng of input DNA.

The company operates a dual business model combining catalog e-commerce sales of consumables (unit-priced $65–$3,825 per kit, pay-as-you-go) with enterprise-direct service quoting for end-to-end epigenomics services including RRBS, WGBS/EM-seq, ChIP-seq profiling, methylation data analysis, cell-free RNA-seq (D-Plex), and the Nu.Q nucleosome-based biomarker discovery service. Go-to-market is sales-led with direct online purchasing, quote-based bulk and service contracts, and content-driven marketing anchored on >1,400 peer-reviewed publications, webinars, protocols, and multi-language website support (EN/JP/CN). Customer segments are academic research institutions (primary), pharmaceutical and biotechnology companies (primary), and clinical research organizations (secondary), served across North America (USA) and Europe (Belgium) with global multilingual reach. The company was led by CEO Didier Allaer as of available data and raised $8.49M in 2016 prior to the Hologic acquisition, later acquiring NXT-Dx in August 2018.

Name

Diagenode

Legal name

Hologic Diagenode

Website

https://diagenode.com

Company type

Private

Founded year

2003

Operating status

Operating

Headcount range

101–250 employees

Short description

Diagenode (Hologic Diagenode) is a Belgium-based provider of epigenomics profiling services and sample preparation products — including shearing instruments, automation, kits, antibodies, and bioinformatics — for academic, pharmaceutical, and biotech customers conducting NGS-based DNA methylation and chromatin research.

Ownership category

akta.pro rank

Product category

Epigenomics Research Reagents and Instruments

NAICS

Medical Laboratories (621511), Analytical Laboratory Instrument Manufacturing (334516), Research and Development in Biotechnology (except Nanobiotechnology) (541714)

SIC

In Vitro & In Vivo Diagnostic Substances (2835), Laboratory Analytical Instruments (3826), Services-Medical Laboratories (8071)

akta.pro primary industry

Epigenomics & Chromatin Profiling Services (HLAGANAF)

akta.pro secondary industries

Bioinformatics & Multi-omics Analysis Software (HLAGAJAD), Molecular Biology & Genomics Instruments (PCR/qPCR, Sequencing, Microarrays) (HLAGAIAF), Genomic & Multi-Omic Biomarkers (NGS panels, transcriptomics, proteomics, metabolomics) (HLAAAMAJ), Bioinformatics, Multi-Omics Data Analysis & Interpretation Services (HLAGANAI)

Keywords

• Epigenomics research tools
• DNA methylation analysis
• Chromatin immunoprecipitation kits
• NGS sample preparation
• Sonication instruments

Headquarters

HQ city

Liège

HQ country

Belgium

HQ region

Europe

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Technology or R&D, Personnel, Supply Chain, Marketing or Sales, Operations

Revenue model

1. Epigenetic Research Products: Sale of reagents, kits, antibodies, and instruments for epigenetics research including DNA methylation kits, chromatin analysis products, antibodies, and sonication devices. Products include MagMeDIP Kit, Premium Bisulfite Kit, Premium RRBS Kit, H3K4me3 antibodies, Bioruptor devices.
2. Epigenomics Services: Comprehensive end-to-end services including RRBS Service, WGBS Service, ChIP-seq, ATAC-seq, Human Methylome analysis, and bioinformatics services. Services include from DNA QC to sequencing raw data delivery.
3. Bioinformatics Analysis: Data analysis services for methylation studies including single-base resolution analysis, differential methylation analysis, gene ontology enrichment, and pathway analysis.

Pricing tiers

Go-to-market motion1 record

Distribution channels3 records

Marketing channels5 records

Core offering

Diagenode (Hologic Diagenode) provides epigenomics profiling services and sample preparation products for next-generation sequencing, proteomics, and epigenetics research. Its portfolio includes sonication instruments (Bioruptor, Megaruptor, One), the IP-Star automation system, reagent kits for DNA methylation and chromatin analysis (bisulfite conversion, MeDIP/hMeDIP, ChIPmentation, CUT&Tag, ATAC-seq), validated ChIP-seq grade antibodies, and end-to-end services such as RRBS, WGBS/EM-seq, ChIP-seq, and methylation bioinformatics analysis.

Product overview

Hologic Diagenode is a provider of epigenomics profiling services and sample preparation products for next-generation sequencing, proteomics, and epigenetics research. The product portfolio includes: (1) Instrument devices for DNA shearing - Bioruptor®, Megaruptor®, and One® sonicators; (2) IP-Star® automation system for walk-away processing; (3) Reagent kits for DNA methylation analysis including bisulfite conversion (Premium Bisulfite Kit, Premium RRBS Kit V2, Premium WGBS Kit), immunoprecipitation (MagMeDIP Kit, hMeDIP Kit, MethylCap Kit), and adapters (Premium Methyl UDI-UMI Adapters); (4) Chromatin analysis products including ChIPmentation™ and CUT&Tag kits; (5) ATAC-seq kits for open chromatin mapping; (6) Quality control standards including DNA methylation and hydroxymethylation control packages; (7) Specialized antibodies including ChIP-seq grade histone modification antibodies (H3K4me3, H3K9me3, H3K27me3) and control antibodies (Mouse IgG); (8) qPCR primer pairs for methylation validation; (9) Epigenomics services including RRBS, WGBS/EM-seq, ChIP-seq profiling, methylation data analysis, cell-free RNA-seq, and Nu.Q® Discover biomarker discovery. The portfolio forms an integrated workflow from sample preparation through sequencing and bioinformatics analysis.

Differentiator

Problem solved

Functional benefit

Products and services

• Bioruptor® Sonication Device Ultrasonic sonication device for DNA shearing used in chromatin shearing, DNA extraction, and sample preparation for NGS applications.
• Megaruptor® Instrument for DNA shearing at higher throughput and longer fragment sizes compared to Bioruptor.
• One® Shearing Device Compact shearing device for DNA shearing applications.
• IP-Star® Automation System Automated system for chromatin immunoprecipitation and other epigenetic assays, enabling walk-away automation of ChIP and related workflows.
• MagMeDIP Kit Methylated DNA Immunoprecipitation kit using antibody against 5-methylcytosine for enrichment of methylated DNA for qPCR or NGS analysis.
• hMeDIP Kit Hydroxymethylated DNA Immunoprecipitation kit for enrichment of hydroxymethylated DNA for genome-wide methylation analysis.
• MethylCap Kit MBD-based kit for capturing methylated DNA using the MBD domain of human MeCP2 protein with differential fractionation capability.
• Premium Bisulfite Kit Bisulfite conversion kit that converts unmethylated cytosine to uracil in 60 minutes for single nucleotide resolution DNA methylation analysis.
• Premium RRBS Kit V2 Reduced Representation Bisulfite Sequencing kit for cost-effective genome-scale DNA methylation analysis at single nucleotide resolution in CpG-rich regions.
• Premium WGBS Kit Whole Genome Bisulfite Sequencing kit for comprehensive DNA methylation profiling of the entire genome at single-base resolution.
• Premium Methyl UDI-UMI Adapters Module Methylated full-length adapters with unique dual indexes (UDI) and unique molecular identifiers (UMI) for bisulfite sequencing library multiplexing and quantitative analysis.
• DNA Methylation Control Package V2 Includes methylated and unmethylated spike-in controls with qPCR primer sets for quality control in methylation profiling experiments.
• ATAC-seq Kit Assay for Transposase-Accessible Chromatin using Tn5 transposase for genome-wide mapping of open chromatin regions, suitable for cells.
• ATAC-seq Package for Tissue Complete ATAC-seq workflow kit optimized for tissue samples including nuclei extraction.
• ChIPmentation™ Kit Chromatin immunoprecipitation method combining ChIP with tagmentation technology for streamlined workflow.
• CUT&Tag Kit Cleavage Under Targets and Tagmentation kit for targeted chromatin profiling with high sensitivity.
• H3K4me3 Monoclonal Antibody ChIP-seq grade monoclonal antibody against histone H3 lysine 4 trimethylation, an active gene mark.
• H3K9me3 Monoclonal Antibody ChIP-seq grade monoclonal antibody against histone H3 lysine 9 trimethylation, associated with gene repression.
• RRBS Service Reduced Representation Bisulfite Sequencing service offering end-to-end workflow from DNA QC to sequencing raw data, detecting up to 7 million CpGs in human samples.
• WGBS and EM-seq Service Whole Genome Bisulfite Sequencing and Enzymatic Methylation sequencing service for comprehensive genome-wide DNA methylation profiling at single-nucleotide resolution.
• Methylation Data Analysis Service Bioinformatics service for methylation data analysis including single-base resolution analysis (WGBS, RRBS, BSAS) and enrichment-based methods (MeDIP-Seq), with standard, advanced, and custom analysis options.
• ChIP-seq Profiling Service Chromatin immunoprecipitation sequencing service for genome-wide mapping of protein-DNA interactions and histone modifications.

Quantifiable outcome

• Up to 7 million CpGs detected in human samples with RRBS service
• +3 more outcomes

Named customers5 records

Segments3 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature8 records

Partnerships

One partnership is on record.

• HologicOthersHologic Diagenode operates as a subsidiary of Hologic, a global medical technology company focused on women's health. The company branding consistently uses 'Hologic Diagenode' indicating ownership structure.

Scale indicators2 records

Recent moves6 records

Expansion highlights5 records

Broad incumbents

• Illumina: Dominant NGS sequencing platform provider whose library prep and methylation offerings (e.g., TruSeq Methylation) sit upstream/downstream of Diagenode's sample prep and bisulfite kits.
• Thermo Fisher Scientific: Diversified life-science platform with ChIP-seq kits, methylation reagents, NGS instruments, and antibodies; bundles competing epigenetics solutions into broader workflows.
• MilliporeSigma: Broad life-science tools portfolio spanning ChIP kits, bisulfite conversion, antibodies, and epigenetics reagents; competes with Diagenode across multiple product lines within a much larger catalog.

Direct peers

• Zymo Research: Provides DNA methylation analysis kits (bisulfite conversion, RRBS), Epigenetics services, and nucleic acid purification reagents, competing head-to-head with Diagenode's bisulfite and RRBS kits and services.
• Abcam: Large antibody provider including ChIP-validated histone modification antibodies and related epigenetics research reagents; competes for the same antibody budgets as Diagenode.
• New England Biolabs: Supplies enzymes and reagents for bisulfite sequencing library prep, methylated adapters, and NGS workflow enzymes (including Tn5 transposase) overlapping with Diagenode's MethylTaq and Tagmentase reagents.
• Active Motif: Specializes in epigenetics research tools including ChIP-seq antibodies, CUT&Tag kits, and chromatin-related reagents; directly overlaps with Diagenode's ChIP, CUT&Tag, and histone antibody portfolios.
• EpiGentek: Offers a broad catalog of epigenetics-focused kits including methylation, ChIP, and histone modification assays, directly competing with Diagenode's research-use-only reagent portfolio.
• Cell Signaling Technology: Major provider of ChIP-grade and ChIP-seq-grade antibodies including histone modification antibodies (H3K4me3, H3K9me3, H3K27me3) that overlap with Diagenode's validated antibody catalog.

Emerging players

• Promega: Supplies nucleic acid purification, amplification reagents, and Maxwell automation that overlap with Diagenode's sample-preparation workflow and compete for bench budgets in epigenetics labs.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat4 records

Key risks6 records

Key highlights6 records

Customer concentration

• Xx.com/diagenode
• Facebookfacebook.com/diagenode
• LinkedInlinkedin.com/company/diagenode

Revenue estimate

Valuation estimate

Number of profiles

Profiles1 record

Funding overview

Funding rounds1 record

Investors4 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A1 record

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Diagenode