Translational Pulmonary & Immunology Research Center

What Translational Pulmonary & Immunology Research Center does

TPIRC is a 501(c)(3) nonprofit clinical care and research center headquartered in Long Beach, California, founded in 2015. It focuses on individualized treatment for rare pulmonary and immunological diseases, serving patients with severe food allergies, cystic fibrosis, bronchiectasis, bronchopulmonary dysplasia (BPD), and related immune system disorders. The organization operates through an integrated research-to-care model, with clinical arms including Lung & Allergy Health Associates (LAHA) and the Food Allergy Institute (FAI), and reports having treated more than 8,000 patients at FAI.

The organization's core technology is the B.A.R.I.C. Data Loop, which connects Diagnostics, Data Science & AI, Clinical Care, and Research in a continuous feedback architecture. Its flagship clinical offering is the Tolerance Induction Program (TIP), a personalized food allergy immunotherapy protocol that uses AI/ML to analyze biomarkers and generate individualized treatment plans. Each patient generates millions of data points used for predictive modeling of disease progression and treatment optimization. Supporting assets include the TPIRC Biobank (a biological samples repository established in 2020) and advanced diagnostics such as Impulse Oscillometry (IOS) and Exercise CPET.

TPIRC's revenue model combines clinical service fees with philanthropic contributions, including individual giving (e.g., a "Changemakers Circle" starting at $25/month), foundation grants, planned giving, and corporate matching. Clinical operations span multiple California locations (Long Beach headquarters, Willow Clinic, San Diego Clinic, Food Lab, TPIRC Diagnostics, and The Hub). Strategic partnerships with Miller Children's Hospital, Chapman University, USC Dornsife, Keck School of Medicine of USC, and The BPD Collaborative provide research collaboration, talent pipelines, and pediatric subspecialty reach.

Name

Translational Pulmonary & Immunology Research Center

Legal name

Translational Pulmonary and Immunology Research Center

Website

https://tpirc.org

Company type

Private

Founded year

2015

Operating status

Operating

Headcount range

101–250 employees

Short description

TPIRC is a 501(c)(3) nonprofit research center in Long Beach, California, developing precision medicine treatments for rare pulmonary and immunological diseases—including severe food allergies, cystic fibrosis, and BPD—through its AI-driven B.A.R.I.C. Data Loop platform and Tolerance Induction Program.

Ownership category

akta.pro rank

Product category

Clinical Research & Translational Medicine

NAICS

Scientific Research and Development Services (5417), Medical and Diagnostic Laboratories (6215)

SIC

Services-Offices & Clinics Of Doctors Of Medicine (8011), Services-Medical Laboratories (8071), Services-Commercial Physical & Biological Research (8731), In Vitro & In Vivo Diagnostic Substances (2835)

akta.pro primary industry

Asthma & Allergy-Related Pulmonary Care (HLAKANAD)

akta.pro secondary industry

Interstitial Lung Disease (ILD) & Pulmonary Fibrosis Care (HLAKANAF)

Keywords

• Pulmonary disease research
• Immunology clinical research
• Food allergy treatment
• Rare disease therapeutics
• Translational medicine research

Headquarters

HQ city

Long Beach

HQ country

United States

HQ region

North America

Offices6 records

Markets served

GTM type

B2C

Offering type

Services

Cost components

Personnel, Technology or R&D, Operations, Infrastructure

Revenue model

1. Donations and Philanthropy: As a 501(c)(3) nonprofit organization (EIN: 47-2364652), TPIRC relies heavily on charitable donations from individuals, including recurring monthly donors (Changemakers Circle starting at $25/month), one-time gifts, and major gift donations.
2. Corporate Matching and Grants: Corporate matching gift programs, foundation grants, and institutional funding for research initiatives.
3. Clinical Services Revenue: Revenue generated through Lung & Allergy Health Associates (LAHA) clinical care services, providing diagnostic and treatment services to patients.
4. Planned Giving: Legacy giving, planned giving options, bequests, and beneficiary designations as part of long-term fundraising strategy.
5. In-Kind Gifts: Gifts of appreciated securities, stocks, real estate, life insurance, and tangible personal property.

Go-to-market motion1 record

Distribution channels3 records

Marketing channels7 records

Core offering

Translational Pulmonary & Immunology Research Center (TPIRC) is a 501(c)(3) nonprofit research institute based in Long Beach, California, founded in 2015, that advances treatments for rare pulmonary and immunological diseases. It integrates clinical care through affiliated entities Lung & Allergy Health Associates (LAHA) and the Food Allergy Institute (FAI) with translational research powered by its AI/ML-driven B.A.R.I.C. Data Loop platform. The institute's flagship clinical offering is the Tolerance Induction Program (TIP), a personalized food allergy treatment program, supported by the TPIRC Biobank for biological sample storage.

Product overview

TPIRC operates as an independent research institute focused on improving patient outcomes through integrated research and precision medicine. The core offerings include the Tolerance Induction Program (TIP) for food allergy treatment, the TPIRC Biobank for biomarker research, and the B.A.R.I.C. Data Loop platform that connects diagnostics, AI/ML analytics, clinical care, and research. The ecosystem is supported by clinical divisions including Lung & Allergy Health Associates (LAHA) and the Food Allergy Institute (FAI), which translate discoveries into patient care. TPIRC employs advanced diagnostics including Impulse Oscillometry and Exercise CPET, combined with AI-driven systems modeling to deliver personalized treatment protocols for rare lung diseases and food allergies.

Differentiator

Problem solved

Functional benefit

Products and services

• Tolerance Induction Program (TIP) A personalized treatment program designed to induce tolerance in patients with food allergies, offered through the Food Allergy Institute under TPIRC's clinical arm. Targeted at pediatric and adult patients with diagnosed food allergies.
• Lung & Allergy Health Associates (LAHA) Clinical care affiliate of TPIRC providing direct medical services for patients with pulmonary and immunological conditions in the Long Beach, California area.
• Food Allergy Institute (FAI) A patient-facing institute operated by TPIRC that delivers the Tolerance Induction Program (TIP) for food allergy treatment to affected individuals and families.
• TPIRC Biobank A biorepository maintained by TPIRC that stores biological samples to support translational research into rare pulmonary and immunological diseases.
• B.A.R.I.C. Data Loop A proprietary AI/ML and big-data analytics platform developed by TPIRC that analyzes aggregated clinical and research data to drive personalized treatment protocols, particularly for the Tolerance Induction Program.

Quantifiable outcome

• Lung function improvement from 40% to 60% FEV1 in cystic fibrosis patient
• +2 more outcomes

Named customers4 records

Segments5 records

Ideal customer profiles2 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

AI capability3 records

Feature5 records

Partnerships

Six partnerships are on record, tiered core and moderate.

• MemorialCare and Miller Children's HospitalcoreStrategic or Co-development PartnerMemorialCare and Miller Children's Hospital are strategic partners of TPIRC and its clinical physician group. TPIRC provides critical services in pediatric pulmonology, clinical immunology, and allergy to one of the largest children's hospitals in the region. This partnership, spanning over 30 years, has enabled both institutions to achieve national recognition, including being ranked among the Top 50 by the U.S. News & World Report.
• Chapman UniversitycoreStrategic or Co-development PartnerTPIRC partners with Chapman University through their premier Food Science program and state-of-the-art processing laboratory. Collaboration focuses on feasibility studies to refine new product development and equipment testing. Key achievements include pioneering methods to denature egg proteins for allergy treatments and optimizing freeze-drying techniques to enhance the shelf stability of therapeutic gummies.
• USC Dornsife Brain and Creativity InstitutemoderateStrategic or Co-development PartnerIn collaboration with USC Dornsife's Brain and Creativity Institute, TPIRC sponsors research examining the impact of social media on neurological function. Research aims to understand brain changes during social media use, measuring effects with applied mathematics. Led by Dr. Antonio Damasio, this research has significant implications for mental health.
• Keck School of Medicine of USCcoreStrategic or Co-development PartnerScientists collaborate closely with the Department of Pediatrics at the Keck School of Medicine of USC to drive critical research into Bronchopulmonary Dysplasia (BPD). Partnership is dedicated to elucidating underlying causes and developing novel, gentler, non-invasive treatments that will significantly improve outcomes for vulnerable newborns.
• The Lundquist Institute and Harbor-UCLA Pulmonology FellowshipmoderateImplementation/ SI/ Consulting PartnerIn partnership with The Lundquist Institute and the Harbor-UCLA Pulmonology Fellowship, the TPIRC Research Lab cultivates physician-scientists. Fellows in advanced subspecialty training receive hands-on experience, enabling them to translate clinical insights into original research by developing and executing projects within the cutting-edge laboratory environment.
• The BPD CollaborativemoderateStrategic or Co-development PartnerTPIRC is a proud member of The BPD Collaborative, a vast network of leading medical and research centers across the globe dedicated to improving lifelong outcomes of infants with severe Bronchopulmonary Dysplasia (BPD). Active sharing of clinical practices, pooled patient data, and quality improvement metrics with international experts accelerates adoption of successful treatments worldwide.

Scale indicators3 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• National Jewish Health: Denver-based nonprofit hospital and research institute specialized in pulmonary, allergy, and immune diseases. It is the closest operational analogue to TPIRC's combination of clinical care, research, and physician training in pulmonology/immunology.
• Sean N. Parker Center for Allergy and Asthma Research at Stanford: Stanford-affiliated precision-medicine research center focused on food allergy and asthma. Directly comparable to TPIRC's TIP platform in mission and methodology, operating within an academic medical center rather than as an independent nonprofit.
• Jaffe Food Allergy Institute at Mount Sinai: Major New York-based food allergy clinical and research program at Mount Sinai. Overlaps with TPIRC on large-volume food allergy patient care, oral immunotherapy research, and integration with pediatric allergy specialists.

Broad incumbents

• Cincinnati Children's Hospital Medical Center: Top-ranked U.S. pediatric academic medical center with major pulmonology, allergy, and cystic fibrosis programs. Comparable to TPIRC in pediatric pulmonary focus but on a much broader scale across all pediatric subspecialties.
• Boston Children's Hospital Pulmonary Medicine Program: Academic pediatric pulmonology clinical and research division within a leading children's hospital. Comparable to TPIRC on pediatric pulmonary clinical/research activity, though embedded in a much larger hospital system.
• Cystic Fibrosis Foundation: National nonprofit driving CF research, care, and drug development. Closely aligned with TPIRC's rare-lung-disease focus, particularly around cystic fibrosis, though it operates as a patient-advocacy and drug-development accelerator rather than a clinical provider.

Others

• Asthma and Allergy Foundation of America: National nonprofit patient organization for asthma and allergic disease. Not a clinical peer, but analogous as a philanthropic, awareness-driven nonprofit in the same patient populations TPIRC serves.

Regional players

• Children's Hospital Los Angeles - Pulmonology: Regional pediatric pulmonology and allergy provider based in Los Angeles, near TPIRC's Long Beach base. Comparable patient mix (pediatric pulmonology, allergy, complex respiratory disease) within an overlapping Southern California catchment area.

Market position

Strengths4 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights6 records

Customer concentration

• Facebookfacebook.com/tpircnow
• LinkedInlinkedin.com/company/translational-pulmonary-and-immunology-research-center
• Instagraminstagram.com/tpirc_org
• TikToktiktok.com/@tpirc.org

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles2 records

Subsidiaries1 record

Funding overview

Funding rounds2 records

Investors1 record

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M&A

Investments

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