What Native BioData Consortium does

Native BioData Consortium (NativeBio) is a 501(c)(3) nonprofit founded in 2018 as the first Indigenous genomic biorepository located within a sovereign American Indian nation—the Cheyenne River Sioux Reservation in Eagle Butte, South Dakota. The organization operates a biospecimen repository and secure data storage infrastructure for tribal biological, genetic, and environmental data, and runs the D4I Tribal Data Repository (TDR) project. Its core technology stack includes the b-IDS (blockchain-based Indigenous Data Sovereignty) platform, which enables secure, transparent sharing of genetic data with participant control, alongside related platforms PrecisionChain and De-Bi. NativeBio also operates wastewater surveillance infrastructure on the Cheyenne River Sioux Reservation for public health monitoring.

The organization serves tribal nations and Indigenous communities as its primary customer segment, with secondary outreach to Indigenous students and emerging researchers via the IndigiData workshop, SING USA genomics internship, and STEAM Camp educational programs. Revenue is generated primarily through federal research grants (notably a $9 million NIH RADx TDR award in December 2023 administered through Stanford University, plus grants from NSF and NARCH), philanthropic donations (via Donorbox and DAF Direct), and tribal consultation and advisory services on data governance and biospecimen storage. Distribution occurs through direct partnerships with tribal governments, health boards, and a research consortium spanning Stanford, University of Wisconsin–Madison, Arizona State University, UC Santa Cruz, Ohio State, and University of Washington.

The organization is governed by a board and tribal community advisory board honoring tribal sovereignty, with co-founders Joseph Yracheta (P'urhépecha), Krystal Tsosie (Diné/Navajo), Keolu Fox (Kanaka Maoli), and Guthrie Ducheneaux (Lakota) in leadership. NativeBio participates in the NIH Bridge2AI initiative exploring voice as a biomarker, contributing to AI/ML ethics frameworks in biomedical research. Notable recent events include a $7 million NIH grant termination in March 2025 as part of broader COVID-19 research cuts, which South Dakota tribes have publicly contested.

Name

Native BioData Consortium

Legal name

Native BioData Consortium

Website

https://nativebio.org

Company type

Private

Founded year

2018

Operating status

Operating

Headcount range

1–10 employees

Short description

Native BioData Consortium is a 501(c)(3) nonprofit operating the first Indigenous genomic biorepository on the Cheyenne River Sioux Reservation, providing secure tribal data storage, biospecimen repositing, and blockchain-based data sovereignty infrastructure for tribal nations and Indigenous communities.

Ownership category

akta.pro rank

Product category

Indigenous Genomic Biorepository and Data Sovereignty Services

NAICS

Blood and Organ Banks (621991), Human Rights Organizations (813311)

SIC

Services-Commercial Physical & Biological Research (8731)

akta.pro primary industry

Tribal/Indigenous Public Health Authorities (HLAJAAAD)

akta.pro secondary industries

Tribal Research Universities & Research Centers (Research-Active TCUs) (EDAHANAD), Tribal Community Colleges (2-Year) (EDAHADAI)

Keywords

• Indigenous data sovereignty
• Genomic biorepository services
• Tribal health research
• Biospecimen storage
• Data sovereignty consulting

Headquarters

HQ city

Eagle Butte

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Technology or R&D, Operations, Infrastructure, Marketing or Sales

Revenue model

1. Federal Research Grants: Primary revenue stream from federal grants including NIH funding. NativeBio received $9 million NIH award for RADx TDR D4I project. Additional grants from National Science Foundation, National Institutes of Health, and Native American Research Centers for Health (NARCH).
2. Donations and Charitable Contributions: 501(c)(3) nonprofit accepting donations to sustain Indigenous data sovereignty, research, and biodata storage work. Accepts Donorbox and DAF Direct contributions.
3. Tribal Consultation and Advisory Services: Provides advisory services for developing guidelines for health research projects and safe data storage. Offers consultation on data governance and policy development for tribal communities.
4. Biodata Storage Services: Operates biospecimen repository and secure data storage facilities for tribal biological and social data samples containing DNA.

Go-to-market motion1 record

Distribution channels2 records

Marketing channels5 records

Core offering

Native BioData Consortium operates an Indigenous-led biorepository and Tribal Data Repository that provides secure biospecimen storage, tribal health data sovereignty infrastructure, and biospecimen management for Native American communities. Its core offerings include the D4I Tribal Data Repository (backed by a $9M NIH award) for secure tribal COVID-19 and health data storage, the b-IDS blockchain-based Indigenous Data Sovereignty platform for participant-controlled genetic data sharing, and Biospecimen Repository facilities for DNA-containing biological samples on the Cheyenne River Sioux Reservation.

Product overview

Native BioData Consortium operates as a unified nonprofit platform combining a biospecimen repository, secure Indigenous data storage infrastructure, and educational programs. The core offerings include the D4I Tribal Data Repository ($9M NIH award) providing secure tribal health data storage and governance frameworks, and the b-IDS blockchain-based Indigenous Data Sovereignty platform for genetic data sharing. These are supported by the Biospecimen Repository for biological samples, tribal advisory services, and complemented by educational initiatives including IndigiData workshops, SING USA genomics training, and STEAM Camp programs—all designed to advance Indigenous health research while strengthening tribal sovereignty and self-governance over genetic and health data.

Differentiator

Problem solved

Functional benefit

Brands

• Tribal Data Repository (TDR): Indigenous-led data repository platform for tribal communities
• D4I
• IndigiData
• SING USA
• SENAHD

Products and services

• Native BioData Consortium (NativeBio) Indigenous Genomic Biorepository
• D4I Tribal Data Repository (RADx TDR)
• Biospecimen Repository
• b-IDS (blockchain-based Indigenous Data Sovereignty platform)
• Tribal Advisory Services
• Tribal Wastewater Surveillance System

Quantifiable outcome

• $9 million NIH award for Indigenous Tribal Data Repository
• +1 more outcomes

Named customers4 records

Segments2 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

AI capability3 records

Feature3 records

Partnerships

14 partnerships are on record, tiered core, flagship and minor.

• Stanford UniversitycoreStrategic or Co-development PartnerPrime awardee and project administrator for RADx Tribal Data Repository. Stanford Medicine Department of Genetics partnership began in 2015 with SAIL Study and BRAICELET biobank projects with Lakota community. Stanford's SPHERE Center helped establish Indigenous research built around community engagement, laying groundwork for NativeBio formation.
• National Institutes of Health (NIH)coreStrategic or Co-development PartnerMajor funder through RADx TDR D4I award ($9 million), Bridge2AI initiative, and National Institute of Health grants. NIH Common Fund initiative supporting Indigenous data sovereignty work and AI innovation in biomedical research.
• University of Wisconsin–MadisonflagshipStrategic or Co-development PartnerRADx TDR consortium member. SING USA 2026 collaborative partner. Matt Anderson, PhD serves as Board Treasurer and co-founded IndigiData workshop.
• Arizona State UniversityflagshipStrategic or Co-development PartnerRADx TDR consortium member. SING USA 2026 collaborative partner. Krystal Tsosie, PhD serves as Board Secretary and co-founder of NativeBio.
• University of California, Santa CruzcoreStrategic or Co-development PartnerRADx TDR consortium member contributing to ethical approaches to data sharing and analysis frameworks.
• Ohio State UniversitycoreStrategic or Co-development PartnerRADx TDR consortium member providing research expertise for tribal data repository development.
• University of North Carolina at Chapel HillcoreStrategic or Co-development PartnerSENAHD initiative partner with Lisa Villamil professor. Supports Southeast Native American Health DNA initiative for tribal health leaders.
• MASS Design GroupflagshipStrategic or Co-development PartnerArchitecture partner for NativeBio Campus plan. Collaborated on Abundant Futures Live 2025 event showcasing Native community and science vision.
• U.S. Indigenous Data Sovereignty NetworkcoreStrategic or Co-development PartnerNetwork partner supporting Indigenous data sovereignty policy work and governance frameworks.
• Duke UniversityminorStrategic or Co-development PartnerListed partner supporting Indigenous health research and data science collaboration.
• Center for Indigenous ScienceflagshipStrategic or Co-development PartnerSING USA 2026 collaborative partner for genomics workshop training Indigenous students in bioinformatics and anticolonial bioethics.
• Black Hills Center for American Indian HealthcoreStrategic or Co-development PartnerPartner in COVID-19 wastewater surveillance research. Jeffrey Henderson leads the project with NativeBio conducting community research on Cheyenne River Sioux Reservation.
• Whole Community HealthminorStrategic or Co-development PartnerPartner organization supporting community health initiatives for tribal populations.
• Odum Institute, Social Science ResearchminorStrategic or Co-development PartnerResearch partner providing social science methodology support for Indigenous data research.

Scale indicators4 records

Recent moves6 records

Expansion highlights5 records

Broad incumbents

• 23andMe: Consumer genomics and biobanking company that has faced criticism from Indigenous communities for genetic data practices. Comparable as a large-scale biorepository, though operating from a fundamentally different governance and consent model that NativeBio's sovereignty framework explicitly contrasts against.
• All of Us Research Program (NIH): NIH flagship program building a diverse biomedical data repository, including engagement with tribal communities. Comparable as a federally funded large-scale biomedical biorepository, though without NativeBio's sovereign-jurisdiction positioning.
• Southcentral Foundation: Alaska Native-owned nonprofit healthcare organization operating tribal health programs for 65,000+ Alaska Native and American Indian people. Comparable as a Native-led health-services and research organization, but with broader healthcare delivery scope.
• Mayo Clinic Biobank: Large-scale academic biorepository storing biological samples for biomedical research. Comparable as a biological sample storage and research platform, though operating as a mainstream academic medical center rather than an Indigenous-led sovereign entity.

Others

• Global Alliance for Genomics and Health (GA4GH): International standards-setting organization for genomic data sharing and governance. Comparable as an enabler in the genomic data sovereignty standards space that NativeBio's b-IDS and D4I frameworks would need to interoperate with or differentiate from.
• PrecisionFDA: FDA-hosted platform for genomic data sharing and precision medicine collaboration. Adjacent enabling platform relevant to NativeBio's blockchain-based PrecisionChain work in genetic data exchange.

Direct peers

• Center for Indigenous Science: Flagship SING USA 2026 collaborator focused on training Indigenous students in bioinformatics and anticolonial bioethics. Directly comparable mission in Indigenous genomics training and data sovereignty.
• Black Hills Center for American Indian Health: Native-led nonprofit focused on American Indian health research on and around the Cheyenne River Sioux Reservation. Named direct partner of NativeBio on the COVID-19 wastewater surveillance project, making it a near-direct peer in mission, geography, and customer base.
• U.S. Indigenous Data Sovereignty Network: Network partner that supports Indigenous data sovereignty policy work and governance frameworks — the same strategic territory NativeBio operates in. Directly comparable mission around Indigenous data governance and policy.

Emerging players

• Sage Bionetworks: Nonprofit biomedical research organization focused on open data sharing, patient-led governance, and Bridge2AI consortium member. Comparable through Bridge2AI participation and emphasis on participant data control, though without an Indigenous-specific mission.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks5 records

Key highlights7 records

Customer concentration

• LinkedInlinkedin.com/company/native-biodata
• Xx.com/NativeBio
• Facebookfacebook.com/NativeBioData

Revenue estimate

Valuation estimate

Number of profiles

Profiles9 records

Funding overview

Funding rounds2 records

Investors1 record

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M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Native BioData Consortium