What Clinical Pharmacogenetics Implementation Consortium (CPIC) does

CPIC is an international nonprofit research consortium founded in 2009 as a joint initiative between PharmGKB and the Pharmacogenomics Research Network (PGRN). It is managed jointly at Stanford University and St. Jude Children's Research Hospital and is funded by NIH grants (U24HG013077) from NHGRI, NICHD, NIDA, and NCI. CPIC's mission is to address barriers to clinical implementation of pharmacogenetic testing by creating, curating, and publishing freely available, peer-reviewed, evidence-based gene/drug clinical practice guidelines. Its core output is a library of 56+ peer-reviewed guideline publications covering dozens of gene-drug pairs (e.g., CYP2D6, CYP2C19, CYP2C9, TPMT, NUDT15, SLCO1B1) across oncology, psychiatry, cardiology, and other therapeutic areas, indexed in PubMed and published in Clinical Pharmacology and Therapeutics.

CPIC's technical stack comprises (i) human-readable guideline documents with systematic evidence grading, (ii) a structured CPIC Database and REST API (api.clinpgx.org) exposing gene-drug pairs, allele function assignments, and diplotype-to-phenotype mappings, (iii) GitHub-hosted versioned data releases (cpicpgx/cpic-data), and (iv) Informatics Working Group resources for EHR/Clinical Decision Support integration. Companion assets within the broader ClinPGx ecosystem include PharmGKB (curated knowledge base) and PharmCAT (variant calling and phenotype reporting). Endorsements from AMP, ASCPT, ASHP, CAP, and ClinGen lend institutional legitimacy, and CPIC® is a registered service mark of the U.S. Department of Health & Human Services.

CPIC does not earn commercial revenue. All guidelines and data are released under Creative Commons (CC0 for guidelines, CC BY-SA for data) at no cost to users worldwide. Operating funding flows from NIH grants, supplemented by an international consortium membership program that requires a signed MOU. End users include healthcare providers, clinical laboratories, researchers, EHR vendors, and indirectly patients receiving PGx-guided therapy; documented clinical outcomes include a reported 30% reduction in adverse drug reactions in pretherapeutic PGx panel testing studies.

Name

Clinical Pharmacogenetics Implementation Consortium (CPIC)

Legal name

Clinical Pharmacogenetics Implementation Consortium (CPIC)

Website

https://cpicpgx.org

Company type

Private

Founded year

2009

Operating status

Operating

Headcount range

11–50 employees

Short description

CPIC is a nonprofit international consortium that develops and freely distributes peer-reviewed, evidence-based pharmacogenetic clinical practice guidelines and a structured gene-drug database, serving clinicians, clinical laboratories, researchers, and EHR vendors worldwide under NIH funding.

Ownership category

akta.pro rank

Product category

Clinical Pharmacogenomics Guidelines

SIC

Services-Commercial Physical & Biological Research (8731)

akta.pro primary industry

Value Dossier & Evidence Generation (AMCP/Global Value Dossier) (HLAIAKAC)

Keywords

• Pharmacogenomics guidelines
• Clinical decision support
• Gene-drug pair annotations
• EHR integration
• Pharmacogenetic testing

Headquarters

HQ city

Memphis

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Technology or R&D, Operations, Infrastructure, Others

Revenue model

1. NIH Funding: CPIC is managed at Stanford University and St. Jude Children's Research Hospital under NIH grants (U24HG013077). As a non-profit research consortium, CPIC operations are funded through NIH/NHGRI/NICHD/NIDA/NCI grants rather than commercial revenue generation.

Pricing tiers

Go-to-market motion1 record

Distribution channels4 records

Marketing channels7 records

Core offering

CPIC is an international consortium that creates, curates, and posts freely available, peer-reviewed, evidence-based gene/drug clinical practice guidelines that translate pharmacogenetic test results into actionable prescribing decisions. Core offerings include the CPIC Guidelines, a structured CPIC Database with a public REST API (api.clinpgx.org), gene reference tables, allele function/diplotype-phenotype resources, and informatics tools for Electronic Health Records and Clinical Decision Support integration.

Product overview

The Clinical Pharmacogenetics Implementation Consortium (CPIC) is an international consortium that develops and freely distributes peer-reviewed, evidence-based clinical practice guidelines for pharmacogenetics. CPIC's core offering is its guidelines (covering gene-drug pairs), accessible via a public API and database. The ecosystem includes PharmGKB (knowledge base), CPIC (guidelines), and PharmCAT (variant identification tool). CPIC guidelines translate genetic laboratory results into actionable prescribing decisions and are indexed in PubMed. The consortium provides supplementary resources including gene tables, allele downloads, SOPs for allele curation, implementation guides for EHR integration, and educational materials. All CPIC resources are freely available under Creative Commons (CC0 for guidelines, CC BY-SA for data).

Differentiator

Problem solved

Functional benefit

Products and services

• CPIC Guidelines Peer-reviewed, evidence-based, updatable clinical practice guidelines that translate pharmacogenetic test results into actionable prescribing decisions for specific gene-drug pairs. Guidelines follow standardized formats with systematic grading of evidence and clinical recommendations, published in partnership with Clinical Pharmacology and Therapeutics and indexed in PubMed.
• CPIC Database and API Structured access to CPIC guideline data including gene-drug pair information, allele function assignments, diplotype-to-phenotype translations, and clinical recommendations. Available via REST API and database downloads with versioned releases on GitHub.
• Gene Tables Reference tables providing curated PGx evidence for genes, including allele function and diplotype-phenotype relationships for pharmacogenes used by clinicians and laboratories.
• CPIC Publications Repository of 56+ peer-reviewed scientific articles written or contributed to by the ClinPGx team, covering implementation guidelines, literature annotations, and supporting research, available as downloadable TSV.
• CPIC Informatics Working Group Resources Technical resources supporting EHR integration, including comprehensive genotype-to-phenotype translation tables, clinical decision support recommendations, and formal knowledge representations for electronic health records.
• PharmCAT A companion tool for identifying pharmacogenetic variants from genomic data and generating phenotype reports, developed as part of the ClinPGx ecosystem alongside PharmGKB and CPIC. Managed at Stanford University and University of Pennsylvania.

Quantifiable outcome

• PGx-guided therapy can reduce adverse drug reactions and healthcare costs
• +1 more outcomes

Named customers4 records

Segments4 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

Yes

API docs

API detail

Core technology

AI maturity

App detail

Feature5 records

Partnerships

Seven partnerships are on record, tiered core and major.

• PharmGKB (Pharmacogenomics Knowledge Base)coreStrategic or Co-development Partner · 1 January 2009PharmGKB and CPIC have a foundational partnership. CPIC started as a shared project between PharmGKB and the Pharmacogenomics Research Network (PGRN) in 2009. PharmGKB provides the infrastructure for ClinPGx, which comprises PharmGKB, CPIC, and PharmCAT. CPIC guidelines are hosted on the ClinPGx platform.
• Pharmacogenomics Research Network (PGRN)coreStrategic or Co-development PartnerCPIC started as a shared project between PharmGKB and PGRN in 2009. PGRN is a research network focused on pharmacogenomics research that collaborated with PharmGKB to launch CPIC.
• Association for Molecular Pathology (AMP)majorStrategic or Co-development PartnerAMP has endorsed CPIC's Term Standardization for Clinical Pharmacogenetics Test Results Project. This endorsement supports the standardization of pharmacogenetic test result terminology across clinical laboratories.
• American Society for Clinical Pharmacology and Therapeutics (ASCPT)majorStrategic or Co-development PartnerASCPT Board of Directors has endorsed CPIC guidelines. CPIC guidelines are published in partnership with ASCPT's journal Clinical Pharmacology and Therapeutics.
• American Society of Health-System Pharmacists (ASHP)majorStrategic or Co-development PartnerASHP has endorsed multiple CPIC guidelines, indicating support for the use of pharmacogenetic guidelines in health-system pharmacy practice.
• College of American Pathologists (CAP)majorStrategic or Co-development PartnerCAP has stated that it 'applauds and supports the objectives, processes and work completed' by CPIC, recognizing efforts to help clinicians, laboratories, healthcare providers, and vendors implement pharmacogenetics.
• ClinGen (Clinical Genome Resource)coreStrategic or Co-development PartnerClinGen references CPIC guidelines. ClinPGx is an affiliate grant of ClinGen and works with ClinGen and ClinVar to improve integration of pharmacogenomics within broader genomic medicine. CPIC's Steering Committee is referred to as CPIC's External Expert Panel.

Scale indicators4 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• PharmCAT: Companion tool in the ClinPGx ecosystem that calls PGx variants from genomic data and produces phenotype reports that feed directly into CPIC guidelines for clinical interpretation.
• PharmGKB (Pharmacogenomics Knowledge Base): Foundational partner and sister organization in the ClinPGx ecosystem; together with CPIC provides annotation, evidence, and implementation assets for pharmacogenomics, and shares NIH funding and Stanford stewardship.
• Clinical Genome Resource (ClinGen): NIH-funded consortium that defines clinical relevance of genes and variants; CPIC is an affiliate grant of ClinGen, and ClinGen references CPIC guidelines to integrate PGx into broader genomic medicine.
• National Comprehensive Cancer Network (NCCN): Produces widely adopted, evidence-based clinical practice guidelines (for oncology); analogous operating model to CPIC in authoring and disseminating consensus-driven, peer-reviewed clinical guidance.
• American College of Medical Genetics and Genomics (ACMG): Professional society that issues evidence-based clinical genomics guidelines and standards overlapping CPIC's domain; relevant comparator for clinical genomics guideline development and dissemination.
• Association for Molecular Pathology (AMP): Endorser of CPIC's Term Standardization project and a peer organization producing molecular pathology practice guidelines; comparable in producing clinical and laboratory standards for genomic testing.
• Pharmacogenomics Research Network (PGRN): Co-founding organization of CPIC in 2009; NIH-funded research network advancing pharmacogenomics research with overlapping scientific leadership and mission.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks7 records

Key highlights7 records

Customer concentration

• Xx.com/cpicpgx
• YouTubeyoutube.com/@ClinPGx
• LinkedInlinkedin.com/company/clinical-pharmacogenetics-implementation-consortium

Revenue estimate

Valuation estimate

Number of profiles

Profiles3 records

Funding overview

Funding rounds1 record

Investors1 record

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M&A

Investments

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Frequently asked questions about Clinical Pharmacogenetics Implementation Consortium (CPIC)