EnTox Sciences

What EnTox Sciences does

EnTox Sciences is a Seattle-area instrumentation company that designs and sells the BaroFuse system, a pressure-driven, pumpless, multi-channel (8–16 channel) perfusion platform for maintaining live tissue in vitro while continuously measuring metabolic and functional parameters. The instrument is differentiated by its ability to control dissolved gas equilibration — O2, CO2, and the gas signaling molecules H2S, CO, and NO — and to perform real-time assessments such as oxygen consumption and lactate production on small tissue samples, including needle biopsies. Companion software (BaroFuse Data Processor, User Interface, and Oxygen Detector Software) supports experiment control and data processing on Windows and Mac.

The company serves life science researchers investigating metabolic, signaling, and secretory function in live tissue, with emphasis on diabetes, retinopathy, and cancer research, and pharmaceutical industry customers conducting drug toxicity analysis, dose-response studies, pharmacokinetics characterization, and lead candidate selection. The technology is positioned as an alternative to expensive, low-throughput animal models, enabling detailed intracellular study while preserving in vivo-like tissue function. The technical foundation is built on a long-standing co-development partnership with Dr. Ian Sweet's laboratory at the University of Washington, supported by NIH and NSF STTR grants, and the work has produced peer-reviewed publications in journals including eLife and Cell Reports Methods.

Commercially, EnTox generates revenue through two streams: direct sale of the BaroFuse 8CH instrument (orders accepted from 2022) and fee-for-service experimental work performed in-house, which functions as an evaluation pathway leading to instrument purchase. Distribution is sales-led and direct, with no third-party resellers identified; sales and technical inquiries are handled by phone and a general email routed to the CSO. Pricing is not publicly disclosed, and the company remains privately held with no venture capital rounds, no parent company, and a headcount of 1–10 employees.

Name

EnTox Sciences

Legal name

EnTox Sciences

Website

https://entoxsciences.com

Company type

Private

Founded year

2013

Operating status

Operating

Headcount range

1–10 employees

Short description

EnTox Sciences designs and sells the BaroFuse, a pressure-driven perfusion instrument for real-time metabolic and dissolved-gas analysis of live tissue, serving academic life science researchers and pharmaceutical drug-development customers focused on diabetes, retinopathy, and metabolic disease research.

Ownership category

akta.pro rank

Product category

Laboratory Instruments

NAICS

Analytical Laboratory Instrument Manufacturing (334516)

SIC

Laboratory Analytical Instruments (3826)

akta.pro primary industry

Liquid Handling & Laboratory Automation (Pipettes, Robots, Workstations) (HLAGAIAD)

Keywords

• Tissue perfusion instruments
• Dissolved gas analysis
• Live tissue assessment
• Pharmaceutical research instruments
• Biomedical perfusion systems

Headquarters

HQ city

Mercer Island

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Technology or R&D, Operations, Marketing or Sales, Infrastructure

Revenue model

1. BaroFuse Instrument Sales: Sale of the BaroFuse 8CH instrument system for tissue analysis. The company began taking orders for instruments starting in 2022.
2. Fee for Service Experiments: EnTox can perform experiments at fee for service, allowing customers to obtain preliminary data to evaluate whether the BaroFuse is appropriate for their research needs before purchasing the instrument.

Pricing tiers

Go-to-market motion1 record

Distribution channels3 records

Marketing channels3 records

Core offering

EnTox Sciences designs, manufactures, and sells the BaroFuse instrument, a pressure-driven, adjustable-throughput perfusion system that maintains live tissue in native structure and provides real-time biochemical and optical assessments of metabolic, signaling, and secretory function in response to dissolved gases and test compounds. The company also offers fee-for-service experiments using the BaroFuse, allowing customers to evaluate the technology and obtain preliminary data before purchase. Companion BaroFuse Software (Data Processor, User Interface, Oxygen Detector) supports instrument operation on Windows and Mac.

Product overview

EnTox Sciences offers a single unified product portfolio centered on the BaroFuse system, a pressure-driven perfusion instrument for real-time tissue assessment. The company provides the BaroFuse Instrument (available in 8-16 channel configurations), three companion software products (BaroFuse Data Processor, BaroFuse User Interface, and BaroFuse Oxygen Detector Software), and fee-for-service experimental capabilities. The system enables precise biochemical and optical assessments of cells and tissues in response to dissolved gases and test compounds, serving pharmaceutical and life science research markets.

Differentiator

Problem solved

Functional benefit

Brands

• BaroFuse: A pressure-driven, adjustable-throughput perfusion system for tissue maintenance and real-time functional assessment of tissue and cells. The system enables precise biochemical and optical assessments of cells and tissues in response to changes in dissolved gases and test compounds.

Products and services

• BaroFuse 8CH Instrument A pressure-driven, adjustable-throughput perfusion system that maintains live tissue in native structure and provides real-time biochemical and optical assessments of cells and tissues in response to dissolved gases and test compounds. Configured with 8 channels (parallel testing of up to 16 tissue types or conditions supported). Sold to pharmaceutical companies and life science research institutions for drug toxicity analysis, dose response, pharmacokinetics, metabolic, and secretory function studies.
• Fee-for-Service Experiments Experimental services performed by EnTox Sciences using the BaroFuse instrument for life science researchers and pharmaceutical industry customers who wish to obtain preliminary data, require analytical services, or evaluate the technology before committing to an instrument purchase. Priced on a pay-as-you-go basis; customers contact Technical Support for details.
• BaroFuse Data Processor Software Companion software for the BaroFuse instrument used to process experimental data acquired from the system. Available in Mac (v2.67.2, beta) and PC (v2.67.2, beta) versions, supported on Windows 10 & 11 and iOS 14. Sold alongside the BaroFuse instrument to researchers conducting metabolic and tissue function analyses.
• BaroFuse User Interface Software Primary software program used to run experiments on the BaroFuse instrument, providing experiment control and user interaction on PC. Released as version 2.30.1 in February 2025. Bundled with the BaroFuse instrument for life science and pharmaceutical researchers.
• BaroFuse Oxygen Detector Software Specialized companion software for the BaroFuse system that supports oxygen detection functionality on the PC (v1.4.1, released January 2024). Used by researchers studying dissolved oxygen effects on tissue metabolism.

Quantifiable outcome

• Islets lose almost 50% of pre-hypoxic OCR following hypoxia, while retina completely recovers
• +2 more outcomes

Named customers2 records

Segments3 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature6 records

Partnerships

One partnership is on record.

• University of Washington - Dr. Ian Sweet's LaboratorycoreStrategic or Co-development Partner · 1 January 2013EnTox Sciences works closely with Dr. Ian Sweet's laboratory at the University of Washington. The collaboration is supported by STTR grants from the NIH and NSF. Ian Sweet serves as Founder and Chief Scientific Officer of EnTox while also serving as Research Associate Professor at UW. This academic-industry partnership enables cutting-edge biotech instrumentation development and provides opportunities for employees to publish in both engineering and life science journals.

Scale indicators4 records

Recent moves8 records

Expansion highlights4 records

Direct peers

• Agilent Technologies (Seahorse XF): Agilent's Seahorse XF analyzers are the dominant live-cell metabolic analysis platform, measuring OCR and ECAR in real time — the closest direct substitute to the BaroFuse for pharma and academic metabolism customers.
• Harvard Apparatus: Long-standing manufacturer of perfusion systems, tissue chambers, and physiological instruments used in the same biomedical research workflows that BaroFuse targets.
• Warner Instruments: Specializes in perfusion chambers and live-cell/tissue recording platforms for electrophysiology and imaging — a direct competitor in tissue-maintenance instrumentation for research labs.
• Bioptechs: Manufacturer of live-cell perfusion and temperature-control instrumentation for microscopy, directly comparable to BaroFuse's real-time tissue assessment use case.
• CellASIC (MilliporeSigma / EMD Millipore): Offers microfluidic live-cell imaging and perfusion systems used by pharma and academic researchers for dynamic cell and tissue analysis — overlapping product category with BaroFuse.
• IonOptix: Provides instrumentation for real-time functional assessment of live muscle, cardiac, and other cells — comparable in approach (live tissue functional readouts) if not in exact application.

Emerging players

• Nanion Technologies: Specializes in automated patch clamp and live-cell functional analysis instrumentation, with overlapping customer segments in pharma screening and academic biophysics.
• InSphero: 3D tissue models and related assay platforms for pharma drug toxicity and metabolism studies; adjacent category with overlapping customer pain points (animal model replacement, tissue-level readouts).

Broad incumbents

• Thermo Fisher Scientific: Broad life-sciences instruments and consumables portfolio serving the same pharma and academic research buyers; could expand into BaroFuse-adjacent perfusion/metabolism categories.
• Revvity (formerly PerkinElmer Life Sciences): Major life-sciences instrumentation vendor with reach into pharma drug discovery and metabolic research workflows — comparable buyer relationships to EnTox.

Market position

Strengths4 records

Weaknesses5 records

Competitive moat3 records

Key risks6 records

Key highlights6 records

Customer concentration

• LinkedInlinkedin.com/company/entox-sciences

Revenue estimate

Valuation estimate

Number of profiles

Profiles7 records

Funding overview

Funding rounds2 records

Investors1 record

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about EnTox Sciences