Ledger Run
Ledger Run operates the ClinRun SaaS platform that unifies clinical trial agreement drafting, site budgeting, site payments, and forecasting into a single CTA-to-Pay workflow for enterprise pharmaceutical sponsors, CROs, biotech, and medical device companies across 65+ countries.
- Company typePrivate
- Founded2018
- HeadquartersRaleigh, United States
- Headcount101–250
- GTM typeB2B
- OfferingSoftware
What Ledger Run does
Ledger Run, Inc. is a private Raleigh, North Carolina-based software and services company founded in 2018 that operates the ClinRun platform, a SaaS solution unifying clinical trial agreement (CTA) drafting, site budgeting, site payments, and financial forecasting into a single "CTA-to-Pay" workflow for the life sciences industry. The platform consists of four integrated modules — Budgets, Contracts, Site Payments, and Forecasting — supported by hundreds of CTA and budget templates and clause libraries for 60+ regions, integrations with EDC and CTMS systems, and complete audit trails. In 2026 the company added AI-powered automation using NLP, rules-based reasoning, and large language models to extract and match PDF invoice details to contract terms, with human-in-the-loop validation.
Ledger Run serves primarily enterprise pharmaceutical sponsors and contract research organizations (CROs), with additional adoption among biotechnology and medical device companies. Its customer base includes 3 of the top 10 pharmaceutical companies, 2 of the top 5 CROs, and 60+ global companies managing 18,000+ sites across approximately 65–70 countries, with over $2B in payments processed through the platform. The company supplements its software with professional services — Contract Services, Payment Services, and a Rescue Study Advantage offering — delivered by in-country legal and operational experts, which gives it a hybrid platform-plus-services revenue model priced on an annual enterprise subscription basis with quote-based engagement. In October 2024 it acquired Assentia, a global pharmaceutical solutions provider, and in September 2025 it added a CTO, CFO, and CCO to its executive team to support scaling.
Ledger Run firmographics
Firmographics- Name
- Ledger Run
- Legal name
- Ledger Run, Inc.
- Website
- https://ledgerrun.com
- Company type
- Private
- Founded year
- 2018
- Operating status
- Operating
- Headcount range
- 101–250 employees
- Short description
- Ledger Run operates the ClinRun SaaS platform that unifies clinical trial agreement drafting, site budgeting, site payments, and forecasting into a single CTA-to-Pay workflow for enterprise pharmaceutical sponsors, CROs, biotech, and medical device companies across 65+ countries.
- Ownership category
- akta.pro rank
Ledger Run industry classification
Industry- Product category
- Clinical Trial Financial Operations Software
- NAICS
- Software Publishers (513210), Financial Transactions Processing, Reserve, and Clearinghouse Activities (522320)
- SIC
- Services-Prepackaged Software (7372), Services-Computer Processing & Data Preparation (7374), Finance Services (6199)
- akta.pro primary industry
- Clinical Trial Financial Management & Payments (Site Budgeting) (HLAGACAM)
- akta.pro secondary industries
- Clinical Trial Informatics (EDC/CTMS/eCOA/eTMF) (HLAGAJAM), Clinical Trial Site Operations & Study Coordination (HLAGACAE), Clinical Operations & Monitoring FSP (CRA/CTM/Start-up) (HLAGAOAA)
Keywords
Where Ledger Run is headquartered
LocationHeadquarters
- HQ city
- Raleigh
- HQ country
- United States
- HQ region
- North America
Offices1 record
Markets served
Ledger Run business model
Business model- GTM type
- B2B
- Offering type
- Software
- Cost components
- Personnel, Technology or R&D, Operations, Marketing or Sales, Infrastructure
Revenue model
- Software Platform (ClinRun): SaaS platform subscription for clinical trial contract and payment management. The platform is used by pharmaceutical companies and CROs to manage site contracts, budgets, and payments.
- Contract Services: In-region CTA creation, budgeting and negotiations delivered by global legal experts across 65+ countries. Includes site feasibility assessment, region-specific budgets, and contract negotiations.
- Payment Services: Global experts in site payment management and oversight including country-specific payment processes, rapid site payments, and accurate budget forecasting.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Subscription | Annual | Enterprise SaaS with Professional Services |
Go-to-market motion2 records
Distribution channels2 records
Marketing channels6 records
Ledger Run product offering
Product offeringCore offering
Ledger Run sells the ClinRun cloud SaaS platform that manages clinical trial financial operations end-to-end — from clinical trial agreement (CTA) drafting and negotiation through site budgeting, site payments, and financial forecasting — and complements the software with professional services delivered by in-country legal and payment experts across 65+ countries. The platform processes over $2B in payments across 18,000+ clinical sites and now includes AI-powered invoice processing automation.
Product overview
Ledger Run offers a unified platform-plus-services solution combining its ClinRun software platform with expert services. The ClinRun platform consists of four integrated modules: Budgets (for instant CTA budget mapping with clause libraries for 60+ regions), Contracts (for drafting CTAs with templates and e-signature), Site Payments (for managing payments from budget to close), and Forecasting (for modeling spend scenarios and tracking budget status). The platform processes over $2B in payments across 18,000+ sites globally. Complementing the software, Ledger Run provides Contract Services (global CTA creation, budgeting, and negotiations) and Payment Services (site payment management and oversight), including a Rescue Study Advantage offering for studies needing rapid turnaround. The platform recently added AI-powered automation capabilities including NLP and LLM-based invoice processing.
Differentiator
Problem solved
Functional benefit
Brands
- ClinRun: Clinical trial management platform for site contracts and payments, offering budget management, contract drafting, site payments, and forecasting capabilities.
Products and services
- ClinRun Platform Cloud SaaS platform for managing clinical trial financial operations end-to-end from CTA to final payment, combining contracts, budgets, site payments, forecasting, compliance tracking, and audit trails. Used by pharmaceutical sponsors and CROs.
- Contract Services Professional services delivering global CTA creation, budgeting, and negotiations. Includes pre-qualified global site network, in-region legal experts across 65+ countries, site feasibility assessment, and region-specific budgets with rapid contract negotiation.
- Payment Services Professional services delivered by global site payment management and oversight experts. Includes country-specific payment processes, rapid site payments, accurate budget forecasting, and payment-to-date tracking.
- Rescue Study Advantage Flexible engagement service for clinical studies in distress or transition, providing proven contracts and payments expertise to keep studies moving without disruption.
Quantifiable outcome
- Reduce invoice processing time by 20%
- +4 more outcomes
Companies that use Ledger Run
Customer profileNamed customers6 records
Segments4 records
Ideal customer profiles3 records
Ledger Run technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Integration2 records
AI capability4 records
Feature6 records
Ledger Run partnerships and signals
Strategic signalPartnerships
Two partnerships are on record, tiered core.
- AssentiacoreLedger Run announced its acquisition of Assentia, a global pharmaceutical solutions provider. This acquisition expands Ledger Run's capabilities in pharmaceutical solutions.
- Blue Star Innovation PartnerscoreLedger Run partnered with Blue Star Innovation Partners to accelerate its growth through a merger or acquisition. The partnership was announced on September 4, 2024.
Scale indicators8 records
Recent moves5 records
Expansion highlights6 records
Ledger Run competitors and assessment
Company assessmentBroad incumbents
- Veeva Systems: Veeva is the dominant CTMS/eTMF incumbent in life sciences with overlapping sponsor relationships; its CTMS and Vault platforms include contract and payment-adjacent functionality and could absorb Ledger Run's niche over time.
- IQVIA Technologies: IQVIA is one of the top five CROs and a broad technology incumbent with site payment and CTMS offerings that overlap with Ledger Run across many of the same sponsor customers.
- Medidata Solutions (Dassault Systèmes): Medidata is a broad incumbent in EDC, CTMS, and decentralized trial technology used by the largest pharma sponsors; its Rave platform includes financial and clinical operations modules with overlap to Ledger Run's site payment workflows.
- Oracle Health Sciences: Oracle Health Sciences offers a broad CTMS and clinical development suite (built around goBalto and Siebel CTMS) that competes across site activation, budgeting, and payment workflows with Ledger Run's ClinRun platform.
Direct peers
- goBalto (Oracle Health Sciences): goBalto, now part of Oracle Health Sciences, is a direct competitor focused on clinical trial site activation, contract management, and budget workflows; it competes head-on with Ledger Run's ClinRun Contracts and Budgets modules for the same sponsor and CRO buyers.
- RealTime Software Solutions: RealTime is a direct competitor with CTMS and eClinical modules that include site payment processing, contract management, and budget workflows targeting sponsors and CROs on a SaaS-plus-services basis similar to Ledger Run.
- Greenlight Clinical (YPrime): YPrime (formerly Greenlight Clinical) is a direct peer offering eClinical and clinical trial financial management solutions, including site payment and contract capabilities, serving the same pharma and CRO segments with comparable enterprise sales motion.
- Greenphire: Greenphire is the closest direct peer, specializing in clinical trial site payments, participant reimbursements, and global investigator payment workflows for pharma sponsors and CROs—essentially the same buyer, problem space, and revenue model as Ledger Run's ClinRun Payments and Payment Services modules.
Emerging players
- Signant Health: Signant Health is an emerging player in eCOA, ePRO, and patient-centric clinical technology serving the same pharma and CRO buyers; its site-facing logistics and payment-adjacent capabilities make it a thematically adjacent emerging peer.
- Castor: Castor is an emerging eClinical platform with growing sponsor adoption; while its core is EDC and ePRO, it increasingly overlaps with budget and payment-adjacent workflows for clinical trials, making it a partial-fit emerging peer.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat5 records
Key risks6 records
Key highlights6 records
Customer concentration
Ledger Run social profiles
Digital presenceLedger Run financial estimates
Financial estimateRevenue estimate
Valuation estimate
Ledger Run leadership team
Management profileNumber of profiles
Profiles8 records
Ledger Run subsidiaries and ownership
Company hierarchySubsidiaries1 record
Ledger Run funding detail
Funding detailFunding overview
Funding rounds1 record
Investors1 record
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Ledger Run M&A and investment
M&A and investmentM&A1 record
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Ledger Run
What does Ledger Run do?
Ledger Run sells the ClinRun cloud SaaS platform that manages clinical trial financial operations end-to-end — from clinical trial agreement (CTA) drafting and negotiation through site budgeting, site payments, and financial forecasting — and complements the software with professional services delivered by in-country legal and payment experts across 65+ countries. The platform processes over $2B in payments across 18,000+ clinical sites and now includes AI-powered invoice processing automation.
Is Ledger Run a public or private company?
Ledger Run is a private company. It is classified as venture growth investor backed and is currently operating.
When was Ledger Run founded?
Ledger Run was founded in 2018. It employs 101 to 250 people.
Where is Ledger Run based?
Ledger Run is headquartered in Raleigh, United States, in the North America region.
How does Ledger Run make money?
Three revenue lines are on record. Software Platform (ClinRun) is the primary driver. The others are contract Services and payment Services.
Who are Ledger Run's main competitors?
Broad incumbents on record are Veeva Systems, IQVIA Technologies, Medidata Solutions (Dassault Systèmes) and Oracle Health Sciences. Direct peers are goBalto (Oracle Health Sciences), RealTime Software Solutions, Greenlight Clinical (YPrime) and Greenphire. Emerging players are Signant Health and Castor.
Does Ledger Run have an API?
No public API is recorded for Ledger Run.
What industry is Ledger Run in?
Ledger Run's product category is Clinical Trial Financial Operations Software. Its primary akta.pro industry code is HLAGACAM, Clinical Trial Financial Management & Payments (Site Budgeting), with a secondary code of HLAGAJAM, Clinical Trial Informatics (EDC/CTMS/eCOA/eTMF). Its NAICS code is 513210 and its SIC code is 7372.