What MOLECUBES does

MOLECUBES, a Bruker Company, designs and manufactures compact benchtop preclinical molecular imaging systems for research laboratories. The company's core product platform consists of three micro-imaging systems: the β-CUBE (micro-PET), γ-CUBE (micro-SPECT), and X-CUBE (micro-CT), which can operate as stand-alone units or in modular combinations. These systems are built on proprietary silicon photomultiplier (SiPM) detector technology coupled to continuous crystals, enabling sub-millimeter spatial resolution across modalities, with throughput of 50+ mice per day in bi-modal configurations. The hardware platform is completed by the CUBEFLOW integrated workflow software and the REMI standalone reconstruction engine (32 TB RAID storage), along with specialized animal beds (Mouse Bed, Rat Bed, Rat XL Bed, Mouse Hotel) that provide physiological monitoring and multi-animal scanning capability.

The company primarily serves academic research institutions, pharmaceutical and biotechnology companies, translational research programs, and imaging core facilities. Documented customers include NYU Langone Health, University of Pennsylvania, University of Chicago, Universitätsklinikum Essen, Uniklinik RWTH Aachen, KU Leuven, and the contract research organization BIOEMTECH. Use cases span drug discovery, pharmacokinetics, target engagement, theranostics, oncology, neurology, and cardiology research, with more than 50 peer-reviewed studies published using the technology.

MOLECUBES generates revenue through hardware sales of imaging systems, recurring software licenses (CUBEFLOW, REMI), technical service contracts (targeting >98% uptime), and application training services. Pricing is quote-based and not publicly disclosed. Sales are executed exclusively through Bruker Preclinical Imaging's specialized global sales organization and a worldwide network of expert distributors. The company is headquartered in Ghent, Belgium (legal entity: Bruker Belgium NV) and employs approximately 25 people, operating as a wholly owned subsidiary within Bruker BioSpin's Preclinical Imaging Division.

Name

MOLECUBES

Legal name

Bruker Belgium NV

Website

https://molecubes.com

Company type

Private

Founded year

2015

Operating status

Operating

Headcount range

11–50 employees

Short description

MOLECUBES designs compact benchtop preclinical PET, SPECT, and CT imaging systems for academic and pharmaceutical research laboratories. Operating as a Bruker subsidiary, the company serves drug discovery, translational research, and core imaging facilities worldwide with proprietary SiPM detector technology.

Ownership category

akta.pro rank

Product category

Preclinical Imaging Systems

NAICS

Analytical Laboratory Instrument Manufacturing (334516)

SIC

Laboratory Analytical Instruments (3826)

akta.pro primary industry

Nuclear Medicine & Molecular Imaging (SPECT/PET) (HLAHABAE)

akta.pro secondary industry

Microscopy, Imaging & Flow Cytometry Instruments (HLAGAIAE)

Keywords

• Preclinical imaging systems
• Molecular imaging equipment
• Benchtop PET scanners
• Small animal imaging
• Micro-CT micro-SPECT

Headquarters

HQ city

Gent

HQ country

Belgium

HQ region

Europe

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Technology or R&D, Operations, Marketing or Sales, Supply Chain

Revenue model

1. Preclinical Imaging Systems: Sale of benchtop PET, SPECT, and CT imaging systems (β-CUBE, γ-CUBE, X-CUBE) as stand-alone units or modular combinations for preclinical research labs
2. Technical Support and Service: Support team provides remote and on-site technical and servicing-related support including preventive servicing, upgrades, and system maintenance with >98% uptime
3. Software Licenses and Upgrades: CUBEFLOW software suite and REMI workstation for image acquisition, reconstruction, and data management
4. Application Training and Support: Application team provides training and application support for scanning protocols, study setup, postprocessing, and research-related questions

Go-to-market motion1 record

Distribution channels3 records

Marketing channels8 records

Core offering

MOLECUBES designs, manufactures, and sells compact benchtop preclinical molecular imaging systems—the X-CUBE (micro-CT), γ-CUBE (micro-SPECT), and β-CUBE (micro-PET)—that work as stand-alone units or in modular combinations for whole-body mouse and rat imaging in research labs. The hardware is paired with the CUBEFLOW workflow software, the REMI reconstruction engine, and specialized animal beds to deliver sub-millimeter resolution, high-throughput scans for drug discovery, translational research, and academic molecular imaging.

Product overview

MOLECUBES offers a modular benchtop preclinical imaging platform consisting of three core micro-imaging systems: the X-CUBE (micro-CT), γ-CUBE (micro-SPECT), and β-CUBE (micro-PET). These compact, high-performance scanners work as stand-alone units or in modular combinations. The platform is supported by the CUBEFLOW workflow software suite that integrates animal preparation, physiological monitoring, image acquisition, and reconstruction. Optional add-ons include the REMI reconstruction engine for centralized data management and specialized animal beds (Mouse Bed, Rat Bed, Rat XL Bed, Mouse Hotel) designed for multi-animal scanning to maximize throughput.

Differentiator

Problem solved

Functional benefit

Products and services

• X-CUBE High-throughput micro-CT benchtop scanner for fast whole-body mouse and rat CT imaging at extremely low dose (<4 mGy) with excellent soft tissue contrast. Self-shielded, mobile, lightweight in-vivo scanner with 50 μm resolution, gated imaging, and dynamic contrast-enhanced imaging workflows.
• γ-CUBE High-sensitivity, high-resolution micro-SPECT benchtop imager for whole-body mouse and rat imaging using patented lofthole technology and laser sintered collimators combined with high-resolution detectors. Achieves resolution <500 μm for mice and <1 mm for rats, and is compatible with all common SPECT-labeled tracers.
• β-CUBE High-performance micro-PET benchtop imager achieving sub-millimeter image resolution through monolithic scintillators, latest photon counting technology, GPU-based event positioning, and iterative image reconstruction. The 5-ring configuration ensures best-in-class sensitivity over a wide field of view for whole-body mouse and rat imaging at high count rate.
• CUBEFLOW Integrated workflow software suite connecting the entire imaging chain from animal preparation and physiological monitoring to wireless image acquisition and reconstruction. Includes quality control, scanning protocols, and data management, enabling any scan to be initiated in fewer than 10 clicks.
• REMI (Reconstruction Engine for Molecular Imaging) Standalone reconstruction engine with 32 TB RAID storage capacity for centralized imaging data management, supporting simultaneous batch reconstruction of multiple datasets with automated data offloading and web-based server access.
• Mouse Bed Small-animal bed for mice up to 35 g, designed for physiological monitoring during PET, SPECT, and CT imaging with integrated anesthesia and temperature control.
• Rat Bed Small-animal bed for rats up to 350 g with integrated physiological monitoring including respiratory and cardiac gating, anesthesia, and active temperature controls.
• Rat XL Bed Extended capacity small-animal bed for rats up to 450 g with full physiological monitoring capabilities for larger animal subjects.
• Mouse Hotel Multi-animal bed enabling simultaneous scanning of up to 4 mice (up to 30 g each) in both PET and CT, and up to 3 mice in SPECT, optimizing throughput for large cohort studies.

Quantifiable outcome

• Daily throughput of 50+ mice in bi-modal PET/CT or SPECT/CT static setup
• +4 more outcomes

Named customers7 records

Segments4 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration1 record

Feature5 records

Partnerships

Four partnerships are on record, tiered core and minor.

• BrukercoreOthersMOLECUBES is a Bruker Company, operating as part of Bruker BioSpin's Preclinical Imaging Division. This provides integration into a larger global organization with established sales channels and technical support infrastructure.
• LabLogiccoreChannel Partner/ Reseller/ DistributorLabLogic supported the installation of a full PET-SPECT-CT imaging platform at NYU Langone Health, acting as a key implementation and distribution partner for the North American market.
• Center for Medical Genetics GhentminorStrategic or Co-development PartnerCollaborative research partner for zebrafish PET-CT imaging study demonstrating sub-millimeter resolution capabilities of the β-CUBE system.
• UMC GroningenminorStrategic or Co-development PartnerNuclear medicine and molecular imaging department collaborated on zebrafish PET-CT imaging research showcasing unprecedented resolution and sensitivity capabilities.

Scale indicators5 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• Mediso Medical Imaging Systems: Hungarian imaging OEM that is the most direct competitor in benchtop and modular preclinical PET, SPECT and CT systems (NanoScan, MiniSPECT, etc.), serving the same drug-discovery and academic core-facility buyers with overlapping modalities.
• MR Solutions: UK-based preclinical imaging specialist offering cryogen-free benchtop MRI and integrated PET/SPECT/CT systems targeted at small-animal researchers who value compact, sit-on-a-bench form factors similar to MOLECUBES.
• Aspect Imaging: Designer of compact preclinical MRI platforms (M-series) that compete for the same lab-friendly, sit-on-the-bench small-animal imaging budgets as MOLECUBES' CUBES in translational research cores.
• Cubresa: Canadian developer of small-animal PET insert systems (e.g., NuPET) designed to integrate with existing preclinical MRI scanners, competing directly for benchtop/translational brain and oncology imaging studies.
• Inviscan (formerly Trifoil Imaging): French preclinical imaging OEM offering the Inliview PET and multi-modality benchtop platforms targeting the same academic and translational research buyers of small-animal PET systems.
• SEDECAL: Spanish manufacturer of preclinical and clinical imaging hardware including small-animal PET/SPECT/CT systems, addressing overlapping academic and pharmaceutical research buyers of compact molecular imaging platforms.

Broad incumbents

• Bruker BioSpin (Preclinical MRI): Parent group and operator of MOLECUBES; the broader Bruker BioSpin division sells high-field preclinical MRI and is now integrating MOLECUBES PET/SPECT/CT for combined multi-modality offerings to translational imaging labs.
• Revvity (formerly PerkinElmer Life Sciences): Large life-science tools provider with preclinical imaging reagents, IVIS optical imaging systems and cellular imaging workflows that compete for adjacent portions of the preclinical research budget at MOLECUBES' customer sites.
• Siemens Healthineers: Major clinical-imaging OEM with a preclinical PET/CT installed base and PETNET radiopharmacy network; competes with MOLECUBES for translational-research labs that prefer a single global service vendor with both clinical and preclinical offerings.
• GE HealthCare: Global medical imaging incumbent offering small-animal PET/SPECT/CT and clinical PET modalities used by translational imaging cores that overlap with MOLECUBES' translational research buyer segment.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/molecubes
• YouTubevimeo.com/user28556477
• LinkedInlinkedin.com/company/10367212

Revenue estimate

Valuation estimate

Number of profiles

Profiles10 records

Funding overview

Funding rounds1 record

Investors1 record

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about MOLECUBES