Sio Capital Management
Sio Capital Management is a New York-based SEC-registered hedge fund founded in 2006 that runs a global equity market neutral long/short strategy exclusively in healthcare equities for institutional investors, using proprietary quantitative screening (Qbert) and fundamental research.
- Company typePrivate
- Founded2006
- HeadquartersNew York, United States
- Headcount1–10
- GTM typeB2B
- OfferingServices
What Sio Capital Management does
Sio Capital Management, LLC is a New York-based, SEC-registered investment advisor founded in 2006 by Dr. Michael Castor. The firm operates as a global equity market neutral healthcare hedge fund, taking long and short positions across healthcare equities spanning market caps, sub-sectors (biotech, specialty pharma, medtech, services, EU pharmaceuticals), and geographies. Its stated objective is to generate uncorrelated returns in both rising and falling markets through a combination of long stock selection and short selling against overvalued names with near-term negative catalysts. The fund is distributed exclusively to institutional investors via direct placement and a private login portal.
The firm's investment process is fundamentally-driven but augmented by proprietary quantitative tooling. The core proprietary system, "Qbert," is a quantitative screening model that ranks stocks on characteristics historically predictive of future out- or under-performance and is used as an idea-generation and research-prioritization engine. The firm supplements Qbert with internally maintained Dividend Discount Models (DDM), analyst comp sheets, and price target lists, and applies a team-based, peer-reviewed investment process. The investment team of six analysts and the founder/PM collectively hold credentials spanning medicine (MD), pharmacology (PhD), law (JD), statistics, computer science, and CFA designations, allowing the firm to underwrite clinical-trial, regulatory, and IP-driven catalysts that generalist funds typically cannot. Operations, compliance, marketing/trading, and accounting functions are run by a separate business team (CEO, COO, CCO, CFO-equivalent, Director of Marketing/Head of Trading, and operations staff), yielding a total headcount of roughly 12+.
Revenue is generated under traditional hedge fund economics — a recurring management fee (industry standard ~2% of AUM) plus a performance/incentive fee (~20% of net profits) — on a privately placed fund vehicle. Implied AUM derived from a single disclosed ~$24.53M position in Organon & Co. (representing ~4% of fund assets) suggests an asset base on the order of ~$600M, but exact AUM, returns, and fee terms are not publicly disclosed. The firm sells exclusively to institutional investors seeking healthcare-specific, market-neutral exposure and maintains no retail or public distribution channels.
Sio Capital Management firmographics
Firmographics- Name
- Sio Capital Management
- Legal name
- Sio Capital Management, LLC
- Website
- https://siocapital.com
- Company type
- Private
- Founded year
- 2006
- Operating status
- Operating
- Headcount range
- 1–10 employees
- Short description
- Sio Capital Management is a New York-based SEC-registered hedge fund founded in 2006 that runs a global equity market neutral long/short strategy exclusively in healthcare equities for institutional investors, using proprietary quantitative screening (Qbert) and fundamental research.
- Ownership category
- akta.pro rank
Sio Capital Management industry classification
Industry- Product category
- Hedge Fund Management (Healthcare Equity)
- NAICS
- Portfolio Management and Investment Advice (523940)
- SIC
- Investment Advice (6282)
- akta.pro primary industry
- Equity Long/Short — Healthcare Focus (FSAHAAAK)
- akta.pro secondary industry
- Market-Neutral Equity Long/Short (FSAHAAAD)
Keywords
Where Sio Capital Management is headquartered
LocationHeadquarters
- HQ city
- New York
- HQ country
- United States
- HQ region
- North America
Offices1 record
Markets served
Sio Capital Management business model
Business model- GTM type
- B2B
- Offering type
- Services
- Cost components
- Personnel, Operations, Marketing or Sales, Technology or R&D, Infrastructure
Revenue model
- Investment Management (Hedge Fund): Sio Capital Management generates returns through a combination of capital growth and capital preservation by investing in healthcare equities. The fund takes both long and short positions in healthcare companies, with diversification across market cap, subsector, and investment thesis. Short investments deliver returns on their own merits and protect the portfolio during market downturns. Revenue is generated through traditional hedge fund economics, including management fees and performance/incentive fees.
Go-to-market motion1 record
Distribution channels1 record
Marketing channels3 records
Sio Capital Management product offering
Product offeringCore offering
Sio Capital Management runs a global equity market neutral healthcare hedge fund that takes both long and short positions in healthcare companies across market capitalizations and sub-sectors. The fund generates returns through prudent stock selection, proprietary quantitative screening (Qbert), and short positions designed to deliver uncorrelated performance and protect capital during market downturns. Capital is raised from institutional investors via private placement.
Differentiator
Problem solved
Functional benefit
Products and services
- Sio Capital Healthcare Equity Market Neutral Hedge Fund A global equity market neutral hedge fund that takes long and short positions in healthcare companies across market capitalizations, sub-sectors, and geographies. Designed for institutional investors seeking diversified, uncorrelated returns and downside protection through short positions during market downturns. Accessed via private placement and subscription agreements.
Companies that use Sio Capital Management
Customer profileSegments1 record
Ideal customer profiles1 record
Sio Capital Management technology and API
TechnologyTechnology focussed No
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Feature1 record
Sio Capital Management partnerships and signals
Strategic signalScale indicators1 record
Recent moves6 records
Expansion highlights5 records
Sio Capital Management competitors and assessment
Company assessmentDirect peers
- Baker Bros. Advisors: Biotech and life sciences-focused long/short fund founded in 2000. Directly comparable healthcare specialist with deep scientific research team and long-tenured analyst model similar to Sio.
- RA Capital Management: Healthcare-focused long/short and long-only investment firm founded in 2001. Directly comparable to Sio due to dedicated healthcare focus, scientific research orientation, and public-equity market-neutral mandate.
- EcoR1 Capital: Biotechnology-focused investment advisor running long/short public equity and private investments. Comparable to Sio through dedicated biotech/healthcare focus and science-driven fundamental research approach.
- Sarissa Capital Management: Healthcare-focused activist hedge fund investing in public healthcare equities. Comparable to Sio in dedicated healthcare specialization and fundamental long/short equity strategy with catalyst-driven theses.
- Perceptive Advisors: Healthcare-focused investment firm running both long/short public equity and life sciences venture strategies. Closely comparable to Sio given its dedicated healthcare specialization and biotech research depth.
Broad incumbents
- OrbiMed Advisors: Large, established healthcare investment firm spanning public equity, private equity, and royalty/structured finance. Comparable to Sio as a healthcare specialist but materially larger and more diversified across strategies.
- Deerfield Management: Healthcare-focused investment firm with public equities, private investments, and structured financing capabilities. Comparable to Sio in healthcare specialization but with broader strategy portfolio and larger scale.
- Millennium Management: Large multi-strategy hedge fund platform that operates pod-style healthcare and equity long/short teams. Comparable to Sio in equity long/short execution but vastly larger and multi-sector.
- Citadel: Global multi-strategy hedge fund with significant equity market-neutral and sector-focused healthcare exposure. Comparable to Sio in market-neutral equity approach but operates at vastly greater scale across multiple sectors.
- Point72 Asset Management: Multi-strategy hedge fund with discretionary long/short equity and sector-focused healthcare investing. Comparable to Sio in long/short equity execution but operates across multiple sectors with substantially larger AUM.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat3 records
Key risks6 records
Key highlights6 records
Customer concentration
Sio Capital Management social profiles
Digital presenceSio Capital Management financial estimates
Financial estimateRevenue estimate
Valuation estimate
Sio Capital Management leadership team
Management profileNumber of profiles
Profiles14 records
Sio Capital Management funding detail
Funding detailFunding overview
Funding rounds
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Sio Capital Management M&A and investment
M&A and investmentM&A
Investments8 records
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Sio Capital Management
What does Sio Capital Management do?
Sio Capital Management runs a global equity market neutral healthcare hedge fund that takes both long and short positions in healthcare companies across market capitalizations and sub-sectors. The fund generates returns through prudent stock selection, proprietary quantitative screening (Qbert), and short positions designed to deliver uncorrelated performance and protect capital during market downturns. Capital is raised from institutional investors via private placement.
Is Sio Capital Management a public or private company?
Sio Capital Management is a private company. It is classified as founder individual operated bootstrapped and is currently operating.
When was Sio Capital Management founded?
Sio Capital Management was founded in 2006. It employs 1 to 10 people.
Where is Sio Capital Management based?
Sio Capital Management is headquartered in New York, United States, in the North America region.
How does Sio Capital Management make money?
One revenue line is on record: investment Management (Hedge Fund).
Who are Sio Capital Management's main competitors?
Direct peers on record are Baker Bros. Advisors, RA Capital Management, EcoR1 Capital, Sarissa Capital Management and Perceptive Advisors. Broad incumbents are OrbiMed Advisors, Deerfield Management, Millennium Management, Citadel and Point72 Asset Management.
Does Sio Capital Management have an API?
No public API is recorded for Sio Capital Management.
What industry is Sio Capital Management in?
Sio Capital Management's product category is Hedge Fund Management (Healthcare Equity). Its primary akta.pro industry code is FSAHAAAK, Equity Long/Short — Healthcare Focus, with a secondary code of FSAHAAAD, Market-Neutral Equity Long/Short. Its NAICS code is 523940 and its SIC code is 6282.