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NuCana BioMed

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uuid0005sd5

Namestring
NuCana BioMed
Legal namestring
NuCana plc
Company typeenum
Public
Founded yearint
1997
Descriptiontext

NuCana BioMed (legal entity: NuCana plc) is a clinical-stage biopharmaceutical company headquartered in Edinburgh, United Kingdom, publicly traded on NASDAQ under the ticker NCNA. The company develops rationally designed nucleoside analogue anti-cancer medicines intended to overcome cancer cell resistance mechanisms. Its technology foundation is the proprietary ProTide platform, a nucleotide analogue delivery architecture engineered to enable nucleoside analogues to enter cancer cells more efficiently and bypass common resistance pathways. The active pipeline consists of two lead candidates, NUC-7738 and NUC-3373, both in clinical development with planned strategic milestones through 2026 and promising clinical signals reported in Q3 2025. The target population is patients with treatment-resistant or refractory cancers.

Short descriptiontext

NuCana BioMed is a clinical-stage biopharmaceutical company developing rationally designed anti-cancer nucleoside analogues using its proprietary ProTide delivery platform, targeting patients with treatment-resistant cancers.

Operating statusenum
Operating
Ownership categoryenum
Headcount rangeband
11–50
akta.pro rankint
HeadquartersEdinburgh, United Kingdom
HQ citystring
Edinburgh
HQ countrystring
United Kingdom
HQ regionstring
Europe
Markets served

Serves global market

Keyword5 values
oncology drug development, anti-cancer medicines, nucleoside analogues, ProTide technology, clinical-stage biopharmaceutical
Industry1 code
1Regulatory Strategy & IND/NDA/BLA Submissions Support
CodeHLAIALAHPrimaryYes
NAICS code2 codes
  • Research and Development in Biotechnology (except Nanobiotechnology)541714
  • Pharmaceutical Preparation Manufacturing325412
SIC code1 code
  • Pharmaceutical Preparations2834
Product category
Oncology Pharmaceuticals
Cost components3 values
Technology or R&D, Personnel, Operations
GTM typeB2B
B2B
Offering typeHardware or Manufacturing
Hardware or Manufacturing
Brand1 of 2 records shown
1NUC-7738
Description

Anti-cancer medicine in clinical development

globenewswire.com
+1 more record
Core offering1 text field

NuCana BioMed is a clinical-stage biopharmaceutical company developing rationally designed anti-cancer medicines using its proprietary ProTide nucleotide analogue delivery platform. Its pipeline centers on two drug candidates, NUC-7738 and NUC-3373, which are nucleoside analogues engineered to bypass cancer cell resistance mechanisms and improve efficacy over conventional chemotherapy.

Differentiator
Functional benefit
Problem solved
Quantifiable outcome1 value
  • Promising data supporting the potential of NUC-7738 and NUC-3373 anti-cancer medicines with new clinical signals
Product overview1 text field

NuCana BioMed is a clinical-stage biopharmaceutical company developing a focused portfolio of anti-cancer medicines. The company's pipeline consists of two lead drug candidates, NUC-7738 and NUC-3373, both in active clinical development with promising data supporting their therapeutic potential. The company operates as a single-product-focus organization advancing these distinct cancer treatments through clinical trials.

Product and service2 records
1NUC-7738
CategoryClinical-stage oncology drug
Description

NUC-7738 is an anti-cancer medicine in clinical development, designed as a nucleoside analogue to overcome cancer cell resistance mechanisms. It is intended for oncology patients with treatment-resistant or refractory cancers.

2NUC-3373
CategoryClinical-stage oncology drug
Description

NUC-3373 is an anti-cancer medicine in clinical development targeting cancer cell resistance pathways. It is intended as a next-generation chemotherapy agent for oncology patients with limited treatment alternatives.

Scale indicator3 records

Each record includes

Type, Value, Description, Source

Recent move4 records

Each record includes

Date, Type, Title, Description, Source

Expansion highlight4 records

Each record includes

Type, Description

Peers10 records
TypeBroad incumbent
Description

Gilead owns sofosbuvir (Sovaldi/Harvoni), the landmark ProTide-based antiviral acquired through the Pharmasset acquisition. As the established commercial leader in ProTide-derived drugs, Gilead is a relevant incumbent comparable for understanding platform validation, regulatory pathway, and market dynamics for ProTide-enabled therapeutics.

TypeDirect peer
Description

Atea Pharmaceuticals develops antivirals using ProTide technology, the same nucleotide analogue delivery platform employed by NuCana. This makes Atea the most directly comparable peer in terms of underlying technology approach, though Atea focuses on antiviral indications rather than oncology.

TypeBroad incumbent
Description

Daiichi Sankyo is a Japanese pharmaceutical company with significant oncology focus, including the Enhertu ADC platform developed with AstraZeneca. It is a relevant incumbent comparable as a major oncology player that has successfully commercialized platform-derived oncology assets.

TypeBroad incumbent
Description

Roche is one of the largest oncology pharmaceutical companies globally with deep clinical development capabilities across small molecules, biologics, and ADCs. It is a relevant incumbent comparable for understanding competitive dynamics and potential acquirer profiles in oncology drug development.

TypeBroad incumbent
Description

Merck is a major oncology pharmaceutical company with Keytruda as its flagship asset and active development in small-molecule and combination oncology therapies. It is a relevant incumbent comparable for understanding the competitive landscape and platform validation dynamics in oncology.

TypeBroad incumbent
Description

Bristol-Myers Squibb is a major oncology pharmaceutical company with significant investment in small-molecule and immuno-oncology therapeutics. It is a relevant incumbent comparable for understanding partnership dynamics and competitive positioning in oncology clinical development.

TypeEmerging player
Description

Bicycle Therapeutics is a UK-based clinical-stage biotech developing bicyclic peptide drug conjugates for oncology. It is comparable to NuCana as a similarly-sized UK-headquartered clinical-stage oncology company with a proprietary technology platform targeting cancer indications.

TypeRegional player
Description

Redx Pharma is a UK-based clinical-stage biotech developing small-molecule therapeutics for oncology and fibrotic diseases. It is comparable to NuCana as a similarly-sized UK-headquartered clinical-stage company focused on small-molecule cancer drug development with similar resourcing profiles.

TypeBroad incumbent
Description

Pfizer is one of the largest pharmaceutical companies globally with substantial oncology operations across small molecules, biologics, and ADCs. It is a relevant incumbent comparable for understanding the competitive landscape and as a representative potential acquirer in oncology drug development.

TypeEmerging player
Description

Antengene is a clinical-stage oncology biotech with operations across Asia-Pacific and a pipeline spanning hematology and solid tumors. It is comparable to NuCana as a similarly-sized clinical-stage oncology company developing novel therapeutics, though Antengene operates primarily in different geographies.

Market position
Strengths5 records

Each record includes

Headline, Details, Source

Weaknesses5 records

Each record includes

Headline, Details, Source

Competitive moat2 records

Each record includes

Type, Details

Key risks6 records

Each record includes

Headline, Details, Source

Key highlights6 records

Each record includes

Headline, Details, Source

Customer concentration

Classification, Details

Segment1 record

Each record includes

Title, Type, Primary, Description, Pain point addressed, Use case, Source

Ideal customer profile1 record

Each record includes

Profile, Firmographic size, Sales motion, Sales cycle length, Buying structure, Purchase trigger, Buyer persona, Geography, Industry vertical, Primary use case, Description, Pain points, Evidence proof points, Target buyer

Technology focused
Yes
API detail
Has APIbool
No

Docs URL, Description

AI maturity
App detail

Has app

Feature2 records

Each record includes

Title, Differentiator, Description, Source

Core technology
Revenue estimate
Valuation estimate
Number of profiles
Profiles6 records

Each record includes

Name, Designation, Designation category, Overview, Profile commentary, Source

No data
No data
Funding overview

Funding stage, Last funding date, Total funding USD

Funding rounds6 records

Each record includes

Round, Amount USD, Date, Pre money valuation, Total investors, Investors, News

Investors6 records

Each record includes

Name, Type, Date of entry, Rounds participated, Website

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Each record includes

Name, Acquisition type, Announced date, Completed date, Status, Website, News

Investment

Each record includes

Name, Round, Announced date, Lead investor, Website, News

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

NuCana BioMed

Oncology Pharmaceuticalsnucanabiomed.com

NuCana BioMed is a clinical-stage biopharmaceutical company developing rationally designed anti-cancer nucleoside analogues using its proprietary ProTide delivery platform, targeting patients with treatment-resistant cancers.

What NuCana BioMed does

NuCana BioMed (legal entity: NuCana plc) is a clinical-stage biopharmaceutical company headquartered in Edinburgh, United Kingdom, publicly traded on NASDAQ under the ticker NCNA. The company develops rationally designed nucleoside analogue anti-cancer medicines intended to overcome cancer cell resistance mechanisms. Its technology foundation is the proprietary ProTide platform, a nucleotide analogue delivery architecture engineered to enable nucleoside analogues to enter cancer cells more efficiently and bypass common resistance pathways. The active pipeline consists of two lead candidates, NUC-7738 and NUC-3373, both in clinical development with planned strategic milestones through 2026 and promising clinical signals reported in Q3 2025. The target population is patients with treatment-resistant or refractory cancers.

NuCana BioMed firmographics

Firmographics
Name
NuCana BioMed
Legal name
NuCana plc
Website
https://nucanabiomed.com
Company type
Public
Founded year
1997
Operating status
Operating
Headcount range
11–50 employees
Short description
NuCana BioMed is a clinical-stage biopharmaceutical company developing rationally designed anti-cancer nucleoside analogues using its proprietary ProTide delivery platform, targeting patients with treatment-resistant cancers.
Ownership category
akta.pro rank

NuCana BioMed industry classification

Industry
Product category
Oncology Pharmaceuticals
NAICS
Research and Development in Biotechnology (except Nanobiotechnology) (541714), Pharmaceutical Preparation Manufacturing (325412)
SIC
Pharmaceutical Preparations (2834)
akta.pro primary industry
Regulatory Strategy & IND/NDA/BLA Submissions Support (HLAIALAH)

Keywords

  • Oncology drug development
  • Anti-cancer medicines
  • Nucleoside analogues
  • ProTide technology
  • Clinical-stage biopharmaceutical

Where NuCana BioMed is headquartered

Location

Headquarters

HQ city
Edinburgh
HQ country
United Kingdom
HQ region
Europe

Markets served

NuCana BioMed business model

Business model
GTM type
B2B
Offering type
Hardware or Manufacturing
Cost components
Technology or R&D, Personnel, Operations

NuCana BioMed product offering

Product offering

Core offering

NuCana BioMed is a clinical-stage biopharmaceutical company developing rationally designed anti-cancer medicines using its proprietary ProTide nucleotide analogue delivery platform. Its pipeline centers on two drug candidates, NUC-7738 and NUC-3373, which are nucleoside analogues engineered to bypass cancer cell resistance mechanisms and improve efficacy over conventional chemotherapy.

Product overview

NuCana BioMed is a clinical-stage biopharmaceutical company developing a focused portfolio of anti-cancer medicines. The company's pipeline consists of two lead drug candidates, NUC-7738 and NUC-3373, both in active clinical development with promising data supporting their therapeutic potential. The company operates as a single-product-focus organization advancing these distinct cancer treatments through clinical trials.

Differentiator

Problem solved

Functional benefit

Brands

  • NUC-7738: Anti-cancer medicine in clinical development
  • NUC-3373

Products and services

  • NUC-7738 NUC-7738 is an anti-cancer medicine in clinical development, designed as a nucleoside analogue to overcome cancer cell resistance mechanisms. It is intended for oncology patients with treatment-resistant or refractory cancers.
  • NUC-3373 NUC-3373 is an anti-cancer medicine in clinical development targeting cancer cell resistance pathways. It is intended as a next-generation chemotherapy agent for oncology patients with limited treatment alternatives.

Quantifiable outcome

  • Promising data supporting the potential of NUC-7738 and NUC-3373 anti-cancer medicines with new clinical signals

Companies that use NuCana BioMed

Customer profile

Segments1 record

Ideal customer profiles1 record

NuCana BioMed technology and API

Technology

Technology focussed Yes

API detail

Has API
No
API docs
API detail

Core technology

AI maturity

App detail

Feature2 records

NuCana BioMed partnerships and signals

Strategic signal

Scale indicators3 records

Recent moves4 records

Expansion highlights4 records

NuCana BioMed competitors and assessment

Company assessment

Broad incumbents

  • Gilead Sciences: Gilead owns sofosbuvir (Sovaldi/Harvoni), the landmark ProTide-based antiviral acquired through the Pharmasset acquisition. As the established commercial leader in ProTide-derived drugs, Gilead is a relevant incumbent comparable for understanding platform validation, regulatory pathway, and market dynamics for ProTide-enabled therapeutics.
  • Daiichi Sankyo: Daiichi Sankyo is a Japanese pharmaceutical company with significant oncology focus, including the Enhertu ADC platform developed with AstraZeneca. It is a relevant incumbent comparable as a major oncology player that has successfully commercialized platform-derived oncology assets.
  • Roche: Roche is one of the largest oncology pharmaceutical companies globally with deep clinical development capabilities across small molecules, biologics, and ADCs. It is a relevant incumbent comparable for understanding competitive dynamics and potential acquirer profiles in oncology drug development.
  • Merck & Co. Merck is a major oncology pharmaceutical company with Keytruda as its flagship asset and active development in small-molecule and combination oncology therapies. It is a relevant incumbent comparable for understanding the competitive landscape and platform validation dynamics in oncology.
  • Bristol-Myers Squibb: Bristol-Myers Squibb is a major oncology pharmaceutical company with significant investment in small-molecule and immuno-oncology therapeutics. It is a relevant incumbent comparable for understanding partnership dynamics and competitive positioning in oncology clinical development.
  • Pfizer: Pfizer is one of the largest pharmaceutical companies globally with substantial oncology operations across small molecules, biologics, and ADCs. It is a relevant incumbent comparable for understanding the competitive landscape and as a representative potential acquirer in oncology drug development.

Direct peers

  • Atea Pharmaceuticals: Atea Pharmaceuticals develops antivirals using ProTide technology, the same nucleotide analogue delivery platform employed by NuCana. This makes Atea the most directly comparable peer in terms of underlying technology approach, though Atea focuses on antiviral indications rather than oncology.

Emerging players

  • Bicycle Therapeutics: Bicycle Therapeutics is a UK-based clinical-stage biotech developing bicyclic peptide drug conjugates for oncology. It is comparable to NuCana as a similarly-sized UK-headquartered clinical-stage oncology company with a proprietary technology platform targeting cancer indications.
  • Antengene: Antengene is a clinical-stage oncology biotech with operations across Asia-Pacific and a pipeline spanning hematology and solid tumors. It is comparable to NuCana as a similarly-sized clinical-stage oncology company developing novel therapeutics, though Antengene operates primarily in different geographies.

Regional players

  • Redx Pharma: Redx Pharma is a UK-based clinical-stage biotech developing small-molecule therapeutics for oncology and fibrotic diseases. It is comparable to NuCana as a similarly-sized UK-headquartered clinical-stage company focused on small-molecule cancer drug development with similar resourcing profiles.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat2 records

Key risks6 records

Key highlights6 records

Customer concentration

NuCana BioMed social profiles

Digital presence

NuCana BioMed financial estimates

Financial estimate

Revenue estimate

Valuation estimate

NuCana BioMed leadership team

Management profile

Number of profiles

Profiles6 records

NuCana BioMed funding detail

Funding detail

Funding overview

Funding rounds6 records

Investors6 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

NuCana BioMed M&A and investment

M&A and investment

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about NuCana BioMed

What does NuCana BioMed do?

NuCana BioMed is a clinical-stage biopharmaceutical company developing rationally designed anti-cancer medicines using its proprietary ProTide nucleotide analogue delivery platform. Its pipeline centers on two drug candidates, NUC-7738 and NUC-3373, which are nucleoside analogues engineered to bypass cancer cell resistance mechanisms and improve efficacy over conventional chemotherapy.

Is NuCana BioMed a public or private company?

NuCana BioMed is a public company. It is classified as public and is currently operating.

When was NuCana BioMed founded?

NuCana BioMed was founded in 1997. It employs 11 to 50 people.

Where is NuCana BioMed based?

NuCana BioMed is headquartered in Edinburgh, United Kingdom, in the Europe region.

Who are NuCana BioMed's main competitors?

Broad incumbents on record are Gilead Sciences, Daiichi Sankyo, Roche, Merck & Co., Bristol-Myers Squibb and Pfizer. Atea Pharmaceuticals is listed as a direct peer. Emerging players are Bicycle Therapeutics and Antengene. Redx Pharma is listed as a regional player.

Does NuCana BioMed have an API?

No public API is recorded for NuCana BioMed.

What industry is NuCana BioMed in?

NuCana BioMed's product category is Oncology Pharmaceuticals. Its primary akta.pro industry code is HLAIALAH, Regulatory Strategy & IND/NDA/BLA Submissions Support. Its NAICS code is 541714 and its SIC code is 2834.

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Live signals
AInvestNuCana's £0.00 EPS Is the Easy Part-the $9M Bet on 2026 DataNuCana is focusing investor attention on its upcoming 2026 Phase 2 data for NUC-7738, a treatment for PD-1 inhibitor-resistant melanoma, rather than its current zero earnings per share. The company's market capitalization of approximately $8.8 million relies on the potential validation of clinical activity signals observed in earlier trial updates. Final readouts from the NuTide:701 expansion study are expected to determine the drug's viability and the company's future valuation trajectory.GlobeNewswireNuCana Presents Latest Data Demonstrating Clinical Activity and Favorable Safety for NUC-7738 in Patients with PD-1-Resistant MelanomaNuCana plc presented updated Phase 2 clinical data at the ESMO Immuno-Oncology Congress 2025 in London, showing that NUC-7738 in combination with pembrolizumab demonstrated clinical activity in patients with PD-1 inhibitor-resistant metastatic melanoma. Among nine patients treated in the Expansion Cohort, the study recorded two partial responses, seven cases of stable disease, and no new safety signals, with enrollment planned for up to 28 additional patients. The findings support NuCana's continued clinical advancement toward a potential registrational pathway for NUC-7738 in advanced melanoma.GlobeNewswireNuCana Presents Encouraging Data on NUC-7738 in Combination with PD-1 Inhibitors using Primary Patient-Derived Organoids and Autologous Tumor-Infiltrating Lymphocytes at the ESMO Congress 2025NuCana plc presented data at the European Society for Medical Oncology Congress 2025 in Berlin demonstrating that NUC-7738 synergizes with PD-1 inhibitors to promote increased tumor cell death in patient-derived organoids from renal cell carcinoma patients. The Phase 1/2 NuTide:701 study has shown a favorable safety profile with meaningful tumor volume reduction and prolonged progression-free survival in PD-1 inhibitor-resistant metastatic melanoma patients. Based on these encouraging results, regulators have approved expansion of the study to recruit an additional 28 patients, and NuCana plans to meet with the FDA to discuss a registration strategy for marketing approval.TradingViewNucana Says Data From Nutide:701 Shows Favorable Safety And Tumor ReductionNucana PLC presented data at the ESMO Congress 2025 showing that their drug NUC-7738, used in combination with PD-1 inhibitors, demonstrated favorable safety profiles and tumor reduction in studies using primary patient-derived organoids and autologous tumor-infiltrating lymphocytes. Regulators have approved expanding the Nutide:701 study to enroll 28 additional patients. The data supports continued development of NUC-7738 as a potential cancer treatment.AInvestNucana Stock Soars 14.58% Despite Sector ChallengesNucana's stock surged 14.58% in pre-market trading on July 21, 2025, despite technical sell signals. Analysts gave a Moderate Buy rating with no sell recommendations, though rising interest rates threaten the healthcare sector.BenzingaDow Falls Over 250 Points; Marriott Posts Upbeat Earnings - bioAffinity Technologies (NASDAQ:BIAF)U.S. stocks declined on Tuesday with the Dow Jones falling over 250 points, while Marriott International reported better-than-expected first-quarter earnings and revenue. Several other companies experienced significant stock volatility, including FOXO Technologies surging 211% after reporting patient numbers at its recovery centers subsidiary, and NuCana plc dropping 64% following a capital offering announcement.GlobeNewswireNuCana BioMed Limited: NuCana's Acelarin achieves high clinical activity and durable disease control in patients with recurrent ovarian cancerNuCana presented Phase Ib results of Acelarin plus carboplatin in recurrent ovarian cancer at ASCO, showing a 30% overall response rate and 95% disease control. Progression-free survival was 6.6 months, and the combination was well tolerated in heavily pre-treated patients. Phase II studies are planned.