Gene by Gene

What Gene by Gene does

Gene by Gene, Ltd. is a privately held specialty genetic testing laboratory headquartered in Houston, Texas, founded in 2000 (firmographic) / 2001 (other records) and operating a 34,000 sq ft CLIA-, CAP-, AABB-, and NYSDoH-authorized Genomics Research Center that runs seven days a week with robotic automation capable of processing approximately five million samples per year. The company offers a full spectrum of genetic testing services spanning next-generation sequencing (whole genome sequencing, whole exome sequencing, custom targeted panels, blended genome exome, and overflow sequencing), traditional Sanger sequencing, microarray, droplet digital PCR-based tryptase CNV testing, pharmacogenomics, nutrigenomics, whole genome and exome clinical reporting, biobanking, paternity/maternity/immigration relationship testing, and clinical validation services. Its wholly-owned subsidiary FamilyTreeDNA operates the world's largest mtDNA database with over 53,000 branches, while myDNA provides clinical reporting under a 92-gene Comprehensive Health Report.

Gene by Gene serves four primary customer segments: healthcare practitioners and physicians seeking clinical genetic testing and reporting; individual consumers purchasing ancestry, wellness, and relationship tests; reference and research laboratories requiring overflow NGS, microarray, and Sanger sequencing capacity; and legal/law enforcement entities requiring AABB-accredited, court-admissible relationship testing. Revenue is generated predominantly through per-test fees (paternity at $189-$425, mtDNA at $159) and quote-based reference lab and clinical contracts, supplemented by white-label/OEM laboratory services to enterprise partners including MyHeritage (whole-genome sequencing), FamilyTreeDNA, and myDNA. Pricing is largely confidential and quote-based for non-consumer services.

The company's strategic posture is anchored by a regulatory moat — multi-state clinical laboratory permits, U.S. Department of State approved-supplier status for immigration testing, and EU/UK/Swiss-U.S. Data Privacy Framework certifications — combined with proprietary technology assets including the only NYSDoH-approved TPSAB1 copy number test (co-developed with NIH) and the blended genome exome sequencing product. Recent strategic actions include a 2025 major NGS technology expansion, an October 2025 whole-genome sequencing partnership with MyHeritage and Ultima Genomics, and a 2026 validation partnership with Twist Bioscience for next-generation library preparation kits. The company has no disclosed funding rounds since 2013, indicating operating cash flow funding, and operates through a holding-company structure with five wholly-owned subsidiaries spanning genealogy, clinical reporting, and direct-to-consumer DNA testing.

Name

Gene by Gene

Legal name

Gene By Gene, LTD.

Website

https://genebygene.com

Company type

Private

Founded year

2001

Operating status

Operating

Headcount range

101–250 employees

Short description

Gene by Gene operates a 34,000 sq ft CLIA/CAP-accredited genetic laboratory in Houston, Texas, offering NGS, Sanger sequencing, relationship testing, pharmacogenomics, and biobanking to healthcare practitioners, consumers, and B2B partners including MyHeritage.

Ownership category

akta.pro rank

Product category

Genetic Testing Laboratory Services

NAICS

Medical Laboratories (621511), Other Scientific and Technical Consulting Services (54169)

SIC

Services-Medical Laboratories (8071), Services-Testing Laboratories (8734), Services-Commercial Physical & Biological Research (8731)

akta.pro primary industry

Molecular Diagnostics & Genomics Laboratories (HLAFAMAE)

akta.pro secondary industries

Molecular & Genetic Testing (PCR/NGS/qPCR) (HLAGADAF), Genetic & Genomic Testing (germline, somatic, carrier, pharmacogenomics) (HLAAALAD), Molecular Cytogenetics & Genomic Variation Services (Karyotyping/FISH/aCGH/CNV) (HLAGANAJ)

Keywords

• DNA sequencing services
• Genetic testing laboratory
• Ancestry DNA testing
• Clinical genomics services
• Pharmacogenomics testing

Headquarters

HQ city

Houston

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B and B2C

Offering type

Services

Cost components

Personnel, Operations, Technology or R&D, Infrastructure, Marketing or Sales

Revenue model

1. Clinical Genetic Testing Services: Gene by Gene generates revenue from a wide range of clinical genetic testing services including Whole Genome Sequencing, Whole Exome Sequencing, Sanger Sequencing, Pharmacogenomics, Nutrigenomics, Tryptase CNV testing, and clinical reporting. These are one-time or per-test revenue streams billed per test ordered by practitioners, hospitals, or consumers.
2. Relationship DNA Testing: The company offers paternity, maternity, and immigration relationship DNA testing services with pricing ranging from $189 for personal tests to $425 for court-admissible tests. These are one-time transaction-based fees charged per test.
3. Reference Lab and B2B Laboratory Services: Gene by Gene provides laboratory services to physicians, hospitals, health centers, and other laboratories who cannot perform tests due to high volumes, specialized equipment, or rarely ordered tests. Services include DNA extraction, microarray, and Next-generation sequencing, with pricing quoted per project or test volume.
4. Biobanking and Sample Storage: DNA Biobanking is offered as secure storage of an individual's genetic material for future analysis and testing for both research and clinical applications. Sample storage fees are charged, with remaining sample material stored for 180 days by default, and longer-term storage available upon request with applicable fees.
5. Sequencing Kit Validation and Partnership Services: Gene by Gene provides validation feedback and testing services to technology partners like Twist Bioscience and Ultima Genomics, supporting product development and quality assurance for sequencing technologies and kits.
6. Partner and White-Label Sequencing Services: Gene by Gene provides whole-genome sequencing and laboratory services to partner companies including MyHeritage (upgraded consumer DNA tests to WGS), FamilyTreeDNA (genealogy products), and myDNA (clinical reporting). This represents a significant B2B revenue stream through long-term partnerships.

Pricing tiers

Go-to-market motion4 records

Distribution channels5 records

Marketing channels6 records

Core offering

Gene by Gene operates a 34,000 sq. ft. CLIA/CAP/AABB-accredited specialty genetic laboratory in Houston, TX, providing the full spectrum of microarray and sequencing-based genetic testing services. Its portfolio spans Next-Generation Sequencing (Whole Genome, Whole Exome, Custom Targeted Panels, BGE), Sanger Sequencing, ddPCR-based Tryptase CNV testing, pharmacogenomics and nutrigenomics reporting (via myDNA), relationship/paternity/immigration DNA testing, reference lab services for other labs and practitioners, biobanking, and genealogy testing through its FamilyTreeDNA subsidiary.

Product overview

Gene by Gene operates as a full-service genetic testing laboratory offering a comprehensive portfolio of sequencing and testing services. The core offerings include Next-Generation Sequencing products (Whole Genome Sequencing, Whole Exome Sequencing, Custom Targeted Panels, Blended Genome Exome, and Overflow Sequencing Service) and traditional Sanger Sequencing. The company provides clinical testing services including Pharmacogenomics, Nutrigenomics, Tryptase CNV Testing, and Whole Genome/Exome Clinical Reporting (delivered through its myDNA subsidiary). Relationship testing services cover Paternity, Maternity, and Immigration DNA testing. The laboratory also offers Reference Lab Services for B2B clients, Biobanking for secure sample storage, and Clinical Validation Services. Consumer genealogy products (FamilyTreeDNA) include Family Finder, mtDNA Sequencing, and Y Chromosomes testing. The company operates a 34,000 sq ft robotic automation facility in Houston, Texas with capacity to process approximately 5 million samples per year, and maintains accreditations including CLIA, CAP, AABB, and NYS DoH.

Differentiator

Problem solved

Functional benefit

Brands

• FamilyTreeDNA: Genealogy and ancestry DNA testing platform offering mtDNA sequencing, Y chromosome testing, Family Finder, and autosomal transfers
• myDNA
• Genomics Research Center

Quantifiable outcome

• Approximately 5 million samples per year processing capacity
• +2 more outcomes

Named customers4 records

Segments5 records

Ideal customer profiles5 records

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature6 records

Partnerships

Six partnerships are on record, tiered core.

• Ultima GenomicscoreStrategic or Co-development Partner · 10 February 2026Ultima Genomics partnered with Gene by Gene and MyHeritage on whole-genome sequencing-based testing. This three-way partnership enables the development and deployment of advanced WGS testing for consumer genetic applications, combining Gene by Gene's laboratory expertise with Ultima Genomics' sequencing platform technology.
• MyHeritagecoreStrategic or Co-development Partner · 14 October 2025MyHeritage partnered with Gene by Gene and Ultima Genomics on whole-genome sequencing-based testing. MyHeritage upgraded its consumer DNA tests to use Gene by Gene's Whole Genome Sequencing (WGS) technology, the most comprehensive method for reading DNA available today. This partnership enables MyHeritage to offer enhanced ancestry and health insights to its consumer base using Gene by Gene's advanced laboratory capabilities.
• FamilyTreeDNAcoreStrategic or Co-development PartnerFamilyTreeDNA is a wholly-owned subsidiary of Gene by Gene providing genealogy and ancestry DNA testing services including Family Finder, mtDNA sequencing, Y Chromosome testing, and autosomal transfers. FamilyTreeDNA operates its own consumer platform and maintains the world's largest mtDNA database with over 53,000 new branches and reports, serving millions of consumers seeking ancestry and genetic genealogy insights.
• myDNAcoreStrategic or Co-development PartnermyDNA is a clinical reporting subsidiary of Gene by Gene providing healthcare practitioners and consumers with easy-to-interpret clinical genetic reports including pharmacogenomics (PGx), nutrigenomics, longevity, detoxification, and methylation reports. myDNA's Comprehensive Health Report covers 92 genes and is available through Gene by Gene's practitioner product channel.
• National Institutes of Health (NIH)coreStrategic or Co-development PartnerGene by Gene collaborated with the NIH to develop a clinical assay to identify people with an increase in alpha-tryptase copy number using droplet digital PCR (ddPCR). This collaboration led to the development of the TPSAB1 Copy Number Test, which is currently the only TPSAB1 copy number test approved by the New York State Department of Health for clinical use. NIH scientists uncovered the genetic explanation for hereditary alpha tryptasemia syndrome.
• Healthcare Providers and Research InstitutionscoreImplementation/ SI/ Consulting PartnerGene by Gene's growth strategy includes partnerships with leading healthcare providers, research institutions, and biopharmaceutical companies to drive further advancements in genomic research and clinical applications. The company positions itself as a trusted partner providing comprehensive genetic data across all fields.

Scale indicators5 records

Recent moves7 records

Expansion highlights6 records

Direct peers

• 23andMe: Direct-to-consumer genetic testing platform offering ancestry, health, and trait reports. Highly comparable to FamilyTreeDNA (Gene by Gene's subsidiary) in DTC consumer genetics business model and target market.
• Ancestry (AncestryDNA): Largest DTC genealogy and consumer DNA testing platform. Directly competes with FamilyTreeDNA in ancestry testing and operates a similar consumer-to-lab genetic testing funnel.
• MyHeritage: DTC genealogy platform that is both a Gene by Gene customer (white-label WGS partner) and a competitor in consumer ancestry DNA testing, making it a closely comparable business.
• Natera: Clinical genetic testing laboratory specializing in reproductive health, oncology, and organ transplantation testing. Comparable as a CLIA-certified, NGS-driven clinical genetics lab serving physicians and patients.
• Invitae: Clinical genetic testing company offering comprehensive medical genetics panels and whole-genome services. Directly comparable to Gene by Gene's clinical genetic testing and reference lab offerings.

Broad incumbents

• Quest Diagnostics: One of the largest clinical laboratory networks in the U.S., offering genetic and molecular diagnostics as part of a broader testing menu. Overlaps with Gene by Gene's clinical and reference lab services but at much larger scale and broader scope.
• Labcorp: Major global clinical laboratory operator with extensive genetic and molecular diagnostic testing services. Competes with Gene by Gene in clinical lab and reference testing but serves a much broader diagnostic menu.

Emerging players

• Sema4: Clinical genomic testing company focused on reproductive health, oncology, and population health. Comparable as a CLIA-certified genomics lab with NGS-based clinical reporting.
• Color Genomics: Clinical genetics testing company offering hereditary cancer, pharmacogenomics, and population genomics programs. Comparable in clinical genetic testing services, particularly PGx and hereditary risk.

Others

• Twist Bioscience: NGS library preparation and synthetic biology tools provider. Gene by Gene served as a validation partner for Twist's NGS kits, making it an adjacent ecosystem participant rather than a direct competitor.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat7 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/GxGene
• LinkedInlinkedin.com/company/gene-by-gene

Compliance13 records

Revenue estimate

Valuation estimate

Number of profiles

Subsidiaries5 records

Funding overview

Funding rounds1 record

Investors1 record

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A1 record

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Gene by Gene