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Neopharmed Gentili

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uuid0006rxc

Namestring
Neopharmed Gentili
Legal namestring
Neopharmed Gentili S.p.A.
Company typeenum
Private
Founded yearint
2011
Operating statusenum
Operating
Ownership categoryenum
Headcount rangeband
101–250
akta.pro rankint
HeadquartersGottolengo, Italy
HQ citystring
Gottolengo
HQ countrystring
Italy
HQ regionstring
Europe
Markets served

Serves global market

Offices1 record

Each record includes

City, Country, Type, Description, Source

Keyword5 values
pharmaceutical commercialization, branded pharmaceuticals, rare disease therapies, therapeutic area portfolio, pharmaceutical licensing
Industry4 codes
1Specialty Care Pharmaceuticals
CodeHLAIAAABPrimaryYes
2Cardiometabolic Pharmaceuticals (Cardiovascular/Diabetes/Obesity)
CodeHLAIAAAEPrimaryNo
3Gastroenterology Specialty Pharmaceuticals
CodeHLAIACAEPrimaryNo
4Nephrology & Urology Specialty Pharmaceuticals
CodeHLAIACAHPrimaryNo
SIC code1 code
  • Pharmaceutical Preparations2834
Product category
Branded Pharmaceuticals
GTM motion2 records

Each record includes

Type, Description, Source

Revenue model2 records
1Pharmaceutical Product Sales
TypeOne Time License
Description

Revenue generated from commercialization of branded pharmaceutical products across multiple therapeutic areas in Italy and Europe

neogen.it
2European Licensing Revenue
TypeLicensing Royalties
Description

Upfront payments and milestone payments received from European licensing agreements, plus ongoing royalty streams from product commercialization rights

fool.com
Marketing channels7 records

Each record includes

Title, Type, Stage, Description, Source

Distribution channels3 records

Each record includes

Title, Type, Scope, Target buyer, Description, Source

Cost components5 values
Supply Chain, Personnel, Marketing or Sales, Operations, Others
GTM typeB2B
B2B
Offering typeHardware or Manufacturing
Hardware or Manufacturing
Core offering1 text field

Neopharmed Gentili commercializes high therapeutic value branded pharmaceutical products across more than ten therapeutic areas in Italy and Europe, including cardio-metabolic, vascular, pneumo-allergological, antibiotic, osteoarticular, gastro-enteric, neuro-psychiatric, otorhinolaryngological, pediatric, and urological conditions. Its portfolio combines in-house and acquired products with licensed brands such as ORLADEYO (berotralstat) and the pipeline asset navenibart for hereditary angioedema, and Plasil (metoclopramide) for gastroenterology. The company reaches patients through a field-based scientific information force, an HCP portal, and standard Italian pharmaceutical distribution channels.

Differentiator
Functional benefit
Problem solved
Quantifiable outcome1 of 2 values shown
  • Over 3 million patients treated in 2024
+1 more record
Product overview1 text field

Neopharmed Gentili is an Italian pharmaceutical company specializing in the commercialization of high therapeutic value solutions across 10+ therapeutic areas including cardio-metabolic, vascular, pulmonary-allergologic, antibiotic, osteoarticular, gastroenterological, neuropsychiatry, otorhinolaryngological, pediatric, and urological conditions. The company operates a multi-brand portfolio approach, commercializing both in-house developed/acquired products and licensed brands. Key products include ORLADEYO® (berotralstat) for hereditary angioedema (acquired from BioCryst in 2025), the pipeline product Navenibart (Phase 3 for HAE), and the gastroenterology brand Plasil® (metoclopramide). The company treats over 3 million patients annually and maintains a business model combining M&A, licensing-in arrangements, and organic portfolio expansion across therapeutic areas.

Product and service13 records
1Cardio-Metabolic Portfolio
2Vascular Portfolio
3Pulmonary-Allergologic Portfolio
4Antibiotic Portfolio
5Osteoarticular Portfolio
6Gastroenterological Portfolio
7Neuropsychiatry Portfolio
8Otorhinolaryngological Portfolio
9Pediatric Portfolio
10Urological Portfolio
11ORLADEYO (berotralstat)
CategoryAcquired rare disease brand
Description

ORLADEYO is an oral, once-daily medication for the prevention of hereditary angioedema (HAE) attacks in adults and pediatric patients 12 years and older. Neopharmed Gentili acquired the European commercial rights from BioCryst Pharmaceuticals in 2025.

12Navenibart (European rights)
CategoryPipeline / Licensed rare disease asset
Description

Navenibart is an investigational long-acting plasma kallikrein inhibitor in Phase 3 development for hereditary angioedema (HAE), for which Neopharmed Gentili acquired exclusive European commercial rights through a licensing agreement with BioCryst Pharmaceuticals.

13Plasil (metoclopramide)
CategoryLicensed/Acquired gastroenterology brand
Description

Plasil is a gastroenterology brand containing metoclopramide, used for gastrointestinal disorders associated with dyspepsia, nausea, and emesis. Neopharmed Gentili acquired the product in February 2025 and later licensed it to Lupin for the Philippines and Brazil markets.

Scale indicator6 records

Each record includes

Type, Value, Description, Source

Partnership3 partners
Strategic tierMinorTypeStrategic or Co-development PartnerAnnounced on2026-01-01
Description

From 2026, Neopharmed Gentili uses FSC-certified packaging materials from Favillini Pharmaceutical Packaging Group SpA for cartons and instructional leaflets, supporting sustainability objectives with materials from responsibly managed forests.

Strategic tierMinorTypeChannel Partner/ Reseller/ DistributorAnnounced on2025-12-18
Description

Lupin granted Neopharmed exclusive licensing rights for the gastroenterology brand Plasil in the Philippines and Brazil, covering distribution rights for this肠胃品牌.

Strategic tierCoreTypeOEM/ Whitelabel/ Licensing PartnerAnnounced on2025-06-27
Description

Neopharmed Gentili acquired the European business of ORLADEYO (berotralstat) from BioCryst Pharmaceuticals for US$250 million upfront with potential additional milestone considerations. The acquisition completed in October 2025. Additionally, Neopharmed Gentili's Irish affiliate received exclusive European commercial rights to navenibart for $70 million upfront plus up to $275 million in milestones and 18-30% tiered royalties.

Recent move6 records

Each record includes

Date, Type, Title, Description, Source

Expansion highlight6 records

Each record includes

Type, Description

Peers10 records
TypeDirect peer
Description

Chiesi is a privately held Italian specialty pharma with strong rare disease franchises (including respiratory and HAE-adjacent areas) and European licensing partnerships, closely comparable to Neopharmed's specialty and rare disease commercialization model.

TypeDirect peer
Description

Angelini Pharma is a privately held Italian pharmaceutical company with a multi-therapeutic portfolio spanning CNS, pain, infectious disease and consumer health across Europe, directly comparable to Neopharmed's breadth-based specialty model.

TypeDirect peer
Description

Recordati is an Italian specialty pharmaceutical group with a similar multi-therapeutic European commercial footprint and a track record of acquiring and developing branded pharmaceuticals across rare diseases, cardiology, urology, and other specialty areas, making it the closest direct peer in business model and geography.

TypeDirect peer
Description

Zambon is an Italian specialty pharma with multi-therapeutic respiratory, CNS, and rare disease products across European markets, with comparable geographic footprint and commercialization-led growth model.

TypeBroad incumbent
Description

Almirall is a European specialty pharmaceutical company focused on dermatology and other specialty areas with strong Southern European commercial reach, relevant as a peer for mid-sized European specialty commercialization strategies.

TypeDirect peer
Description

Molteni is an Italian specialty pharmaceutical company with a focus on pain, addiction, and rare disease therapeutics in European markets, sharing Neopharmed's privately held Italian specialty pharma profile.

TypeDirect peer
Description

Dompé is a privately held Italian biopharma with both proprietary and licensed specialty products, including rare disease ophthalmology, comparable to Neopharmed's mix of branded specialty and rare disease commercialization.

TypeBroad incumbent
Description

Menarini is a much larger privately held Italian pharmaceutical group with a broad multi-therapeutic European portfolio, providing a benchmark for an Italian pharma peer that has scaled internationally while remaining private.

TypeBroad incumbent
Description

Stada is a European specialty and generics pharma group active across multiple therapeutic areas with significant presence in Italy, comparable to Neopharmed as a broader, PE-influenced European specialty commercializer.

TypeDirect peer
Description

Italfarmaco is a privately held Italian pharma group with specialty and rare disease products sold internationally, sharing Neopharmed's profile as a mid-sized Italian specialty pharmaceutical company pursuing geographic expansion.

Market position
Strengths5 records

Each record includes

Headline, Details, Source

Weaknesses5 records

Each record includes

Headline, Details, Source

Competitive moat4 records

Each record includes

Type, Details

Key risks6 records

Each record includes

Headline, Details, Source

Key highlights6 records

Each record includes

Headline, Details, Source

Customer concentration

Classification, Details

Named customers2 records

Each record includes

Name, Industry, Type, Use case, Source, UUID

Segment7 records

Each record includes

Title, Type, Primary, Description, Pain point addressed, Use case, Source

Ideal customer profile3 records

Each record includes

Profile, Firmographic size, Sales motion, Sales cycle length, Buying structure, Purchase trigger, Buyer persona, Geography, Industry vertical, Primary use case, Description, Pain points, Evidence proof points, Target buyer

Technology focused
No
API detail
Has APIbool
No

Docs URL, Description

AI maturity
App detail

Has app

Feature1 record

Each record includes

Title, Differentiator, Description, Source

Core technology
Revenue estimate
Valuation estimate
Number of profiles
Profiles2 records

Each record includes

Name, Designation, Designation category, Overview, Profile commentary, Source

Subsidiaries1 record

Each record includes

Name, Acquired on, Relationship type, Type, Business focus

Compliance4 records

Each record includes

Name, Class, Description

Funding overview

Funding stage, Last funding date, Total funding USD

Funding rounds1 record

Each record includes

Round, Amount USD, Date, Pre money valuation, Total investors, Investors, News

Investors1 record

Each record includes

Name, Type, Date of entry, Rounds participated, Website

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A1 record

Each record includes

Name, Acquisition type, Announced date, Completed date, Status, Website, News

Investment

Each record includes

Name, Round, Announced date, Lead investor, Website, News

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Neopharmed Gentili

Branded Pharmaceuticalsneogen.it

Neopharmed Gentili firmographics

Firmographics
Name
Neopharmed Gentili
Legal name
Neopharmed Gentili S.p.A.
Website
http://www.neogen.it
Company type
Private
Founded year
2011
Operating status
Operating
Headcount range
101–250 employees
Ownership category
akta.pro rank

Neopharmed Gentili industry classification

Industry
Product category
Branded Pharmaceuticals
SIC
Pharmaceutical Preparations (2834)
akta.pro primary industry
Specialty Care Pharmaceuticals (HLAIAAAB)
akta.pro secondary industries
Cardiometabolic Pharmaceuticals (Cardiovascular/Diabetes/Obesity) (HLAIAAAE), Gastroenterology Specialty Pharmaceuticals (HLAIACAE), Nephrology & Urology Specialty Pharmaceuticals (HLAIACAH)

Keywords

  • Pharmaceutical commercialization
  • Branded pharmaceuticals
  • Rare disease therapies
  • Therapeutic area portfolio
  • Pharmaceutical licensing

Where Neopharmed Gentili is headquartered

Location

Headquarters

HQ city
Gottolengo
HQ country
Italy
HQ region
Europe

Offices1 record

Markets served

Neopharmed Gentili business model

Business model
GTM type
B2B
Offering type
Hardware or Manufacturing
Cost components
Supply Chain, Personnel, Marketing or Sales, Operations, Others

Revenue model

  1. Pharmaceutical Product Sales: Revenue generated from commercialization of branded pharmaceutical products across multiple therapeutic areas in Italy and Europe
  2. European Licensing Revenue: Upfront payments and milestone payments received from European licensing agreements, plus ongoing royalty streams from product commercialization rights

Go-to-market motion2 records

Distribution channels3 records

Marketing channels7 records

Neopharmed Gentili product offering

Product offering

Core offering

Neopharmed Gentili commercializes high therapeutic value branded pharmaceutical products across more than ten therapeutic areas in Italy and Europe, including cardio-metabolic, vascular, pneumo-allergological, antibiotic, osteoarticular, gastro-enteric, neuro-psychiatric, otorhinolaryngological, pediatric, and urological conditions. Its portfolio combines in-house and acquired products with licensed brands such as ORLADEYO (berotralstat) and the pipeline asset navenibart for hereditary angioedema, and Plasil (metoclopramide) for gastroenterology. The company reaches patients through a field-based scientific information force, an HCP portal, and standard Italian pharmaceutical distribution channels.

Product overview

Neopharmed Gentili is an Italian pharmaceutical company specializing in the commercialization of high therapeutic value solutions across 10+ therapeutic areas including cardio-metabolic, vascular, pulmonary-allergologic, antibiotic, osteoarticular, gastroenterological, neuropsychiatry, otorhinolaryngological, pediatric, and urological conditions. The company operates a multi-brand portfolio approach, commercializing both in-house developed/acquired products and licensed brands. Key products include ORLADEYO® (berotralstat) for hereditary angioedema (acquired from BioCryst in 2025), the pipeline product Navenibart (Phase 3 for HAE), and the gastroenterology brand Plasil® (metoclopramide). The company treats over 3 million patients annually and maintains a business model combining M&A, licensing-in arrangements, and organic portfolio expansion across therapeutic areas.

Differentiator

Problem solved

Functional benefit

Products and services

  • Cardio-Metabolic Portfolio
  • Vascular Portfolio
  • Pulmonary-Allergologic Portfolio
  • Antibiotic Portfolio
  • Osteoarticular Portfolio
  • Gastroenterological Portfolio
  • Neuropsychiatry Portfolio
  • Otorhinolaryngological Portfolio
  • Pediatric Portfolio
  • Urological Portfolio
  • ORLADEYO (berotralstat) ORLADEYO is an oral, once-daily medication for the prevention of hereditary angioedema (HAE) attacks in adults and pediatric patients 12 years and older. Neopharmed Gentili acquired the European commercial rights from BioCryst Pharmaceuticals in 2025.
  • Navenibart (European rights) Navenibart is an investigational long-acting plasma kallikrein inhibitor in Phase 3 development for hereditary angioedema (HAE), for which Neopharmed Gentili acquired exclusive European commercial rights through a licensing agreement with BioCryst Pharmaceuticals.
  • Plasil (metoclopramide) Plasil is a gastroenterology brand containing metoclopramide, used for gastrointestinal disorders associated with dyspepsia, nausea, and emesis. Neopharmed Gentili acquired the product in February 2025 and later licensed it to Lupin for the Philippines and Brazil markets.

Quantifiable outcome

  • Over 3 million patients treated in 2024
  • +1 more outcomes

Companies that use Neopharmed Gentili

Customer profile

Named customers2 records

Segments7 records

Ideal customer profiles3 records

Neopharmed Gentili technology and API

Technology

Technology focussed No

API detail

Has API
No
API docs
API detail

Core technology

AI maturity

App detail

Feature1 record

Neopharmed Gentili partnerships and signals

Strategic signal

Partnerships

Three partnerships are on record, tiered minor and core.

  • Favillini Pharmaceutical Packaging Group SpAminorStrategic or Co-development Partner · 1 January 2026From 2026, Neopharmed Gentili uses FSC-certified packaging materials from Favillini Pharmaceutical Packaging Group SpA for cartons and instructional leaflets, supporting sustainability objectives with materials from responsibly managed forests.
  • Lupin LimitedminorChannel Partner/ Reseller/ Distributor · 18 December 2025Lupin granted Neopharmed exclusive licensing rights for the gastroenterology brand Plasil in the Philippines and Brazil, covering distribution rights for this肠胃品牌.
  • BioCryst PharmaceuticalscoreOEM/ Whitelabel/ Licensing Partner · 27 June 2025Neopharmed Gentili acquired the European business of ORLADEYO (berotralstat) from BioCryst Pharmaceuticals for US$250 million upfront with potential additional milestone considerations. The acquisition completed in October 2025. Additionally, Neopharmed Gentili's Irish affiliate received exclusive European commercial rights to navenibart for $70 million upfront plus up to $275 million in milestones and 18-30% tiered royalties.

Scale indicators6 records

Recent moves6 records

Expansion highlights6 records

Neopharmed Gentili competitors and assessment

Company assessment

Direct peers

  • Chiesi Farmaceutici S.p.A. Chiesi is a privately held Italian specialty pharma with strong rare disease franchises (including respiratory and HAE-adjacent areas) and European licensing partnerships, closely comparable to Neopharmed's specialty and rare disease commercialization model.
  • Angelini Pharma: Angelini Pharma is a privately held Italian pharmaceutical company with a multi-therapeutic portfolio spanning CNS, pain, infectious disease and consumer health across Europe, directly comparable to Neopharmed's breadth-based specialty model.
  • Recordati S.p.A. Recordati is an Italian specialty pharmaceutical group with a similar multi-therapeutic European commercial footprint and a track record of acquiring and developing branded pharmaceuticals across rare diseases, cardiology, urology, and other specialty areas, making it the closest direct peer in business model and geography.
  • Zambon S.p.A. Zambon is an Italian specialty pharma with multi-therapeutic respiratory, CNS, and rare disease products across European markets, with comparable geographic footprint and commercialization-led growth model.
  • Molteni Farmaceutici S.p.A. Molteni is an Italian specialty pharmaceutical company with a focus on pain, addiction, and rare disease therapeutics in European markets, sharing Neopharmed's privately held Italian specialty pharma profile.
  • Dompé Farmaceutici S.p.A. Dompé is a privately held Italian biopharma with both proprietary and licensed specialty products, including rare disease ophthalmology, comparable to Neopharmed's mix of branded specialty and rare disease commercialization.
  • Italfarmaco S.p.A. Italfarmaco is a privately held Italian pharma group with specialty and rare disease products sold internationally, sharing Neopharmed's profile as a mid-sized Italian specialty pharmaceutical company pursuing geographic expansion.

Broad incumbents

  • Almirall S.A. Almirall is a European specialty pharmaceutical company focused on dermatology and other specialty areas with strong Southern European commercial reach, relevant as a peer for mid-sized European specialty commercialization strategies.
  • Menarini Group: Menarini is a much larger privately held Italian pharmaceutical group with a broad multi-therapeutic European portfolio, providing a benchmark for an Italian pharma peer that has scaled internationally while remaining private.
  • Stada Arzneimittel AG: Stada is a European specialty and generics pharma group active across multiple therapeutic areas with significant presence in Italy, comparable to Neopharmed as a broader, PE-influenced European specialty commercializer.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat4 records

Key risks6 records

Key highlights6 records

Customer concentration

Neopharmed Gentili social profiles

Digital presence

Neopharmed Gentili compliance and trust

Trust signal

Compliance4 records

Neopharmed Gentili financial estimates

Financial estimate

Revenue estimate

Valuation estimate

Neopharmed Gentili leadership team

Management profile

Number of profiles

Profiles2 records

Neopharmed Gentili subsidiaries and ownership

Company hierarchy

Subsidiaries1 record

Neopharmed Gentili funding detail

Funding detail

Funding overview

Funding rounds1 record

Investors1 record

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

Neopharmed Gentili M&A and investment

M&A and investment

M&A1 record

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Neopharmed Gentili

What does Neopharmed Gentili do?

Neopharmed Gentili commercializes high therapeutic value branded pharmaceutical products across more than ten therapeutic areas in Italy and Europe, including cardio-metabolic, vascular, pneumo-allergological, antibiotic, osteoarticular, gastro-enteric, neuro-psychiatric, otorhinolaryngological, pediatric, and urological conditions. Its portfolio combines in-house and acquired products with licensed brands such as ORLADEYO (berotralstat) and the pipeline asset navenibart for hereditary angioedema, and Plasil (metoclopramide) for gastroenterology. The company reaches patients through a field-based scientific information force, an HCP portal, and standard Italian pharmaceutical distribution channels.

Is Neopharmed Gentili a public or private company?

Neopharmed Gentili is a private company. It is classified as private equity controlled and is currently operating.

When was Neopharmed Gentili founded?

Neopharmed Gentili was founded in 2011. It employs 101 to 250 people.

Where is Neopharmed Gentili based?

Neopharmed Gentili is headquartered in Gottolengo, Italy, in the Europe region.

How does Neopharmed Gentili make money?

Two revenue lines are on record. Pharmaceutical Product Sales are the primary driver. The others are european Licensing Revenue.

Who are Neopharmed Gentili's main competitors?

Direct peers on record are Chiesi Farmaceutici S.p.A., Angelini Pharma, Recordati S.p.A., Zambon S.p.A., Molteni Farmaceutici S.p.A., Dompé Farmaceutici S.p.A. and Italfarmaco S.p.A.. Broad incumbents are Almirall S.A., Menarini Group and Stada Arzneimittel AG.

Does Neopharmed Gentili have an API?

No public API is recorded for Neopharmed Gentili.

What industry is Neopharmed Gentili in?

Neopharmed Gentili's product category is Branded Pharmaceuticals. Its primary akta.pro industry code is HLAIAAAB, Specialty Care Pharmaceuticals, with a secondary code of HLAIAAAE, Cardiometabolic Pharmaceuticals (Cardiovascular/Diabetes/Obesity). Its SIC code is 2834.

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Live signals
Simply Wall StHow Investors May Respond To BioCryst (BCRX) Hiring Its First CSO To Drive Rare-Disease DealsBioCryst Pharmaceuticals appointed David W. Jenkins as its first Chief Scientific Officer in July 2026, reporting to Chief R&D Officer Dr. Sandeep Menon, to build and lead a research team focused on external innovation and partnerships in rare disease therapies. The hire signals BioCryst's deeper commitment to pipeline expansion beyond its primary drug ORLADEYO, supported by a recent license agreement granting Neopharmed Gentili rights to navenibart in Europe. The company projects $930.1 million revenue and $131.3 million earnings by 2029, though heavy reliance on ORLADEYO remains a key risk.AInvestLupin unit in licensing pact for its two oncology programsLupin Limited, through its subsidiaries in the Philippines and Brazil, has entered into multiple licensing agreements to expand its oncology and specialty portfolio. The agreements include exclusive marketing rights for the gastroenterology brand Plasil from Italian company Neopharmed Gentili S.p.A., and an exclusive licensing and supply deal with DKSH to commercialize five biosimilars, including two undisclosed biosimilars for immunology and oncology. These partnerships are aimed at strengthening Lupin's presence in oncology and specialty markets across key regions.GlobeNewswireNEOPHARMED PRE Stabilization NoticeNeopharmed Gentili S.p.A. has announced a EUR 890 million Senior Secured Floating Rate Notes issuance (7-year maturity), with BNP Paribas serving as Stabilisation Coordinator. A syndicate of seven banks including Banca Akros, CACIB, Goldman Sachs, IMI, JPMorgan, and Natixis will act as Stabilisation Managers during the expected stabilization period starting 18 June 2026. The pre-stabilisation notice is a standard regulatory announcement providing information about potential market stabilisation activities for the securities offering.BeBeezNeopharmed Gentili rifinanzia il bond da 400 mln euro in scadenza 2030 con una nuova emissione secured da 425 mln - BeBeezNeopharmed Gentili issued a new senior secured floating-rate bond of €425 million maturing in 2033. Proceeds will repay the €400 million bond due in 2030 and partially repay a 2031 PIK bond. The group reported FY2025 revenue of €316.5 million and EBITDA of €139.7 million.PR NewswireHereditary angioedema, a European initiative to shine a spotlight on a still under-recognized conditionBioCryst Ireland, a Neopharmed Gentili company, organized an international event in Milan on May 13, 2026, bringing together leading European experts to raise awareness of Hereditary Angioedema (HAE), a rare genetic disease affecting approximately 1 in 50,000 people, ahead of World HAE Day on May 16. The event highlighted the challenges of delayed diagnosis, noting that in Germany it still takes an average of around 10 years from symptom onset to correct diagnosis due to symptoms overlapping with more common conditions. Neopharmed Gentili's CEO emphasized the company's commitment to rare diseases through innovative therapies and awareness initiatives aimed at shortening diagnostic timelines and improving patient outcomes.The Motley FoolBioCryst (BCRX) Q1 2026 Earnings TranscriptBioCryst Pharmaceuticals reported Q1 2026 earnings with ORLADEYO net revenue of $148.3 million, reflecting 21% year-over-year growth excluding the European divestiture impact, while non-GAAP operating profit increased 25% to $54 million. The company completed enrollment ahead of schedule for the pivotal ALPHA-ORBIT Phase 3 trial of navenibart and finalized a European license agreement with Neopharmed Gentili providing $70 million upfront cash plus up to $275 million in milestones and 18-30% tiered royalties. Management also reported that the pediatric ORLADEYO pellet launch has experienced fulfillment delays due to a manufacturing specification issue unrelated to capsule supply, though this is not expected to impact 2026 revenue guidance of $625-645 million.Stock TitanBioCryst Q1 ORLADEYO revenue rises 11% to $148.3MBioCryst Pharmaceuticals reported Q1 2026 ORLADEYO net revenue of $148.3 million, representing an 11% year-over-year increase, and on a non-GAAP basis recorded an operating profit of $54.2 million despite a GAAP operating loss of $701.6 million due to a $697.8 million non-cash charge for acquired in-process research and development from the Astria Therapeutics acquisition. The company also entered into a licensing agreement with Neopharmed Gentili for exclusive European commercial rights to navenibart, receiving $70 million upfront with potential milestone payments up to $275 million. BioCryst maintained its 2026 full-year guidance for global ORLADEYO revenue of $625-645 million and total revenue of $635-660 million.BenzingaFull Transcript: BioCryst Pharma Q1 2026 Earnings Call - BioCryst Pharma (NASDAQ:BCRX)BioCryst Pharma reported Q1 2026 net revenue of $148.3 million, representing 17% year-over-year growth, with Orladeo generating $148 million (up 21% YoY excluding European divestiture impact) and non-GAAP operating profit of $54 million. The company is managing a manufacturing issue affecting the pediatric formulation of Orladeo but does not expect it to impact full-year 2026 revenue guidance of $625–645 million. Development of Nevenibart is progressing well with Phase 3 Alpha Orbit trial enrollment expected to complete by end of June, and the company closed a licensing deal with NeoPharmed Gentile for European commercialization of Nevenibart ($70 million upfront plus up to $275 million in milestones).GlobeNewswireBioCryst Reports First Quarter 2026 Financial Results and Provides Business UpdateBioCryst reported Q1 2026 ORLADEYO net revenue of $148.3 million, up 11% year-over-year. The company announced a licensing agreement for European commercial rights to navenibart, with $70 million upfront and up to $275 million in milestone payments. It also maintained its full-year 2026 revenue guidance.Investing.comBioCryst licenses navenibart rights in Europe for $70M upfront By Investing.comBioCryst granted an Irish affiliate of Neopharmed Gentili exclusive rights to commercialize navenibart, an investigational long-acting plasma kallikrein inhibitor in Phase 3 development for hereditary angioedema, across Europe. BioCryst will receive $70 million upfront, up to $275 million in regulatory and sales milestone payments, and tiered royalties of 18% to 30% on net sales. The agreement builds on a prior 2025 transaction where Neopharmed Gentili acquired BioCryst's European ORLADEYO business, with BioCryst retaining U.S. commercialization rights for navenibart.