Developer docs
API playgroundTry for free, no card

Search company profiles

The Francis Crick Institute

Full company profile

uuid0006s5e

Namestring
The Francis Crick Institute
Legal namestring
The Francis Crick Institute Limited
Websiteurl
crick.ac.uk
Company typeenum
Private
Founded yearint
2015
Descriptiontext

The Francis Crick Institute is a London-based biomedical discovery institute established in 2015 through a unique partnership consortium of six founding institutions: the Medical Research Council (UKRI), Cancer Research UK, Wellcome, University College London, Imperial College London, and King's College London. Registered as a charitable company limited by shares (charity no. 1140062) and headquartered at 1 Midland Road, London NW1 1AT, the institute operates as one of Europe's largest biomedical research laboratories, employing more than 1,500 scientists across cancer biology, infectious disease, developmental biology, genomics, proteomics, and translational research. Its stated mission is to understand the biology underlying human health and disease, with the goal of driving discoveries that benefit human health through translation, training, and public engagement.

The institute's technology base spans cutting-edge discovery research platforms and proprietary methodologies, including a 14-protein plasma biomarker signature validated across eight international datasets that can predict lung cancer risk more than five years before diagnosis, identification of Aurora-related kinase 1 (ARK1) as a malaria drug target, the first human lung-on-a-chip model using stem cells from a single donor capable of simulating breathing motions for personalized medicine, and ancient DNA analysis methods demonstrated on Anglo-Saxon archaeological remains. The Crick operates an Open Science Policy ensuring research outputs are broadly accessible and collaborates extensively through a Snowflake-powered Trusted Research Environment that enables secure cross-border data collaboration across 38 countries.

The Crick does not sell commercial products or services. Its operating model is funded primarily through its six founding partners as a registered charity, with secondary revenue streams from technology transfer activities including spin-out companies (e.g., ALTx Therapeutics, launched February 2026 with £12.55 million in funding) and licensing arrangements. Translational research is increasingly executed through strategic partnerships with industry — notably Flagship Pioneering (November 2025) and Charles River Laboratories (October 2025) — and minority investments in AI-enabled healthtech (PulseAI) and biotech (LinkGevity). The institute serves a dual customer base: the global scientific research community seeking collaborative access to world-class platforms, and the healthcare and pharmaceutical industry pursuing therapeutic and diagnostic breakthroughs.

Short descriptiontext

The Francis Crick Institute is a London-based charitable biomedical discovery institute founded in 2015 through a consortium of six leading UK research organizations, employing over 1,500 scientists to conduct fundamental research into the biology of health and disease and translate discoveries into therapeutic and diagnostic applications.

Operating statusenum
Operating
Ownership categoryenum
Headcount rangeband
1,001–5,000
akta.pro rankint
HeadquartersLondon, United Kingdom
HQ citystring
London
HQ countrystring
United Kingdom
HQ regionstring
Europe
Markets served

Serves global market

Offices1 record

Each record includes

City, Country, Type, Description, Source

Keyword5 values
biomedical discovery research, cancer research, infectious disease research, translational medicine, genomics and proteomics
Industry2 codes
1Real-World Evidence (RWE), HEOR & Epidemiology CROs
CodeHLAGAAAKPrimaryYes
2Central Laboratory & Clinical Trial Testing CROs
CodeHLAGAAAEPrimaryNo
NAICS code2 codes
  • Research and Development in the Physical, Engineering, and Life Sciences54171
  • Scientific Research and Development Services5417
SIC code1 code
  • Services-Commercial Physical & Biological Research8731
Product category
Biomedical Research
GTM motion1 record

Each record includes

Type, Description, Source

Revenue model2 records
1Research funding from founding partners
TypeSubscription Recurring
Description

The Crick is funded by six founding partners: Medical Research Council (UKRI), Cancer Research UK, Wellcome, University College London, Imperial College London, and King's College London. This provides core operational funding for discovery research.

crick.ac.uk
2Spin-out company creation and licensing
TypeLicensing Royalties
Description

The Crick creates spin-out companies from its research discoveries, such as ALTx Therapeutics, and receives funding from these arrangements.

pharmiweb.com
Marketing channels6 records

Each record includes

Title, Type, Stage, Description, Source

Distribution channels3 records

Each record includes

Title, Type, Scope, Target buyer, Description, Source

Cost components4 values
Personnel, Technology or R&D, Infrastructure, Operations
GTM typeB2B
B2B
Offering typeServices
Services
Core offering1 text field

The Francis Crick Institute is a biomedical discovery institute that conducts world-class research to understand how living things work and to drive benefits for human health. It is home to more than 1,500 scientists and operates as a consortium of six founding partners (MRC, Cancer Research UK, Wellcome, UCL, Imperial College London, and King's College London), producing scientific discoveries, training researchers, enabling research partnerships, and commercialising outputs through spin-out companies and licensing.

Differentiator
Functional benefit
Problem solved
Quantifiable outcome1 of 3 values shown
  • 14-protein blood signature correctly identified over 75% of future lung cancer cases in validation cohort
+2 more records
Product overview1 text field

The Francis Crick Institute is a biomedical discovery institute focused on world-class research to understand how living things work and drive benefits for human health. It is not a product or technology company; it does not offer commercial products or services for sale. The institute operates as a research organization with over 1,500 scientists conducting discovery research across various biological and medical domains, supported by partnerships with six founding universities (UCL, Imperial College London, King's College London, Medical Research Council, Cancer Research UK, and Wellcome).

Product and service7 records
1Biomedical Discovery Research
CategoryResearch services
Description

Core discovery research across cancer, infectious disease, developmental biology, genomics, proteomics, and translational science, conducted by over 1,500 scientists.

2Research Platforms and Facilities
CategoryResearch infrastructure
Description

State-of-the-art scientific platforms and facilities available to internal researchers and external collaborators, supporting advanced biomedical research activities.

3Research Partnerships and Collaborations
CategoryResearch services
Description

Strategic research partnerships with academic institutions, pharmaceutical companies, and biotech firms, including collaborations with Charles River Laboratories and Flagship Pioneering.

4Spin-out Companies and Technology Licensing
CategoryTechnology transfer
Description

Creation of spin-out companies such as ALTx Therapeutics to commercialise research discoveries, with licensing of intellectual property to pharmaceutical and biotech partners.

5Scientific Training and Education
CategoryEducation and training
Description

Training programmes for PhD students, postdocs, clinical fellows, and technical staff, including technical training for researchers outside the Crick.

6Public Engagement Programmes
CategoryPublic engagement
Description

Public events, exhibitions including 'We go way back', seminars, lectures, symposia, the Crick Gallery, podcasts, and educational content for the public and schools (Crick Kids).

7Trusted Research Environment
CategoryResearch infrastructure
Description

Secure cross-border research collaboration environment using Snowflake technology, enabling data-driven research across 38 countries.

Scale indicator5 records

Each record includes

Type, Value, Description, Source

Partnership13 partners
1ALTx Therapeutics
Strategic tierCoreTypeTechnology or IntegrationAnnounced on2026-02-06
Description

ALTx Therapeutics launched as a spin-out from The Francis Crick Institute with £12.55 million funding. The company develops first-in-class therapeutics targeting the Alternative Lengthening of Telomeres pathway in cancers, based on pioneering research by Simon Boulton.

pharmiweb.com
Strategic tierMinorTypeStrategic or Co-development PartnerAnnounced on2026-02-06
Description

UK-Israel genomics delegation visited The Francis Crick Institute as part of bilateral collaboration to strengthen life sciences innovation between UK and Israel.

Strategic tierCoreTypeStrategic or Co-development PartnerAnnounced on2025-11-18
Description

Flagship Pioneering and the Francis Crick Institute announced a collaboration to advance life sciences innovation in the UK. The partnership aims to develop scientific platforms and therapeutic pipelines, leveraging the Crick's research excellence and Flagship's biotech model.

Strategic tierCoreTypeStrategic or Co-development PartnerAnnounced on2025-10-22
Description

Charles River and the Francis Crick Institute combine expertise in antibody-drug conjugate development, leveraging Charles River's research products and services capabilities with the Crick's research excellence.

Strategic tierCoreTypeStrategic or Co-development Partner
Description

Researchers from the Francis Crick Institute and AlveoliX developed the first human lung-on-a-chip model using stem cells from a single donor, capable of simulating breathing motions and replicating lung disease for personalized medicine applications.

Strategic tierCoreTypeStrategic or Co-development Partner
Description

One of six founding partners and partner university of The Francis Crick Institute.

Strategic tierCoreTypeStrategic or Co-development Partner
Description

One of six founding partners and partner university of The Francis Crick Institute.

Strategic tierCoreTypeStrategic or Co-development Partner
Description

One of six founding partners and partner university of The Francis Crick Institute.

Strategic tierCoreTypeStrategic or Co-development Partner
Description

Collaborated on 14-protein blood signature research for lung cancer prediction, using machine learning on data from over 48,000 UK Biobank participants.

Strategic tierMinorTypeStrategic or Co-development Partner
Description

International team including University of Nottingham, National Institute of Immunology, University of Groningen, and Francis Crick Institute identified ARK1 as target for future malaria drugs.

Strategic tierMinorTypeStrategic or Co-development Partner
Description

International team identified ARK1 as critical protein essential for malaria parasite cell division and transmission.

Strategic tierMinorTypeStrategic or Co-development Partner
Description

International team identified ARK1 as critical protein essential for malaria parasite cell division and transmission.

Strategic tierCoreTypeTechnology or Integration
Description

The Francis Crick Institute uses Snowflake's Trusted Research Environment enabling secure cross-border research collaboration across 38 countries.

Recent move6 records

Each record includes

Date, Type, Title, Description, Source

Expansion highlight6 records

Each record includes

Type, Description

Market position
Competitive moat5 records

Each record includes

Type, Details

Key risks5 records

Each record includes

Headline, Details, Source

Key highlights7 records

Each record includes

Headline, Details, Source

Customer concentration

Classification, Details

Named customers2 records

Each record includes

Name, Industry, Type, Use case, Source, UUID

Segment3 records

Each record includes

Title, Type, Primary, Description, Pain point addressed, Use case, Source

Ideal customer profile3 records

Each record includes

Profile, Firmographic size, Sales motion, Sales cycle length, Buying structure, Purchase trigger, Buyer persona, Geography, Industry vertical, Primary use case, Description, Pain points, Evidence proof points, Target buyer

Technology focused
No
API detail
Has APIbool
No

Docs URL, Description

AI maturity
App detail

Has app

Feature4 records

Each record includes

Title, Differentiator, Description, Source

Core technology
Revenue estimate
Valuation estimate
Number of profiles
Profiles4 records

Each record includes

Name, Designation, Designation category, Overview, Profile commentary, Source

Subsidiaries1 record

Each record includes

Name, Acquired on, Relationship type, Type, Business focus

Compliance5 records

Each record includes

Name, Class, Description

Funding overview

Funding stage, Last funding date, Total funding USD

Funding rounds

Each record includes

Round, Amount USD, Date, Pre money valuation, Total investors, Investors, News

Investors

Each record includes

Name, Type, Date of entry, Rounds participated, Website

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Each record includes

Name, Acquisition type, Announced date, Completed date, Status, Website, News

Investment10 records

Each record includes

Name, Round, Announced date, Lead investor, Website, News

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

The Francis Crick Institute

Biomedical Researchcrick.ac.uk

The Francis Crick Institute is a London-based charitable biomedical discovery institute founded in 2015 through a consortium of six leading UK research organizations, employing over 1,500 scientists to conduct fundamental research into the biology of health and disease and translate discoveries into therapeutic and diagnostic applications.

What The Francis Crick Institute does

The Francis Crick Institute is a London-based biomedical discovery institute established in 2015 through a unique partnership consortium of six founding institutions: the Medical Research Council (UKRI), Cancer Research UK, Wellcome, University College London, Imperial College London, and King's College London. Registered as a charitable company limited by shares (charity no. 1140062) and headquartered at 1 Midland Road, London NW1 1AT, the institute operates as one of Europe's largest biomedical research laboratories, employing more than 1,500 scientists across cancer biology, infectious disease, developmental biology, genomics, proteomics, and translational research. Its stated mission is to understand the biology underlying human health and disease, with the goal of driving discoveries that benefit human health through translation, training, and public engagement.

The institute's technology base spans cutting-edge discovery research platforms and proprietary methodologies, including a 14-protein plasma biomarker signature validated across eight international datasets that can predict lung cancer risk more than five years before diagnosis, identification of Aurora-related kinase 1 (ARK1) as a malaria drug target, the first human lung-on-a-chip model using stem cells from a single donor capable of simulating breathing motions for personalized medicine, and ancient DNA analysis methods demonstrated on Anglo-Saxon archaeological remains. The Crick operates an Open Science Policy ensuring research outputs are broadly accessible and collaborates extensively through a Snowflake-powered Trusted Research Environment that enables secure cross-border data collaboration across 38 countries.

The Crick does not sell commercial products or services. Its operating model is funded primarily through its six founding partners as a registered charity, with secondary revenue streams from technology transfer activities including spin-out companies (e.g., ALTx Therapeutics, launched February 2026 with £12.55 million in funding) and licensing arrangements. Translational research is increasingly executed through strategic partnerships with industry — notably Flagship Pioneering (November 2025) and Charles River Laboratories (October 2025) — and minority investments in AI-enabled healthtech (PulseAI) and biotech (LinkGevity). The institute serves a dual customer base: the global scientific research community seeking collaborative access to world-class platforms, and the healthcare and pharmaceutical industry pursuing therapeutic and diagnostic breakthroughs.

The Francis Crick Institute firmographics

Firmographics
Name
The Francis Crick Institute
Legal name
The Francis Crick Institute Limited
Website
https://crick.ac.uk
Company type
Private
Founded year
2015
Operating status
Operating
Headcount range
1,001–5,000 employees
Short description
The Francis Crick Institute is a London-based charitable biomedical discovery institute founded in 2015 through a consortium of six leading UK research organizations, employing over 1,500 scientists to conduct fundamental research into the biology of health and disease and translate discoveries into therapeutic and diagnostic applications.
Ownership category
akta.pro rank

The Francis Crick Institute industry classification

Industry
Product category
Biomedical Research
NAICS
Research and Development in the Physical, Engineering, and Life Sciences (54171), Scientific Research and Development Services (5417)
SIC
Services-Commercial Physical & Biological Research (8731)
akta.pro primary industry
Real-World Evidence (RWE), HEOR & Epidemiology CROs (HLAGAAAK)
akta.pro secondary industry
Central Laboratory & Clinical Trial Testing CROs (HLAGAAAE)

Keywords

  • Biomedical discovery research
  • Cancer research
  • Infectious disease research
  • Translational medicine
  • Genomics and proteomics

Where The Francis Crick Institute is headquartered

Location

Headquarters

HQ city
London
HQ country
United Kingdom
HQ region
Europe

Offices1 record

Markets served

The Francis Crick Institute business model

Business model
GTM type
B2B
Offering type
Services
Cost components
Personnel, Technology or R&D, Infrastructure, Operations

Revenue model

  1. Research funding from founding partners: The Crick is funded by six founding partners: Medical Research Council (UKRI), Cancer Research UK, Wellcome, University College London, Imperial College London, and King's College London. This provides core operational funding for discovery research.
  2. Spin-out company creation and licensing: The Crick creates spin-out companies from its research discoveries, such as ALTx Therapeutics, and receives funding from these arrangements.

Go-to-market motion1 record

Distribution channels3 records

Marketing channels6 records

The Francis Crick Institute product offering

Product offering

Core offering

The Francis Crick Institute is a biomedical discovery institute that conducts world-class research to understand how living things work and to drive benefits for human health. It is home to more than 1,500 scientists and operates as a consortium of six founding partners (MRC, Cancer Research UK, Wellcome, UCL, Imperial College London, and King's College London), producing scientific discoveries, training researchers, enabling research partnerships, and commercialising outputs through spin-out companies and licensing.

Product overview

The Francis Crick Institute is a biomedical discovery institute focused on world-class research to understand how living things work and drive benefits for human health. It is not a product or technology company; it does not offer commercial products or services for sale. The institute operates as a research organization with over 1,500 scientists conducting discovery research across various biological and medical domains, supported by partnerships with six founding universities (UCL, Imperial College London, King's College London, Medical Research Council, Cancer Research UK, and Wellcome).

Differentiator

Problem solved

Functional benefit

Products and services

  • Biomedical Discovery Research Core discovery research across cancer, infectious disease, developmental biology, genomics, proteomics, and translational science, conducted by over 1,500 scientists.
  • Research Platforms and Facilities State-of-the-art scientific platforms and facilities available to internal researchers and external collaborators, supporting advanced biomedical research activities.
  • Research Partnerships and Collaborations Strategic research partnerships with academic institutions, pharmaceutical companies, and biotech firms, including collaborations with Charles River Laboratories and Flagship Pioneering.
  • Spin-out Companies and Technology Licensing Creation of spin-out companies such as ALTx Therapeutics to commercialise research discoveries, with licensing of intellectual property to pharmaceutical and biotech partners.
  • Scientific Training and Education Training programmes for PhD students, postdocs, clinical fellows, and technical staff, including technical training for researchers outside the Crick.
  • Public Engagement Programmes Public events, exhibitions including 'We go way back', seminars, lectures, symposia, the Crick Gallery, podcasts, and educational content for the public and schools (Crick Kids).
  • Trusted Research Environment Secure cross-border research collaboration environment using Snowflake technology, enabling data-driven research across 38 countries.

Quantifiable outcome

  • 14-protein blood signature correctly identified over 75% of future lung cancer cases in validation cohort
  • +2 more outcomes

Companies that use The Francis Crick Institute

Customer profile

Named customers2 records

Segments3 records

Ideal customer profiles3 records

The Francis Crick Institute technology and API

Technology

Technology focussed No

API detail

Has API
No
API docs
API detail

Core technology

AI maturity

App detail

Feature4 records

The Francis Crick Institute partnerships and signals

Strategic signal

Partnerships

13 partnerships are on record, tiered core and minor.

  • ALTx TherapeuticscoreTechnology or Integration · 6 February 2026ALTx Therapeutics launched as a spin-out from The Francis Crick Institute with £12.55 million funding. The company develops first-in-class therapeutics targeting the Alternative Lengthening of Telomeres pathway in cancers, based on pioneering research by Simon Boulton.
  • Weizmann Institute of ScienceminorStrategic or Co-development Partner · 6 February 2026UK-Israel genomics delegation visited The Francis Crick Institute as part of bilateral collaboration to strengthen life sciences innovation between UK and Israel.
  • Flagship PioneeringcoreStrategic or Co-development Partner · 18 November 2025Flagship Pioneering and the Francis Crick Institute announced a collaboration to advance life sciences innovation in the UK. The partnership aims to develop scientific platforms and therapeutic pipelines, leveraging the Crick's research excellence and Flagship's biotech model.
  • Charles River Laboratories InternationalcoreStrategic or Co-development Partner · 22 October 2025Charles River and the Francis Crick Institute combine expertise in antibody-drug conjugate development, leveraging Charles River's research products and services capabilities with the Crick's research excellence.
  • AlveoliXcoreStrategic or Co-development PartnerResearchers from the Francis Crick Institute and AlveoliX developed the first human lung-on-a-chip model using stem cells from a single donor, capable of simulating breathing motions and replicating lung disease for personalized medicine applications.
  • University College LondoncoreStrategic or Co-development PartnerOne of six founding partners and partner university of The Francis Crick Institute.
  • Imperial College LondoncoreStrategic or Co-development PartnerOne of six founding partners and partner university of The Francis Crick Institute.
  • King's College LondoncoreStrategic or Co-development PartnerOne of six founding partners and partner university of The Francis Crick Institute.
  • University College LondoncoreStrategic or Co-development PartnerCollaborated on 14-protein blood signature research for lung cancer prediction, using machine learning on data from over 48,000 UK Biobank participants.
  • University of NottinghamminorStrategic or Co-development PartnerInternational team including University of Nottingham, National Institute of Immunology, University of Groningen, and Francis Crick Institute identified ARK1 as target for future malaria drugs.
  • University of GroningenminorStrategic or Co-development PartnerInternational team identified ARK1 as critical protein essential for malaria parasite cell division and transmission.
  • National Institute of ImmunologyminorStrategic or Co-development PartnerInternational team identified ARK1 as critical protein essential for malaria parasite cell division and transmission.
  • SnowflakecoreTechnology or IntegrationThe Francis Crick Institute uses Snowflake's Trusted Research Environment enabling secure cross-border research collaboration across 38 countries.

Scale indicators5 records

Recent moves6 records

Expansion highlights6 records

The Francis Crick Institute competitors and assessment

Company assessment

Market position

Competitive moat5 records

Key risks5 records

Key highlights7 records

Customer concentration

The Francis Crick Institute social profiles

Digital presence

The Francis Crick Institute compliance and trust

Trust signal

Compliance5 records

The Francis Crick Institute financial estimates

Financial estimate

Revenue estimate

Valuation estimate

The Francis Crick Institute leadership team

Management profile

Number of profiles

Profiles4 records

The Francis Crick Institute subsidiaries and ownership

Company hierarchy

Subsidiaries1 record

The Francis Crick Institute funding detail

Funding detail

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

The Francis Crick Institute M&A and investment

M&A and investment

M&A

Investments10 records

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about The Francis Crick Institute

What does The Francis Crick Institute do?

The Francis Crick Institute is a biomedical discovery institute that conducts world-class research to understand how living things work and to drive benefits for human health. It is home to more than 1,500 scientists and operates as a consortium of six founding partners (MRC, Cancer Research UK, Wellcome, UCL, Imperial College London, and King's College London), producing scientific discoveries, training researchers, enabling research partnerships, and commercialising outputs through spin-out companies and licensing.

Is The Francis Crick Institute a public or private company?

The Francis Crick Institute is a private company. It is classified as nonprofit foundation owned and is currently operating.

When was The Francis Crick Institute founded?

The Francis Crick Institute was founded in 2015. It employs 1,001 to 5,000 people.

Where is The Francis Crick Institute based?

The Francis Crick Institute is headquartered in London, United Kingdom, in the Europe region.

How does The Francis Crick Institute make money?

Two revenue lines are on record. Research funding from founding partners are the primary driver. The others are spin-out company creation and licensing.

Does The Francis Crick Institute have an API?

No public API is recorded for The Francis Crick Institute.

What industry is The Francis Crick Institute in?

The Francis Crick Institute's product category is Biomedical Research. Its primary akta.pro industry code is HLAGAAAK, Real-World Evidence (RWE), HEOR & Epidemiology CROs, with a secondary code of HLAGAAAE, Central Laboratory & Clinical Trial Testing CROs. Its NAICS code is 54171 and its SIC code is 8731.

Unlock the full company data

50 free credits on sign-up, no credit card required.

Contact sales
Live signals
Mirage NewsImmune Cells Defy Textbook ClassificationsResearchers at the Francis Crick Institute, King's College London, and Complutense University of Madrid found that γδ T cells use adaptive immune receptors to drive rapid, innate-like responses to tissue stress, inflammation, and cancer. Removing the receptor impaired tissue surveillance and reduced control of skin, colorectal, and melanoma cancers in mouse and human models.MedicalxpressFast-acting immune cells blur traditional divide between innate and adaptive immunityResearchers at the Francis Crick Institute and Complutense University of Madrid found that γδ T cells require adaptive immune receptors to maintain rapid tissue surveillance, challenging the innate-adaptive divide. Removing the receptor impaired cancer control in mouse models and reduced restriction of melanoma and colorectal cancer cells in human cells.AOL.comNew discovery puts 'women at the centre of early Bronze Age society'DNA analysis by the Francis Crick Institute has revealed that a 4,000-year-old skeleton found near Stonehenge in 1803, originally identified as a "stout man," was in fact a woman who was likely a metalworker and shaman. The findings are part of a wider project studying 1,000 ancient people, and the Wiltshire Museum has updated its display to reflect this new understanding.CamCambridge releases statistics for use of animals in research in 2025Ten major research organizations in Great Britain, including the University of Cambridge (182,562 procedures), the Francis Crick Institute (216,508), and eight other institutions, have released their 2025 animal research statistics totaling 1,347,667 procedures. The data, published as part of the Concordat on Openness on Animal Research in the UK, shows over 99% of procedures involved mice, fish, rats, and birds, with 82% classified as causing pain equivalent to or less than an injection. A case study highlights Dr. Andrew Blagborough's malaria transmission research at the University of Cambridge, which uses mouse models to study parasite transmission from humans to mosquitoes.FocustaiwanNTUH-linked study shows how lung cancer uses nerves to weaken immunity - Focus TaiwanAn international research team with Taiwanese participation discovered that lung cancer activates sensory nerves to release CGRP, which prevents the formation of tertiary lymphoid structures near tumors that help the body organize attacks on cancer cells. In mouse models, blocking this nerve signal restored anti-tumor immunity and slowed tumor growth, offering a potential new treatment approach for the disease that has been Taiwan's leading cause of cancer deaths for over two decades. The study was published in Cell in mid-May and involved researchers from the Francis Crick Institute, NTUH, Harvard Medical School, and Columbia University.PharmaTimesFrancis Crick Institute and Medicines Discovery Catapult open applications for next KQ Labs cohortApplications opened for the ninth cohort of KQ Labs, a five-month accelerator for data-driven health start-ups. The programme will select up to ten companies, and prior cohorts have raised over £230 million. Medicines Discovery Catapult joined as a strategic partner in 2025.Mirage NewsEarly Immune Clues Key in TB DevelopmentResearchers at the Francis Crick Institute, in collaboration with the University Hospitals of Leicester NHS Trust, published a study in Nature Immunology identifying immune signatures in the lungs that distinguish people who control TB infection from those who develop active disease. The study found that individuals with active TB had airways dominated by neutrophils expressing type I interferon signaling genes, while those who controlled the infection had T-cells in a protective 'stem-like' state. These findings suggest the balance between inflammatory neutrophils and T-cells may be a key determinant of disease progression, offering potential for early intervention through biomarkers or host-directed therapies.TimesNowNew Blood Test Shows Promise in Predicting Lung Cancer Before It StartsA multinational research team led by Charles Swanton at the Francis Crick Institute identified a 14-protein blood signature capable of predicting lung cancer risk years before diagnosis, with the model correctly identifying over 75% of future lung cancer cases in a validation cohort of approximately 12,000 UK Biobank participants. The biomarker, validated across eight additional datasets including non-smokers, also showed that participants with the signature experienced a 50% reduction in lung cancer risk when treated with canakinumab in the CANTOS trial. Researchers caution that the test still requires validation in diverse populations and development of a practical, cost-effective diagnostic tool before clinical implementation.The HinduScientists find a blood test that predicts lung cancer years earlyScientists from a multinational team led by Charles Swanton at the Francis Crick Institute have identified a set of 14 blood plasma proteins that can predict lung cancer years before diagnosis, according to findings published in Cell. The "14-protein signature" requires further validation across more diverse populations before it can be developed into a diagnostic test. Lung cancer currently causes about 2.5 million new cases and 1.8 million deaths annually worldwide.BioWorldPre-disease plasma signature may help redefine lung cancer riskResearchers identified a 14-protein blood signature that predicts lung cancer risk up to five years before diagnosis. The study, published in Cell and co-led by Clare Weeden, could help identify people who might benefit from preventive drugs.