Karyosoft

What Karyosoft does

Karyosoft Inc. is a private genomics software company founded in 2017 and headquartered in Carmel, Indiana, with additional offices in Huntsville, Alabama and Dallas, Texas. The company builds a secure, in-house, no-code genomics platform that performs secondary and tertiary Next Generation Sequencing (NGS) analytics for agricultural biotechnology companies, research institutions, bioinformatics teams, molecular geneticists, and sequencing/CRO partners. The platform is built on modern web technologies (JavaScript, Python, React), cloud infrastructure (AWS, GCP, Azure), NoSQL databases, and integrates industry-standard bioinformatics tools such as GATK and JBrowse, packaged behind guided graphical workflows that allow non-programming scientists to execute complex pipelines without scripting.

The product portfolio consists of three integrated modules: Loci (an in-house GenBank alternative for organizing, searching, BLAST-ing, and visually exploring thousands of public and proprietary genomes), Variants (a mutation discovery platform that reduces variant analysis from days to roughly four hours per four samples with annotated SNP/Indel output), and Variant Mining Studio (a centralized repository for managing millions of variants across projects and organisms). Karyosoft also offers professional NGS analytics services covering secondary analytics (genome assembly, annotation), tertiary analytics (genomic selection, association mapping, pangenome construction), and multi-omics work (metagenomics, amplicon sequencing, metabolomics), alongside sequencing partnerships with HudsonAlpha Sequencing Center and Solis Agrosciences.

Karyosoft generates revenue primarily through annual subscription-based access to its software platforms with quote-based, customizable enterprise pricing, supplemented by professional NGS analytics services. The company operates a sales-led go-to-market motion with a business development manager engaging agricultural biotech enterprises, academic labs, and C-level executives via product webinars, industry conferences (notably PAG), and accelerator-driven visibility. Disclosed funding to date is modest (under $200K across Right Side Capital Management, Health Wildcatters, Purdue Ag-celerator, and gbeta), supplemented by up to $100,000 from the Fall 2024 HudsonAlpha AgTech Accelerator. The company is founder-led by Dr. Rajesh Perianayagam and remains at an early commercial stage with a small team (1-10 employees).

Name

Karyosoft

Legal name

Karyosoft Inc.

Website

https://karyosoft.com

Company type

Private

Founded year

2017

Operating status

Operating

Headcount range

1–10 employees

Short description

Karyosoft is a private, Indiana-based software company founded in 2017 that builds a no-code genomics platform (Loci, Variants, Variant Mining Studio) for secondary and tertiary NGS analytics, serving agricultural biotech firms, research institutions, bioinformatics teams, and sequencing/CRO partners.

Ownership category

akta.pro rank

Product category

Bioinformatics Software

NAICS

Research and Development in Biotechnology (except Nanobiotechnology) (541714)

SIC

Services-Commercial Physical & Biological Research (8731)

akta.pro primary industry

Genomics & Next-Generation Sequencing (NGS) Services (HLAGANAA)

akta.pro secondary industry

Molecular & Genomic LIMS (NGS/Bioinformatics Lab Ops) (HLACAMAC)

Keywords

• No-code genomics
• NGS analytics
• Variant discovery
• Genome data management
• Bioinformatics software

Headquarters

HQ city

Carmel

HQ country

United States

HQ region

North America

Offices3 records

Markets served

GTM type

B2B

Offering type

Software

Cost components

Technology or R&D, Personnel, Marketing or Sales, Operations, Infrastructure

Revenue model

1. Software Platform Subscriptions: Karyosoft generates revenue through subscription-based access to their no-code genomics platforms (Loci, Variants, Variant Mining Studio). The platform is designed for in-house deployment with secure, controlled data environments.
2. NGS Services: Professional analytics services including secondary NGS analytics (genome assembly, annotation), tertiary NGS analytics (genomic selection, association mapping), and multi-omics services (metagenomics, metabolomics).

Pricing tiers

Go-to-market motion1 record

Distribution channels3 records

Marketing channels6 records

Core offering

Karyosoft develops a secure, in-house no-code genomics platform for Next Generation Sequencing (NGS) analytics covering secondary and tertiary workflows. The product suite includes Loci (genome data management with BLAST and JBrowse), Variants (SNP and Indel mutation discovery), and Variant Mining Studio (centralized variant repository). The company also offers NGS analytics services spanning genome assembly, annotation, genomic selection, GWAS, pangenome construction, metagenomics, and metabolomics.

Product overview

Karyosoft offers a unified no-code genomics platform complemented by specialized modules and NGS services. The core platform combines three main products: Loci (genome data management), Variants (mutation discovery), and Variant Mining Studio (variant data repository). Loci serves as an in-house secure GenBank for organizing, searching, and visualizing genomes with integrated BLAST and JBrowse tools. Variants provides streamlined SNP/Indel discovery with guided workflows delivering results in hours versus days. Variant Mining Studio extends the portfolio as a centralized repository for managing millions of variants across projects and organisms. The platform is supported by comprehensive NGS services including secondary analytics (genome assembly, annotation), tertiary analytics (genomic selection, GWAS, pangenome construction), multi-omics analysis (metagenomics, metabolomics), and partnerships with HudsonAlpha and Solis Agrosciences for sequencing services.

Differentiator

Problem solved

Functional benefit

Products and services

• Loci An in-house secure genome data management platform functioning as a GenBank for organizing, searching, and exploring thousands of public and proprietary genomes, with interactive search by taxonomy, genes, and proteins, flexible Single/Multi/Custom BLAST analyses, and integrated JBrowse for interactive genome visualization. Designed for bioinformatics teams and molecular geneticists who need to manage proprietary genomic data without additional installation requirements.
• Variants A mutation discovery platform enabling scientists to identify SNPs, Indels, and genomic variants through a web-based interface with guided workflows, delivering whole-genome variant distribution reports with gene, effect, region, and other annotations. Processes 4 samples in approximately 4 hours and supports up to 168 days of time savings for 96 samples. Targets molecular geneticists and bioinformaticians conducting variant characterization in plants and animals.
• Variant Mining Studio A centralized SNP and Indel data management system serving as a repository for millions of genetic variants organized by project and organism, with VCF file uploads, one-click variant data mining, search by gene name/annotation/chromosome location, and retrieval of genotypic data including homozygous/heterozygous calls and missing data across samples. Designed for research teams managing large-scale variant repositories.
• NGS Analytics Services Professional NGS analytics services covering Secondary NGS Analytics (genome assembly from FASTQ data, FASTA-format annotation), Tertiary NGS Analytics (genomic selection with ML/DL prediction models and spatial correlation modeling, GWAS and transcriptomic association mapping, pangenome construction for diploid and polyploid organisms), and Multi-Omics & Advanced Analytics (metagenomics with supervised/unsupervised ML microbial community discovery, amplicon sequencing, comparative metabolomics with PCA and ML/DL modeling). Targeted at agricultural biotechnology companies and research institutions.
• Next Generation Sequencing Services End-to-end next-generation sequencing services delivered through partnerships with HudsonAlpha Sequencing Center (Illumina and PacBio platforms including DNA/RNA extractions, resequencing, RNA-Seq, ISO-Seq, HiFi sequencing, methylation analysis, metagenome sequencing) and Solis Agrosciences (Complete Genomics platform with tailored DNA extractions for leaf, seed, blood, semen, and tissue, library creation, and 150bp paired-end sequencing).

Quantifiable outcome

• Analysis time reduced from days to hours (4 hours per 4 samples for variant discovery)
• +2 more outcomes

Named customers3 records

Segments5 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

AI capability5 records

Feature4 records

Partnerships

Three partnerships are on record, tiered core.

• HudsonAlpha Institute for BiotechnologycoreStrategic or Co-development Partner · 1 October 2024Karyosoft is backed by HudsonAlpha and participated in their AgTech Accelerator program. The partnership provides investment (up to $100,000), coaching, mentorship, and access to over 100 mentors and investors. HudsonAlpha's ecosystem supports Karyosoft's growth in the north Alabama agtech sector.
• HudsonAlpha Sequencing CentercoreTechnology or Integration · 1 January 2024Partnership for Illumina and PacBio sequencing services including DNA/RNA extractions, resequencing, RNA-Seq, ISO-Seq, HiFi sequencing, methylation analysis, and metagenome sequencing. Complete workflow from sample preparation to data generation.
• Solis AgrosciencescoreTechnology or Integration · 1 January 2024Partnership for Complete Genomics sequencing services including tailored DNA extractions for various tissue types (leaf, seeds, blood, semen, tissue), library creation, and 150bp paired-end sequencing with no clonal errors or index hopping.

Scale indicators4 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• Lifebit: Lifebit provides a federated genomics data and analytics platform with NGS pipelines and researcher-facing interfaces. Comparable to Karyosoft's Loci and Variants products in enabling secure genomic data exploration and analysis for research and translational genomics customers.
• Velsera (formerly Seven Bridges Genomics): Velsera provides a genomics data platform for secondary and tertiary NGS analytics, including variant calling, annotation, and multi-omics workflows. Closely aligned with Karyosoft's Loci/Variants/Variant Mining Studio stack in both product functionality and target customers (research consortia, pharma, agricultural genomics).
• Genestack: Genestack provides a genomics data management and analytics platform with a focus on multi-omics data exploration for research and pharma customers. Comparable to Karyosoft in delivering user-facing interfaces over standardized genomic data formats and pipelines.
• BC Platforms: BC Platforms delivers a genomics data platform integrating genomic and clinical data for research and precision medicine. Comparable to Karyosoft's data management and analytics offering, with overlap in serving research institutions and biobanks that require secure, in-house style deployments.
• Eagle Genomics: Eagle Genomics offers an AI-led platform for genomics and multi-omics data analytics targeted at consumer goods, agritech, and life sciences R&D. Most directly comparable to Karyosoft in the agricultural biotech/agrigenomics vertical and in delivering no-code or low-code analytics for scientific users.

Broad incumbents

• Benchling: Benchling is a cloud platform for life sciences R&D spanning molecular biology, process development, and analytics. While broader than Karyosoft, it increasingly competes for the same R&D budget at biotech customers and offers integrated NGS and sample/data management capabilities relevant to agrigenomics teams.
• DNAnexus: DNAnexus is a cloud-based genomics data management and analytics platform serving clinical, research, and pharmaceutical customers. Comparable to Karyosoft as a genomics workflow and analytics SaaS provider, but operating at significantly larger scale with broader multi-omics and clinical genomics focus.
• Qiagen (CLC Genomics Workbench / QIAGEN Digital Insights): Qiagen's bioinformatics unit offers CLC Genomics Workbench and related NGS analysis tools widely used in agricultural and clinical genomics. Directly competes with Karyosoft on variant discovery and NGS analytics for non-programming scientists, but as part of a much larger life sciences tools portfolio.

Emerging players

• Form Bio (formerly Desktop Genetics): Form Bio offers a bioinformatics workflow platform with pre-built pipelines for genomics and multi-omics analysis. Similar in spirit to Karyosoft's no-code genomics approach for life science researchers, though focused more on synthetic biology and gene therapy customers than agricultural biotech.

Others

• Solis Agrosciences: Solis Agrosciences is an agricultural contract research organization offering sequencing, genotyping, and bioinformatics services to plant biotech customers. Already a named Karyosoft sequencing partner, and adjacent rather than competitive, but representative of the broader ag-genomics services ecosystem Karyosoft operates in.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat4 records

Key risks6 records

Key highlights6 records

Customer concentration

• YouTubeyoutube.com/channel/UClpfeHh6yBPXK_aF6SLvDbQ?view_as=subscriber
• LinkedInlinkedin.com/company/karyosoft

Revenue estimate

Valuation estimate

Number of profiles

Profiles1 record

Funding overview

Funding rounds5 records

Investors4 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Karyosoft