NUANCE MEDICAL

What NUANCE MEDICAL does

Nuance Medical is a privately held Carlsbad, California-based medical device and pharmaceutical products company that markets a portfolio of topical anesthetics, cryotherapy systems, and silicone scar management products to healthcare professionals and consumers. The company's product lineup spans four portfolios — Pain Management (HurriCaine, Hurri-Freeze, InstaNumb, CryoDose TA), Scar & Skincare (Biodermis, BIOCORNEUM), Cryotherapy (CryoDose V at -70°C, CryoDose H at -55°C), and Dental (HurriCaine anesthetics, HurriView plaque indicators, HurriSeal desensitizers) — distributed through medical-surgical distributors and pharmacy wholesalers to over 25,000 offices and hospitals in the U.S. and 50+ countries internationally, with consumer SKUs also sold through Amazon and direct e-commerce.

The portfolio was assembled through three consecutive acquisitions: Biodermis (2022, silicone scar management), Beutlich Pharmaceuticals and the HurriCaine brand (2023, topical anesthetics), and BIOCORNEUM (April 2024, acquired from Sientra in a court-administered Chapter 11 sale). Proprietary technology differentiators include the first FDA-cleared HFO (hydrofluoroolefin) topical anesthetic spray with 99% lower global warming potential than HFC-based sprays (Hurri-Freeze, patent pending) and the first unit-dose non-aerosol topical anesthetic spray in both benzocaine and lidocaine formulations (HurriCaine ONE). The cryotherapy line delivers precision temperature control via touch-sensitive actuators with multiple dosing cones.

The go-to-market combines enterprise channels (medical-surgical distributors, pharmacy wholesalers, GPO contracts, direct regional sales representatives) with consumer channels (Amazon, DTC). Products are sold as one-time unit purchases across both OTC and professional/clinical pricing tiers. The company operates fulfillment facilities in California, Nevada, and Florida, is expanding operations in Southern Nevada under state tax incentive approval, and announced a partnership with the American Breast Cancer Foundation in March 2026 for oncology/recovery patient outreach. Recent product launches include HurriCaine ONE Lidocaine (June 2026, APIC 2026) and BIOCORNEUM SiliSilk (early 2026, winner of the 2026 NewBeauty Award for Best Scar Gel). Leadership includes a President, CFO, and VPs of Sales, Product Management, Operations, Marketing, and Quality/Regulatory. Revenue is not publicly disclosed.

Name

NUANCE MEDICAL

Legal name

Nuance Medical

Website

https://nuancemedical.com

Company type

Private

Founded year

2004

Operating status

Operating

Headcount range

1–10 employees

Short description

Nuance Medical is a Carlsbad, California-based medical device company that markets FDA-cleared topical anesthetics, cryotherapy systems, and silicone scar management products across its HurriCaine, Hurri-Freeze, Biodermis, BIOCORNEUM, and CryoDose brands, serving healthcare professionals in medical, dental, dermatology, and plastic surgery settings plus consumers in 50+ countries.

Ownership category

akta.pro rank

Product category

Medical Devices and Topical Anesthetics

NAICS

Pharmaceutical and Medicine Manufacturing (3254), Pharmaceutical Preparation Manufacturing (325412), Medical Equipment and Supplies Manufacturing (3391)

SIC

Pharmaceutical Preparations (2834), Surgical & Medical Instruments & Apparatus (3841)

akta.pro primary industry

Pain Management & Anesthesiology Pharmaceuticals (HLAIAAAN)

akta.pro secondary industries

Dermatology & Aesthetics Pharmaceuticals (HLAIAAAK), Personal Medical Devices & Home Diagnostics (Thermometers, Blood Pressure Monitors, Glucose Meters, Rapid Tests) (CRADAMAK)

Keywords

• Topical anesthetics
• Medical device manufacturing
• Scar management products
• Cryotherapy equipment
• Dental care products

Headquarters

HQ city

Carlsbad

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Operations, Personnel, Marketing or Sales, Technology or R&D, Others

Revenue model

1. Medical Device and Pharmaceutical Product Sales: Nuance Medical generates revenue through the sale of proprietary medical devices and pharmaceutical products including topical anesthetics, cryotherapy systems, and scar management products. Products are sold through multiple channels including medical-surgical distributors, pharmacy wholesalers, and direct e-commerce. The company operates with fulfillment facilities and sells into more than 50 countries through international distributor relationships.
2. Scar Management and Skincare Products: Revenue from premium silicone scar management products under Biodermis and BIOCORNEUM brands, sold to dermatologists, plastic surgeons, and directly to patients. Products include silicone sheeting, gels, ointments, and scar sticks.

Pricing tiers

Go-to-market motion3 records

Distribution channels5 records

Marketing channels6 records

Core offering

Nuance Medical manufactures and sells proprietary medical devices and pharmaceutical products for healthcare professionals and consumers, including topical anesthetic sprays, gels and liquids (benzocaine and lidocaine formulations), portable cryotherapy/cryosurgical systems, and professional-grade silicone scar management products. The portfolio spans brands such as HurriCaine, Hurri-Freeze, InstaNumb, CryoDose, Biodermis, and BIOCORNEUM, distributed through medical-surgical distributors, pharmacy wholesalers, e-commerce channels, and international distributors across 50+ countries.

Product overview

Nuance Medical is a healthcare company with a multi-brand portfolio organized into four product categories: Pain Management, Scar & Skincare, Cryotherapy, and Dental. The Pain Management portfolio includes topical anesthetic products under the HurriCaine, Hurri-Freeze, InstaNumb, and CryoDose TA brands, featuring various delivery formats (sprays, gels, liquids, unit-dose applicators) with active ingredients including Benzocaine and Lidocaine. The Scar & Skincare division encompasses BIOCORNEUM (acquired 2024 from Sientra) and Biodermis (acquired 2022), offering professional-grade silicone scar management products including gels, sheeting, and ointments. Cryotherapy products include CryoDose V (-70°C) and CryoDose H (-55°C) portable cryosurgical systems. Dental products include HurriCaine anesthetics, HurriView plaque indicators, and HurriSeal dentin desensitizers. The company also offers health supplements including Peridin-C and CEO-TWO laxatives. Products are sold through more than 50 countries via international distributors with fulfillment facilities in CA, NV, and FL.

Differentiator

Problem solved

Functional benefit

Brands

• BIOCORNEUM: Leading brand in advanced silicone gel scar treatment, trusted by physicians and patients for over a decade. Part of the Biodermis scar treatment portfolio.
• Biodermis
• HurriCaine
• CryoDose
• CryoDose V
• CryoDose H
• HurriCaine ONE
• Hurri-Freeze

Products and services

• Hurri-Freeze The first FDA-cleared HFO (hydrofluoroolefin) topical anesthetic spray for use on skin, minor open wounds, and intact oral mucous membranes. Available in Medium Stream and Mist Spray in 115 mL and 35 mL sizes with 360° spray. Provides instant cooling for pain associated with injections, IV starts, venipuncture, minor surgical/cosmetic procedures, and minor athletic injuries. For healthcare professionals.
• HurriCaine ONE Benzocaine
• HurriCaine ONE Lidocaine Single-use, unit-dose 4% Lidocaine non-aerosol spray combining lidocaine, BZK, and alcohol for temporary pain relief during minor procedures and injections. First and only unit-dose non-aerosol topical anesthetic spray. Fast onset within 5 minutes with duration of 10+ minutes. Features barcode tracking for BCMA protocols. For healthcare professionals.
• InstaNumb Safe and cost-effective HFC topical anesthetic spray (vapocoolant) for use on skin that temporarily controls pain. Available in Mist or Medium Stream in 115 mL and 35 mL sizes. Only HFC vapocoolant on GPO contract, FDA-cleared as substantially equivalent to Ethyl Chloride with more use indications including minor open wounds. For healthcare professionals.
• CryoDose TA HAZMAT-free topical anesthetic spray for use on skin, minor open wounds, and intact oral mucous membranes. Available in Mist or Medium Stream in 115 mL and 35 mL sizes. Clinically and therapeutically equivalent to hazardous Ethyl Chloride but safer with no inhalation precautions required. For healthcare professionals.
• HurriCaine Topical Anesthetic Spray Fast-acting 20% Benzocaine spray providing temporary relief from occasional minor irritation and pain associated with sore mouth and throat, canker sores, minor dental procedures, and minor injury of the mouth and gums. Available in 2 oz. can or spray kit with Original Wild Cherry flavor. For medical and dental professionals and OTC consumer use.
• HurriCaine Topical Anesthetic Gel Fast, temporary oral pain relief with 20% Benzocaine. Available in Original Wild Cherry, Piña Colada, Fresh Mint, Watermelon, and Strawberry flavors. Works within 30 seconds with no artificial dyes. For dental and medical professionals.
• HurriCaine Gel Unit Dose Unit-dose format of HurriCaine Topical Anesthetic Gel that helps eliminate cross-contamination. Available in Original Wild Cherry, Watermelon, and Strawberry flavors. Box of 60 individually wrapped unit doses. For dental and medical professionals.
• HurriCaine Topical Anesthetic Gel Prefilled Unit Dose Syringes Prefilled unit dose gel syringes with flexible plastic irrigation tips for gentle subgingival application. Specially formulated for root planing, scaling, and full mouth debridement. Available in Original Wild Cherry and Piña Colada flavors. Package contains 4 x 1.2 g prefilled syringes and 4 dispensing tips. For dental professionals.
• HurriCaine Topical Anesthetic Gel Pharmacy Pack Fast, temporary oral pain relief with 20% Benzocaine in Original Wild Cherry flavor. Pharmacy pack includes twelve 5.25 g tubes. For pharmacy retail and dental professional use.
• CryoDose V Portable precision cryosurgical treatment kit for non-invasive cryotherapy for skin lesions, warts, and cosmetic concerns. Features touch-sensitive actuator, reaches -70°C, includes six dosing cones with splash guards, arrow and round buds. Five-year shelf life. For healthcare professionals.
• CryoDose H Portable cryosurgical system treatment kit using dimethyl ether (DME) with button-style actuator dispensing via treatment buds reaching -55°C. Designed for treating benign lesions and skin problems. Three-year shelf life. For healthcare professionals.
• BIOCORNEUM Leading advanced scar treatment brand combining innovation with effectiveness for minimizing scar appearance and supporting healing at every stage. Includes SiliSilk premium silicone gel products. Trusted by physicians and patients for over a decade. For dermatologists, plastic surgeons, and patients.
• BIOCORNEUM SiliSilk Non-SPF silicone gel for scar recovery with lightweight, fast-drying formula. Forms a breathable, flexible layer supporting optimal healing for all-day wear. Winner of the 2026 NewBeauty Award for Best Scar Gel. Effective on new and existing scars. For dermatologists, plastic surgeons, and patients.
• Biodermis Scar Management Products Professional-grade silicone scar management products including compression foam, silicone sheeting, ointments, skin repair serums, and a patented on-the-go scar stick. Trusted by more than 7,000 plastic surgeons, dermatologists, and medical professionals worldwide. For dermatologists, plastic surgeons, and patients.
• HurriView Plaque Indicating Swabs Plaque indicating swabs for preventive dental care. Available in Snap-n-Go format with 72 count boxes. For dental professionals.
• HurriView II Plaque Indicating Swabs Second generation plaque indicating swabs for preventive dental care. Available in Snap-n-Go format with 72 count boxes. For dental professionals.
• HurriSeal Dentin Desensitizer Dental product used to treat and prevent dentinal hypersensitivity. Available in 12 mL bottle. For dental professionals.
• Dental Saliva pH Paper Dental saliva pH paper strip roll for monitoring oral acidity. For dental professionals.
• Peridin-C Vitamin C Supplement Vitamin C supplement with bioflavonoids effective in relieving hot flashes. Clinical study showed 53% complete relief and 34% reduction in menopausal hot flash symptoms. Available in bottles of 100 tablets. For consumer use.
• CEO-TWO Laxative Suppositories CO2 releasing laxative suppository combining Sodium Bicarbonate and Potassium Bitartrate in a Polyethylene Glycol Base. Produces carbon dioxide gas upon insertion creating reflex stimulation for bowel emptying within 30 minutes. Available in 2 ct., 6 ct., and 54 ct. boxes. For consumer use.

Quantifiable outcome

• Products tested to introduce no additional bioburden, meeting USP <61> and <62> microbiological quality standards
• +3 more outcomes

Named customers5 records

Segments4 records

Ideal customer profiles4 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature5 records

Partnerships

One partnership is on record.

• American Breast Cancer Foundation (ABCF)minorGTM or Marketing Partner · 11 March 2026Nuance Medical partnered with the American Breast Cancer Foundation to support patients throughout their healthcare and recovery journey. The partnership connects individuals with preventive care resources and recovery support. Nuance provides educational resources on scar recovery, guidance on post-procedure scar care options, and in-kind product support with an estimated annual retail value of up to $2,000 in complimentary scar care products for individuals navigating breast cancer recovery.

Scale indicators4 records

Recent moves7 records

Expansion highlights6 records

Direct peers

• ScarAway (Enaltus): Enaltus owns the ScarAway brand, the most direct competitor in retail silicone scar sheets and gels. Directly comparable to Nuance's Biodermis and BIOCORNEUM lines in product category, target consumer, and clinical positioning.
• Moberg Pharma AB: Swedish specialty pharma focused on topical treatments including the Kelo-cote silicone scar gel franchise. Comparable to Nuance in scar-treatment category, dermatology channel, and premium OTC positioning.
• Ferndale Healthcare: U.S. specialty pharma marketing topical dermatology and surgical recovery products to clinicians. Closely comparable to Nuance in niche topical pharma distribution model and professional-channel GTM.

Broad incumbents

• Colgate-Palmolive Company: Global oral care incumbent with Colgate, elmex, and Meridol franchises. Directly comparable to Nuance's dental portfolio (HurriCaine, HurriView plaque swabs) at the broad category level, though far larger and more diversified.
• Perrigo Company: Leading OTC store-brand and topical pharmaceutical manufacturer with deep retail and pharmacy distribution. Comparable to Nuance's OTC topical anesthetic and pharmacy-wholesaler channel strategy.
• Church & Dwight Co., Inc. Major U.S. consumer health company with brands like Batiste, Orajel (topical oral anesthetic — direct overlap with HurriCaine), and Arm & Hammer. Highly comparable OTC, oral-care, and consumer-retail model to Nuance's broader GTM.
• Bausch Health Companies (Ortho Dermatologics): Specialty pharma with significant dermatology and aesthetics franchises including topical Rx and aesthetics products. Comparable to Nuance's dermatology/aesthetics scar treatment and topical channels at the portfolio level.
• Beiersdorf AG: Global skin care company behind Eucerin, Hansaplast/Elastoplast (scar treatment), and La Prairie. Direct overlap with Nuance's scar-care and dermatology skincare portfolio through Hansaplast wound/scar line.
• Prestige Consumer Healthcare: OTC consumer healthcare roll-up with franchises in oral care, dermatology, and topical pain relief. Highly comparable business model to Nuance — acquiring and scaling niche OTC healthcare brands through mass retail.
• Haleon plc: Global consumer healthcare spinoff of GSK with leading oral care (Sensodyne, Aquafresh), pain relief (Voltaren), and topical health brands. Comparable to Nuance in OTC topical anesthetics, oral care, and international distribution scale.

Market position

Strengths5 records

Weaknesses4 records

Competitive moat4 records

Key risks6 records

Key highlights7 records

Customer concentration

• YouTubeyoutube.com/@NuanceMedicalLLC
• Facebookfacebook.com/profile.php?id=61576310917406
• LinkedInlinkedin.com/company/nuancemedical

Revenue estimate

Valuation estimate

Number of profiles

Profiles7 records

Subsidiaries3 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A1 record

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about NUANCE MEDICAL