Dynamic42
Dynamic42 GmbH develops and sells immunocompetent organ-on-chip platforms (DynamicOrgan® System) and provides contract research services to pharmaceutical, biotech, and academic customers for preclinical drug testing, toxicology, and human disease modeling.
- Company typePrivate
- Founded2018
- HeadquartersJena, Germany
- Headcount11–50
- GTM typeB2B
- OfferingHardware or Manufacturing
What Dynamic42 does
Dynamic42 GmbH is a German biotechnology company founded in 2018 as a spin-off from the Integrated Research and Treatment Center for Sepsis Control and Care (CSCC) at the University Hospital Jena. The company develops and commercializes immunocompetent organ-on-chip (microfluidic biochip) in vitro test systems that replicate key functions of human organs, including vasculature, immune cells, microbiome, and pathogens, for preclinical drug testing, toxicology, and disease modeling applications.
The company's core platform is the DynamicOrgan® System, a modular organ-on-chip architecture featuring biochips with low compound adsorption, integrated pumps, and a portfolio of add-on kits: 2-Channel, 3-Channel, Spheroid, Tumor Microenvironment (TME), TEER-Sensor (embedded gold electrodes for barrier integrity), and O2-Sensor (developed with PyroScience) kits. The platform supports multiple organ models (gut, liver, lung, vasculature, cancer, spheroid) and multi-organ configurations such as gut-liver axis. Manufacturing and services operate under ISO 9001 and ISO 13485 quality standards, and Dynamic42 is a founding member of IAMPS, Europe's first industry association for microphysiological systems providers.
Dynamic42 generates revenue through three streams: (1) hardware sales of the DynamicOrgan System and modular kits, (2) fee-for-service Contract Research (CRO) offerings including toxicology screenings, lead identification/optimization, and custom in vitro model development, and (3) the Dynamic42 Academy training programs for organ-on-chip users. The customer base spans pharmaceutical and chemical companies (BASF, Sanofi via iDEA-iTECH Award, Bayer Consumer Health), academic and research institutions (Jena University Hospital, Leibniz-HKI, HZI Braunschweig, MLU Halle-Wittenberg, Freie Universität Berlin), and CROs. Distribution combines direct sales from Jena headquarters with regional distributors (Axon Lab AG for Central Europe, Ohio Lumex for the U.S./Canada) as the company expands internationally, including a planned U.S. market entry supported by a mid-seven-figure Series A round closed in June 2023.
Dynamic42 firmographics
Firmographics- Name
- Dynamic42
- Legal name
- Dynamic42 GmbH
- Website
- https://dynamic42.com
- Company type
- Private
- Founded year
- 2018
- Operating status
- Operating
- Headcount range
- 11–50 employees
- Short description
- Dynamic42 GmbH develops and sells immunocompetent organ-on-chip platforms (DynamicOrgan® System) and provides contract research services to pharmaceutical, biotech, and academic customers for preclinical drug testing, toxicology, and human disease modeling.
- Ownership category
- akta.pro rank
Dynamic42 industry classification
Industry- Product category
- Organ-on-chip Technology
- NAICS
- Research and Development in Biotechnology (except Nanobiotechnology) (541714), Electromedical and Electrotherapeutic Apparatus Manufacturing (334510)
- SIC
- Electromedical & Electrotherapeutic Apparatus (3845)
- akta.pro primary industry
- Organoids & Organ-on-Chip (regenerative models) (HLAAAGAD)
- akta.pro secondary industry
- In Vitro Model Systems & Organoid Platforms (iPSC/organoids, microphysiological systems) (HLAAAIAJ)
Keywords
Where Dynamic42 is headquartered
LocationHeadquarters
- HQ city
- Jena
- HQ country
- Germany
- HQ region
- Europe
Offices2 records
Markets served
Dynamic42 business model
Business model- GTM type
- B2B
- Offering type
- Hardware or Manufacturing
- Cost components
- Technology or R&D, Personnel, Operations, Marketing or Sales, Infrastructure, Supply Chain, Others
Revenue model
- DynamicOrgan System and Kits Sales: Sale of the DynamicOrgan System platform, biochips, and various developer, sensor, and reagent kits including 2-Channel Kit, 3-Channel Kit, Spheroid Kit, TME Kit, TEER-Sensor Kit, and O2-Sensor Kit.
- Contract Research Services (CRO): Fee-for-service offerings including toxicology screenings, lead identification and optimization, and custom in vitro model development using the company's organ-on-chip platforms.
- Dynamic42 Academy Training: On-site and online training courses through the Dynamic42 Academy for researchers wanting to integrate organ-on-chip technology into their lab work.
Go-to-market motion3 records
Distribution channels4 records
Marketing channels7 records
Dynamic42 product offering
Product offeringCore offering
Dynamic42 develops and sells the DynamicOrgan® System, an organ-on-chip (microfluidic biochip) platform with modular kits (2-Channel, 3-Channel, Spheroid, TME, TEER-Sensor, O2-Sensor) that recreate human organ functions including vascularization, immune cells, microbiome, and pathogens. The company also offers fee-for-service contract research (toxicology screenings, lead optimization, custom model development) and training via the Dynamic42 Academy to pharmaceutical, biotech, and academic customers.
Product overview
Dynamic42 offers the DynamicOrgan® System as its core platform for organ-on-chip technology, accompanied by a modular kit portfolio including 2-Channel, 3-Channel, Spheroid, TME (Tumor Microenvironment), TEER-Sensor, and O2-Sensor kits. These kits are designed to work with the DynamicOrgan® System to create various organ models (Gut, Liver, Lung, Vasculature, Spheroid, Cancer-on-Chip). The platform is designed for immunocompetent infection and disease models with vascularization and organ-specific perfusion capabilities. The company also provides Contract Research Services for toxicology screenings, lead optimization, and custom model development, along with Dynamic42 Academy training programs.
Differentiator
Problem solved
Functional benefit
Brands
- DynamicOrgan® System: User-friendly organ-on-chip system with ISO-certified, medical-grade standards for creating diverse organ models including gut, lung, liver, vasculature, cancer, and spheroid-on-chip.
Products and services
- DynamicOrgan® System Core organ-on-chip platform that enables physiological cell and tissue culture. The system includes biochips and a pump that integrate seamlessly into existing workflows for creating human disease and infection models with vascularization, immune cells, microbiome, and pathogens. Sold to pharmaceutical, biotech, and academic researchers.
- DynamicOrgan® 2-Channel Kit Biochip kit with two channels for creating in vitro human disease and infection models in a dynamically perfused environment, sold separately to laboratories building organ-on-chip models.
- DynamicOrgan® 2-Channel Kit – precious Specialized version of the 2-channel kit designed for working with precious or limited cell samples; sold as a standalone SKU.
- DynamicOrgan® 3-Channel Kit Three-channel biochip kit that enables more complex multi-layer tissue models and co-culture setups, sold as a standalone product for advanced organ-on-chip applications.
- DynamicOrgan® Spheroid Kit Kit designed for spheroid culture within the DynamicOrgan System, enabling 3D tumor and tissue model development. Sold to researchers building 3D spheroid-on-chip applications.
- DynamicOrgan® TME Kit Tumor Microenvironment Kit for cancer research, enabling biomimetic matrix integration in 3-channel biochips for advanced cancer models with stromal and immune components.
- DynamicOrgan® TEER-Sensor Kit Sensor kit enabling integrated Trans-Epithelial/Trans-Endothelial Electrical Resistance (TEER) measurement, with embedded gold electrodes for real-time, non-invasive barrier integrity monitoring within the biochip architecture.
- DynamicOrgan® O2-Sensor Kit Sensor kit for real-time oxygen tracking in organ-on-chip models, developed in collaboration with PyroScience, enabling monitoring of oxygen levels experienced by cells in the microfluidic environment.
- Contract Research Services Fee-for-service contract research offerings including toxicology screenings, lead identification and optimization, and custom in vitro model development using Dynamic42's immune-competent organ models; offered directly to pharmaceutical, biotech, and chemical customers.
- Dynamic42 Academy Training program offering on-site and online courses for learning organ-on-chip technology, including chip handling, cell culture, and organ model development. Available to researchers integrating organ-on-chip technology into their laboratory work.
Quantifiable outcome
- Verifying recycling process of therapeutic antibodies without compromising cell viability or tissue integrity in liver-on-chip model
- +2 more outcomes
Companies that use Dynamic42
Customer profileNamed customers8 records
Segments3 records
Ideal customer profiles2 records
Dynamic42 technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Integration2 records
Feature5 records
Dynamic42 partnerships and signals
Strategic signalPartnerships
Nine partnerships are on record, tiered core and minor.
- EPO Experimental Pharmacology & Oncology Berlin-Buch GmbHcoreStrategic collaboration to integrate organ-on-chip technologies into preclinical glioblastoma research. First joint projects target glioblastoma and blood-brain barrier (BBB) using Dynamic42's human-based BBB-on-chip model. The partnership includes model development, commercialization strategies, and scientific exchange between researchers from both organizations. Joint presentation at AACR Annual Meeting 2026.
- IAMPS (Industry Alliance for Microphysiological Systems)coreWorld's first industry association dedicated to representing microphysiological systems providers across Europe. Founding member along with Alveolix, BiomimX, Chiron, InSphero, MIMETAS, NETRI, React4Life, and TissUse. IAMPS will work to increase regulatory acceptance of MPS data, create data-sharing platforms, and advance device standardization. Expected to become operational Q2 2026.
- Heinrich Heine University Düsseldorf (Institute of Pharmaceutical Biology and Biotechnology)coreCollaboration to develop tumour-on-chip model replicating pancreatic ductal adenocarcinoma (PDAC) microenvironment. Joint research with Prof. Dr. Nicole Teusch's team. Results published in Lab on a Chip journal. Model tested FDA-approved drug Vorinostat on PDAC spheroids.
- ATHANA Alliance Partners (SmartDyeLivery, Jena Bioscience, BioControl Jena, Hapila, Dyomics, Leibniz-HKI, Jena University Hospital)coreRUBIN Alliance (ATHANA - antifungal therapy approaches with nanoparticle-based targeting) developing innovative therapeutic approaches for infectious diseases, particularly fungal infections. BMBF funding of almost 6 million euros over three years. Dynamic42 contributes organ-on-chip models for infection research. Alliance covers entire value chain for nanoparticle-based pharmaceutical development.
- Sanofi (iDEA-iTECH Award Program)coreFunded project investigating pharmacokinetic properties of drugs in a biochip-based liver organ model. Analysis of recycling, viability and vascular permeability of two frequently used monoclonal antibodies (mAbs). Initial results presented at MPS World Summit and EUROoCS annual meeting.
- Axon Lab AGcoreRegional distribution partner for Switzerland, Slovakia, Slovenia, Poland, and Croatia handling product requests for Dynamic42's organ-on-chip products and systems.
- Ohio LumexcoreRegional distribution partner for the United States and Canada handling product requests for Dynamic42's organ-on-chip products and systems.
- MPSlabsminorCollaboration on multi-organ-on-chip model for improving drug safety during pregnancy. Joint webinar and development of interactive computational software to understand blood-placenta-barrier crossing.
- Wolfgang Kintzel (Strategic Advisor)coreInternational experienced manager with over 35 years in Life Sciences industry. Engaged as strategic advisor to support business model scaling and planned U.S. market entry. Previously served as Sparring partner for strategic questions on product positioning, commercialization, and internationalization.
Scale indicators5 records
Recent moves7 records
Expansion highlights7 records
Dynamic42 competitors and assessment
Company assessmentDirect peers
- MIMETAS: Dutch organ-on-chip company offering the OrganoPlate platform for 3D tissue models and high-throughput screening. Closest direct competitor in European microphysiological systems and a fellow IAMPS founding member.
- InSphero: Swiss provider of 3D organ-on-chip and organoid models for drug discovery and toxicology, with strong pharma services revenue. Another IAMPS founding member and direct head-to-head competitor in European MPS.
- TissUse: Berlin-based organ-on-chip company focused on multi-organ (MOC) and HUMIMIC platforms. Same geographic base as Dynamic42, fellow IAMPS founding member, and competes on multi-organ-chip applications.
- Emulate: US-based organ-on-chip leader (founded out of Wyss Institute) offering the Organ-Chip platform and Human Emulation System. Larger, better-capitalized competitor addressing the same pharma customer base.
- CN Bio: UK-based organ-on-chip company offering the PhysioMimix platform for single- and multi-organ models, with strong pharma and CRO partnerships. Directly comparable product positioning and customer base.
- Alveolix: Swiss lung-on-chip specialist serving respiratory disease modeling, drug discovery, and inhalation toxicology. Fellow IAMPS founding member with narrower organ focus.
- NETRI: French organ-on-chip company providing microfluidic devices for neuro-inflammation and industrial applications. Fellow IAMPS founding member with overlapping pharma/biotech customer base.
- BiomimX: Italian organ-on-chip company focused on immune-competent disease models using proprietary uBeat platform. Fellow IAMPS founding member with similar immunocompetence angle.
- Kirkstall: UK-based organ-on-chip company offering the Quasi Vivo multi-organ flow system for ADMET and toxicology. Competes in adjacent organ-on-chip platforms for pharma research.
- React4Life: Italian organ-on-chip company providing the MIVO (Multi-In Vitro Organ) platform for drug testing. Fellow IAMPS founding member with overlapping pharma services and 3D tissue model offerings.
Market position
Strengths4 records
Weaknesses4 records
Competitive moat6 records
Key risks5 records
Key highlights6 records
Customer concentration
Dynamic42 social profiles
Digital presenceDynamic42 compliance and trust
Trust signalCompliance2 records
Dynamic42 financial estimates
Financial estimateRevenue estimate
Valuation estimate
Dynamic42 leadership team
Management profileNumber of profiles
Profiles5 records
Dynamic42 funding detail
Funding detailFunding overview
Funding rounds2 records
Investors3 records
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Dynamic42 M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Dynamic42
What does Dynamic42 do?
Dynamic42 develops and sells the DynamicOrgan® System, an organ-on-chip (microfluidic biochip) platform with modular kits (2-Channel, 3-Channel, Spheroid, TME, TEER-Sensor, O2-Sensor) that recreate human organ functions including vascularization, immune cells, microbiome, and pathogens. The company also offers fee-for-service contract research (toxicology screenings, lead optimization, custom model development) and training via the Dynamic42 Academy to pharmaceutical, biotech, and academic customers.
Is Dynamic42 a public or private company?
Dynamic42 is a private company. It is classified as venture growth investor backed and is currently operating.
When was Dynamic42 founded?
Dynamic42 was founded in 2018. It employs 11 to 50 people.
Where is Dynamic42 based?
Dynamic42 is headquartered in Jena, Germany, in the Europe region.
How does Dynamic42 make money?
Three revenue lines are on record. DynamicOrgan System and Kits Sales are the primary driver. The others are contract Research Services (CRO) and dynamic42 Academy Training.
Who are Dynamic42's main competitors?
Direct peers on record are MIMETAS, InSphero, TissUse, Emulate, CN Bio, Alveolix, NETRI, BiomimX, Kirkstall and React4Life.
Does Dynamic42 have an API?
No public API is recorded for Dynamic42.
What industry is Dynamic42 in?
Dynamic42's product category is Organ-on-chip Technology. Its primary akta.pro industry code is HLAAAGAD, Organoids & Organ-on-Chip (regenerative models), with a secondary code of HLAAAIAJ, In Vitro Model Systems & Organoid Platforms (iPSC/organoids, microphysiological systems). Its NAICS code is 541714 and its SIC code is 3845.