Sentieon
- Company typePrivate
- Founded2017
- HeadquartersMountain View, United States
- Headcount1–10
- GTM typeB2B
- OfferingSoftware
Sentieon firmographics
Firmographics- Name
- Sentieon
- Legal name
- Sentieon, Inc.
- Website
- https://sentieon.com
- Company type
- Private
- Founded year
- 2017
- Operating status
- Operating
- Headcount range
- 1–10 employees
- Ownership category
- akta.pro rank
Sentieon industry classification
Industry- Product category
- Bioinformatics Software
- NAICS
- Computer Systems Design and Related Services (54151), Computing Infrastructure Providers, Data Processing, Web Hosting, and Related Services (51821), Research and Development in Biotechnology (except Nanobiotechnology) (541714)
- SIC
- Services-Prepackaged Software (7372), Services-Computer Programming, Data Processing, Etc. (7370), Services-Commercial Physical & Biological Research (8731)
- akta.pro primary industry
- Bioinformatics & Multi-omics Analysis Software (HLAGAJAD)
- akta.pro secondary industry
- Multiplex & High-Throughput Diagnostics Platforms (microarrays, digital PCR, lab automation-enabled assays) (HLAAALAL)
Keywords
Where Sentieon is headquartered
LocationHeadquarters
- HQ city
- Mountain View
- HQ country
- United States
- HQ region
- North America
Offices1 record
Markets served
Sentieon business model
Business model- GTM type
- B2B
- Offering type
- Software
- Cost components
- Personnel, Technology or R&D, Operations, Marketing or Sales
Revenue model
- Software Licenses: Annual time-based licenses sold as flat-fee subscriptions priced on estimated usage. Licenses provide access to all software capabilities. Includes technical support and updates for license duration. License server model allows concurrent use across multiple nodes or clusters.
- Academic Licensing: Initial free tier available for qualified academic institutions, with paid academic pricing licenses available for continued use beyond the free evaluation period.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Subscription | Annual | Annual Time-Based License |
| Freemium | Annual | Academic Free Tier |
| Subscription | Annual | Enterprise License with Concurrent Usage |
Go-to-market motion2 records
Distribution channels5 records
Marketing channels6 records
Sentieon product offering
Product offeringCore offering
Sentieon develops and supplies accelerated bioinformatics secondary analysis software tools for processing genomic sequencing data. Its CPU-accelerated tools function as drop-in replacements or improvements for BWA-MEM, STAR, Minimap2, GATK, and Mutect2, processing FASTQ-BAM-VCF-GVCF formats. Core products include DNAscope (ML-powered germline variant calling), DNAseq (GATK-compliant pipeline), TNscope/TNseq (somatic variant calling), and CNVscope (copy number detection), all running on standard x86 and ARM servers without GPUs.
Product overview
Sentieon develops and supplies accelerated bioinformatics secondary analysis tools for processing genomics data. The core product portfolio includes DNAscope (machine learning-powered germline variant calling for short and long reads), DNAseq (GATK-compliant germline pipeline), TNscope/TNseq (somatic variant calling), and specialized sub-products like DNAscope Pangenome (graph reference), DNAscope LongRead, DNAscope Hybrid (combined short/long reads), and CNVscope (copy number variation). Supporting modules include accelerated aligners (BWA, STAR, Minimap2), deduplication tools with UMI handling, BQSR/VQSR recalibration tools, and GVCFtyper for large cohort joint calling. The software is CPU-accelerated (x86 and ARM), runs on standard servers without GPUs, and processes FASTQ-BAM-VCF-GVCF formats with award-winning accuracy.
Differentiator
Problem solved
Functional benefit
Brands
- DNAscope: Germline variant calling pipeline supporting short reads and long reads from all mainstream sequencing platforms. Features improved accuracy through better active region detection, more powerful local assembly, and machine learning models.
- DNAseq
- TNscope
- TNseq
- DNAscope Pangenome
- DNAscope LongRead
- DNAscope Hybrid
- CNVscope
Products and services
- DNAscope Primary germline variant calling pipeline supporting short reads and long reads from all mainstream sequencing platforms, using machine learning models for improved accuracy in SNP, Indel, SV, and CNV detection for genomics and clinical research customers.
- DNAseq GATK-compliant germline variant calling pipeline for short reads that provides drop-in replacement for GATK with identical output and faster processing for genomics researchers and clinical labs.
- TNscope Somatic variant calling pipeline for short reads with UMI processing support, calling SNP, Indel, and structural variants in tumor-normal or tumor-only analysis for cancer research and clinical oncology customers.
- TNseq GATK-compliant somatic variant calling pipeline for short reads that provides drop-in replacement for GATK Mutect2 with identical output for cancer genomics and clinical oncology customers.
- DNAscope Pangenome DNAscope variant calling pipeline using graph reference genome (pangenome, including HPRC pangenomes) instead of linear reference, enabling germline calling for SNP, Indel, SV, CNV, and segmental duplication genes for advanced genomics research customers.
- DNAscope LongRead DNAscope variant calling pipeline optimized for long-read sequencing data from PacBio and Oxford Nanopore, supporting SNP, Indel, and SV detection for long-read sequencing customers.
- DNAscope Hybrid Novel integrated pipeline combining short- and long-read data from the same sample, performing integrated alignment and variant calling and outputting SNP/Indel/SV/CNV from a single pipeline for hybrid-sequencing genomics customers.
- CNVscope Germline copy number variant calling tool for whole-genome sequencing using machine learning models, outputting VCF files with copy-number state annotations (CN=0 to CN=4) for clinical and research genomics customers.
- GVCFtyper Large-scale cohort joint calling tool for processing multiple gVCF files into multi-sample VCF, supporting distributed processing across multiple servers for population-scale genomics customers.
Quantifiable outcome
- 30x WGS processing time reduced to under 30 minutes
- +7 more outcomes
Companies that use Sentieon
Customer profileNamed customers6 records
Segments6 records
Ideal customer profiles5 records
Sentieon technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Integration5 records
AI capability4 records
Feature9 records
Sentieon partnerships and signals
Strategic signalPartnerships
Nine partnerships are on record, tiered core and minor.
- Microsoft AzurecoreMicrosoft Azure cloud platform integration with Sentieon software. Sentieon is featured on Microsoft Healthcare Blog demonstrating $0.33 whole genome analysis cost on Azure spot instances. Azure deployment guides available for Sentieon customers.
- AMDcoreAMD partnered with Sentieon to publish white paper demonstrating 12x cheaper and faster long reads analysis on 4th Gen AMD EPYC processors. Joint optimization of Sentieon software for AMD hardware.
- ARM / AWS GravitoncoreARM HPC Blog highlights Sentieon software support for AWS Graviton and other ARM CPUs. Partnership enables ARM-based cloud deployment options for customers.
- IntelcoreIntel Health Analytics customer case study featuring Berlin Institute of Health using Sentieon for ONT long-read single-cell rapid analysis. Joint performance validation on Intel platforms.
- Dell TechnologiescoreDell Technologies published whitepaper providing direct comparison between Sentieon and NVIDIA Parabricks on short and long reads. Joint benchmark validation.
- DNAnexuscoreDNAnexus genomics cloud platform offers Sentieon software as integrated analysis solution. Customers can access Sentieon tools through DNAnexus platform.
- Amazon HealthOmicscoreAWS HealthOmics service integrates Sentieon pipelines for customer genomics analysis workflows on AWS infrastructure.
- Golden HelixminorGolden Helix genomics analysis platform integrates Sentieon tools for their customers' sequencing data processing needs.
- Google Cloud PlatformcoreArticle evaluating Sentieon DNASeq and Clara Parabricks Germline performance on Google Cloud Platform in clinical context, with deployment tutorial for healthcare settings.
Scale indicators13 records
Recent moves6 records
Expansion highlights5 records
Sentieon competitors and assessment
Company assessmentDirect peers
- NVIDIA Parabricks: GPU-accelerated genomics secondary analysis suite from NVIDIA. The most direct competitor to Sentieon, with Dell benchmarking the two head-to-head; both target germline/somatic variant calling pipelines for clinical and research customers.
- Google DeepVariant: Open-source deep-learning-based variant caller from Google, deployed by major genomics service providers. Competes with Sentieon's DNAscope on accuracy, especially for long-read data, and is the leading free alternative.
- Broad Institute GATK: The open-source gold standard for germline and somatic variant calling. Sentieon's DNAseq and TNseq pipelines are explicitly designed as drop-in replacements for GATK, making this the most important free benchmark.
Broad incumbents
- Illumina DRAGEN: Illumina's hardware-accelerated (FPGA) secondary analysis platform, tightly bundled with Illumina sequencers. Comparable to Sentieon on germline/somatic variant calling and the dominant choice for Illumina-only clinical labs.
- DNAnexus: Cloud genomics analysis platform that both distributes Sentieon and competes by offering integrated pipelines. Comparable because it occupies the same genomic analysis workflow layer, just delivered as a platform rather than a tool.
- Golden Helix: Genomics analysis software vendor serving clinical and research customers; distributes Sentieon within its platform. Comparable as a workflow-level genomics software provider with overlapping customer base.
- Velsera: Genomics clinical interpretation platform formed from the merger of Seven Bridges, PierianDx, and others. Comparable as a genomics workflow platform targeting the same pharma, hospital, and clinical diagnostic customer segments.
Emerging players
- Fabric Genomics: Clinical variant interpretation platform for hereditary disease and oncology. Comparable because it sits adjacent to Sentieon in the clinical genomics workflow, absorbing secondary analysis into interpretation reporting.
- Gencove: Low-pass whole genome sequencing and imputation platform, profiled alongside Sentieon in the ARM/AWS Graviton partnership. Comparable as a cloud-native genomics analysis provider serving population-scale genomics customers.
- Lifebit: Cloud genomics and biomedical data platform offering federated analysis pipelines. Comparable as an enterprise genomics analysis software vendor competing for the same pharma and national genomics program budgets.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat5 records
Key risks6 records
Key highlights7 records
Customer concentration
Sentieon social profiles
Digital presenceSentieon compliance and trust
Trust signalCompliance2 records
Sentieon financial estimates
Financial estimateRevenue estimate
Valuation estimate
Sentieon leadership team
Management profileNumber of profiles
Profiles1 record
Sentieon funding detail
Funding detailFunding overview
Funding rounds2 records
Investors12 records
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Sentieon M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Sentieon
What does Sentieon do?
Sentieon develops and supplies accelerated bioinformatics secondary analysis software tools for processing genomic sequencing data. Its CPU-accelerated tools function as drop-in replacements or improvements for BWA-MEM, STAR, Minimap2, GATK, and Mutect2, processing FASTQ-BAM-VCF-GVCF formats. Core products include DNAscope (ML-powered germline variant calling), DNAseq (GATK-compliant pipeline), TNscope/TNseq (somatic variant calling), and CNVscope (copy number detection), all running on standard x86 and ARM servers without GPUs.
Is Sentieon a public or private company?
Sentieon is a private company. It is classified as venture growth investor backed and is currently operating.
When was Sentieon founded?
Sentieon was founded in 2017. It employs 1 to 10 people.
Where is Sentieon based?
Sentieon is headquartered in Mountain View, United States, in the North America region.
How does Sentieon make money?
Two revenue lines are on record. Software Licenses are the primary driver. The others are academic Licensing.
Who are Sentieon's main competitors?
Direct peers on record are NVIDIA Parabricks, Google DeepVariant and Broad Institute GATK. Broad incumbents are Illumina DRAGEN, DNAnexus, Golden Helix and Velsera. Emerging players are Fabric Genomics, Gencove and Lifebit.
Does Sentieon have an API?
No public API is recorded for Sentieon.
What industry is Sentieon in?
Sentieon's product category is Bioinformatics Software. Its primary akta.pro industry code is HLAGAJAD, Bioinformatics & Multi-omics Analysis Software, with a secondary code of HLAAALAL, Multiplex & High-Throughput Diagnostics Platforms (microarrays, digital PCR, lab automation-enabled assays). Its NAICS code is 54151 and its SIC code is 7372.