Structura Biotechnology

What Structura Biotechnology does

Structura Biotechnology Inc. (also operating as Structura Bio) is a Toronto-based, privately held scientific software company that develops CryoSPARC, an end-to-end computational platform for single-particle cryo-electron microscopy (cryo-EM). Founded in 2016, the company applies computer vision, machine learning, and 3D reconstruction algorithms to convert cryo-EM image data into high-resolution atomic structures of proteins and protein-ligand complexes, with particular strength on challenging samples such as membrane proteins, GPCRs, ion channels, and flexible or heterogeneous complexes. Its product portfolio comprises the core CryoSPARC platform plus two add-on modules: CryoSPARC Live, which performs real-time data processing and quality assessment during acquisition, and Embedded CryoSPARC Live, a version embedded directly onto Thermo Scientific cryo-TEM hardware in collaboration with Thermo Fisher Scientific and integrated with CryoFlow and Smart EPU software.

Name

Structura Biotechnology

Legal name

Structura Biotechnology Inc.

Website

https://structura.bio

Company type

Private

Founded year

2016

Operating status

Operating

Headcount range

11–50 employees

Short description

Structura Biotechnology develops CryoSPARC, an AI-driven cryo-EM image analysis platform used by academic labs and pharmaceutical companies for high-resolution 3D structure determination in drug discovery and life science research.

Ownership category

akta.pro rank

Product category

Structural Biology Software

akta.pro primary industry

Protein Interaction & Structural Biology Platforms (cryo-EM, X-ray, NMR, biophysics) (HLAAAIAH)

Keywords

• Cryo-EM software
• Structural biology software
• Drug discovery platforms
• Single-particle analysis
• 3D structure reconstruction

Headquarters

HQ city

Toronto

HQ country

Canada

HQ region

North America

Markets served

GTM type

B2B

Offering type

Software

Cost components

Personnel, Technology or R&D, Operations, Marketing or Sales

Revenue model

1. CryoSPARC Software Licenses: Enterprise software licensing for CryoSPARC and CryoSPARC Live platforms. The company develops and sells computational solutions for cryo-EM image analysis, providing end-to-end software platforms for single-particle cryo-EM data processing. Revenue is generated through software licenses to academic institutions and pharmaceutical companies.

Go-to-market motion1 record

Distribution channels2 records

Marketing channels4 records

Core offering

Structura Biotechnology develops and sells CryoSPARC, an end-to-end computational platform for single-particle cryo-electron microscopy (cryo-EM) image analysis and 3D reconstruction of proteins, protein-ligand complexes, and other biological molecules. The platform is augmented by CryoSPARC Live for real-time data processing during acquisition and Embedded CryoSPARC Live for direct integration with Thermo Scientific cryo-TEM hardware.

Product overview

Structura Biotechnology offers a platform-plus-modules product architecture centered on CryoSPARC, a comprehensive end-to-end single-particle cryo-EM processing platform. Two add-on modules extend the core platform: CryoSPARC Live enables real-time cryo-EM data processing and quality assessment during data acquisition sessions, while Embedded CryoSPARC Live extends that real-time capability by embedding it directly onto Thermo Scientific cryo-TEM microscope hardware for in-situ analysis during collection.

Differentiator

Problem solved

Functional benefit

Brands

• CryoSPARC: End-to-end platform for single-particle cryo-EM, combining cutting-edge 3D reconstruction algorithms with an intuitive, streamlined workflow for high-resolution structure determination.
• CryoSPARC Live
• Embedded CryoSPARC Live

Products and services

• CryoSPARC An end-to-end platform for single-particle cryo-EM combining cutting-edge 3D reconstruction algorithms with an intuitive workflow. It enables high-resolution structure determination from motion correction to atomic resolution, including challenging samples such as membrane proteins, GPCRs, ion channels, and flexible or heterogeneous complexes. Used by academic research labs and pharmaceutical companies.
• CryoSPARC Live

Quantifiable outcome

• Thousands of structures solved by users worldwide using CryoSPARC

Named customers2 records

Segments2 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration3 records

AI capability5 records

Feature6 records

Partnerships

One partnership is on record.

• Thermo Fisher ScientificcoreTechnology or IntegrationIn collaboration with Thermo Fisher Scientific, Structura Biotechnology developed Embedded CryoSPARC Live — a version of CryoSPARC Live designed for seamless integration with Thermo Scientific cryo-TEM systems. It is embedded directly onto microscope hardware and works in tandem with Thermo Scientific CryoFlow and Smart EPU software, bringing real-time data analysis directly into the cryo-EM environment. This is a flagship OEM/embedded integration partnership.

Scale indicators1 record

Recent moves6 records

Expansion highlights5 records

Broad incumbents

• OpenEye Scientific (Cadence Design Systems): Molecular modeling and computational chemistry software suite serving pharma drug discovery. Competes in adjacent workflows for structure-based drug design and computational chemistry used by similar pharma customers.
• Thermo Fisher Scientific: Dominant cryo-EM instrument vendor and Structura's OEM partner. Operates the broader cryo-EM ecosystem (cryo-TEMs, CryoFlow, Smart EPU software) and represents both a partner and a potential competitive threat if they vertically integrate software.
• Schrödinger: Public computational chemistry and molecular simulation platform serving pharma drug discovery. Adjacent competitor in structure-based drug design workflows, with broader scope across molecular modeling beyond cryo-EM.

Regional players

• JEOL: Japanese manufacturer of cryo-EM instruments and electron microscopes with global scientific markets. Represents an alternative hardware ecosystem that could partner with or compete against Structura's software outside the Thermo Fisher footprint.

Emerging players

• Phenix: Software suite for macromolecular structure determination including crystallography and cryo-EM. Targets overlapping structural biology workflows with academic and pharmaceutical users solving 3D structures.

Others

• Gatan (AMETEK): Manufacturer of cryo-EM detectors and electron microscopy accessories, now part of AMETEK. Provides complementary hardware and software (e.g., DigitalMicrograph) integrated into cryo-EM workflows alongside Structura's offerings.
• Cambridge Crystallographic Data Centre (CCDC): Not-for-profit provider of structural databases and software for small-molecule and macromolecular crystallography. Adjacent in structural biology tooling, serving overlapping pharma and academic customers with complementary modalities.

Direct peers

• CCP-EM: Collaborative Computational Project for Electron cryo-microscopy, providing community-maintained software pipelines and tools for cryo-EM. Academic peer competing in single-particle reconstruction and cryo-EM processing tooling.
• RELION: Open-source single-particle cryo-EM reconstruction software widely used in academic structural biology. Direct competitor to CryoSPARC's core functionality, competing on algorithm quality and processing speed in the same target customer base.
• Scipion: Open-source integrative framework for cryo-EM image processing that combines multiple algorithms (including RELION and others) into a unified workflow. Competes with CryoSPARC in academic cryo-EM processing environments.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights6 records

Customer concentration

• LinkedInca.linkedin.com/company/structura-biotechnology
• Xx.com/structurabio

Revenue estimate

Valuation estimate

Number of profiles

Profiles6 records

Funding overview

Funding rounds1 record

Investors2 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Structura Biotechnology