Cell Signaling Technology

What Cell Signaling Technology does

Cell Signaling Technology (CST) is a privately held, family-owned life sciences reagent manufacturer founded circa 1999-2000 and headquartered in Danvers, Massachusetts. The company develops, manufactures, and commercializes research-grade antibodies, kits, and proteomics tools used by academic research institutions, pharmaceutical and biotechnology companies, and diagnostic laboratories. Its catalog spans more than 10,000 products, including 11,532 primary antibodies and a broad secondary antibody, conjugate, ELISA, ChIP, flow cytometry, cellular assay, recombinant protein, and siRNA offering.

CST's core technology is built around antibody development and multi-application validation for workflows including Western blot, immunohistochemistry, immunofluorescence, flow cytometry, ELISA, ChIP, and chromatin profiling. The company has built several proprietary technology platforms that extend beyond consumables: SignalStar multiplex IHC for spatial biology, CUT&RUN and CUT&Tag for low-cell-number chromatin profiling (covered by U.S. patents 11,885,814 and 11,733,248), InTraSeq for single-cell transcriptomic and proteomic profiling compatible with 10x Genomics workflows, SimpleChIP kits, PTMScan proteomics using immobilized antibody beads, and FastScan and PathScan ELISA lines. PhosphoSitePlus, an NIH-supported PTM database curated by CST scientists, functions as both a research resource and a data moat underpinning the company's positioning in post-translational modification research.

The business model is a direct-to-customer B2B catalog sales motion. Products are sold globally through an owned e-commerce storefront, phone orders, and email-based ordering, supported by dedicated technical support and a Product Performance Guarantee. Revenue is generated primarily through one-time reagent and kit purchases by institutional buyers, with pricing provided on a quote basis and promotional discounts for new labs and recent publication authors. Marketing is multi-channel, anchored on educational content, scientific webinars, conference presence, and a technical resource library. A June 2026 co-development partnership with Quantum-Si extends CST's reach into next-generation single-molecule protein sequencing.

Name

Cell Signaling Technology

Legal name

Cell Signaling Technology, Inc.

Website

https://cellsignal.com

Company type

Private

Founded year

2000

Operating status

Operating

Headcount range

501–1,000 employees

Short description

Cell Signaling Technology (CST) is a privately held, family-owned life sciences company founded circa 1999 in Danvers, Massachusetts that manufactures validated research antibodies, kits, and proteomics tools for academic researchers, pharmaceutical companies, and biotechnology firms worldwide.

Ownership category

akta.pro rank

Product category

Research Antibodies & Life Science Reagents

NAICS

In-Vitro Diagnostic Substance Manufacturing (325413), Biological Product (except Diagnostic) Manufacturing (325414), Research and Development in Biotechnology (except Nanobiotechnology) (541714), Medical Laboratories (621511)

SIC

In Vitro & In Vivo Diagnostic Substances (2835), Biological Products, (No Disgnostic Substances) (2836), Services-Medical Laboratories (8071)

akta.pro primary industry

Reagents, Chemicals & Assay Kits (Buffers, Antibodies, ELISA, Enzymes) (HLAGAIAI)

akta.pro secondary industries

Antibody Discovery & Engineering Platforms (display tech, bispecifics, Fc engineering) (HLAAAIAB), Biomarker Assay & Reagent Development (LDT/IVD assay design, antibodies/standards/controls) (HLAAAMAL), Proteomics & Biomarker Analytical Testing (HLAGADAG)

Keywords

• Research antibodies
• Life science reagents
• Proteomics kits
• Cell signaling assays
• Antibody validation services

Headquarters

HQ city

Danvers

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Technology or R&D, Operations, Supply Chain, Marketing or Sales, Infrastructure

Revenue model

1. Research Antibodies and Reagents: Sale of primary and secondary antibodies, antibody conjugates, and reagents for life science research applications including Western blot, immunohistochemistry, flow cytometry, and ELISA.

Go-to-market motion1 record

Distribution channels3 records

Marketing channels7 records

Core offering

Cell Signaling Technology manufactures and sells more than 11,500 primary antibodies, along with related kits, reagents, and proteomics tools, used by academic, pharmaceutical, and biotechnology researchers to study cell signaling, cancer, neuroscience, and immunology. Its catalog is supported by proprietary platforms such as PhosphoSitePlus®, SignalStar®, SimpleChIP®, CUT&RUN/CUT&Tag, InTraSeq™, and PTMScan® for chromatin profiling, multiplex imaging, and post-translational modification analysis.

Product overview

Cell Signaling Technology is a research products company offering a comprehensive portfolio of over 10,000 antibodies, kits, and reagents for life science research. The product line centers on Primary Antibodies (11,532 products) as the core offering, complemented by Secondary Antibodies, Antibody Conjugates, and specialized kits including SignalStar™ Multiplex IHC, SimpleChIP®, CUT&RUN/CUT&Tag, and InTraSeq™ for single cell analysis. ELISA solutions include FastScan™ and PathScan® kits. The company provides PTMScan® proteomics technology and maintains the PhosphoSitePlus® online PTM database as a knowledge resource. Additional products encompass cellular assay kits, recombinant proteins, siRNA reagents, cytokines, activators/inhibitors, and buffers. Services include custom antibody formulations, peptide synthesis, proteomics analytics, and custom conjugation. The portfolio is unified by extensive application validation across Western blot, immunohistochemistry, immunofluorescence, flow cytometry, ChIP, and proteomics workflows.

Differentiator

Problem solved

Functional benefit

Brands

• SignalStar: Multiplex IHC kits and reagents for spatial biology applications.
• SimpleChIP
• PathScan
• FastScan
• PhosphoSitePlus
• SignalSilence
• CUT&RUN
• CUT&Tag
• InTraSeq

Products and services

• Primary Antibodies (catalog of 11,500+) A catalog of more than 11,500 primary antibodies, validated for applications such as Western blot, IHC, immunofluorescence, flow cytometry, ChIP, and ChIP-seq, sold to academic, pharmaceutical, and biotechnology researchers studying cell signaling, cancer, neuroscience, and immunology.
• PhosphoSitePlus® A curated, proprietary knowledgebase and online resource of phosphorylation sites, post-translational modifications, and related reagents, used by researchers to identify and study signaling pathways and to select CST antibodies.
• SignalStar® Multiplex IHC A proprietary multiplex tissue imaging platform that enables simultaneous detection of multiple RNA or protein targets in formalin-fixed paraffin-embedded tissue samples, used by translational and pathology researchers.
• SimpleChIP® Chromatin Immunoprecipitation Assays Kits and reagents for chromatin immunoprecipitation experiments that allow researchers to study protein-DNA interactions, histone modifications, and epigenetic regulation.
• CUT&RUN and CUT&Tag Assays Reagents and kits for cleavage under targets and release using nuclease (CUT&RUN) and cleavage under targets and tagmentation (CUT&Tag) chromatin profiling, used as alternatives to traditional ChIP-seq for sensitive detection of protein-DNA interactions.
• InTraSeq™ Single-Cell Proteomics A proprietary single-cell proteomics platform that enables multiplexed analysis of intracellular proteins at single-cell resolution, supporting immunology, oncology, and cell biology research.
• PTMScan® Proteomics Services Mass spectrometry-based proteomics service using PTMScan technology to identify and quantify post-translational modifications such as phosphorylation, ubiquitination, and acetylation, offered to academic and pharmaceutical researchers.
• Cell Signaling Technology Kits and Reagents Supporting kits and reagents, including ELISA kits, ChIP kits, and pathway analysis reagents, that complement CST's antibody portfolio for use in cell signaling and disease research applications.

Segments3 records

Ideal customer profiles2 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature6 records

Partnerships

One partnership is on record.

• Quantum-SicoreStrategic or Co-development Partner · 10 June 2026Partnership to advance post-translational modification analysis on Quantum-Si's Proteus single-molecule protein sequencing platform. The collaboration integrates CST's PTM detection expertise and generates datasets to build and refine Quantum-Si's kinetic signature database for site-resolved protein detection. In the second phase, Proteus platform results will be benchmarked against orthogonal mass spectrometry data from CST to validate the platform's PTM analysis capabilities.

Scale indicators3 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• Abcam: Abcam is one of the largest independent research antibody suppliers globally, with an extensive catalog of primary antibodies, kits and reagents covering similar applications (Western blot, IHC, flow cytometry, ELISA) to CST, serving the same academic and biopharma research customer base.
• Bio-Techne (R&D Systems): Bio-Techne's R&D Systems brand is a direct peer in research-grade antibodies, ELISA kits, recombinant proteins and cytokines, serving the same academic and biopharma customers with comparable catalog depth in cell signaling and immunology reagents.
• Santa Cruz Biotechnology: Santa Cruz Biotechnology is a long-standing direct competitor in research antibodies, particularly for cell signaling and cancer-related targets, with a similarly broad catalog targeting academic and biomedical research customers.
• Atlas Antibodies: Atlas Antibodies specializes in highly validated antibodies targeting human proteins, with a strong focus on IHC applications and tissue-specific validation, directly competing with CST's IHC and tissue-based reagent portfolio in the academic pathology and cell biology research market.
• Rockland Immunochemicals: Rockland Immunochemicals manufactures antibodies and antibody-based reagents for life science and diagnostic research, with comparable offerings in secondary antibodies, conjugates and custom antibody services used in similar academic and industrial research workflows as CST.

Broad incumbents

• Thermo Fisher Scientific (Life Sciences): Thermo Fisher offers an integrated portfolio of life science reagents, antibodies (Invitrogen), instruments and consumables that directly overlaps with CST's antibody and kits catalog, while also providing broader capabilities (instruments, services) that compete with CST's reagent focus in pharma and academic accounts.
• Bio-Rad Laboratories: Bio-Rad supplies research antibodies and life science reagents alongside protein analysis instruments (e.g., Western blot systems, Bio-Plex multiplex), making it a broader incumbent competing with CST in antibody reagents and multiplex immunoassay workflows.
• MilliporeSigma (Merck KGaA Life Science): MilliporeSigma is a broad life science incumbent offering antibodies, reagents, kits and instruments across nearly every workflow CST serves. Its scale and catalog breadth position it as a one-stop-shop alternative to CST for academic and industrial customers.
• BD Biosciences: BD Biosciences supplies antibodies and kits for flow cytometry, cell biology and immunology applications that overlap with CST's flow cytometry reagents and antibody offering, while also operating as a larger tools and instruments provider to research and clinical labs.

Emerging players

• GenScript: GenScript provides custom antibody services, recombinant proteins and cell therapy reagents, competing with CST in custom antibody production and recombinant protein categories while building a stronger catalog of off-the-shelf research antibodies in cell biology and immunology.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/cellsignal
• Facebookfacebook.com/cellsignal

Revenue estimate

Valuation estimate

Number of profiles

Profiles2 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Cell Signaling Technology