Chrono-log

What Chrono-log does

Chrono-log Corporation is a privately held US medical device company headquartered in Havertown, Pennsylvania, that designs, manufactures, and distributes specialized instruments and reagents for platelet function testing. Founded in 1968 (per company history), it is among the earliest manufacturers of platelet aggregometers and pioneered both Lumi-Aggregometry (simultaneous measurement of platelet aggregation and ATP secretion) and whole-blood impedance aggregometry. Its core products are the Model 490 4+4 optical aggregometer (for PRP-based light transmission aggregation) and the Model 700 whole-blood/optical Lumi-Aggregometer, supported by proprietary consumables under the CHRONO-PAR (ADP, Collagen, Thrombin, Arachidonic Acid, Epinephrine, Ristocetin) and CHRONO-LUME (luciferin-luciferase) reagent brands, plus a Ristocetin CoFactor Assay kit and AGGRO/LINK data collection software. Revenue is generated primarily through instrument sales, recurring reagent and consumable sales, and service/loaner contracts covering calibration and repair in the US and Canada. The company sells directly in the US/Canada and through an independent distributor network spanning more than 75 countries across six continents, targeting clinical and hospital laboratories, university and pharmaceutical research institutions, and pharma companies running anti-platelet drug trials. Chrono-log holds two issued US patents (6,004,818 in 1999 and 9,081,002 B2 in 2015) plus a pending EU application, maintains ISO 13485:2016 certification with MDSAP auditing, and has FDA-cleared aggregation systems and reagents.

Name

Chrono-log

Legal name

Chrono-log Corporation

Website

https://chronolog.com

Company type

Private

Founded year

1968

Operating status

Operating

Headcount range

11–50 employees

Short description

Chrono-log Corporation is a privately held US medical device company that designs, manufactures, and distributes platelet aggregation instruments (Model 490, Model 700) and proprietary reagents (CHRONO-PAR, CHRONO-LUME) to clinical laboratories, hospitals, research universities, and pharmaceutical companies across more than 75 countries.

Ownership category

akta.pro rank

Product category

Platelet Function Testing Equipment

NAICS

Analytical Laboratory Instrument Manufacturing (334516)

SIC

In Vitro & In Vivo Diagnostic Substances (2835), Laboratory Analytical Instruments (3826)

akta.pro primary industry

Reagents, Chemicals & Assay Kits (Buffers, Antibodies, ELISA, Enzymes) (HLAGAIAI)

akta.pro secondary industry

Clinical Chemistry, Hematology & Coagulation Testing (Trial Support) (HLAGAEAE)

Keywords

• Platelet aggregation testing
• Platelet function diagnostics
• Lumi-aggregometry instruments
• Platelet aggregation reagents
• Coagulation laboratory equipment

Headquarters

HQ city

Havertown

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Operations, Technology or R&D, Personnel, Marketing or Sales

Revenue model

1. Instrument Sales: Sale of platelet aggregation and Lumi-Aggregation instruments including Model 490 4+4 (optical) and Model 700 (whole blood/optical Lumi) systems with various channel configurations.
2. Reagent Sales: Sale of CHRONO-PAR platelet aggregation reagents (ADP, Collagen, Thrombin, Arachidonic Acid, Epinephrine, Ristocetin), CHRONO-LUME luciferin-luciferase reagents for ATP measurement, and Ristocetin CoFactor Assay kits.
3. Supplies and Consumables: Sale of cuvettes, stir bars, disposable electrodes, pipettes, tips, and other aggregation testing accessories and supplies.
4. Service Contracts and Calibration: Annual calibration services and Service/Loaner Contracts covering parts, labor, shipping, loan instruments, and software upgrades. Offered for biomedical instruments in USA and Canada.

Pricing tiers

Go-to-market motion1 record

Distribution channels2 records

Marketing channels4 records

Core offering

Chrono-log designs, develops, and manufactures platelet aggregation and Lumi-Aggregation instruments (Model 490 4+4 Optical Aggregometer and Model 700 Whole Blood/Optical Lumi-Aggregometer) along with a complete line of platelet aggregation reagents (CHRONO-PAR), ATP luminescence reagents (CHRONO-LUME), Ristocetin CoFactor Assay kits, consumables, and supporting data analysis software (AGGRO/LINK, vW CoFactor). The products are sold to clinical and research laboratories for diagnosing platelet function disorders, monitoring anti-platelet drug therapy, and supporting pharmaceutical research.

Product overview

Chrono-log provides a comprehensive portfolio of platelet function testing products centered around two instrument lines: Model 490 4+4 Optical Aggregometers for PRP-based testing and Model 700 Whole Blood/Optical Lumi-Aggregometers for simultaneous aggregation and ATP secretion measurement. The product ecosystem includes CHRONO-PAR aggregation reagents (ADP, Collagen, Thrombin, Arachidonic Acid, Epinephrine, Ristocetin), CHRONO-LUME luminescence reagents for ATP detection, and Ristocetin CoFactor Assay kits for von Willebrand disease diagnosis. Supporting software includes AGGRO/LINK for data collection and vW CoFactor Software for specialized assay analysis. Consumable accessories, supplies, and service options complete the offering for clinical and research laboratories.

Differentiator

Problem solved

Functional benefit

Brands

• CHRONO-PAR: Platelet aggregation reagents including ADP, Collagen, Thrombin, Ristocetin, Epinephrine, and Arachidonic Acid
• CHRONO-LUME
• AGGRO/LINK

Products and services

• Model 490 4+4 Optical Aggregometer 4 or 8 channel optical platelet aggregation system for testing PRP, washed platelets, or gel-filtered platelets using Light Transmission methodology based on the Born method; features improved optical calibration and continuous monitoring with warning messages. Sold to clinical and research laboratories.
• Model 700 Whole Blood/Optical Lumi-Aggregometer Up to 4-channel system that measures platelet function in whole blood (impedance) or PRP (optical) samples with simultaneous ATP release detection via luminescence; includes Ristocetin Cofactor Assay capability. Sold to clinical and research laboratories.
• CHRONO-PAR Reagents Complete line of platelet aggregation reagents including ADP, Collagen, Thrombin, Arachidonic Acid, Epinephrine, and Ristocetin for use in PRP or Whole Blood samples. Sold as consumables to clinical and research laboratories.
• CHRONO-LUME Reagents Luciferin-luciferase reagent kit for quantitative measurement of ATP release during platelet aggregation, enabling simultaneous secretion studies with aggregation. Sold as consumables to clinical and research laboratories.
• Ristocetin CoFactor Assay Kit Quantitative determination kit for Factor VIII Ristocetin Cofactor Activity in citrated plasma, including Ristocetin, Lyophilized Human Platelets, von Willebrand Reference Plasma (Normal and Deficient), and Tris Buffered Saline. Used with Optical Aggregometer and vW CoFactor Software for diagnosing von Willebrand Disease.
• Disposable Electrodes Single-use impedance electrodes for Whole Blood Aggregation that eliminate the need for electrode cleaning and reduce testing time to approximately 6 minutes. Sold as accessories for the Model 700 Whole Blood Aggregometer.
• Water and Saline Reagents (P/N 397 and P/N 398) Saline 0.9% 15mL (P/N 397) and Purified Water 15mL (P/N 398) reagent products offering improved accuracy, reduced costs, and time/sample/reagent savings for platelet aggregation testing workflows.
• AGGRO/LINK Software Windows-compatible computer interface software for aggregation and secretion data collection and analysis with Chrono-log instruments. Sold as a standalone software product to clinical and research laboratories.
• vW CoFactor Software Software package for von Willebrand Ristocetin Cofactor Assay with standard curve creation (up to 6 points), CV/CD monitoring, and automatic calculation of slope and CoFactor activity. Sold as a standalone software product for use with the Ristocetin CoFactor Assay Kit.
• Service/Loaner Contracts Annual service contracts covering all parts, labor, shipping to and from Chrono-log, loan instruments, and software upgrades for biomedical instruments in USA and Canada. On-site contract option available; travel expenses for on-site service billed separately unless On Site Contract is selected; non-warranty repairs invoiced Time and Materials.

Quantifiable outcome

• Turnaround time reduced to under 30 minutes for whole blood testing vs 1.5-3 hours for PRP
• +2 more outcomes

Segments3 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature6 records

Partnerships

Seven partnerships are on record, tiered core and minor.

• Dicipa S.A. de C.V. (Mexico)coreChannel Partner/ Reseller/ DistributorExclusive distributor for Mexico, located at Avenida Patriotismo No. 201, piso 8, Colonia San Pedro de los Pinos, Benito Juarex, Mexico City. Handles sales, applications support, and technical service for Chrono-log products in Mexico.
• PROMED, S.A. (Panama)coreChannel Partner/ Reseller/ DistributorDistributor for Panama, located at Parque Industrial Costa del Este, Calle 2da. Edificio Promed, Panama. Contact: [email protected], Tel: (507) 303-3100.
• Labmedics (UK)coreChannel Partner/ Reseller/ DistributorDistributor for United Kingdom and Ireland, located at D5 Culham Science Centre, Abbington On Thames, Oxfordshire OX14 3DB, UK.
• Triolab Group (Scandinavia)coreChannel Partner/ Reseller/ DistributorRegional distributor covering Denmark (Triolab AS), Finland (Triolab Oy), Norway (Triolab AS), and Sweden (Triolab AB). Offices in Brondby, Turku, Kjeller, and Molndal.
• DKSH Australia and New ZealandcoreChannel Partner/ Reseller/ DistributorDistributor for Australia (DKSH Australia Pty Ltd, Braeside Victoria) and New Zealand (DKSH New Zealand Ltd, Auckland). Covers Australia/Oceania region.
• Bio Top Medical (Netherlands)minorChannel Partner/ Reseller/ DistributorEC Representative for European Union regulatory compliance, located at Poortgebouw Noord, Rijnsburgerweg 10, 2333 AA Leiden, Netherlands.
• Obelis UK Ltd. (UK)minorChannel Partner/ Reseller/ DistributorUK Responsible Person (UKRP) for UK regulatory compliance, located at Sanford Gate, East Point Business Park, Oxford, OX4 6LB, UK.

Scale indicators4 records

Recent moves6 records

Expansion highlights5 records

Broad incumbents

• Siemens Healthineers: Siemens Healthineers offers broad clinical laboratory and hemostasis solutions including platelet function assays through its ADVIA Centaur and Atellica platforms, competing with Chrono-log at the integrated lab system level rather than instrument-for-instrument.
• Roche Diagnostics: Roche Diagnostics offers comprehensive coagulation and specialty testing menus on its cobas platforms, competing indirectly with Chrono-log for hospital and reference lab platelet function testing workflows.
• Haemonetics: Haemonetics operates the TEG (Thromboelastograph) hemostasis platform, which competes with aggregometry in platelet function assessment in surgical and critical care settings, and represents a broader incumbent alternative to Chrono-log's specialized instrumentation.
• Sysmex: Sysmex is a global leader in hematology and hemostasis diagnostics with automated platelet function testing capabilities, providing a scalable platform alternative to Chrono-log's lower-throughput specialty aggregometers.
• Stago: Stago is a major hemostasis diagnostics vendor with a broad coagulation and platelet testing menu; while not a direct optical aggregometry competitor, it competes for the same hospital lab budget allocated to platelet function testing.
• Werfen (Instrumentation Laboratory): Werfen's IL division offers the ROTEM viscoelastic testing platform and broader hemostasis diagnostics, providing an alternative testing paradigm to Chrono-log's traditional optical and impedance platelet aggregometry.
• Abbott Diagnostics: Abbott's diagnostics division provides broad hospital lab testing platforms including platelet-related assays, representing a competing budget allocation for clinical labs evaluating platelet function testing investments.

Emerging players

• Sienco (Sonoclot): Sienco's Sonoclot viscoelastic analyzer provides whole-blood platelet function analysis as an alternative to traditional light-transmission aggregometry, representing an adjacent modality that overlaps with Chrono-log's whole-blood impedance testing use cases.

Direct peers

• Bio/Data Corporation: Bio/Data Corporation offers the PAP-8E and other platelet aggregation instruments plus reagents, competing head-to-head with Chrono-log in the same specialty platelet function testing category.
• Helena Biosciences: Helena Biosciences manufactures the AggRAM platelet aggregometer and related reagents, directly competing with Chrono-log's Model 490 and Model 700 platforms in clinical and research platelet function testing laboratories.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks5 records

Key highlights6 records

Customer concentration

Compliance2 records

Revenue estimate

Valuation estimate

Number of profiles

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Chrono-log