What Kolosis BIO does

Kolosis BIO is a privately held, pure-play surgical biologics company founded in 2019 and headquartered in Salt Lake City, Utah. The company commercializes a portfolio of allograft and synthetic bone grafts, extracellular matrices, and cardiac surgery products across three categories: orthobiologics, surgical incision management, and cardiac surgery. Its product lineup includes Kore Fiber, the DBX family (Putty, Mix, Fiber), Summit Matrix, Prime HD, APEXecm, ATLAS, and IKON, all sourced through an exclusive partnership with MTF Biologics, a nonprofit tissue processor whose proprietary aseptic processing preserves native collagen architecture, matrix proteins, and osteoinductive potential that terminal sterilization methods would damage.

Kolosis generates revenue by selling surgical biologics to hospitals and surgeons for use in spine fusion, orthopedic bone grafting, cardiac surgery, and wound care procedures. The go-to-market combines an enterprise field sales team with a network of over 400 independent distributors covering all 50 US states and Canada, with products approved in over 5,800 facilities through GPO and IDN contracts accessed via MTF Biologics. The company's 35,000+ fusion procedures over the trailing 12 months reflect established clinical adoption, supported by comparative preclinical data and a sales organization drawn heavily from NuVasive, Orthofix, Medtronic Spine and Biologics, and Globus Medical.

The business model is asset-light distribution of partner-processed tissue, with Kolosis focused on commercial execution, surgeon relationships, and product portfolio expansion rather than tissue processing R&D. Recent strategic activity includes three product launches within roughly 14 months (Summit Matrix in 2025, APEXecm and DBX Fiber in early 2026), entry into cardiac surgery and ECM wound management, and additions to the executive team including a CFO in 2025 and a Southeast AVP in 2026 to support continued national scale.

Name

Kolosis BIO

Legal name

Kolosis BIO, LLC

Website

https://kolosis.com

Company type

Private

Founded year

2019

Operating status

Operating

Headcount range

11–50 employees

Short description

Kolosis BIO is a privately held, pure-play surgical biologics company that commercializes allograft and synthetic bone grafts, extracellular matrices, and cardiac surgery products through an exclusive partnership with MTF Biologics, selling to hospitals and surgeons across spine, orthopedic, cardiac, and wound care procedures.

Ownership category

akta.pro rank

Product category

Surgical Biologics / Orthobiologics

NAICS

Surgical Appliance and Supplies Manufacturing (339113), Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers (423450), Medical Equipment and Supplies Manufacturing (3391)

SIC

Orthopedic, Prosthetic & Surgical Appliances & Supplies (3842), Wholesale-Medical, Dental & Hospital Equipment & Supplies (5047)

akta.pro primary industry

Bone Graft Substitutes & Orthobiologics (Synthetic/Allograft/DBM) (HLAHAEAG)

akta.pro secondary industries

Cartilage, Bone & Musculoskeletal Regeneration (HLAAAGAH), Skin Substitutes & Biologic/Regenerative Wound Therapies (Matrices, Grafts) (HLAHALAE), Wound Healing & Skin Regeneration (advanced dressings, skin substitutes) (HLAAAGAG)

Keywords

• Orthobiologics products
• Surgical bone grafts
• Allograft tissue matrices
• Spine biologics
• Cardiac surgery matrices

Headquarters

HQ city

Salt Lake City

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Personnel, Marketing or Sales, Operations, Technology or R&D

Revenue model

1. Surgical Biologics Products: Kolosis generates revenue through the sale of surgical biologics products including bone grafts, allograft matrices, and extracellular matrix products. Products are sold to hospitals and surgeons for use in orthopedic, spine, cardiac, and wound care procedures. Revenue is generated through direct sales and distributor relationships with products approved in over 5,800 facilities.
2. Orthobiologics: Sale of orthobiologic products including Kore Fiber, DBX family (Putty, Mix, Fiber), Summit Matrix, and Prime HD for spinal fusion and orthopedic procedures.
3. Cardiac Surgery Solutions: Revenue from cardiac surgery products including ATLAS sternal repair matrix and IKON protective barrier for sternal incisions.
4. Surgical Incision Management: Sale of APEXecm extracellular matrix products for surgical incision management and wound healing applications.

Go-to-market motion3 records

Distribution channels3 records

Marketing channels5 records

Core offering

Kolosis BIO commercializes a portfolio of aseptically processed surgical biologics including demineralized bone matrices (DBX family, Kore Fiber, Prime HD), synthetic bone grafts (Summit Matrix), extracellular matrices for wound healing (APEXecm, Salera), and allograft matrices for cardiac surgery (ATLAS, IKON). All products are sourced exclusively from MTF Biologics and sold to hospitals and surgeons for spine fusion, orthopedic, cardiac surgery, and surgical incision management applications across the US and Canada.

Product overview

Kolosis BIO is a pure-play surgical biologics company offering a portfolio of biologics products across three categories: Orthobiologics (including Kore Fiber, DBX family products like DBX Putty and DBX Mix, DBX Fiber, Summit Matrix, and Prime HD for bone grafting in spine and orthopedic procedures), Surgical Incision Management (APEXecm with Mini Tile Matrix configuration), and Cardiac Surgery solutions (ATLAS for sternal fusion and IKON for sternal incision protection). All bone graft products are processed by exclusive partner MTF Biologics using proprietary aseptic processing to preserve native matrix proteins and osteoinductive properties.

Differentiator

Problem solved

Functional benefit

Brands

• DBX: Demineralized bone matrix product family including DBX Putty and DBX Mix, providing moldable consistency with proven osteoinductive potential.
• Kore Fiber
• Summit Matrix
• Prime HD
• APEXecm
• ATLAS
• IKON
• Salera

Products and services

• Kore Fiber Aseptic-processed pure cortical bone graft combining demineralized cortical fibers with exceptional osteoinductivity data and outstanding handling characteristics, available in moldable putty and compressed strip formats; intended for spine and orthopedic fusion procedures.
• DBX (Putty and Mix) Demineralized bone matrix family with a scientifically optimized sodium hyaluronate carrier, featuring greater than 95% bone content by volume and validated osteoinductive potential, available in Putty and Mix formulations for spine and orthopedic fusion.
• DBX Fiber Fiber tissue form addition to the DBX demineralized bone matrix portfolio, processed to provide surgeons with superior handling and osteoinductive potential when addressing complex anatomy and challenging fusion environments.
• Summit Matrix Synthetic bone graft powered by NanoLift surface technology with nanoscale plate-like topography and biomimetic HCA chemistry that enhances cellular interactions and creates an environment favorable for bone formation, available in Strip and Moldable formulations.
• Prime HD Pre-hydrated, ready-to-use demineralized bone matrix comprised of elongated demineralized bone particles pre-hydrated in a preservative solution, offering greater than 95% bone by volume with excellent handling properties and verified osteoinductive potential.
• APEXecm Next-generation 100% allogenic extracellular matrix featuring Mini Tile Matrix configuration, designed to cover and protect in the natural wound healing environment; comprised of collagen, proteoglycans, and native ECM structural proteins for surgical wound healing.
• ATLAS 100% demineralized cortical bone allograft engineered for sternal fusion, inserted between sternal edges prior to closure to support stabilization and fusion of the sternum in challenging cardiac surgery patients; available in 1x10 cm strip.
• IKON 100% allograft matrix from MTF Biologics designed to act as a protective barrier for sternal incisions, using proprietary aseptic processing to retain native extracellular matrix structure; available in Mini Matrix in 80mg and 160mg sizes.
• Salera Allograft membrane designed to help optimize surgical outcomes and reduce complications in poor healing patients by supporting surgical wound healing applications.

Quantifiable outcome

• Kore Fiber demonstrates higher osteoinductivity than commercially available grafts from Medtronic, SeaSpine, and Zimmer Biomet in head-to-head testing
• +3 more outcomes

Segments4 records

Ideal customer profiles4 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature5 records

Partnerships

One partnership is on record.

• MTF BiologicscoreStrategic or Co-development PartnerKolosis BIO exclusively partners with MTF Biologics for all tissue forms. MTF Biologics is a global nonprofit organization headquartered in Edison, New Jersey, with over 30 years of experience in tissue processing. The partnership provides Kolosis access to premium allograft technologies including demineralized bone matrix, cortical fiber allografts, and extracellular matrices. MTF's proprietary aseptic processing preserves biological matrices and osteoinductive properties that terminal sterilization would damage. Kolosis commercializes the full range of MTF tissue forms across orthobiologics, cardiac surgery, and wound care verticals.

Scale indicators5 records

Recent moves6 records

Expansion highlights5 records

Market position

Competitive moat5 records

Key risks5 records

Key highlights6 records

Customer concentration

• LinkedInlinkedin.com/company/kolosis-bio-inc

Revenue estimate

Valuation estimate

Number of profiles

Profiles17 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Kolosis BIO