Phenome Health

Name

Phenome Health

Legal name

Phenome Health

Website

https://phenomehealth.org

Company type

Private

Founded year

2020

Operating status

Operating

Headcount range

11–50 employees

Short description

Phenome Health is a Seattle-based 501(c)(3) nonprofit research organization that develops AI-enabled multi-omic data platforms and the ARK Engine for predictive health and disease prevention, partnering with research institutions and healthcare organizations.

Ownership category

akta.pro rank

Product category

Healthspan Science and Predictive Health Research

NAICS

Administration of Public Health Programs (92312)

SIC

Services-Health Services (8000), Services-Computer Programming, Data Processing, Etc. (7370)

akta.pro primary industry

Health Data, Vital Statistics & Population Health Informatics (BPAIAJAM)

akta.pro secondary industry

Program Monitoring, Evaluation & Learning (MEL) (HLAJANAA)

Keywords

• Predictive health research
• Multi-omic data analysis
• AI health platforms
• Healthspan science
• Genomic data integration

Headquarters

HQ city

Seattle

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Technology or R&D, Operations, Infrastructure, Marketing or Sales

Revenue model

1. Research Grants and ARPA-H Funding: As an ARPA-H funded nonprofit research organization, Phenome Health operates primarily through government research grants and funding awards, with $65M+ awarded since 2024.

Go-to-market motion1 record

Distribution channels1 record

Marketing channels2 records

Core offering

Phenome Health is a nonprofit research organization that develops data-driven infrastructure, multi-omic insights, and AI-enabled systems to predict disease earlier and personalize prevention. Its two flagship offerings are the ARK Engine (an AI-assisted knowledge engine that synthesizes health evidence with individual biology to deliver actionable recommendations) and the Phenomic Data Platform (a generative AI platform that integrates genomic, clinical, behavioral, and environmental data into unified predictive frameworks).

Product overview

Phenome Health offers a suite of AI-driven healthspan science products centered around its phenomic data platform and the ARK Engine knowledge engine. The phenomic data platform serves as the foundational infrastructure, combining multi-omic data (genomic, clinical, behavioral, and environmental) for analysis. The ARK Engine, built on this platform, is the consumer-facing intelligence layer that synthesizes health evidence and delivers actionable, personalized recommendations to shift healthcare from reactive to proactive.

Differentiator

Problem solved

Functional benefit

Brands

• ARK Engine: AI-assisted actionable recommendations knowledge engine being developed by Phenome Health, enabling consumer-facing organizations to shift from reactive healthcare to predictive, preventative health. The platform synthesizes robust health evidence with individual biology.

Products and services

• ARK Engine AI-assisted actionable recommendations knowledge engine that synthesizes robust health evidence against an individual's unique biology. Designed to serve as an intelligence layer enabling consumer-facing organizations to shift away from reactive healthcare toward predictive, personalized health strategies. Built on the premise that healthcare options should reflect biological individualized needs.
• Phenomic Data Platform Generative AI platform that integrates genomic, clinical, behavioral, and environmental data into unified frameworks to power AI-driven discoveries about health and disease. Supports predictive models identifying early transitions from health to dysfunction, longitudinal health trajectory modeling, and pre-diagnostic biomarker research for conditions such as diabetes and Alzheimer's. Aims to reduce the financial and personal burdens of the reactive health system.

Quantifiable outcome

• 96% of US healthcare spending is for post diagnosis - Phenome Health aims to shift this through predictive health

Segments2 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

AI capability7 records

Feature3 records

Partnerships

Three partnerships are on record, tiered core.

• Weissman Hood InstitutecoreStrategic or Co-development Partner · 1 January 2024Strategic partnership for rural healthcare pilot programs addressing gaps in access, data, and delivery through community-centered and culturally responsive approaches.
• Hudson Biotechnology InstitutecoreStrategic or Co-development Partner · 1 January 2024Collaborating partner in rural healthcare initiative combining cutting-edge health technologies with community-centered approaches for scalable pathways to equitable health outcomes.
• HudsonAlpha Institute for BiotechnologycoreStrategic or Co-development Partner · 1 January 2024Partnership focused on developing scalable models for early Alzheimer's prevention by analyzing pre-diagnostic biomarker data and testing personalized intervention strategies across at-risk populations.

Scale indicators5 records

Recent moves6 records

Expansion highlights6 records

Broad incumbents

• Tempus AI: Public commercial company applying AI to multi-omic and clinical data for precision medicine. Comparable in multi-omic + AI integration thesis, but operates commercially with reimbursement-driven GTM rather than the nonprofit research model.
• Howard Hughes Medical Institute: The largest US biomedical research nonprofit, supporting investigators across many institutions. Comparable in nonprofit biomedical research model but vastly larger in scale and scope; functions as an umbrella rather than a single disease-area platform.
• Scripps Research: Major nonprofit biomedical research institute with deep drug discovery and translational science programs. Comparable as a nonprofit science organization that produces both foundational research and biotech spinouts.

Direct peers

• Institute for Systems Biology: Seattle-based nonprofit systems biology research organization also founded by Dr. Lee Hood. Closely comparable in scientific approach (multi-omic, systems biology) and Seattle geography, representing the predecessor model for Phenome Health.
• Arc Institute: Nonprofit research organization combining biomedical science with AI/ML at scale. Comparable as a younger nonprofit pairing deep biology with cutting-edge AI to attack complex disease — a closely aligned structural and strategic model.
• HudsonAlpha Institute for Biotechnology: Nonprofit genomics and bioinformatics research institute. Already an active Phenome Health partner on Alzheimer's pre-diagnostic biomarker research, sharing both nonprofit structure and genomics-first research orientation.
• Buck Institute for Research on Aging: Independent nonprofit biomedical research institute focused on aging and age-related disease. Co-recipient of the same ARPA-H program alongside Phenome Health, sharing the healthspan-science mission and federal funding pathway.
• Salk Institute for Biological Studies: Independent nonprofit biological research institute with broad multi-disciplinary disease programs. Comparable as a federally and philanthropically funded nonprofit conducting foundational biomedical research that seeds commercial follow-ons.
• Allen Institute: Large nonprofit research organization founded by Paul Allen, conducting large-scale science initiatives and building open scientific platforms. Comparable as a well-funded nonprofit that translates data-intensive research into widely shared scientific resources.
• New York Genome Center: Nonprofit academic genomics research organization pooling institutional resources for large-scale sequencing and computational biology. Comparable as a nonprofit research consortium advancing genomic science through shared infrastructure.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat4 records

Key risks5 records

Key highlights6 records

Customer concentration

• Xx.com/phenomehealth
• Facebookfacebook.com/PhenomeHealth
• LinkedInlinkedin.com/company/phenome-health

Revenue estimate

Valuation estimate

Number of profiles

Profiles1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Phenome Health