Natural Medtech

What Natural Medtech does

Natural MedTech Pty Ltd is a privately held Australian pharmaceutical manufacturer founded in 2021 that uses biosynthesis (precision fermentation) to produce active pharmaceutical ingredients (APIs) and finished dose forms. It is the only psilocybin and MDMA API manufacturer in Australia, operating under cGMP with Schedule 8 and Schedule 9 controlled-substance licences and TGO 112/TGO 113 compliance. The company supplies two commercial products (psilocybin API and MDMA API) and claims cGMP capability across three molecular families — indole/tryptamines, ergoline/lysergamides, and phenethylamines — positioning biosynthesis as an alternative to traditional chemistry for complex, multi-ring, asymmetric molecules.

The company's underlying technology is an end-to-end biosynthetic manufacturing platform covering gene design, engineering, fermentation, purification, and release under a single quality system, supported by proprietary computational design tools that prioritize gene sequence candidates for pathway optimization. Manufacturing uses continuous fermentation with sugar and nutrients in clean, sealed tanks, avoiding petroleum precursors and harsh solvents. The company has supplied 10+ Phase 2 or later clinical trials in Australia and globally and holds finished inventory for rapid delivery.

Natural MedTech sells exclusively B2B through direct enterprise sales channels to authorized prescribers in Australia and clinical trial sponsors globally, with manufacturing partnerships and licensing conversations handled through dedicated contact pathways. Pricing is not publicly disclosed. The leadership team comprises co-founders Luke McFarlane (CEO), Mark Hestermann (COO), and Mark Riccio (Director), with a board including Doug Drysdale (Chair), John Skerritt (former head of Australia's TGA), and Mario Gattino (former Pfizer executive). No funding rounds, revenue figures, or institutional investors are disclosed.

Name

Natural Medtech

Legal name

Natural MedTech Pty Ltd

Website

https://naturalmedtech.com

Company type

Private

Founded year

2021

Operating status

Operating

Headcount range

1–10 employees

Short description

Natural MedTech is an Australian cGMP manufacturer founded in 2021 that uses biosynthesis to produce psilocybin and MDMA APIs and finished dose forms for authorized prescribers and clinical trial sponsors globally. It is the only manufacturer of these APIs in Australia.

Ownership category

akta.pro rank

Product category

Pharmaceutical Manufacturing (Active Pharmaceutical Ingredients)

NAICS

Pharmaceutical and Medicine Manufacturing (3254), Pharmaceutical Preparation Manufacturing (325412)

SIC

Medicinal Chemicals & Botanical Products (2833)

akta.pro primary industry

Small-Molecule API Commercial Manufacturing (HLAGAHAB)

akta.pro secondary industries

Small-Molecule CMC Documentation & Regulatory Support (DMF/CMC) (HLAGAHAM), GMP Scale-Up, Tech Transfer & Process Validation (PPQ) (HLAGAHAL), CMC & Pharmaceutical Development (Formulation/Process/Analytical Development) (HLAIALAD)

Keywords

• Pharmaceutical manufacturing
• Active pharmaceutical ingredients
• Biosynthesis manufacturing
• Controlled substance APIs
• Psychedelic drug manufacturing

Headquarters

HQ city

Melbourne

HQ country

Australia

HQ region

Oceania

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Operations, Technology or R&D, Infrastructure, Supply Chain

Revenue model

1. Active Pharmaceutical Ingredient (API) Sales: Sale of cGMP-manufactured psilocybin and MDMA APIs to authorized prescribers and clinical trial sponsors. The company supplies both API and finished dose forms, holding finished inventory on hand.
2. Finished Dose Form Sales: Supply of finished dose products alongside APIs to authorized prescribers in Australia and clinical trial sponsors internationally.

Go-to-market motion1 record

Distribution channels3 records

Marketing channels3 records

Core offering

Natural Medtech manufactures cGMP-grade psilocybin and MDMA active pharmaceutical ingredients (APIs) and finished dose forms using proprietary biosynthesis and continuous precision fermentation at its Australian facility. The company holds Schedule 8 and Schedule 9 licences and is positioned as the only Australian manufacturer of these controlled APIs, supplying authorised prescribers, clinical trial sponsors, and commercial partners under contract.

Product overview

Natural MedTech is a biosynthesis-based pharmaceutical manufacturer offering two commercial active pharmaceutical ingredients (Psilocybin API and MDMA API) and finished dose forms. The company operates an end-to-end biosynthesis manufacturing platform that engineers biological pathways for producing complex pharmaceutical molecules. Beyond its two commercial products, NMT provides cGMP manufacturing capability across three molecular families: Indole/Tryptamine (psilocin, DMT, 5-MeO-DMT, melatonin, tryptamine), Ergoline/Lysergamide (LSD), and Phenethylamines. All manufacturing is conducted under one quality system in Australia, covering gene design, engineering, fermentation, purification, and release.

Differentiator

Problem solved

Functional benefit

Products and services

• Psilocybin API
• MDMA API
• Finished Dose Forms

Quantifiable outcome

• 10+ Phase 2 or later clinical trials supplied in Australia and globally
• +1 more outcomes

Segments3 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature3 records

Scale indicators5 records

Recent moves2 records

Expansion highlights4 records

Emerging players

• GH Research: Clinical-stage company developing mebufotenin (5-MeO-DMT) therapy; a customer/peer for tryptamine-family APIs that Natural MedTech lists as a manufacturing capability.
• Wavelength Pharmaceuticals: CDMO specializing in complex APIs including psychedelics and controlled substances. Comparable as a niche manufacturer targeting the same clinical-trial customer base.

Direct peers

• Filament Health: Canadian botanical psychedelic drug developer producing cGMP psilocybin and other natural psychedelic APIs. Competes in the same regulated botanical API category for clinical trials.
• Cybin: Clinical-stage psychedelics company developing psilocybin-based therapies; Doug Drysdale (now NMT Chair) previously led Cybin. Direct overlap in psychedelic API manufacturing and clinical supply.

Broad incumbents

• Lonza Group: Global CDMO leader in small-molecule and biologics manufacturing. Broad incumbent comparator for cGMP API manufacturing scale and quality systems.
• Compass Pathways: Lead developer of COMP360 synthetic psilocybin therapy with pivotal-stage trials. A large, well-funded buyer and developer in the same psilocybin API category that Natural MedTech supplies.
• MindMed: Public psychedelic medicine developer advancing MDMA and LSD-based therapies. Overlaps with Natural MedTech's MDMA API business and clinical trial supply segment.
• atai Life Sciences: Clinical-stage platform with multiple psychedelic and mental health programs including psilocybin candidates. Comparable as a downstream buyer and developer in the psychedelic API market.
• Siegfried Holding: Swiss-listed CDMO with controlled substance capabilities and global manufacturing footprint. Comparable as an established small-molecule API contract manufacturer serving pharma.

Others

• Cayman Chemical: Supplier of research-grade and cGMP APIs including controlled substances to researchers and clinical developers. Adjacent supplier rather than direct competitor in commercial API supply.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights6 records

Customer concentration

Compliance5 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles7 records

Funding overview

Funding rounds1 record

Investors1 record

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Natural Medtech