Regenstrief Institute, Inc.

What Regenstrief Institute, Inc. does

Regenstrief Institute, Inc. is an independent nonprofit healthcare research organization founded in 1969 and headquartered in Indianapolis, Indiana. It develops and maintains LOINC, the universal code system for medical laboratory observations and clinical measurements that enables health data interoperability across healthcare systems globally, and operates the Indiana Network for Patient Care (INPC), a statewide health information exchange that has grown into a public health data engine. The institute is organized around specialized centers covering biomedical informatics, health services research, and aging research, and operates Regenstrief Data Services (RDS) for data infrastructure and analytics.

The institute's revenue model is built on federal research grants (primarily from NIH and the National Institute on Aging), corporate research partnerships with pharmaceutical companies including Merck, Eli Lilly, and Roche, academic collaborations with Indiana University and Purdue University, and licensing royalties from LOINC commercial implementations. Its technology stack centers on health informatics and biomedical data standards, with proprietary features spanning LOINC, a Learning Health System model, and an expanding portfolio of AI/ML capabilities including predictive models for cardiovascular risk, dementia, and chronic wound outcomes, NLP for clinical notes, and process automation for advance care planning. The Public Health Emergency Surveillance System (PHESS) has been in operation for 20 years.

Regenstrief serves healthcare delivery systems, academic medical research institutions, government health agencies, and global standards bodies. It distributes outputs through open-source channels (LOINC is free for non-commercial use), peer-reviewed publications, annual conferences, and direct research collaborations. The institute has 101-250 employees and an independent governance structure with no parent company, venture capital, or private equity backing.

Name

Regenstrief Institute, Inc.

Legal name

Regenstrief Institute, Inc.

Website

https://regenstrief.org

Company type

Private

Founded year

1969

Operating status

Operating

Headcount range

101–250 employees

Short description

Independent nonprofit healthcare research institute founded in 1969, developer and steward of LOINC, the global standard for health data interoperability, serving healthcare systems, researchers, and federal agencies through grants, partnerships, and standards.

Ownership category

akta.pro rank

Product category

Healthcare Informatics Research

NAICS

Scientific Research and Development Services (5417)

SIC

Services-Health Services (8000), Services-Computer Programming, Data Processing, Etc. (7370), Services-Misc Health & Allied Services, Nec (8090)

akta.pro primary industry

Health Information Exchange & Public Health Data Integration (HLAJAJAD)

akta.pro secondary industries

Data Linkage, Registries & Longitudinal Cohort Surveillance (HLAJANAM), Public Health & Immunization Data Exchange (ELR, case reporting, registry reporting) (HLACABAL)

Keywords

• Health informatics research
• Clinical data standards
• Biomedical informatics services
• Health information exchange
• Healthcare data analytics

Headquarters

HQ city

Indianapolis

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Technology or R&D, Operations, Infrastructure, Marketing or Sales

Revenue model

1. Federal Research Grants: Primary funding from federal agencies including NIH, National Institute on Aging (NIA), and other government health agencies for research programs and clinical trials.
2. Corporate Partnerships: Collaborative research partnerships with pharmaceutical companies (Merck, Lilly, Roche), healthcare systems, and technology companies.
3. Licensing Royalties: LOINC licensing and health data standards licensing generates revenue through international adoption of their standards.

Pricing tiers

Go-to-market motion1 record

Distribution channels3 records

Marketing channels7 records

Core offering

Regenstrief Institute develops and maintains LOINC, a universal health data interoperability standard for laboratory and clinical observations, and operates Regenstrief Data Services (RDS) and the Indiana Network for Patient Care (INPC) health information exchange. The institute conducts biomedical informatics, aging, care delivery, and health disparities research, translating findings into evidence-based programs such as APPROACHES advance care planning and iRecovery. It funds operations primarily through federal grants, corporate research partnerships, and LOINC commercial licensing.

Product overview

Regenstrief Institute is a healthcare research organization that develops and maintains several key products and programs. Its flagship product is LOINC, a universal health data standard for clinical and laboratory observations that enables interoperability across healthcare systems globally. The institute also operates Regenstrief Data Services (RDS), providing data infrastructure for research, and supports the Indiana Network for Patient Care (INPC), a statewide health information exchange. Research is organized through specialized centers including the Center for Biomedical Informatics (encompassing Dental Health Informatics, Global Health Informatics, Learning Health Informatics, and Public Health Informatics) and the Center for Aging Research. The institute also develops intervention programs like APPROACHES for advance care planning and operates the Public Health Emergency Surveillance System. As a research-focused organization, it does not offer a unified commercial product but rather provides standards, data services, and research programs to advance healthcare informatics.

Differentiator

Problem solved

Functional benefit

Brands

• LOINC & Health Data Standards: Health data standards program that develops and maintains the LOINC terminology standard for health data interoperability
• Regenstrief Data Services (RDS)
• AI / Machine Learning
• Care Delivery
• Health Disparities Research
• Applied Aging Research
• Informatics
• Alzheimer's & Related Dementias

Products and services

• LOINC

Quantifiable outcome

• 41% of intervention nursing homes achieved robust implementation (documenting ACP conversations for more than 75% of eligible residents)
• +2 more outcomes

Named customers5 records

Segments5 records

Ideal customer profiles5 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

AI capability7 records

Feature4 records

Partnerships

16 partnerships are on record, tiered core, major and minor.

• Indiana UniversitycoreStrategic or Co-development PartnerRegenstrief Institute's academic home with investigators from IU School of Medicine, IU School of Nursing, and other IU schools. Deep collaboration on research initiatives, training programs, and clinical trials.
• Purdue UniversitycoreStrategic or Co-development PartnerAcademic partner with investigators from Purdue College of Pharmacy, Purdue Industrial Engineering, and Purdue Healthcare Advisors collaborating on health services research.
• MerckmajorStrategic or Co-development PartnerCollaboration on clinical trials and research initiatives including partnership with Merck on generating evidence across full disease arc.
• Eli Lilly and CompanymajorStrategic or Co-development PartnerCollaborative research partnerships including study on obesity medications' impact with Fairbanks, Lilly, and Indiana employers.
• RochemajorStrategic or Co-development PartnerHealthcare research collaboration with pharmaceutical company Roche on various health services research initiatives.
• Indiana University HealthcoreStrategic or Co-development PartnerMajor healthcare system partner providing clinical settings for research and collaboration on AI-enabled trial screening and other initiatives.
• Eskenazi HealthmajorStrategic or Co-development PartnerHealthcare delivery partner in Indianapolis providing clinical research settings and collaborative care improvement initiatives.
• Kaiser PermanentemajorStrategic or Co-development PartnerNational healthcare system collaborating on research initiatives including cancer screening and population health.
• SNOMED InternationalcoreTechnology or IntegrationCollaboration on LOINC Ontology development expanding health data standards interoperability globally.
• Indiana Health Information ExchangecoreTechnology or IntegrationStatewide health information exchange enabling data sharing across Indiana healthcare organizations.
• Cook MedicalminorStrategic or Co-development PartnerMedical device company collaborating on healthcare research initiatives.
• Indiana Clinical and Translational Sciences InstitutecoreStrategic or Co-development PartnerCollaborative research training and translation of scientific discoveries into clinical practice.
• IU Simon Comprehensive Cancer CentermajorStrategic or Co-development PartnerComprehensive cancer center partnership for oncology research and cancer screening studies.
• Reagan-Udall Foundation of the Food and Drug AdministrationminorStrategic or Co-development PartnerFoundation partnership supporting FDA research and regulatory science initiatives.
• NEST Collaborative CommunityminorStrategic or Co-development PartnerInitiative of MDIC focused on medical device evaluation and regulatory science.
• U.S. President's Emergency Plan for AIDS Relief (PEPFAR)minorStrategic or Co-development PartnerGlobal health partnership supporting HIV/AIDS research through AMPATH program.

Scale indicators5 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• SNOMED International: Global standards body for clinical healthcare terminology. Most directly comparable to Regenstrief as a peer steward of a foundational health data standard; Regenstrief and SNOMED International are also collaboration partners on LOINC Ontology.
• Health Level Seven International (HL7): Standards organization behind FHIR and related interoperability frameworks. Operates in the same health data interoperability space as LOINC, defining how clinical data is exchanged across systems globally.
• NORC at the University of Chicago: Independent research organization affiliated with a major US university, conducting health services, policy, and survey research funded by federal agencies. Operates a similar nonprofit research model with comparable funding structure to Regenstrief.
• RTI International: Large nonprofit research institute conducting health, social, and scientific research for government and commercial clients. Comparable to Regenstrief in mission, federal grant dependence, and applied health services research footprint.
• Mathematica: Nonprofit research and data analytics consultancy with strong health policy and health services research practices. Comparable in funding mix (federal, foundation, commercial) and research-to-practice orientation.
• IHME (Institute for Health Metrics and Evaluation): University-affiliated research institute producing global health data and evidence. Comparable in mission (data-driven health improvement) and operating model, anchored at the University of Washington with major foundation and federal funding.
• Westat: Employee-owned research firm conducting health, social, and survey research for federal agencies. Comparable as a research organization with federal grants as a core funding stream and applied health services research capabilities.

Broad incumbents

• Health Catalyst: Commercial health data and analytics platform serving health systems. Comparable to Regenstrief's data services and analytics capabilities but operates at commercial scale with venture backing and a broader enterprise product portfolio.
• InterSystems: Provides the HealthShare platform for health information exchange and interoperability. Comparable to Regenstrief's INPC and interoperability work, but as a commercial vendor serving health systems globally rather than a nonprofit.

Emerging players

• Datavant: Health data linkage and de-identification technology company enabling data exchange across organizations. Comparable to Regenstrief's data linkage work and is also an active partner of the institute.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/Regenstrief
• Facebookfacebook.com/regenstriefinstitute
• LinkedInlinkedin.com/company/regenstrief-institute

Revenue estimate

Valuation estimate

Number of profiles

Profiles12 records

Funding overview

Funding rounds

Investors

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M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Regenstrief Institute, Inc.