SoftGenetics
SoftGenetics develops and licenses Windows-based genetic analysis software for Sanger, next-generation, and long-read sequencing, fragment analysis, and forensic DNA profiling, serving research, clinical, and forensic laboratories globally, now operating as a subsidiary of Dotmatics Ltd.
- Company typePrivate
- Founded2001
- HeadquartersState College, United States
- Headcount11–50
- GTM typeB2B
- OfferingSoftware
What SoftGenetics does
SoftGenetics, LLC is a Pennsylvania-based bioinformatics software company founded in 2001 and headquartered in State College, PA. The company develops and markets a portfolio of Windows-based genetic analysis software tools serving three core customer segments: research laboratories performing Sanger and next-generation sequencing variant analysis, forensic laboratories conducting human identification and DNA mixture interpretation, and clinical/healthcare laboratories performing chimerism and transplant monitoring. Its product suite spans Sequencing (Mutation Surveyor, NextGENe, NextGENeLR, Geneticist Assistant), Fragment Analysis (GeneMarker, ChimeRMarker), and Forensic DNA (GeneMarkerHID, GeneMarkerHTS, MaSTR, NOCIt) categories. Underlying technical differentiators include patented anti-correlation trace comparison technology (U.S. Patent 8,086,410), multi-step alignment algorithms for indel detection, Hidden Markov Model-based CNV and structural variant detection, and an NDIS-approved expert system for forensic human identification.
The company monetizes entirely through annual subscription licenses priced between $1,900 and $8,250 per year per product, including free upgrades and technical support during the subscription term. Distribution is hybrid: direct online sales supplemented by a global network of regional distributors across North America, Oceania, Europe, Asia, the Middle East, and Latin America. Go-to-market relies on free 35-day trials, an extensive on-demand webinar series (Analysis Corner), active conference presence (AAFS, ISHI, ESHG, ASHG, AMP), and co-development partnerships with Mayo Clinic (Geneticist Assistant) and Penn State's Forensic Science Program (GeneMarkerHID). All products are labeled Research Use Only and are not cleared for diagnostic procedures. SoftGenetics was acquired by Dotmatics Ltd., a US-based scientific informatics software firm, in June 2023, and now operates as a subsidiary within Dotmatics' broader Scientific R&D Platform that includes Geneious, SnapGene, GraphPad Prism, Protein Metrics, and other life-science software brands. The company employs 11-50 people and is privately held.
SoftGenetics firmographics
Firmographics- Name
- SoftGenetics
- Legal name
- SoftGenetics, LLC
- Website
- https://softgenetics.com
- Company type
- Private
- Founded year
- 2001
- Operating status
- Acquired
- Headcount range
- 11–50 employees
- Short description
- SoftGenetics develops and licenses Windows-based genetic analysis software for Sanger, next-generation, and long-read sequencing, fragment analysis, and forensic DNA profiling, serving research, clinical, and forensic laboratories globally, now operating as a subsidiary of Dotmatics Ltd.
- Ownership category
- akta.pro rank
SoftGenetics industry classification
Industry- Product category
- Bioinformatics Software
- NAICS
- Software Publishers (5132)
- SIC
- Services-Commercial Physical & Biological Research (8731)
- akta.pro primary industry
- Genetic & Genomic Testing (germline, somatic, carrier, pharmacogenomics) (HLAAALAD)
- akta.pro secondary industries
- Molecular Biology & Genomics Instruments (PCR/qPCR, Sequencing, Microarrays) (HLAGAIAF), Molecular Diagnostics (PCR/qPCR, NGS-based assays) (HLAAALAA), Genomics & Next-Generation Sequencing (NGS) Services (HLAGANAA), Transcriptomics & Gene Expression Profiling Services (HLAGANAE)
Keywords
Where SoftGenetics is headquartered
LocationHeadquarters
- HQ city
- State College
- HQ country
- United States
- HQ region
- North America
Offices1 record
Markets served
SoftGenetics business model
Business model- GTM type
- B2B
- Offering type
- Software
- Cost components
- Personnel, Technology or R&D, Operations, Marketing or Sales
Revenue model
- Annual Software Licenses: Annual subscription licenses for software products including Mutation Surveyor ($1,900/year), NextGENe ($3,850/year), GeneMarker ($2,495), and forensic products. Includes free upgrades, updates, fixes, technical support during subscription term.
- Forensic Software Licenses: Annual subscription licenses for forensic products including GeneMarkerHID ($3,050), GeneMarkerHTS ($2,420), MaSTR ($4,305), and NOCIt ($4,180)
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Subscription | Annual | Mutation Surveyor - DNA variant analysis from Sanger sequencing |
| Subscription | Annual | NextGENe - Next generation sequencing analysis |
| Subscription | Annual | NextGENeLR - Long-read sequencing analysis |
| Subscription | Annual | GeneMarker - Fragment analysis for genotyping |
| Subscription | Annual | ChimeRMarker - Automated chimerism analysis |
| Subscription | Annual | GeneMarkerHID - Human identity/forensic STR analysis |
| Subscription | Annual | GeneMarkerHTS - Forensic MPS mtDNA and STR data |
| Subscription | Annual | MaSTR - Probabilistic mixture analysis |
| Subscription | Annual | NOCIt - Number of contributors software |
Go-to-market motion1 record
Distribution channels2 records
Marketing channels4 records
SoftGenetics product offering
Product offeringCore offering
SoftGenetics develops and licenses bioinformatics software for genetic analysis, including Sanger and next-generation sequencing (NGS) data interpretation, mutation detection, and forensic DNA analysis. The company's products serve molecular diagnostics laboratories, genomics research labs, and forensic identification labs that need specialized software for variant detection, sequence alignment, and STR/mitochondrial analysis.
Product overview
SoftGenetics provides a comprehensive portfolio of genetic analysis software organized into three categories: Sequencing products (Mutation Surveyor, NextGENe, NextGENeLR, Geneticist Assistant) for research and clinical variant analysis from Sanger and next-generation sequencing platforms; Fragment analysis products (GeneMarker, ChimeRMarker) for genotype analysis and chimerism monitoring; and Forensic DNA products (GeneMarkerHID, GeneMarkerHTS, MaSTR, NOCIt) for human identity and forensic DNA mixture interpretation. All products run on Windows operating systems with biologist-friendly interfaces and are research use only. SoftGenetics was acquired by Dotmatics Ltd. in June 2023.
Differentiator
Problem solved
Functional benefit
Products and services
- Mutation Surveyor
- NextGENe
- NextGENeLR
- Geneticist Assistant Automated NGS data interpretation tool that classifies variants and generates clinical reports for genetic testing workflows.
- GeneMarker Software for fragment analysis including STR (short tandem repeat), microsatellite instability, and AFLP analysis used in research and applied markets.
- ChimeRMarker Chimeric transcript detection and visualization tool for analyzing gene fusions from RNA sequencing data.
- GeneMarkerHID Forensic human identification software designed for STR-based forensic DNA analysis workflows in forensic laboratories.
- GeneMarkerHTS High-throughput screening version of GeneMarker for processing large-scale fragment analysis datasets.
- MaSTR Massively parallel STR analysis software for processing forensic STR loci sequenced on NGS platforms.
- NOCIt Software for non-coding RNA analysis supporting identification and annotation of non-coding transcripts from sequencing data.
Quantifiable outcome
- Accuracy up to 99.5% with Phred 20 bi-directional sequences
- +6 more outcomes
Companies that use SoftGenetics
Customer profileSegments3 records
Ideal customer profiles3 records
SoftGenetics technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Integration25 records
AI capability9 records
Feature6 records
SoftGenetics partnerships and signals
Strategic signalPartnerships
Five partnerships are on record, tiered flagship, core and minor.
- Dotmatics Ltd.flagshipIn June 2023, Dotmatics Ltd. acquired SoftGenetics to strengthen its genomics data analysis capabilities in precision medicine. SoftGenetics became part of the Dotmatics scientific R&D platform, which now includes SoftGenetics products alongside other scientific software brands.
- Mayo CliniccoreGeneticist Assistant NGS Interpretative Workbench was developed in collaboration with the Laboratory Medicine, Information Technology, and Health Science Research departments of Mayo Clinic for the management, control, visualization, functional interpretation, and knowledge database of next-generation sequencing whole exome data.
- Pennsylvania State University - Forensic Science ProgramcoreGeneMarkerHID was developed in collaboration with Mitchell Holland, Ph.D., Pennsylvania State University's Forensic Science Program for expert system human identity software optimized for forensic profiling applications.
- Roche 454 Life SciencesminorRoche 454 Life Sciences and SoftGenetics signed a co-promotion agreement for Next-Gen Sequencing Software Tools, expanding market reach for both companies' products.
- Ambry GeneticsminorAmbry Genetics and SoftGenetics formed an exclusive alliance for extended bioinformatics support for Next Generation Sequencing projects, providing comprehensive NGS analysis solutions.
Scale indicators1 record
Recent moves6 records
Expansion highlights6 records
SoftGenetics competitors and assessment
Company assessmentDirect peers
- Geneious by Biomatters: Closest direct competitor offering integrated molecular biology and NGS analysis software with biologist-friendly interface. Overlaps with Mutation Surveyor, NextGENe, and GeneMarker for general genomics workflows across research and clinical audiences.
- Partek Flow (Partek / Illumina): NGS analysis software specializing in gene expression, variant detection, and copy number analysis. Competes with NextGENe in RNA-Seq and somatic variant detection workflows.
- DNAnexus: Cloud-based bioinformatics platform supporting NGS analysis pipelines, data management, and collaboration for clinical and research customers. Competes with NextGENe at the pipeline/orchestration layer.
- DNASTAR Lasergene: Long-standing sequence analysis software suite offering Sanger and NGS analysis tools directly competitive with Mutation Surveyor and NextGENe in research and clinical variant detection.
- Strand NGS (Strand Life Sciences): NGS analysis software platform offering variant calling, RNA-Seq, and clinical interpretation. Overlaps with NextGENe and Geneticist Assistant in research and clinical genomics markets.
- Genoox: Cloud-based clinical NGS interpretation platform offering variant annotation and clinical reporting. Competes with Geneticist Assistant for clinical exome and panel interpretation workloads.
- QIAGEN CLC Genomics Workbench: Enterprise-grade NGS analysis platform competing head-to-head with NextGENe for variant calling, RNA-Seq, and structural variant analysis. Targets similar research and clinical customer base with broader bioinformatics portfolio.
Emerging players
- Staden Package / Gap5: Open-source and academic bioinformatics tools for sequence assembly and analysis — primarily competing on price points with SoftGenetics' forensic and research-grade Sanger/NGS tools in budget-constrained labs.
Broad incumbents
- Illumina BaseSpace / DRAGEN: Largest sequencing platform vendor bundling analysis with its sequencing instruments. Broad incumbent offering overlapping variant calling and interpretation capabilities as part of an end-to-end sequencing portfolio.
- Thermo Fisher (Ion Torrent + S5 software): Broad incumbent in sequencing instruments (Ion Torrent) and配套 analysis software. Competes with NextGENe's Ion Torrent pipelines and offers integrated instrument-to-analysis bundles.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat5 records
Key risks5 records
Key highlights7 records
Customer concentration
SoftGenetics social profiles
Digital presenceSoftGenetics compliance and trust
Trust signalCompliance2 records
SoftGenetics financial estimates
Financial estimateRevenue estimate
Valuation estimate
SoftGenetics leadership team
Management profileNumber of profiles
SoftGenetics funding detail
Funding detailFunding overview
Funding rounds1 record
Investors1 record
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
SoftGenetics M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about SoftGenetics
What does SoftGenetics do?
SoftGenetics develops and licenses bioinformatics software for genetic analysis, including Sanger and next-generation sequencing (NGS) data interpretation, mutation detection, and forensic DNA analysis. The company's products serve molecular diagnostics laboratories, genomics research labs, and forensic identification labs that need specialized software for variant detection, sequence alignment, and STR/mitochondrial analysis.
Is SoftGenetics a public or private company?
SoftGenetics is a private company. It is classified as corporate owned and is currently acquired.
When was SoftGenetics founded?
SoftGenetics was founded in 2001. It employs 11 to 50 people.
Where is SoftGenetics based?
SoftGenetics is headquartered in State College, United States, in the North America region.
How does SoftGenetics make money?
Two revenue lines are on record. Annual Software Licenses are the primary driver. The others are forensic Software Licenses.
Who are SoftGenetics's main competitors?
Direct peers on record are Geneious by Biomatters, Partek Flow (Partek / Illumina), DNAnexus, DNASTAR Lasergene, Strand NGS (Strand Life Sciences), Genoox and QIAGEN CLC Genomics Workbench. Staden Package / Gap5 is listed as an emerging player. Broad incumbents are Illumina BaseSpace / DRAGEN and Thermo Fisher (Ion Torrent + S5 software).
Does SoftGenetics have an API?
No public API is recorded for SoftGenetics.
What industry is SoftGenetics in?
SoftGenetics's product category is Bioinformatics Software. Its primary akta.pro industry code is HLAAALAD, Genetic & Genomic Testing (germline, somatic, carrier, pharmacogenomics), with a secondary code of HLAGAIAF, Molecular Biology & Genomics Instruments (PCR/qPCR, Sequencing, Microarrays). Its NAICS code is 5132 and its SIC code is 8731.