What Mastelli does

Mastelli is an Italian bio-pharmaceutical company founded in 1952 in Sanremo, province of Imperia, that develops, manufactures, and commercializes drugs, Class III medical devices, dermocosmetics, and food supplements. The company is the worldwide originator of PDRN (Polydeoxyribonucleotide) and its derivative Polynucleotides HPT, DNA fragments extracted from fish gonads via a proprietary method that serve as the active ingredient in a regenerative-medicine portfolio organized across five therapeutic areas: aesthetic medicine and dermocosmetics, wound healing, gynecology, osteoarticular health, and dermatology. Primary customer segments include dermatologists, aesthetic medicine practitioners, gynecologists, orthopedists, pharmacists, hospitals, and Local Health Authorities in Italy, with indirect international reach through appointed foreign distributors.

The core technology rests on a proprietary polynucleotide extraction process from natural fish-gonad sources, complemented by an exclusive Three HA Technology (THT) for ultrapure monophasic cross-linked hyaluronic acid fillers produced via bio-fermentation. Mastelli holds patents covering key products — NEWEST (Polynucleotides HPT + Hyaluronic Acid + Mannitol), Condrotide (intra-articular Polynucleotides HPT gel), NEWEST One, and the THT process — and its Class III medical devices carry CE 0373 certification from the Italian Health Institute. The portfolio includes the PLINEST and NEWEST intradermal skin rejuvenator lines, the TRIPLEST hyaluronic acid filler line, IALEST, intra-articular devices (Condrotide, Condrotide HA, SavetYal, SavetYal CL), gynecological devices (Turnover Intimo, Turnover Recto, Turnover Ovuli, Turnover Plus), wound care (Placentex, Nucliaskin), a Micoxolamina gynecological drug line, and home-care cosmeceuticals (PlinestCARE, ioMask). Mastelli also performs contract manufacturing for third parties.

Mastelli is a privately held, family-owned business led by the Cattarini Mastelli family (four family members in Chairperson, Medical Manager, Business Development, and CFO roles) that converted to a Benefit Corporation in 2024. Revenue is generated primarily through a field force of Scientific Informants (Pharmaceutical Sales Representatives) conducting direct scientific information visits to Italian healthcare professionals, with secondary channels in pharmacy/wholesale distribution, direct hospital and ASL supply, and international export via appointed foreign distributors. The company employs 51-100 staff, holds ISO 13485:2016 (BSI), ISO 9001 (RINA), and UNI/PdR 125:2022 certifications, is a member of Farmindustria and Confindustria Dispositivi Medici, and has received EU co-financing for regenerative-medicine R&D.

Name

Mastelli

Legal name

Mastelli Srl

Website

https://mastelli.com

Company type

Private

Founded year

1952

Operating status

Operating

Headcount range

51–100 employees

Short description

Mastelli is an Italian bio-pharmaceutical company founded in 1952 that manufactures drugs, Class III medical devices, dermocosmetics, and supplements based on proprietary polynucleotides. It serves healthcare professionals across aesthetic medicine, wound care, gynecology, orthopedics, and dermatology through direct sales and international distributors.

Ownership category

akta.pro rank

Headquarters

HQ city

Imperia

HQ country

Italy

HQ region

Europe

Offices4 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Operations, Supply Chain, Personnel, Technology or R&D, Marketing or Sales, Infrastructure

Revenue model

1. Pharmaceutical Drugs: Production and marketing of drugs composed of pharmacologically active raw materials including PDRN. Products include Placentex for wound healing and other therapeutic applications. Distributed throughout Italian territory.
2. Medical Devices: Class III Medical Devices composed of Polynucleotides HPT including intradermal skin rejuvenators (PLINEST, NEWEST), fillers (TRIPLEST), and other aesthetic/therapeutic devices. Certified by Italian Health Institute.
3. Dermocosmetics: Production and marketing of dermocosmetic products including PLINESTcare home care line and ioMask cosmetic masks for post-treatment skincare.
4. Dietary Supplements: Distribution of food supplements including Condrotide Moveo for osteoarticular health. Only dietary supplements marketed, not produced.
5. Contract Manufacturing/Licensing: Produces drugs and medical devices for third parties using its state-of-the-art production facility. Manufacturing licensing services for external companies.
6. International Distribution: Exports drugs, medical devices, cosmetics, and supplements managing trade relations with foreign distributors in multiple countries worldwide.

Go-to-market motion2 records

Distribution channels4 records

Marketing channels5 records

Core offering

Mastelli is a bio-pharmaceutical company that manufactures and markets drugs, Class III medical devices, dermocosmetic products, and food supplements based on proprietary PDRN (Polydeoxyribonucleotide) and Polynucleotides HPT active ingredients derived from fish gonads. Its products serve therapeutic areas including aesthetic medicine, wound healing, gynecology, osteoarticular health, and dermatology, and are sold through its own scientific sales force, pharmacies, hospitals, and international distributors.

Product overview

Mastelli is an Italian bio-pharmaceutical company founded in 1952 in Sanremo, operating as a Benefit Corporation. Its product portfolio spans four categories: Drugs (medicinals), Class III Medical Devices (CE 0373), Dermocosmetics, and Food Supplements. The company is the worldwide originator of PDRN (Polydeoxyribonucleotide) and its key active ingredient Polynucleotides HPT®, derived from fish gonads. The portfolio is organized across five therapeutic areas: Aesthetic Medicine & Dermocosmetics (skin rejuvenators PLINEST, NEWEST, IALEST, hyaluronic acid fillers TRIPLEST, home care lines PlinestCARE and ioMask), Wound Healing (Placentex PDRN-based drugs, Nucliaskin devices), Gynecology (Micoxolamina drugs, Turnover gynecological device line), Osteoarticular/Orthopedics (Condrotide, SavetYal intra-articular devices, Condrotide Moveo supplements, Placentex injectables), and Dermatology. The aesthetic medicine products PLINEST and NEWEST are the core Class III Medical Device intradermal skin rejuvenator lines, while TRIPLEST is the hyaluronic acid filler line. Home care is delivered through PlinestCARE (anti-aging creams, serums, oils, body cream) and ioMask cosmetic masks. The orthopedic portfolio centers on Condrotide and SavetYal injectable devices for intra-articular treatment.

Differentiator

Problem solved

Functional benefit

Brands

• PLINEST: Intradermal skin rejuvenators based on Polynucleotides (Class III Medical Device)
• NEWEST
• IALEST
• TRIPLEST
• PLINEST Care
• PLINESTCARE
• ioMask
• Placentex
• Condrotide
• Condrotide HA
• SavetYal
• SavetYal CL
• Condrotide Moveo
• Turnover Ginecologica
• Micoxolamina
• Nucliaskin

Products and services

• PLINEST® Polynucleotides Injectable Line Class III Medical Device (CE 0373) Polynucleotides gel injectable skin rejuvenators for intradermal use, derived from fish gonads. Multiple variants target general facial rejuvenation, periocular area, scalp, and body applications. Intended for use by aesthetic medicine practitioners.
• NEWEST® Polynucleotides and Hyaluronic Acid Line Class III Medical Device (CE 0373) injectable skin rejuvenator combining Polynucleotides HPT, Hyaluronic Acid, and Mannitol. Available in 2ml pre-filled syringes and 5x4ml vials. Original Mastelli patented product for aesthetic medicine professionals.
• IALEST® Hyaluronic Acid Injectable Class III Medical Device (CE 0373) natural free Hyaluronic Acid gel injectable skin rejuvenator for intradermal infiltrations, supplied in 2ml pre-filled syringes for aesthetic medicine practitioners.
• TRIPLEST® Hyaluronic Acid Filler Line Class III Medical Device line of ultrapure monophasic cross-linked hyaluronic acid dermal fillers (25mg/ml) produced using exclusive Three HA Technology (THT) bio-fermentation. Includes TRIPLEST Classic, Lips Smile, and Volume variants for aesthetic medicine professionals.
• NEWGyn Bio-Revitalizing Gel Bio-revitalizing intradermal gel based on Polynucleotides HPT designed for the vulvo-vaginal area, for use by gynecologists and aesthetic medicine practitioners.
• PlinestCARE Home Care Cosmetic Line Anti-aging home care cosmetic line based on Polynucleotides, Hyaluronic Acid, and Vitamin E. Includes day cream (with and without SPF20), night cream, eye contour cream, face serum, body oil, and body cream for post-treatment skincare.
• ioMask Cosmetic Mask Line Cosmetic face mask line for completion of aesthetic treatments, including ioMask Tensor (lifting effect), ioMask Repair (with Polynucleotides), ioMask Lightening (brightening), and ioMask Anti-Aging.
• Placentex PDRN Pharmaceutical Drug Drug based on Polydeoxyribonucleotide (PDRN) for wound healing. Available as 5.625mg/3ml and 2.25mg/3ml injectable solutions, 0.75mg/3ml cutaneous solution, and 0.08% cream. Distributed in Italian territory.
• Condrotide Intra-Articular Polynucleotides Gel Class III Medical Device (CE 0373) intra-articular injectable gel based on Polynucleotides HPT for management of arthropathies and tendinopathies. 2ml pre-filled syringe. Original Mastelli patented product for orthopedic specialists.
• Condrotide HA Intra-Articular Gel Class III Medical Device (CE 0373) intra-articular injectable gel combining Polynucleotides HPT, Hyaluronic Acid, and Mannitol for joint treatment. 2.5ml pre-filled syringe for orthopedic specialists.
• SavetYal Hyaluronic Acid Gel Intra-articular injectable Hyaluronic Acid gel for joint lubrication and treatment. 2ml pre-filled syringe for orthopedic specialists.
• SavetYal CL Cross-Linked Hyaluronic Acid Gel Intra-articular injectable cross-linked Hyaluronic Acid gel for enhanced joint treatment. 3ml pre-filled syringe for orthopedic specialists.
• Condrotide Moveo Food Supplement Food supplement for osteoarticular health based on chondroitin sulfate, glucosamine, Hyaluronic Acid, nucleotides, and collagen. 20 tablets per pack; distributed but not produced by Mastelli.
• Micoxolamina Gynecological Drug Ciclopiroxolamine based drug for gynecological use. Available as 1% vaginal cream (75g), 1% gynecological foam (60ml), and 100mg vaginal suppositories (6 units).
• Turnover Gynecological Polynucleotides Line Class III Medical Device (CE 0373) gynecological product line based on Polynucleotides HPT for vulvo-vaginal and perianal protection and trophism. Includes Turnover Intimo (vaginal cream), Turnover Recto (rectal gel), Turnover Ovuli (vaginal suppositories), and Turnover Plus (vaginal suppositories with terpinenol).
• Contract Manufacturing and Licensing Services Contract manufacturing services producing drugs and medical devices for third-party companies at Mastelli's state-of-the-art Sanremo production facility. Includes licensing arrangements.

Segments6 records

Ideal customer profiles4 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature4 records

Partnerships

Six partnerships are on record, tiered core and minor.

• UniversitiescoreStrategic or Co-development PartnerMastelli cooperates continuously with universities for R&D activities, including clinical trials and pharmacological studies. The partnership focuses on developing new knowledge and expanding research capabilities in regenerative medicine, aesthetic medicine, and pharmaceutical development.
• HospitalscoreStrategic or Co-development PartnerOngoing collaboration with hospitals for clinical research, clinical trials, and pharmacological studies. Hospitals serve as clinical trial sites and research partners for developing and validating new therapeutic applications of PDRN and Polynucleotides.
• Qualified AuditorsminorOthersMastelli works with qualified auditors to develop and broaden its research works, ensuring compliance with regulatory standards and quality requirements for pharmaceutical and medical device development.
• Farmindustria (National Association of Pharmaceutical Industry)coreOthersMastelli adheres to the Farmindustria Code of Ethics and follows its guidelines for certification of procedures related to scientific information activities. The association represents the Italian pharmaceutical industry.
• Confindustria Dispositivi MedicicoreOthersMastelli is a member of Confindustria Dispositivi Medici and adheres to their Code of Ethics. Follows guidelines for medical device promotion and interaction with healthcare professionals.
• Foreign DistributorscoreChannel Partner/ Reseller/ DistributorMastelli exports products managing trade relations with several foreign distributors in different countries of the world. These distributors handle local market access, product registration, and commercial distribution in their respective territories.

Scale indicators4 records

Recent moves7 records

Expansion highlights6 records

Broad incumbents

• Merz Aesthetics: Aesthetics arm of Merz Pharma offering hyaluronic acid fillers (Belotero), biostimulators (Radiesse, Sculptra), and toxin alternatives. Competes with Mastelli's TRIPLEST fillers and PLINEST regenerative platform in the practitioner channel globally.
• Galderma: Global dermatology and aesthetics leader with hyaluronic acid fillers (Restylane, Emervel) and broader skin health portfolio. Directly competes with Mastelli's TRIPLEST filler line and PLINEST regenerative aesthetic devices, though Galderma's portfolio is far broader across therapeutics and OTC skincare.
• Relife (Menarini Group): Aesthetics and dermatology business of the Menarini Group, offering hyaluronic acid fillers, biorevitalization injectables, and dermo-cosmetic ranges. Competes with Mastelli in Italy and across Europe in regenerative injectables and medical-grade skincare.

Direct peers

• Sinclair Pharma: Aesthetics-focused specialty pharma with hyaluronic acid and biostimulator portfolio (MaiLi, Lanluma, Ellansé). Comparable go-to-market through physician channels and similar positioning in regenerative aesthetic medicine versus Mastelli's PLINEST/NEWEST/TRIPLEST lines.
• Croma-Pharma: Austrian aesthetics company producing hyaluronic acid fillers, PRP kits, and bio-stimulators. Similar size, product mix, and physician-channel distribution to Mastelli, with overlapping competition in fillers and regenerative aesthetic devices.
• Teoxane: Swiss manufacturer of hyaluronic acid-based dermal fillers and cosmeceuticals (Teosyal range). Directly comparable to Mastelli in hyaluronic acid fillers and skin rejuvenation injectables, with a similar premium specialty positioning.
• IBSA Farmaceutici: Italian pharmaceutical company with a strong aesthetic medicine and hyaluronic acid injection portfolio (Profhilo, Viscoderm). Closest direct competitor in size and Italian origin, competing head-to-head with Mastelli in regenerative injectables and orthopedics viscosupplementation.
• Caregen: Korean biotech developing biomimetic peptides and polynucleotides for aesthetic and dermatology applications. Direct technology overlap with Mastelli in polynucleotides, and a leading force in the global PDRN category boom that is reshaping the regenerative aesthetics market.

Emerging players

• Huons Global: Korean pharmaceutical and aesthetics company with hyaluronic acid fillers and a growing regenerative medicine portfolio. Emerging peer driving the global PDRN trend that is creating both opportunity and competitive pressure for Mastelli.
• BioScience GmbH: German specialist in injectable medical devices and biopolymers for aesthetic and orthopedic indications. Competes with Mastelli's Condrotide and hyaluronic acid-based intra-articular products in orthopedics and physiatry segments.

Market position

Strengths4 records

Weaknesses4 records

Competitive moat5 records

Key risks5 records

Key highlights7 records

Customer concentration

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Compliance3 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles8 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Mastelli