Proliant Biologicals

What Proliant Biologicals does

Proliant Health & Biologicals (PHB) is a privately held manufacturer of purified protein ingredients serving the diagnostic, cell culture, biopharmaceutical, veterinary, and human nutrition industries. Founded in 2000 and headquartered in Ankeny, Iowa, PHB operates as a subsidiary of the diversified LGI group and employs 251-500 people. The company's core technology is a proprietary closed-loop manufacturing system that controls the entire production chain — from USDA/MPI-certified raw material collection through sealed stainless steel processing, closed membrane/centrifuge systems, and clean-in-place (CIP) operations — to deliver high-purity, lot-consistent protein products. Manufacturing is conducted at two identical facilities in Boone, Iowa (50,000 sq ft including a 10,000 sq ft lyophilization suite) and Feilding, New Zealand, providing globally redundant production.

PHB's product portfolio spans three primary verticals: Diagnostics (BSA variants such as Standard Grade, Fatty-Acid Free, Sulfhydryl Blocked, and Cohn Analog; Bovine Gamma Globulin; recombinant human albumin AlbufreeDX); Cell Culture (Adult Bovine Serum with industry-leading 20,000L single lot size, Newborn Calf Serum, AlbuRich, animal-derived extracts, and classical/custom media with 2.45 million liters/year capacity); and Nutrition (serum-derived bovine immunoglobulin products Immunolin, EnteraGam, and NutraGamax). In 2022, PHB launched its recombinant protein platform through a partnership with Dyadic International, leveraging Dyadic's C1 filamentous fungal production platform to commercialize animal-free AlbufreeDX with planned extensions into cell culture (AlbufreeTX) and cell/gene therapy (AlbufreeCGT) applications.

The company operates a partnership-driven enterprise B2B sales model combining direct account management (led by VPs of Global Sales, Business Development, and Manufacturing) with a global distributor network covering 15+ countries across the Americas, Europe, Asia-Pacific, the Middle East, and Latin America. Revenue is generated through B2B protein product sales (bulk powders, solutions, and media under multi-year contracts), custom formulation and co-development services, and recombinant protein licensing. Pricing is quote-based and not publicly disclosed. Certifications across FDA cGMP, USDA/APHIS Technical Blood Facility, EU Regulations (EC) 1069/2009 and 142/2011, and ISO 9001:2015 create a regulatory moat in regulated end markets. Named customers and partners include Mindray, J Sights, Yarewell Biotechnology, Veritas, Silver Fern Brand, Cryptobiotix, Biophyll, Duksan Pure Chemicals, and Dyadic International.

Name

Proliant Biologicals

Legal name

PROLIANT BIOLOGICALS LLC

Website

https://phb1.com

Company type

Private

Founded year

2000

Operating status

Operating

Headcount range

51–100 employees

Short description

Proliant Health & Biologicals is a privately held manufacturer of purified protein ingredients — including BSA variants, bovine sera, recombinant human albumin, and immunoglobulin products — serving diagnostic, cell culture, biopharmaceutical, and nutrition companies globally via two manufacturing facilities (Iowa, USA and New Zealand).

Ownership category

akta.pro rank

Product category

Protein Ingredients

NAICS

Biological Product (except Diagnostic) Manufacturing (325414)

SIC

Biological Products, (No Disgnostic Substances) (2836)

akta.pro primary industry

Bioprocess Consumables & Reagents (resins, membranes, media components, buffers) (HLAAAJAI)

akta.pro secondary industries

Bioprocess Development & Scale-Up/Scale-Down Platforms (DoE, high-throughput, modeling) (HLAAAJAF), Veterinary Pharmacy, Vaccine & Biologics Services (AFAEANAK)

Keywords

• Purified protein ingredients
• Diagnostic grade BSA
• Cell culture sera
• Recombinant human albumin
• Serum-derived immunoglobulins

Headquarters

HQ city

Ankeny

HQ country

United States

HQ region

North America

Offices4 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Operations, Personnel, Technology or R&D, Marketing or Sales, Infrastructure

Revenue model

1. B2B Protein Product Sales: PHB generates revenue through the sale of purified animal-derived proteins (BSA, BGG, colostrum derivatives) and recombinant proteins to diagnostic, cell culture, and nutrition companies. Products are sold in bulk powder, solution, and media formats under long-term supply agreements and per-order arrangements.
2. Custom Formulation & Development Services: PHB offers bespoke R&D and formulation services co-developed with partner companies. Revenue is derived from development fees, custom product minimums, and long-term supply contracts tied to co-developed solutions across diagnostic and cell culture applications.
3. Recombinant Protein Licensing (Dyadic Partnership): Through its partnership with Dyadic International, PHB commercializes recombinant human albumin products developed using Dyadic's C1 protein production platform. Revenue derives from product sales of AlbufreeDX with planned expansion to AlbufreeTX (cell culture) and AlbufreeCGT (cell and gene therapy).

Pricing tiers

Go-to-market motion2 records

Distribution channels2 records

Marketing channels6 records

Core offering

Proliant Health & Biologicals manufactures purified animal-derived proteins (BSA, Bovine Gamma Globulin, bovine sera, animal extracts) and recombinant proteins (AlbufreeDX recombinant human albumin) for in-vitro diagnostics, cell culture/biopharmaceutical manufacturing, and human nutrition supplement companies. Production is performed under a proprietary closed-loop manufacturing system replicated across facilities in Boone, Iowa (USA) and Feilding, New Zealand, with full regulatory compliance (FDA cGMP, ISO 9001:2015, USDA/APHIS). PHB also offers custom formulation, one-on-one R&D collaboration, and 24/7 technical support as bundled services tied to long-term B2B supply agreements.

Product overview

Proliant Health & Biologicals offers a diversified portfolio of purified proteins across three primary market segments: Diagnostics (BSA variants, Bovine Gamma Globulin, extract powders, and recombinant proteins), Cell Culture (sera, albumin derivatives, extracts, and classical/custom media), and Nutrition (serum-derived immunoglobulin and protein supplements). The company operates with a closed-loop manufacturing system and produces from facilities in Boone, Iowa (USA) and Feilding, New Zealand. The AlbufreeDX recombinant human albumin line represents the company's expansion into animal-free recombinant proteins, with plans to extend to AlbufreeTX for cell culture and AlbufreeCGT for cell and gene therapy workflows. Distribution spans across global markets including North America, Europe, Asia-Pacific, and Latin America through a network of regional distributors.

Differentiator

Problem solved

Functional benefit

Brands

• Albufree: Line of recombinant proteins including AlbufreeDX for diagnostics and future products AlbufreeTX for cell culture and AlbufreeCGT for cell and gene therapy
• Immunolin
• EnteraGam
• NutraGamax 45

Products and services

• AlbufreeDX Recombinant Human Albumin (rHA) Diagnostic-grade recombinant human albumin (rHA) produced through precision fermentation using a fungal-derived cell line. Animal-free alternative to HSA for high-throughput diagnostic assays, immunoassays, flow cytometry, and serology.
• Standard Grade (Caprylate Stabilized) BSA pH 7.0

Quantifiable outcome

• ≥ 98% BSA purity with ≤ 1 EU/mg endotoxin for Standard Grade Caprylate Stabilized BSA, ensuring minimal interference in the most demanding diagnostic applications
• +5 more outcomes

Named customers5 records

Segments5 records

Ideal customer profiles4 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature4 records

Partnerships

15 partnerships are on record, tiered core and minor.

• Dyadic InternationalcoreStrategic or Co-development Partner · 17 February 2026PHB and Dyadic International co-launched AlbufreeDX recombinant human albumin produced using Dyadic's C1 filamentous fungal protein production platform. The partnership commercializes animal-free recombinant albumin for diagnostic applications, with planned expansion to AlbufreeTX for cell culture and AlbufreeCGT for cell and gene therapy workflows. Dyadic serves as the technology provider while PHB handles product commercialization and distribution.
• Silver Fern FarmscoreOthersLong-term supply agreement with Silver Fern Farms, the largest bovine packing company in New Zealand, providing steady supply of raw materials for PHB's Feilding manufacturing facility. Under the agreement, PHB controls all raw material collection processes and owns all processing equipment at each collection facility, ensuring full supply chain control.
• Yarewell Biotechnology Ltd.coreChannel Partner/ Reseller/ DistributorYarewell Biotechnology is listed as a key partner company working with PHB to advance human and animal health. Yarewell serves as a distributor in the China market and is referenced as a satisfied customer with direct engagement in custom product development and supply.
• MindraycoreStrategic or Co-development PartnerMindray, a global medical device and diagnostics company, is listed as a partner working with PHB to advance human health. Mindray distributes and integrates PHB's diagnostic protein products within its broader diagnostics instrumentation ecosystem.
• CryptobiotixminorStrategic or Co-development PartnerCryptobiotix, a microbiome and animal health company, partners with PHB. CSO Pieter Van den Abbeele has co-authored peer-reviewed publications with PHB's R&D team and specifically recommends the partnership for rigorous scientific evidence and collaborative research outcomes.
• Silver Fern BrandcoreChannel Partner/ Reseller/ DistributorSilver Fern Brand is a key nutrition partner and customer of PHB, using Immunolin (serum-derived bovine immunoglobulin) in its Cleanse Daily Detox gut health supplement. The partnership exemplifies PHB's entry into the human nutrition segment with clinically proven ingredients.
• Biophyll GmbHcoreChannel Partner/ Reseller/ DistributorBiophyll GmbH (Germany) serves as PHB's distributor in the European market, representing PHB's diagnostic and cell culture protein products across Europe under the distributor network covering Germany and surrounding regions.
• DK Enzymes & ChemicalscoreChannel Partner/ Reseller/ DistributorDK Enzymes & Chemicals (India) serves as PHB's distributor covering the Indian market for diagnostic and life science protein products. Located in Mumbai, they distribute PHB's BSA, BGG, and recombinant protein product lines.
• Duksan Pure ChemicalscoreChannel Partner/ Reseller/ DistributorDuksan Pure Chemicals (South Korea) is a therapeutic segment distributor for PHB, providing distribution coverage in South Korea for PHB's protein ingredients targeting the biopharmaceutical and cell culture markets.
• J Sights CorporationminorStrategic or Co-development PartnerJ Sights Corporation (Japan), led by CEO Masato Saito, is a key partner that attests to PHB's long history as a leader, with commitment to quality, world-class support, and on-time deliveries exceeding expectations.
• MP BiomedicalscoreChannel Partner/ Reseller/ DistributorMP Biomedicals is listed as a partner company working with PHB, serving as a global distributor and life sciences reagent company that integrates PHB's protein ingredients into its broad portfolio for research and diagnostic applications.
• SUNFCOminorChannel Partner/ Reseller/ DistributorSUNFCO is listed as a partner company working with PHB to advance human and animal health. Serves as a distributor in the nutrition and health ingredients market.
• Veritas CorporationcoreChannel Partner/ Reseller/ DistributorVeritas Corporation (Japan) is a key distribution partner and customer of PHB, distributing BSA and related diagnostic proteins in the Japanese market. Sales & Marketing Manager Takahiro Hiramoto credits PHB's personalized attention and tailored solutions in transforming their business.
• Fermbox BiominorStrategic or Co-development PartnerFermbox Bio is a commercial partner alongside PHB in Dyadic's C1 platform ecosystem. Fermbox Bio and PHB are both listed as commercial product launch partners with Dyadic, indicating parallel but related engagement with the C1 fungal protein production platform.
• IBT BioservicesminorStrategic or Co-development PartnerIBT Bioservices is a commercial partner in the Dyadic C1 platform ecosystem alongside PHB. IBT signed an OEM distribution agreement with Dyadic related to C1-produced proteins, and is listed in the same commercial ecosystem as PHB's AlbufreeDX launch.

Scale indicators12 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• Bio-Techne: Direct competitor in protein reagents for diagnostics and life sciences. Bio-Techne manufactures BSA, BGG, recombinant proteins, and cell culture reagents serving IVD and research customers—strong overlap in catalog and B2B motion with PHB.
• InVitria: Direct competitor in animal-free recombinant proteins for diagnostics and cell culture, including recombinant human albumin. Targets the same IVDR-compliance and ESG-aligned customer needs as AlbufreeDX.
• Rocky Mountain Biologicals: Direct competitor in sera, BSA, BGG, and animal-derived protein ingredients for diagnostics and life sciences. Operates a similar niche-manufacturer model with vertically integrated raw material sourcing.

Broad incumbents

• Lonza: Broad incumbent supplying cell culture media, sera, and bioprocessing services to pharma and biotech customers, with overlapping products and bioprocess focus relative to PHB's cell culture portfolio.
• Thermo Fisher Scientific: Broad life sciences incumbent supplying cell culture sera, BSA, and protein reagents via its Gibco and Pierce brands. Significant overlap with PHB's diagnostics and cell culture product portfolio, though embedded in a much broader offering.
• Avantor: Broad life sciences manufacturer and distributor supplying sera, BSA, and bioprocessing reagents. Overlaps with PHB's diagnostic and cell culture portfolio and increasingly serves similar B2B enterprise customers.
• Sartorius: Broad bioprocessing incumbent. Its acquisition of Albumedix adds a recombinant human albumin franchise that directly competes with PHB's AlbufreeDX in the cell culture and CGT customer set.
• Corning Life Sciences: Broad incumbent in cell culture media and sera through its Falcon and Corning brands, supplying biopharma and research customers. Overlaps with PHB's cell culture and media segment.
• Merck KGaA (MilliporeSigma): Broad incumbent in bioprocessing and life science reagents through its Life Science and Applied Solutions segments. Overlaps with PHB on sera, BSA, cell culture media, and recombinant proteins used by diagnostics and biopharma manufacturers.
• Cytiva (Danaher): Broad incumbent supplying cell culture media and sera (including the HyClone product line) plus other process reagents to biopharma manufacturers—direct overlap with PHB's cell culture product line.

Market position

Strengths4 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• LinkedInlinkedin.com/company/proliant-biologicals
• Facebookfacebook.com/Proliant-Biologicals-587065974762863

Compliance5 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles7 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Proliant Biologicals