Scale-up Systems

What Scale-up Systems does

Scale-up Systems is a privately held Irish software company founded in 1994 and headquartered in Dublin, specializing in drug substance process development and scale-up software for the pharmaceutical industry. Its flagship product, the Scale-up Suite, comprises three core offerings: Dynochem for chemical process modeling (reactions, heat transfer, crystallization, filtration, drying, mixing), Dynochem Biologics for bioprocess development (mAb, ADC, oligonucleotide processes), and Reaction Lab for reaction kinetics integrated with electronic lab notebooks (ELNs). A range of add-on modules extends the platform — RunScript Automation for Python-based workflow automation, the Mixing Web App and Reaction Profiler for data-rich experiment visualization, plus specialized toolboxes for crystallization, VLLE prediction, drug product stability, and equipment data services.

The platform is built on proprietary kinetic modeling algorithms and unit operation models developed over 20+ years, validated across an extensive customer publication record from major pharmaceutical companies. A deep technology integration partnership with Mettler Toledo ties Scale-up Systems' software to Mettler Toledo's automated lab reactors (EasyMax, OptiMax) and process analytical technology (ReactIR, FBRM, RC1 calorimeter), creating a closed-loop workflow from automated data collection to model-based scale-up prediction.

The company operates an enterprise B2B software licensing model serving three primary segments: pharmaceutical manufacturers (Merck, Pfizer, Lilly, Novartis, AbbVie, AstraZeneca, GSK, BMS, Amgen, Janssen, Takeda), CDMOs (Olon, Hovione, Siegfried, Seqens, Axplora, ST Pharm, Ajinomoto Bio Pharma Services), and academic institutions (Purdue, University of Limerick, Mannheim). Go-to-market relies on enterprise field sales, content-driven demand generation through extensive webinars and customer publications, and recurring conference presence (AIChE Annual Meeting participation from 2010 through 2025), with regional training programs in Asia Pacific serving as a geographic expansion channel.

Name

Scale-up Systems

Legal name

Scale-up Systems

Website

https://scale-up.com

Company type

Private

Founded year

1994

Operating status

Operating

Headcount range

11–50 employees

Short description

Scale-up Systems is an Irish privately held software company that provides drug substance process development and scale-up software to the pharmaceutical industry, with Dynochem for chemical processes, Dynochem Biologics for bioprocess development, and Reaction Lab for kinetics and ELN integration.

Ownership category

akta.pro rank

Product category

Pharmaceutical Process Development Software

NAICS

Computer Systems Design Services (541512)

SIC

Services-Prepackaged Software (7372)

akta.pro primary industry

AI/ML Platforms for Drug Discovery & Experiment Optimization (HLAGAJAO)

akta.pro secondary industries

CMC & Pharmaceutical Development (Formulation/Process/Analytical Development) (HLAIALAD), Small-Molecule API Process Development & Route Scouting (HLAGAHAA), GMP Scale-Up, Tech Transfer & Process Validation (PPQ) (HLAGAHAL)

Keywords

• Pharmaceutical process software
• Drug substance development
• Chemical process modeling
• Bioprocess scale-up
• Reaction kinetics software

Headquarters

HQ city

Dublin

HQ country

Ireland

HQ region

Europe

Offices1 record

Markets served

GTM type

B2B

Offering type

Software

Cost components

Personnel, Technology or R&D, Marketing or Sales, Operations, Infrastructure

Revenue model

1. Software Licensing: Scale-up Suite software licensing model providing access to Dynochem, Dynochem Biologics, and Reaction Lab tools for pharmaceutical process development and scale-up.

Go-to-market motion1 record

Distribution channels1 record

Marketing channels6 records

Core offering

Scale-up Systems develops and sells the Scale-up Suite, a unified software platform for pharmaceutical drug substance process development and scale-up. The suite comprises Dynochem for chemical process modeling (reactions, heat transfer, crystallization, filtration, mixing, distillation), Dynochem Biologics for bioprocess and biologics scale-up, and Reaction Lab for reaction kinetic modeling with ELN integration. The software enables scientists and engineers to predict process performance from laboratory to manufacturing scale, supporting Quality by Design (QbD), regulatory submissions, and process safety assessments.

Product overview

Scale-up Systems offers Scale-up Suite, a unified platform combining multiple specialized software products for pharmaceutical drug substance process development and scale-up. The core portfolio includes Dynochem for chemical process development, Dynochem Biologics for bioprocess development, and Reaction Lab for kinetic analysis integrated with ELN systems. These products work together to enable scientists to predict process performance from laboratory to manufacturing scale, supporting Quality by Design (QbD) approaches. Additional capabilities are extended through specialized modules including RunScript Automation for Python-based workflow automation, the Mixing Web App for mixing analysis, Reaction Profiler for data-rich experiment visualization, and specialized toolboxes for crystallization, stability, and other unit operations.

Differentiator

Problem solved

Functional benefit

Brands

• Dynochem®: Accelerating Chemical Process Development - world's leading drug substance process development and scale-up software for the pharmaceutical industry
• Dynochem Biologics™
• Reaction Lab™
• Scale-up Suite™

Products and services

• Scale-up Suite The world's leading drug substance process development and scale-up software platform for scientists and engineers working in the pharmaceutical industry, providing a unified environment for predictive modeling across multiple unit operations.
• Dynochem

Quantifiable outcome

• Enabled PEG-lipid project for COVID vaccines to be fully developed and manufactured for commercial use within 9 months (Merck)
• +3 more outcomes

Named customers23 records

Segments3 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature6 records

Partnerships

One partnership is on record.

• Mettler ToledocoreTechnology or IntegrationDeep technology integration partnership where Scale-up Systems software integrates with Mettler Toledo lab reactors (EasyMax, OptiMax) and process analytical technology (ReactIR, FBRM, RC1 calorimeter). This enables a seamless workflow from automated data collection to kinetic modeling and scale-up prediction.

Scale indicators1 record

Recent moves6 records

Expansion highlights5 records

Direct peers

• Sartorius (Umetrics / MODDE): Sartorius's Umetrics suite (MODDE, SIMCA) is the closest direct competitor in bioprocess and pharmaceutical DoE/PAT modeling software. Both target process development scientists with model-based scale-up tools, and both have strong Mettler-Toledo-adjacent customer bases.
• ACD/Labs (Advanced Chemistry Development): ACD/Labs provides analytical and chemistry software for pharma including physicochemical property prediction and reaction modeling. Closely comparable in serving pharma process and analytical scientists with domain-specialized desktop tools.
• Genedata: Genedata offers biopharma R&D informatics platforms used in process development and biologics workflows. Comparable in serving enterprise pharma/biotech R&D scientists with specialized informatics rather than generic lab software.
• Dotmatics (Revvity): Dotmatics provides scientific informatics for R&D labs including ELN, data management, and analysis workflows. Comparable as a domain-specialized informatics platform serving pharma process development and analytical scientists.
• Siemens Process Systems Engineering (gPROMS): gPROMS (formerly PSE) is a leading mechanistic process modeling platform used in pharma for process development, optimization, and digital twins. One of the most direct competitors to Dynochem in advanced pharma process modeling.

Broad incumbents

• Dassault Systèmes BIOVIA: BIOVIA offers a broad pharma R&D software portfolio including process development and QbD capabilities. Larger, multi-product platform that overlaps with Scale-up Systems in pharmaceutical process modeling but serves a much wider enterprise customer base.
• Aspen Technology: Aspen Plus and aspenONE are widely used for chemical process simulation, with growing pharma applications. A much larger incumbent whose process modeling capabilities overlap with Dynochem, particularly in reaction and distillation modeling.
• Siemens Simcenter / Siemens Xcelerator: Siemens's Simcenter portfolio includes process simulation and digital twin capabilities that overlap with parts of Dynochem's mixing, heat transfer, and reactor modeling. A broad industrial incumbent rather than a pharma specialist.

Emerging players

• Schrödinger: Schrödinger is expanding from molecular simulation into broader drug substance development workflows including process optimization. An emerging competitor at the intersection of physics-based modeling and ML that could overlap with Scale-up's predictive modeling roadmap.
• Benchling: Benchling is a cloud-native biotech R&D platform with growing process development and ELN capabilities. An emerging competitor whose SaaS delivery model and breadth could encroach on parts of Scale-up's enterprise footprint.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat4 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/DynoChem
• Facebookfacebook.com/ScaleupSystems
• LinkedInlinkedin.com/company/scale-up-systems

Revenue estimate

Valuation estimate

Number of profiles

Profiles4 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Scale-up Systems