Complete Genomics

What Complete Genomics does

Complete Genomics, Inc. is a U.S.-based genomic sequencing technology company headquartered in San Jose, California, that develops and commercializes the DNBSEQ platform — a DNA nanoball sequencing architecture using rolling circle replication and combinatorial probe-anchor synthesis chemistry — across three throughput tiers (DNBSEQ-G99 benchtop, DNBSEQ-T1+ mid-throughput, and DNBSEQ-T7+ high-throughput at $800,000 per instrument, 48 billion reads in 24 hours). The company's portfolio also includes the Stereo-seq spatial transcriptomics product family (fresh frozen and FFPE formats, single-cell resolution at 0.5 µm with capture areas up to 13 cm × 13 cm), the DNBSEQ-G400 FluoXpert multi-omics system combining sequencing with multiplex immunofluorescence, a full lab-automation suite (SP-NE32/384 extraction, SP-Smart8/100/960 library prep, STP-3000/7000 sample management), and supporting kits, bioinformatics software (MegaBOLT, ZTRON, SAW, StereoMap), and the open-source PanVariants AI variant-calling framework.

The company monetizes through a razor-and-blade model: capital sales of DNBSEQ instruments to research institutions, service providers, and clinical labs, followed by recurring consumables (extraction kits, library prep, sequencing reagents, flow cells) tied to instrument utilization, supplemented by licensing revenue from the CoolMPS technology agreement with Swiss Rockets AG and a certified service-provider network (Gene by Gene, Praxis Genomics, Psomagen, PacGenomics, UCSD CMI, UCLA TCGB, Northwestern, U Colorado, Vancouver Prostate Centre) that delivers DNBSEQ-based sequencing as a service. Customers span academic and research institutions (primary segment), clinical research and diagnostics (via SOPHiA GENETICS and Memorial Sloan Kettering integrations), population-scale genomics programs, agrigenomics, and microbiology applications.

Complete Genomics was founded in 2006, previously listed on NASDAQ (GNOM) prior to delisting, and was controlled by Chinese MGI Tech Co. before entering a definitive agreement in February 2026 to be acquired by Basel-based Swiss Rockets AG, which also exclusively licensed the CoolMPS sequencing chemistry for commercialization outside Asia-Pacific. The repositioning explicitly addresses U.S. Biosecure Act concerns, with the company continuing to operate from San Jose under existing management led by CSO Rade Drmanac and a newly expanded board including former U.S. Ambassador Edward T. McMullen Jr.

Name

Complete Genomics

Legal name

Complete Genomics, Inc.

Website

https://completegenomics.com

Company type

Private

Founded year

2006

Operating status

Operating

Headcount range

251–500 employees

Short description

Complete Genomics is a U.S.-based (San Jose) genomic sequencing company that develops and sells the DNBSEQ DNA nanoball sequencing platform, Stereo-seq spatial transcriptomics, and lab automation products to academic, clinical, and service-provider customers globally, now under Swiss Rockets AG ownership.

Ownership category

akta.pro rank

Product category

DNA Sequencing Instruments and Genomics Platforms

NAICS

Analytical Laboratory Instrument Manufacturing (334516), Research and Development in Biotechnology (except Nanobiotechnology) (541714), Medical Laboratories (621511)

SIC

Laboratory Analytical Instruments (3826), Services-Commercial Physical & Biological Research (8731), In Vitro & In Vivo Diagnostic Substances (2835)

akta.pro primary industry

Molecular Biology & Genomics Instruments (PCR/qPCR, Sequencing, Microarrays) (HLAGAIAF)

akta.pro secondary industries

Transcriptomics & Gene Expression Profiling Services (HLAGANAE), Bioinformatics, Multi-Omics Data Analysis & Interpretation Services (HLAGANAI), Library & Diversity Generation Platforms (display libraries, DNA-encoded libraries for biologics, variant libraries) (HLAAAIAL)

Keywords

• DNA sequencing instruments
• Spatial transcriptomics
• Genomic analysis software
• Sequencing lab automation
• NGS consumables reagents

Headquarters

HQ city

Mountain View

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Technology or R&D, Personnel, Supply Chain, Operations, Marketing or Sales, Infrastructure

Revenue model

1. Sequencing Instruments: Sale of DNBSEQ sequencing platforms (G99, T1+, T7+) as capital equipment. Instruments priced at $800,000 for DNBSEQ-T7+ in US market. Represents core hardware revenue from direct sales to research institutions and labs.
2. Consumables and Reagents: Ongoing revenue from kits and reagents including extraction kits, library preparation kits, sequencing reagents, and flow cells required for DNBSEQ platform operation. Recurring revenue stream tied to instrument utilization.
3. Technology Licensing: Exclusive licensing of CoolMPS sequencing technology to Swiss Rockets AG for development and commercialization outside Asia-Pacific region. Includes expanded license and supply agreements.
4. Service Provider Network: Network of certified sequencing service providers offering DNBSEQ-based services. Providers include Gene by Gene, university cores, and commercial labs. Revenue through instrument sales to service providers and potentially reagent supply agreements.

Pricing tiers

Go-to-market motion1 record

Distribution channels4 records

Marketing channels6 records

Core offering

Complete Genomics develops and commercializes the DNBSEQ DNA sequencing platform based on DNA nanoball (DNB) and rolling circle replication chemistry, offering benchtop (G99), mid-throughput (T1+), and high-throughput (T7+) sequencers. The portfolio also includes Stereo-seq spatial transcriptomics, CoolMPS sequencing chemistry, the DNBSEQ-G400 FluoXpert multi-omics system, kits and reagents, bioinformatics software (MegaBOLT, ZTRON), and laboratory automation instruments, sold to research institutions, pharmaceutical companies, clinical research labs, and agrigenomics users.

Product overview

Complete Genomics is a genomic sequencing technology company offering a comprehensive portfolio of DNBSEQ sequencing platforms, spatial transcriptomics solutions, and laboratory automation products. The core product line includes three DNBSEQ sequencers (DNBSEQ-G99 benchtop, DNBSEQ-T1+ mid-throughput, and DNBSEQ-T7+ high-throughput) utilizing proprietary DNA nanoball technology with rolling circle replication. Spatial transcriptomics is enabled through Stereo-seq technology offering true single-cell resolution with multiple chip formats for fresh frozen and FFPE samples, complemented by the DNBSEQ-G400 FluoXpert multi-omics system. Laboratory automation includes sample management systems (STP-3000, STP-7000), nucleic acid extraction instruments (SP-NE32, SP-NE384), and library preparation platforms (SP-Smart8, SP-100, SP-960). Supporting products include extraction and library preparation kits, bioinformatics software (MegaBOLT, ZTRON, SAW, StereoMap), and a global network of certified sequencing service providers. The company was acquired by Swiss Rockets AG in 2026 and offers over 40 compatible third-party products for DNA/RNA sequencing, single-cell analysis, exome sequencing, spatial transcriptomics, epigenetics, oncology, reproductive health, and transplant testing.

Differentiator

Problem solved

Functional benefit

Products and services

• DNBSEQ-T7+ High-Throughput Sequencer High-throughput DNBSEQ sequencing platform delivering 48 billion reads within 24 hours across four independent flow cells; processes 28,000+ whole genomes per year with Q40 per-base accuracy at $1 per gigabase or $100 per genome. Sold as capital equipment to large research institutions, pharmaceutical companies, and population-scale genomics programs in the U.S. and Canada.
• DNBSEQ-T1+ Mid-Throughput Sequencer Mid-throughput DNBSEQ Q40 sequencer delivering 25Gb to 1.2Tb output in under 24 hours. All-in-one platform compatible with SOPHiA GENETICS MSK-IMPACT and MSK-ACCESS assays for precision oncology testing. Targeted to clinical and translational labs running cancer genomic profiling, liquid biopsy, and solid tumor testing.
• DNBSEQ-G99 Benchtop Sequencer Benchtop DNBSEQ sequencer delivering up to 48 Gb in less than 12 hours with two independent flow cells that can run at any time. Targeted to smaller labs and clinical settings needing fast, flexible sequencing.
• DNBSEQ-G400 FluoXpert Multi-Omics System Multi-omics system combining genomics, transcriptomics, and proteomics in one instrument; integrates multiplex immunofluorescence staining (up to 24 protein targets) with sequencing capability delivering up to 1440 Gb per run. Targeted to labs requiring combined genomic and proteomic profiling on a single platform.
• Stereo-seq Transcriptomics (FF) Spatial transcriptomics solution for fresh frozen (FF) tissues achieving true single-cell resolution with 0.22 µm spot diameter and 0.5 µm center-to-center distance, supporting capture areas up to 13 cm x 13 cm. Targeted to academic and translational researchers needing high-resolution spatial gene expression profiling.
• Stereo-seq Transcriptomics Large Chip Design (LCD) Ultra-wide spatial profiling solution for large tissues and whole organs. Available in 1 cm x 2 cm, 2 cm x 2 cm, and 2 cm x 3 cm chip sizes for centimeter-scale tissue sections at single-cell resolution. Targeted to researchers profiling whole organs or large tissue sections.
• Stereo-seq OMNI (FFPE) Spatial Transcriptomics Spatial transcriptomics solution for formalin-fixed paraffin-embedded (FFPE) tissue samples enabling whole-transcriptome analysis from archived clinical specimens. Targeted to clinical researchers and translational studies using biobanked FFPE tissues.
• DNA/RNA Extraction Kits Comprehensive range of DNA and RNA extraction kits (genomic DNA, microbial DNA, RNA, viral DNA/RNA) using superparamagnetic bead technology. Compatible with Complete Genomics SP-NE32, SP-NE384, SP-Smart8, SP-100, and SP-960 automation platforms. Sold as recurring consumables to labs running DNBSEQ workflows.
• Library Preparation Kits Automation-friendly library preparation kits including DNBSEQ Fast PCR-FREE FS Library Prep Set V2.0, Fast FS Library Prep Set, Fast RNA Library Prep Set, and Library Conversion Kits for third-party kit compatibility. Sold as recurring consumables to DNBSEQ platform users.
• MegaBOLT Bioinformatics Workstation Bioinformatics accelerator workstation/server for fast secondary analysis of DNBSEQ sequencing data, designed to speed up alignment and variant calling workflows. Sold to labs running high-throughput DNBSEQ production pipelines.
• ZTRON Lite and Pro Data Management and Analysis Platform Integrated hardware and software solutions for sequencing data management and bioinformatics analysis, available in Lite and Pro configurations. Targeted to labs requiring integrated storage, management, and analysis of DNBSEQ data.
• Go Optical STOmics Microscope STOmics microscope designed specifically for Stereo-seq spatial transcriptomics workflows with 12-megapixel resolution imaging, motorized XY travel of 100 mm x 70 mm, and auto-focus capability scanning 10 mm x 10 mm chips in under 70 seconds. Targeted to Stereo-seq users needing high-resolution tissue imaging.
• STP-3000 Automated Sample Management System Automated sample accessioning system that transfers 96 samples from sealed collection tubes to 96-well microplates in 40 minutes with automatic de/re-capping. Targeted to labs needing standardized sample intake for DNBSEQ workflows.
• STP-7000 High-Throughput Sample Management System Highest-throughput automated liquid sample transfer system with freestanding, fully enclosed, HEPA-filtered design for processing large sample volumes. Targeted to production-scale genomics labs.
• SP-NE32 Nucleic Acid Extraction System Nucleic acid extraction system processing 32 samples per run for DNA and RNA extraction from blood, tissue, and microbial samples. Targeted to small-to-mid-sized genomics labs.
• SP-NE384 High-Throughput Nucleic Acid Extraction System High-throughput nucleic acid extraction system processing 384 samples for genomic DNA, microbial DNA, and viral nucleic acid extraction. Targeted to production-scale genomics and clinical labs.
• SP-Smart8 Benchtop Library Preparation System Compact benchtop library preparation system supporting 8 samples for automated NGS library preparation. Targeted to small labs needing standardized library prep.
• SP-100 Mid-Throughput Library Preparation System Mid-throughput automated library preparation system processing 8–32 samples per run with 40–80 minute assay times. Targeted to mid-sized genomics labs.
• SP-960 High-Throughput Library Preparation System High-throughput automated library preparation system processing 192 samples per 60 minutes for large-scale sequencing projects. Targeted to production genomics labs.
• PanVariants AI-Driven Variant Calling Framework Open-source AI-driven variant calling framework for DNBSEQ sequencing data demonstrating up to 73% reduction in genome analysis errors versus standard industry pipelines, available across T1+, T7, and T7+ platforms. Targeted to genomic researchers running secondary analysis on DNBSEQ data.
• Sequencing Service Provider Network Network of certified sequencing service providers offering access to DNBSEQ platforms including Gene by Gene, University of Colorado Cancer Center Genomics Shared Resource, Northwestern NUSeq Core Facility, Praxis Genomics, Psomagen, UCSD Center for Microbiome Innovation, UCLA TCGB, Vancouver Prostate Centre, and others. Enables researchers without capital equipment to access DNBSEQ sequencing services.
• Spatial Certified Service Provider Network Certified service providers trained on Stereo-seq and DNBSEQ spatial workflows including Gene by Gene, Admera Health, Clemson University, UCSD CMI, UNC Chapel Hill HTSF, UCLA TCGB, and Vancouver Prostate Centre. Provides researchers with outsourced access to spatial transcriptomics services.

Quantifiable outcome

• 73% reduction in genome analysis errors using PanVariants AI-trained models versus standard pipelines
• +6 more outcomes

Named customers8 records

Segments5 records

Ideal customer profiles6 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration38 records

AI capability9 records

Feature6 records

Partnerships

Eight partnerships are on record, tiered core and major.

• SOPHiA GENETICScoreTechnology or Integration · 11 November 2025Collaboration to integrate SOPHiA GENETICS' MSK-IMPACT and MSK-ACCESS assays (developed with Memorial Sloan Kettering Cancer Center) with Complete Genomics' DNBSEQ-T1+ sequencing platform. Provides laboratories with end-to-end sample-to-report workflow for liquid biopsy and solid tumor testing. Joint evaluations demonstrated concordant variant calls with lower background noise and reduced turnaround times.
• MGI TechcoreTechnology or Integration · 29 October 2025Exclusive licensing agreement for CoolMPS sequencing technology from MGI Tech to Swiss Rockets AG and Complete Genomics for development and commercialization outside Asia-Pacific and Greater China. Covers USA, Europe, Latam, Africa, and Central Asia regions with option to expand into Asia-Pacific.
• Mayo ClinicmajorStrategic or Co-development Partner · 14 October 2025Strategic partnership announced at ASHG 2025 for collaborative development and research initiatives.
• Bio-RadmajorTechnology or Integration · 14 October 2025Partnership announced at ASHG 2025 for integration of Bio-Rad products with Complete Genomics sequencing platforms.
• STOmicscoreTechnology or Integration · 14 October 2025STOmics provides Stereo-seq spatial transcriptomics products including Transcriptomics kits, Go Optical microscope, and certified service provider program for spatial solutions.
• Gene by GenecoreChannel Partner/ Reseller/ Distributor · 13 October 2025Gene by Gene announced as Complete Genomics' newest sequencing service provider at ASHG 2025, offering WGS and consulting services using DNBSEQ-G400 and DNBSEQ-T7 platforms.
• VelseramajorTechnology or Integration · 28 April 2025Partnership to integrate sequencing and analysis platforms for enhanced clinical genomics workflows.
• Human Cell AtlasmajorStrategic or Co-development Partner · 25 March 2025Commercial partnership to offer Human Cell Atlas members access to Stereo-seq spatial transcriptomics technology at NextGen Omics & Spatial Biology Conference.

Scale indicators5 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• Illumina: Dominant NGS sequencing platform provider with the broadest installed base and reagent ecosystem. Direct competitor across short-read sequencing applications where Complete Genomics competes on cost-per-genome and accuracy.
• Oxford Nanopore Technologies: Nanopore-based long-read sequencing competitor. Competes in applications requiring long-read data; Complete Genomics' cWGS phasing solution is positioned against Oxford Nanopore's traditional strengths.
• Pacific Biosciences: Long-read sequencing platform provider (PacBio Revio, Onso). Competes at the high-accuracy end of sequencing and complements Complete Genomics' phased WGS offering with DNBSEQ Complete WGS.
• MGI Tech: China-based developer of DNBSEQ sequencing technology and Complete Genomics' former parent. Closest technical peer given shared DNA nanoball technology base, though now operates as a licensor/supplier relationship.

Emerging players

• Ultima Genomics: High-throughput low-cost sequencing competitor pursuing a similar $100/genome cost target. Most direct head-to-head on population-scale sequencing economics where Complete Genomics positions the T7+.
• Element Biosciences: Challenger sequencing platform (AVITI) targeting the mid-throughput segment with competing chemistry. Direct head-to-head competitor with DNBSEQ-T1+ for benchtop and clinical research customers.
• Singular Genomics: Multi-omics sequencing platform (G4) competing in the benchtop/mid-throughput segment. Targets similar academic and clinical research customers as Complete Genomics' lower-throughput instruments.
• 10x Genomics: Single-cell and spatial biology platform with overlapping spatial transcriptomics territory through Visium HD/Xenium. Competes with Stereo-seq for spatial omics research dollars while also integrating as a compatible upstream for DNBSEQ.

Regional players

• BGI Genomics: China-based genomic services and sequencing platform provider, co-targeted with Complete Genomics under the Biosecure Act. Comparable DNBSEQ-based service offering but primarily operates in Asia-Pacific rather than competing directly in US markets.

Broad incumbents

• Thermo Fisher Scientific (Ion Torrent): Diversified life sciences tools giant offering Ion Torrent semiconductor sequencing alongside broader analytical instruments and reagents. Competes in mid-throughput sequencing segments relevant to DNBSEQ-T1+ positioning.

Market position

Strengths5 records

Weaknesses4 records

Competitive moat6 records

Key risks5 records

Key highlights7 records

Customer concentration

• LinkedInlinkedin.com/company/complete-genomics-inc.
• Xx.com/CompleteGenomic
• Facebookfacebook.com/171211069602027

Revenue estimate

Valuation estimate

Number of profiles

Profiles3 records

Funding overview

Funding rounds6 records

Investors7 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Complete Genomics