What Corticale does

Corticale is an Italian neurotechnology company developing high-density CMOS-based neural probe systems for neuroscience research and brain-computer interface (BCI) applications. The company's core technology, SiNAPS (Signals Neural Active Pixel Sensor), comprises patented active-pixel-sensor CMOS probes capable of simultaneous recording from up to 1,024 independent electrodes per probe, with 14×14 μm electrode sites at 30 μm pitch, on-shank time-division multiplexing, and full-band sampling (0.1 Hz–5 kHz at 20 kHz). Probe configurations span 256 to 1,024 channels in single- and multi-shank formats, available in acute and chronic variants, with a patented wireless UWB data link capable of 600 Mbit/s transmission and bidirectional (recording + stimulation) functionality.

Corticale sells an integrated ecosystem: SiNAPS probes, the Corti-Q acquisition system (up to 1,024 channels at 20 kHz with 16 digital input ports), Corti-V real-time visualization software, and Corti-X analysis software featuring integrated Kilosort spike sorting, GPU acceleration, atlas brain mapping, and NWB export. Revenue is generated through hardware sales (probes and acquisition systems), software licenses (one-time), and professional services (installation, setup, and ongoing technical/scientific support). Go-to-market combines direct enterprise sales with channel distribution through Plexon, Neuronexus, and Atlas Neuro.

The customer base is concentrated in academic neuroscience research, with named end users at NYU Neuroscience Institute (György Buzsáki), DZNE Germany (Hayder Amin), and Newcastle University (Stuart Baker). The company is headquartered in Genoa, Italy, with a Milan branch office, 1–10 employees, €177,000 share capital as an Italian SRL, and an explicit forward-looking positioning toward clinical BCI applications including motor and speech restoration.

Name

Corticale

Legal name

Corticale SRL

Website

https://corticale.com

Company type

Private

Founded year

2019

Operating status

Operating

Headcount range

1–10 employees

Short description

Corticale is an Italian neurotechnology company that develops high-density SiNAPS CMOS neural probes (up to 1,024 channels per probe) bundled with acquisition hardware and analysis software, sold to neuroscience research laboratories and brain-computer-interface developers worldwide through direct sales and neurotech distributors.

Ownership category

akta.pro rank

Product category

Brain-Computer Interface Hardware

NAICS

Electromedical and Electrotherapeutic Apparatus Manufacturing (334510), Instrument Manufacturing for Measuring and Testing Electricity and Electrical Signals (334515)

SIC

Electromedical & Electrotherapeutic Apparatus (3845), Instruments For Meas & Testing Of Electricity & Elec Signals (3825)

akta.pro primary industry

Implantable Neuromodulation & Neurostimulation (SCS/DBS/VNS/PNS) (HLAHAEAK)

akta.pro secondary industries

Neurological Monitoring (EEG, Seizure/Sleep/Neuro Wearables) (HLAHACAE), Test & Measurement Equipment (Oscilloscopes, DAQ, signal analyzers, calibration benches) (IMAGAFAC)

Keywords

• CMOS neural probes
• Brain-computer interfaces
• Intracortical implants
• Electrophysiology equipment
• Neural recording systems

Headquarters

HQ city

Genova

HQ country

Italy

HQ region

Europe

Offices2 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Technology or R&D, Operations, Marketing or Sales, Infrastructure

Revenue model

1. Hardware - SiNAPS Neural Probes: Sale of SiNAPS neural probe hardware including acute and chronic formats. Probes are available in multiple models (256 to 1024 channels) with various shank configurations.
2. Hardware - Corti-Q Acquisition System: Sale of Corti-Q high-performance acquisition system designed for SiNAPS probe compatibility with up to 1024 channels.
3. Software Licenses: Corti-V (real-time visualization) and Corti-X (data analysis) software solutions bundled with hardware ecosystem.
4. Technical Support Services: Comprehensive installation, setup, and ongoing technical/scientific support services including on-site or remote support during recordings, troubleshooting, and workflow optimization.

Go-to-market motion1 record

Distribution channels4 records

Marketing channels3 records

Core offering

Corticale designs, manufactures, and supports SiNAPS — a CMOS-based neural probe technology providing up to 1024 simultaneously recording electrodes per probe at 30 micrometer pitch for minimally invasive intracortical recording with single-cell resolution. The offering is delivered as an integrated hardware-and-software ecosystem: SiNAPS probes (available in acute and chronic formats with single- or multi-shank configurations ranging from 256 to 1024 channels), the Corti-Q dedicated acquisition hardware, Corti-V real-time visualization software, and Corti-X analysis software, complemented by installation, setup, and ongoing technical/scientific support services.

Product overview

Cortiale offers an integrated hardware and software ecosystem for high-density neural electrophysiology research. The core product is SiNAPS, a CMOS-based neural probe technology featuring up to 1024 simultaneously recording electrodes per probe with single-cell resolution. The ecosystem includes Corti-Q (dedicated acquisition hardware system), Corti-V (real-time visualization and monitoring software), and Corti-X (data analysis and exploration software with integrated spike sorting and brain mapping). The company also provides comprehensive support services including installation, setup, and ongoing technical consultation.

Differentiator

Problem solved

Functional benefit

Brands

• SiNAPS: High-density CMOS-based neural probes capable of simultaneous recording from up to 1024 electrodes with single-cell resolution
• Corti-Q
• Corti-V
• Corti-X

Products and services

• SiNAPS Neural Probes CMOS-based intracortical neural probes for neuroscience research with up to 1024 simultaneously recording electrodes per probe, micrometric-size neural sensors, low-noise amplification at each electrode site, on-shank time-division multiplexing, and modular single- or multi-shank configurations available in acute and chronic formats (256–1024 channels). Designed for minimally invasive implantation in research animals and for use as the sensing element in brain-computer interface systems.
• Corti-Q Acquisition System High-performance acquisition hardware system designed to fully harness SiNAPS probes. Records simultaneously from all available electrodes at 20 kHz and enables real-time synchronization with third-party experimental tools through up to 16 digital input ports. Provided as part of the SiNAPS ecosystem to research laboratories conducting electrophysiology experiments.
• Corti-V Real-Time Visualization Software Software interface providing real-time acquisition control and visualization of neural signals recorded with SiNAPS probes through Corti-Q. Provides full experimental control, live data insight, automatic quality feedback, free trace selection, online metrics, on-the-fly filtering, and real-time RMS histogram visualization for researchers running electrophysiology experiments.
• Corti-X Analysis Software Data exploration and analysis software environment for high-density neural data acquired with Corti-Q. Includes dataset navigation, feature extraction, integrated spike sorting (Kilosort-compatible), integrated atlas brain mapping, frequency analysis, GPU acceleration, and NWB format export. Provided to neuroscience researchers analyzing SiNAPS probe recordings.
• Technical and Scientific Support Services Professional services covering on-site or remote installation, setup, troubleshooting, workflow optimization, and ongoing technical/scientific support during recordings. Delivered to research laboratories and BCI development teams purchasing the SiNAPS hardware and software ecosystem.

Quantifiable outcome

• 1024 simultaneous recording channels per probe - highest density neural interface
• +4 more outcomes

Named customers3 records

Segments3 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration3 records

AI capability3 records

Feature8 records

Partnerships

Three partnerships are on record, tiered core.

• PlexoncoreChannel Partner/ Reseller/ DistributorPlexon is an authorized distributor of SiNAPS probes. As a leading neurotechnology company offering neural recording solutions, Plexon provides sales and distribution access to SiNAPS technology through their established customer network.
• NeuronexuscoreChannel Partner/ Reseller/ DistributorNeuronexus distributes SiNAPS probes as part of their electrode array product portfolio. The partnership extends market reach for Cortiale's high-density neural probes.
• Atlas NeurocoreChannel Partner/ Reseller/ DistributorAtlas Neuro distributes SiNAPS probes as neural exploration tools, expanding accessibility of Cortiale's technology to research laboratories worldwide.

Scale indicators10 records

Recent moves6 records

Expansion highlights6 records

Emerging players

• Atlas Neuro: Emerging neurotechnology company that both distributes SiNAPS probes and develops its own neural exploration tools. Partially overlaps with Corticale through distribution and through emerging competing offerings to the same research customer base.

Direct peers

• Neuralink: Direct competitor developing high-channel-count implantable brain-computer interfaces for clinical applications. While Neuralink focuses on fully wireless, high-bandwidth implants for human use, both companies compete in the same broad BCI category targeting motor/speech restoration with high-density electrode platforms.
• InBrain Neuroelectronics: European-based competitor developing graphene-based neural interfaces for both neurological disease treatment and BCI applications. Competes with Corticale in the European clinical neurotechnology space and on the high-resolution neural interface dimension.
• Synchron: Competitor in the clinical BCI space pursuing a vascular (stentrode) approach rather than intracortical probes. While the implant modality differs, Synchron competes directly for the same clinical BCI application market (motor restoration in paralyzed patients) and competes for strategic investor and partner attention.
• Blackrock Neurotech: Direct competitor in implantable high-channel-count neural recording arrays used for both neuroscience research and clinical BCI applications. Blackrock's Utah Array and NeuroPort system overlap directly with SiNAPS in target customers (research labs) and use cases (large-scale neural recording).
• Cambridge NeuroTech: Direct competitor producing high-density silicon multi-electrode arrays for neuroscience research. Cambridge NeuroTech's probes target the same electrophysiology research market as SiNAPS, with comparable chronic implant offerings for animal research.
• Paradromics: Direct competitor building high-data-rate intracortical neural probe technology with thousands of channels per device for both research and clinical BCI applications. Paradromics' Connexus platform competes head-to-head with SiNAPS on channel density and clinical BCI positioning.
• Plexon: Direct competitor and distribution partner. Plexon manufactures its own multi-channel neural recording systems and probes for research applications, while simultaneously distributing Corticale's SiNAPS probes — creating both product overlap and channel partnership dynamics.
• Neuronexus: Direct competitor that also serves as a distribution partner for SiNAPS. Neuronexus manufactures its own high-density silicon neural probes for research applications, creating both channel partnership and product overlap with Corticale's SiNAPS offering.

Broad incumbents

• Imec: Large established semiconductor R&D organization with a major neurotechnology program (including Neuropixels probes). Imec competes in the high-density neural probe space at greater scale and with deeper institutional backing, and represents a strategic competitor that could out-execute Corticale on probe manufacturing scale.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights6 records

Customer concentration

• LinkedInlinkedin.com/company/corticale-srl

Revenue estimate

Valuation estimate

Number of profiles

Profiles15 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Corticale