Bio-Gram
Bio-Gram Diagnostics GmbH, founded in 2019 in Worms, Germany, develops and manufactures automated smear staining systems (ColorJet Nano, JetStainer 60H, Etzel I) and proprietary alcohol-free JetDye-AF reagents. The company sells to clinical and microbiology diagnostic laboratories across 25+ countries via direct B2B sales, OEM partnerships, and international distributors.
- Company typePrivate
- Founded2019
- HeadquartersWorms, Germany
- Headcount11–50
- GTM typeB2B
- OfferingHardware or Manufacturing
What Bio-Gram does
Bio-Gram Diagnostics GmbH is a Germany-based in-vitro diagnostic (IVD) company founded in 2019 and headquartered in Worms, with integrated development and production facilities in Ludwigshafen am Rhein. The company develops and manufactures automated smear staining systems and sample preparation devices — notably the ColorJet Nano (up to 60 slides/hour), JetStainer 60H (up to 120 slides/hour), Etzel I automated blood smear creator and Alberich I vortex mixer — alongside a proprietary alcohol-free reagent portfolio branded JetDye-AF, FixOstar-Hema fixation, JetBuffer pH 6.8 and JaClean cleaning solution. Its core technical differentiator is Flow-Stream-Staining-Technology (FS²T), a precision stain-application method combined with Capillary Nanotechnology and a 'world's first' alcohol-free ready-to-use reagent line that eliminates fire hazards, toxic fumes and VOC emissions.
The company primarily serves clinical and microbiology diagnostic laboratories performing hematology, Gram staining and related smear workflows, with secondary exposure to point-of-care settings, histology labs and OEM/instrumentation partners seeking to embed Bio-Gram chemistry and modules. Customer pain points addressed include operator-dependent staining variability, safety hazards from alcohol-based reagents, environmental compliance, and throughput bottlenecks in manual workflows.
Bio-Gram generates revenue through four streams: capital sales of automated staining hardware, recurring consumable reagent sales (the razor-and-blade core), OEM/white-label licensing and supply agreements with medical device companies, and professional services including after-sales support. Distribution is hybrid: direct B2B enterprise sales combined with international channel partners across 25+ countries and OEM embedding partnerships. Pricing is quote-based and not publicly disclosed. The company is privately held by four managing directors (Petrit Blakaj, Dr. Bayram Cucu, Sebastian Kluth, Jörg Mayer) with no disclosed external institutional investors.
Bio-Gram firmographics
Firmographics- Name
- Bio-Gram
- Legal name
- Bio-Gram Diagnostics GmbH
- Website
- https://bio-gram.net
- Company type
- Private
- Founded year
- 2019
- Operating status
- Operating
- Headcount range
- 11–50 employees
- Short description
- Bio-Gram Diagnostics GmbH, founded in 2019 in Worms, Germany, develops and manufactures automated smear staining systems (ColorJet Nano, JetStainer 60H, Etzel I) and proprietary alcohol-free JetDye-AF reagents. The company sells to clinical and microbiology diagnostic laboratories across 25+ countries via direct B2B sales, OEM partnerships, and international distributors.
- Ownership category
- akta.pro rank
Bio-Gram industry classification
Industry- Product category
- In-Vitro Diagnostic Equipment
- NAICS
- In-Vitro Diagnostic Substance Manufacturing (325413), Analytical Laboratory Instrument Manufacturing (334516), Medical Equipment and Supplies Manufacturing (3391)
- SIC
- In Vitro & In Vivo Diagnostic Substances (2835), Laboratory Analytical Instruments (3826)
- akta.pro primary industry
- Clinical Chemistry & Hematology Diagnostics (automated analyzers, blood testing) (HLAAALAH)
- akta.pro secondary industries
- Microbiology & Infectious Disease Diagnostics (culture, rapid antigen, syndromic panels) (HLAAALAC), Reagents, Chemicals & Assay Kits (Buffers, Antibodies, ELISA, Enzymes) (HLAGAIAI), Biomarker Assay & Reagent Development (LDT/IVD assay design, antibodies/standards/controls) (HLAAAMAL)
Keywords
Where Bio-Gram is headquartered
LocationHeadquarters
- HQ city
- Worms
- HQ country
- Germany
- HQ region
- Europe
Offices2 records
Markets served
Bio-Gram business model
Business model- GTM type
- B2B
- Offering type
- Hardware or Manufacturing
- Cost components
- Personnel, Operations, Technology or R&D, Supply Chain, Marketing or Sales, Infrastructure
Revenue model
- Automated Staining Equipment Sales: Sale of automated smear staining systems including ColorJet Nano, JetStainer 60H, Etzel I, and Alberich I. Hardware systems are sold as benchtop units to laboratories and diagnostic centers with pricing based on system capabilities and throughput.
- Consumable Reagent Sales: Recurring revenue from JetDye-AF alcohol-free staining reagents including Gram Polychrome, Wright, Giemsa, Wright-Giemsa, May-Gruenwald, MGG, Methylene Blue variants, JetBuffer pH 6.8, and JaClean cleaning solution. Reagents are sold in catalog numbered formats (RG2209012, etc.) for use with Bio-Gram automated systems.
- OEM/White-label Partnerships: B2B OEM partnerships where Bio-Gram provides diagnostic solutions for embedding or white-labeling by partner companies, generating licensing and supply revenue.
- Professional Services: Customer support, after-sales service, and technical support for system maintenance and troubleshooting, including dedicated support hotline.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Unit Pricing | Multi-year contract | Automated staining systems with varying throughput capacities |
| Unit Pricing | Pay-as-you-go | JetDye-AF reagent portfolio |
Go-to-market motion3 records
Distribution channels3 records
Marketing channels6 records
Bio-Gram product offering
Product offeringCore offering
Bio-Gram develops, manufactures, and sells in-vitro diagnostic solutions for smear staining and sample preparation, comprising automated staining systems (ColorJet Nano, JetStainer 60H), the Etzel I automated blood smear creator, the Alberich I vortex mixer, and a portfolio of proprietary alcohol-free JetDye-AF staining reagents, fixation solutions, buffers, and cleaning agents. All products are developed and produced in Germany and are sold to clinical laboratories, microbiology laboratories, histology labs, point-of-care settings, and OEM medical device partners.
Product overview
Bio-Gram provides a comprehensive ecosystem of in-vitro diagnostic solutions focused on smear staining and sample preparation, all proudly 'Made in Germany.' The portfolio centers on two automated staining systems—ColorJet Nano and JetStainer 60H—paired with Etzel I for automated blood smear creation and Alberich I vortex mixer. These instruments are designed to work with the company's proprietary JetDye-AF alcohol-free reagent line, which includes staining reagents (Gram Polychrome, Wright, Giemsa, Wright-Giemsa, May-Gruenwald, MGG, Methylene Blue), FixOstar-Hema fixation solution, JetBuffer pH 6.8, and JaClean cleaning solution. This integrated ecosystem delivers standardized, reproducible results while eliminating alcohol-based reagents for enhanced safety and environmental sustainability.
Differentiator
Problem solved
Functional benefit
Products and services
- ColorJet Nano Automated benchtop smear staining system that uses Bio-Gram's proprietary Flow-Stream-Staining-Technology (FS²T) to deliver precise, controlled, and uniform staining of up to 60 slides per hour, with a 7-inch touch display, six-slide simultaneous staining, and customizable protocols for clinical and microbiology laboratories.
- JetStainer 60H Compact standalone benchtop automated staining system that processes up to 120 slides per hour with a 4.3-inch touch display, built-in capacity sensors, and customizable staining protocols, delivering consistent, standardized results for high-throughput diagnostic laboratories.
- Etzel I Automated blood smear creation device that achieves reproducible, standardized smear quality through automatic control, with continuously adjustable speed and adaptable length and thickness settings for clinical hematology workflows.
- Alberich I Compact benchtop vortex mixer with an adjustable rotation speed range of 3000-4500 rpm, force-activated operation, minimalistic design, and compatibility with various container types for laboratory sample preparation.
- JetDye-AF Reagents Alcohol-free, ready-to-use staining reagent portfolio for hematological, microbiological, and histological smear staining, including Gram Polychrome, Wright, Giemsa, Wright-Giemsa, May-Gruenwald, MGG, and Methylene Blue variants, designed for use with Bio-Gram automated staining systems and to remove fire, fume, and VOC hazards from alcohol-based workflows.
- FixOstar - Hema Non-hazardous, alcohol-free fixation solution for hazard-free fixation of hematological samples, preserving cellular integrity as part of the JetDye-AF alcohol-free reagent portfolio.
- JetBuffer pH 6.8 Phosphate buffer solution (according to WEISE, pH 6.8) used as a rinsing agent for Wright, Giemsa, May-Gruenwald, and Pappenheim staining solutions within the Bio-Gram staining workflow.
- JaClean Alcohol-free cleaning solution for instruments and cuvettes, designed to clean the reagent tubing pathway of Bio-Gram staining machines by removing pigments, rough dirt, and fragments.
Quantifiable outcome
- Up to 60 slides processed per hour with ColorJet Nano, up to 120 slides per hour with JetStainer 60H
- +3 more outcomes
Companies that use Bio-Gram
Customer profileSegments5 records
Ideal customer profiles3 records
Bio-Gram technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Feature7 records
Bio-Gram partnerships and signals
Strategic signalPartnerships
Three partnerships are on record, tiered core and minor.
- B2B Partners (Unnamed)coreBio-Gram maintains active B2B partnerships with laboratories, diagnostic centers, and healthcare facilities globally. The company positions itself as a singular partner handling both development and production, offering unrivaled innovation and efficiency with uncompromising quality standards.
- OEM Partners (Unnamed)coreBio-Gram serves as a reliable B2B and OEM partner offering innovative diagnostic products at competitive prices. The company provides white-label and embedding opportunities for medical device companies seeking to integrate alcohol-free staining technology into their instrumentation platforms.
- International Distribution Partners (Unnamed)minorDistribution partnerships supporting Bio-Gram's presence in 25+ countries through regional reseller and distributor networks for laboratory equipment and reagent supplies.
Scale indicators5 records
Recent moves5 records
Expansion highlights5 records
Bio-Gram competitors and assessment
Company assessmentBroad incumbents
- Sysmex Corporation: Global leader in hematology analyzers with integrated slide-making and staining reagents; competes in the same clinical lab workflows Bio-Gram serves with ColorJet Nano and JetStainer 60H but offers broader hematology workcells.
- Beckman Coulter (Danaher): Major hematology analyzer and IVD reagent provider whose staining reagents and automated systems compete with Bio-Gram's JetDye-AF line; part of a much broader diagnostics portfolio owned by Danaher.
- Abbott Diagnostics: Global diagnostics incumbent offering hematology analyzers and staining reagents for clinical laboratories; overlaps with Bio-Gram in smear staining and sample preparation workflows across hospital and reference lab channels.
- Siemens Healthineers: Large diagnostics platform with hematology and laboratory automation solutions including slide staining, competing with Bio-Gram's benchtop staining systems in mid-to-high volume clinical labs.
- bioMérieux: Microbiology and infectious disease diagnostics leader with Gram staining reagents and instruments; directly comparable to Bio-Gram's microbiology lab offering around Gram Polychrome and alcohol-free workflows.
- Merck KGaA / MilliporeSigma: Global life science tools and reagents supplier whose stains and chemicals portfolio competes with Bio-Gram's JetDye-AF reagent line; benefits from much broader catalog and global lab supply reach.
Direct peers
- Hardy Diagnostics: Manufacturer and distributor of microbiology stains, reagents, and prepared media; small-to-mid sized competitor to Bio-Gram in microbiology staining reagents and laboratory consumables.
- ELITechGroup: Specialized IVD company with a focused portfolio of hematology and microbiology staining reagents (e.g., Aerospray and Wescor cytocentrifuge systems); the closest mid-sized peer to Bio-Gram's reagent-and-instrument bundling approach.
- Medica Corporation: Smaller hematology analyzer maker (EasyCell, EasyLyte) serving small-to-mid volume clinical labs; similar size and customer profile to Bio-Gram and an alternative vendor in the same automated hematology staining workflow.
Others
- Hologic: Diversified diagnostics company with cytology and sample preparation products adjacent to Bio-Gram's histology and smear preparation offerings; not a direct competitor but operates in overlapping laboratory channels.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat4 records
Key risks6 records
Key highlights7 records
Customer concentration
Bio-Gram social profiles
Digital presenceBio-Gram financial estimates
Financial estimateRevenue estimate
Valuation estimate
Bio-Gram leadership team
Management profileNumber of profiles
Profiles4 records
Bio-Gram funding detail
Funding detailFunding overview
Funding rounds
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Bio-Gram M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Bio-Gram
What does Bio-Gram do?
Bio-Gram develops, manufactures, and sells in-vitro diagnostic solutions for smear staining and sample preparation, comprising automated staining systems (ColorJet Nano, JetStainer 60H), the Etzel I automated blood smear creator, the Alberich I vortex mixer, and a portfolio of proprietary alcohol-free JetDye-AF staining reagents, fixation solutions, buffers, and cleaning agents. All products are developed and produced in Germany and are sold to clinical laboratories, microbiology laboratories, histology labs, point-of-care settings, and OEM medical device partners.
Is Bio-Gram a public or private company?
Bio-Gram is a private company. It is classified as founder individual operated bootstrapped and is currently operating.
When was Bio-Gram founded?
Bio-Gram was founded in 2019. It employs 11 to 50 people.
Where is Bio-Gram based?
Bio-Gram is headquartered in Worms, Germany, in the Europe region.
How does Bio-Gram make money?
Four revenue lines are on record. Automated Staining Equipment Sales are the primary driver. The others are consumable Reagent Sales, OEM/White-label Partnerships and professional Services.
Who are Bio-Gram's main competitors?
Broad incumbents on record are Sysmex Corporation, Beckman Coulter (Danaher), Abbott Diagnostics, Siemens Healthineers, bioMérieux and Merck KGaA / MilliporeSigma. Direct peers are Hardy Diagnostics, ELITechGroup and Medica Corporation. Hologic is listed as an others.
Does Bio-Gram have an API?
No public API is recorded for Bio-Gram.
What industry is Bio-Gram in?
Bio-Gram's product category is In-Vitro Diagnostic Equipment. Its primary akta.pro industry code is HLAAALAH, Clinical Chemistry & Hematology Diagnostics (automated analyzers, blood testing), with a secondary code of HLAAALAC, Microbiology & Infectious Disease Diagnostics (culture, rapid antigen, syndromic panels). Its NAICS code is 325413 and its SIC code is 2835.