What Hooke Laboratories does

Hooke Laboratories, LLC is a privately held preclinical contract research organization (CRO) and research products company founded in 2007 in Lawrence, Massachusetts, with a planned relocation to Salem, New Hampshire in Q1 2027. The company specializes in rodent models of inflammation and autoimmunity, offering both catalog products and full-service research capabilities to pharmaceutical, biotechnology, and academic customers worldwide.

The company's core product line is the Hooke Kit™ family of pre-filled emulsion kits used to induce disease models in rodents — principally experimental autoimmune encephalomyelitis (EAE) for multiple sclerosis research, collagen-induced arthritis (CIA) for rheumatoid arthritis research, and general immunization kits — alongside a catalog of biological specimens (tissue, cells, and serum) harvested from animals at defined disease stages. These products are differentiated by proprietary pre-characterization and lot-to-lot potency adjustment that delivers 90-100% disease incidence in EAE. Complementing the product business, Hooke operates as a full-service CRO running in vivo efficacy studies, histology/IHC, RNA-seq and scRNA-seq, bioinformatics, flow cytometry, and short-term assays including TDAR, PK, MTD, and PCA. The company claims customers include 8 of the top 10 and 15 of the top 20 international pharmaceutical companies, plus venture-funded biotechs and academic institutions.

Hooke generates revenue through two streams: catalog product sales priced on a per-kit/per-unit basis (EAE kits $296-$2,212, CIA kits $360-$453, tissue products $114-$758) and quote-based CRO service contracts. Distribution is direct to most countries, with free samples available for evaluation. Pricing follows standard Net 30 terms with a 1.5% per month late fee. The go-to-market relies on scientific reputation, a content-rich website with published protocol references, and academic collaboration rather than traditional marketing spend. Founder-led since inception with no layoffs in 18 years, Hooke has remained private and organically financed, owning trademarks for Hooke Kit™ and Hooke Control Kits™ product lines.

Name

Hooke Laboratories

Legal name

Hooke Laboratories, LLC

Website

https://hookelabs.com

Company type

Private

Founded year

2007

Operating status

Operating

Headcount range

11–50 employees

Short description

Hooke Laboratories is a privately held preclinical CRO and research products company specializing in rodent models of inflammation and autoimmunity, serving 8 of the top 10 international pharmas, biotechs, and academic institutions with proprietary Hooke Kit™ emulsion products and full-service contract research.

Ownership category

akta.pro rank

Product category

Preclinical Contract Research Services

NAICS

Scientific Research and Development Services (5417)

SIC

Services-Commercial Physical & Biological Research (8731), Services-Medical Laboratories (8071)

akta.pro primary industry

Preclinical CROs (Discovery/Pharmacology/DMPK) (HLAGAAAB)

akta.pro secondary industries

Toxicology & Safety Assessment CROs (GLP) (HLAGAAAC), Bioanalytical & Biomarker CROs (PK/PD/Immunogenicity) (HLAGAAAD)

Keywords

• Preclinical CRO services
• Rodent inflammation models
• Autoimmune disease research
• Research reagent kits
• Pharmaceutical contract research

Headquarters

HQ city

Lawrence

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Operations, Supply Chain, Technology or R&D, Infrastructure, Marketing or Sales

Revenue model

1. Product Sales: Sale of Hooke Emulsion Kits™, tissue products, serum, cells, antigens, and control kits. Products are sold directly to customers for use in their own laboratories.
2. Contract Research Services: Full-service preclinical CRO services including in vivo efficacy studies, histology, IHC, multiplex immunofluorescence, RNA-seq, scRNA-seq, bioinformatics, cytokine analysis, and flow cytometry services.

Pricing tiers

Go-to-market motion1 record

Distribution channels2 records

Marketing channels4 records

Core offering

Hooke Laboratories is a preclinical contract research organization (CRO) that sells proprietary Hooke Kit™ emulsion products (EAE, CIA, immunization, control kits) in pre-filled syringes, along with disease-model tissues, cells, serum, and antigens. Complementing these products, Hooke provides full-service preclinical CRO studies in rodent models of inflammation and autoimmunity, including disease model execution, histology/IHC, and short-term assays (TDAR, PK, MTD, PCA, DTH), serving pharmaceutical companies, biotechs, and academic institutions.

Product overview

Hooke Laboratories is a preclinical CRO and laboratory products company offering a unified portfolio of research tools for immunological and autoimmune disease research. The core offerings consist of Hooke Kit™ emulsion products (EAE induction kits for multiple sclerosis models, CIA induction kits for rheumatoid arthritis models, and general immunization kits) delivered in pre-filled syringes, along with a comprehensive catalog of biological specimens (tissue, cells, and serum from disease model and control mice). These kit products are complemented by Contract Research Organization services including disease model studies (EAE, CIA, colitis, diabetes, atopic dermatitis, psoriasis, SLE, Sjögren's syndrome), histology and pathology services, and specialized assays (TDAR, PK, MTD, DTH, PCA). The portfolio is designed to serve researchers conducting preclinical drug efficacy and immunotoxicity studies.

Differentiator

Problem solved

Functional benefit

Products and services

• EAE Induction Hooke Kits™ Pre-filled syringe emulsions for inducing experimental autoimmune encephalomyelitis (EAE) in rodents as models for multiple sclerosis. Includes MOG35-55, MOG1-125, PLP139-151, and gpMBP69-88 antigen formulations with optional pertussis toxin. For preclinical researchers in pharma, biotech, and academia.
• CIA Induction Hooke Kits™ Collagen-induced arthritis (CIA) emulsion kits for inducing rheumatoid arthritis models in DBA/1 mice, available with chicken or bovine collagen in CFA or IFA. For preclinical arthritis researchers.
• Immunization Hooke Kits™ General immunization emulsion kits for antibody production and T cell response studies, including MOG35-55/CFA, PLP139-151/CFA, MBP1-17/CFA, OVA323-339/CFA, mBSA/CFA, and Ovalbumin emulsions. For immunology researchers.
• Hooke Control Kits™ Control emulsions for use with corresponding induction and immunization kits, containing adjuvant only without antigen. For preclinical researchers using Hooke induction kits.
• Tissue From Mice With CIA Snap frozen hind paw, spleen, and serum from DBA/1 mice at various stages of collagen-induced arthritis (24-48 hours, 4-5 days, or 2-3 weeks after disease onset). For arthritis researchers.
• Serum From Mice With CIA Serum from DBA/1 mice with collagen-induced arthritis, collected 20+ days after CIA onset, available with chicken or bovine collagen antigens. For arthritis researchers.
• Tissue and Cells From Mice With EAE Snap frozen spleen and spinal cord tissue from C57BL/6 and SJL mice at various EAE disease stages (onset, peak, recovery, relapse), plus fresh spleen and lymph node cells from MOG or PLP-immunized mice. For multiple sclerosis researchers.
• Tissue From Mice With SLE Kidney, half spleen, blood, and serum from (NZB x NZW)F1 hybrid and MRL/lpr mice with systemic lupus erythematosus, at various disease stages. For lupus researchers.
• Serum From Immunized Mice Serum from mice immunized with various antigens (MOG35-55, MOG1-125, Ovalbumin, mBSA) collected at specified time points post-immunization. For immunology researchers.
• Control and Naive Tissue, Cells, and Serum Snap frozen tissue, fresh cells, and serum from control mice (immunized with adjuvant only) and naive (unimmunized) mice for use as experimental controls. For preclinical researchers.
• Antigens in Solution Peptide antigens dissolved in PBS or tissue culture media for in vitro restimulation of antigen-specific T cells, including MOG35-55, PLP139-151, MBP1-17, OVA323-339, and mBSA. For immunology researchers.
• Preclinical CRO Services Full-service preclinical CRO specializing in rodent models of inflammation and autoimmunity, including disease models (EAE, CIA, colitis, diabetes, GvHD, atopic dermatitis, psoriasis, SLE, Sjögren's), histology services, and short-term assays (TDAR, PK, MTD, DTH, PCA). For pharmaceutical and biotech drug development teams.

Quantifiable outcome

• 90-100% disease incidence in EAE models
• +3 more outcomes

Named customers3 records

Segments3 records

Ideal customer profiles3 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature2 records

Scale indicators2 records

Recent moves5 records

Expansion highlights4 records

Direct peers

• Psychogenics: Specialty preclinical CRO running rodent in vivo disease models and behavioral/immunological phenotyping. Direct competitor for sponsor autoimmune and CNS efficacy work, with a similar scientific-expertise-led value proposition rather than scale-led.
• Inotiv: Preclinical CRO with rodent model services, surgical models, and research products. Overlaps directly with Hooke on rodent in vivo study execution and on consumables/reagents sold into academic and pharma labs.
• Jackson Laboratory: Non-profit rodent-genetics and disease-model organization selling mouse models, services, and training. Comparable to Hooke's academic-facing customer base and to its rodent-model expertise, though JAX spans many disease areas rather than specializing in autoimmunity.

Broad incumbents

• Charles River Laboratories: Largest preclinical CRO globally, offering rodent and large-animal efficacy, safety, and discovery services. Competes with Hooke for autoimmune disease-model RFPs and offers a much broader portfolio that sponsors may prefer for integrated programs.
• Cell Signaling Technology: Antibodies and immunoassay reagents company used widely in autoimmune and inflammation research. Comparable on the research-reagent product side and competes for the same lab reagent budget as Hooke's kits and tissue/cell products.
• Bio-Techne: Major life-science reagents company (R&D Systems, Tocris, etc.) selling proteins, antibodies, and immunoassay kits. Comparable on the products side — immunology reagents sold to academic and pharma labs that may use Hooke kits — though Bio-Techne is a broad incumbent across many research areas.
• Labcorp Drug Development (previously Covance): Global CRO with extensive preclinical and clinical capabilities. Competes on full-service preclinical packages; relevant benchmark for sponsor outsourcing decisions that include autoimmune efficacy work.

Emerging players

• Bionova Scientific: Specialty preclinical CRO offering rodent efficacy, immunology, and analytical services. Comparable specialty-positioning to Hooke — small, expertise-led — competing for outsourced autoimmune and inflammation preclinical studies.
• Pharmaron: Preclinical CRO with in vivo pharmacology and immunology services, often used by biotech sponsors for outsourced rodent efficacy. Competes for outsourced autoimmune and inflammation studies, particularly from biotech customers.

Regional players

• Taconic Biosciences: Rodent model supplier and breeding services provider with overlap in supporting autoimmune research (e.g., NOD, MRL/lpr, SJL lines). Comparable on the rodent-model ecosystem side rather than direct CRO services.

Market position

Strengths4 records

Weaknesses4 records

Competitive moat4 records

Key risks5 records

Key highlights7 records

Customer concentration

Revenue estimate

Valuation estimate

Number of profiles

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Hooke Laboratories